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2. 发明公开

EP2119457A1 Method of magnetic resonance investigation with hyperpolarised contrast agents 有权
标题翻译： Verfahren zur Herstellung eines hyperpolarisierten Kontrastmittels
公开(公告)号：EP2119457A1
公开(公告)日：2009-11-18
申请号：EP09009608.2
申请日：1998-12-23
申请人： GE Healthcare AS
发明人： Ardenkjaer-Larsen, Jan Henrik , Axelsson, Oskar , Golman, Klaes , Hansson, Georg , Leunbach, Ib , Petersson, Stefan , Wistrand, Lars-Göran
IPC分类号： A61K49/06 , A61K49/08 , G01R33/28 , G01R33/62
CPC分类号： G01R33/5601 , A61K49/08 , A61K49/10 , A61K49/18 , A61K49/1815 , G01R33/282 , G01R33/62
摘要： This invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising:
(i) producing a hyperpolarised solution of a high T 1 agent by dissolving in a physiologically tolerable solvent a hyperpolarised solid sample of said high T 1 agent;
(ii) where the hyperpolarisation of the solid sample of said high T 1 agent in step (i) is effected by means of a polarising agent, optionally separating the whole, substantially the whole, or a portion of said polarising agent from said high T 1 agent;
(iii) administering said hyperpolarised solution to said sample;
(iv) exposing said sample to a second radiation of a frequency selected to excite nuclear spin transitions in selected nuclei eg the MR imaging nuclei of the high T 1 agent;
(v) detecting magnetic resonance signals from said sample; and
(vi) optionally, generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (eg. pH, pO 2 , pCO 2 , temperature or ionic concentrations) or metabolic data from said detected signals,

wherein said high T 1 agent in said hyperpolarised solution has a T 1 value (at a field strength in the range 0.01-5T and a temperature in the range 20-40°C) of at least 5 seconds.
摘要翻译：本发明提供了一种样品，优选人或非人动物体的磁共振研究方法，所述方法包括：（i）通过将高T 1试剂溶解在生理上可耐受的溶剂中制成超极化溶液所述高T 1试剂的固体样品; （ii）其中步骤（i）中所述高T 1试剂的固体样品的超极化是通过偏振剂进行的，任选地从所述高T分离整个，基本上全部或部分所述偏振剂 1代理; （iii）将所述超极化溶液施用于所述样品; （iv）将所述样品暴露于所选频率的第二辐射，以激发所选择的核中的核自旋跃迁，例如高T 1试剂的MR成像核; （v）检测来自所述样品的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像，动态流动数据，扩散数据，灌注数据，生理数据（例如pH，pO 2，pCO 2，温度或离子浓度）或代谢数据，其中所述高T 所述超极化溶液中的一种试剂具有至少5秒的T 1值（在0.011-5T的范围内的场强和20-40℃的温度）。

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