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1. 发明公开

EP3361252A1 PIVKA-II ASSAY METHOD AND METHOD FOR MANUFACTURING REAGENT OR KIT FOR PIVKA-II IMMUNOASSAY 审中-实审转让
公开(公告)号：EP3361252A1
公开(公告)日：2018-08-15
申请号：EP16853698.5
申请日：2016-10-06
申请人： Fujirebio Inc. , Sekisui Medical Co., Ltd.
发明人： KITAMURA, Yoshiyuki , AOYAGI, Katsumi
IPC分类号： G01N33/53 , C07K16/36 , C07K16/40 , C12N15/02 , C12P21/08
CPC分类号： G01N33/573 , C07K16/36 , C07K16/40 , C12N15/02 , G01N33/53 , G01N2333/96433
摘要： Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.

2. 发明公开

EP3511713A1 TUMOR MARKER MEASUREMENT METHOD AND MEASUREMENT REAGENT 有权
公开(公告)号：EP3511713A1
公开(公告)日：2019-07-17
申请号：EP17848733.6
申请日：2017-09-05
申请人： Fujirebio Inc.
发明人： YAMAMOTO, Kosuke , KITAMURA, Yoshiyuki , YAGI, Shintaro , AOYAGI, Katsumi
IPC分类号： G01N33/574 , G01N33/531
摘要： A measurement method and a measurement reagent which can reduce, in measurement of a tumor marker in a biological sample, occurrence of falsely low values due to the influence of autoantibody or the like, and falsely high values due to the influence of HAMA or the like, thereby enabling more accurate measurement, are disclosed. The measurement method for a tumor marker, wherein the tumor marker in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of a tumor marker includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

3. 发明公开

EP3511712A1 METHOD AND REAGENT FOR MEASURING THYROGLOBULIN 有权
公开(公告)号：EP3511712A1
公开(公告)日：2019-07-17
申请号：EP17848732.8
申请日：2017-09-05
申请人： Fujirebio Inc.
发明人： YAMAMOTO, Kosuke , KITAMURA, Yoshiyuki , YAGI, Shintaro , AOYAGI, Katsumi
IPC分类号： G01N33/53
摘要： A measurement method and a measurement reagent for thyroglobulin, which enable measurement of a more accurate amount of thyroglobulin by a single test without being influenced by interference of anti-thyroglobulin antibody, are disclosed. The measurement method for thyroglobulin, wherein thyroglobulin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of thyroglobulin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

4. 发明公开

EP3929584A1 METHOD FOR MEASURING THYROGLOBULIN 审中-实审转让
公开(公告)号：EP3929584A1
公开(公告)日：2021-12-29
申请号：EP21187667.7
申请日：2017-09-05
申请人： Fujirebio Inc.
发明人： YAMAMOTO, Kosuke , KITAMURA, Yoshiyuki , YAGI, Shintaro , AOYAGI, Katsumi
IPC分类号： G01N33/53 , G01N33/78 , G01N33/84
摘要： A measurement method and a measurement reagent for thyroglobulin, which enable measurement of a more accurate amount of thyroglobulin by a single test without being influenced by interference of anti-thyroglobulin antibody, are disclosed. The measurement method for thyroglobulin, wherein thyroglobulin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of thyroglobulin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

5. 发明公开

EP3514539A1 CARDIAC TROPONIN ASSAY METHOD AND ASSAY REAGENT 审中-实审转让
公开(公告)号：EP3514539A1
公开(公告)日：2019-07-24
申请号：EP17850867.7
申请日：2017-09-12
申请人： Fujirebio Inc.
发明人： SAKAKI, Mizuho , KITAMURA, Yoshiyuki , YAGI, Shintaro , AOYAGI, Katsumi
IPC分类号： G01N33/53
摘要： A measurement method and a measurement reagent for cardiac troponin which enable accurate measurement of the amount of cardiac troponin contained in a sample irrespective of the type of the sample and the presence or absence of other components are disclosed. The measurement method for cardiac troponin, wherein cardiac troponin in a sample separated from a body is measured by an immunoassay, includes a pretreatment step of mixing the sample separated from a body with a pretreatment liquid containing one or both of a surfactant and an acidifier. The reagent for immunoassay of cardiac troponin includes a pretreatment liquid containing one or both of a surfactant and an acidifier.

6. 发明公开

EP3315966A1 STANDARD THYROID GLAND HORMONE SOLUTION 审中-公开
标题翻译：标准的甲状腺激素解决方案
公开(公告)号：EP3315966A1
公开(公告)日：2018-05-02
申请号：EP16817859.8
申请日：2016-06-27
申请人： Fujirebio Inc.
发明人： IBANEZ, Yukina , UMEDA, Kazuyuki , KITAMURA, Yoshiyuki
IPC分类号： G01N33/50
CPC分类号： G01N33/50 , G01N33/96
摘要： Disclosed are a standard solution of a thyroid hormone which is easily adjusted from lot to lot for consistent performance and a method of preparing a standard curve in an immunoassay using the same. The standard solution of a thyroid hormone contains the thyroid hormones and a cyclodextrin or a derivative thereof in a buffer solution. The method of generating a standard curve includes: preparing a plurality of standard solutions of a thyroid hormone containing the thyroid hormone at different known concentrations and a cyclodextrin or a derivative thereof in a buffer solution; and subjecting each standard solution of the thyroid hormone to the immunoassay to prepare a standard curve based on the relationship between the concentration of the thyroid hormone contained in each standard solution of the thyroid hormone and the signal in the immunoassay.
摘要翻译：公开了一种标准的甲状腺激素溶液，其可以容易地根据批次的不同进行调整以获得一致的性能，并且提供了使用该标准溶液在免疫测定中制备标准曲线的方法。甲状腺激素的标准溶液在缓冲溶液中含有甲状腺激素和环糊精或其衍生物。产生标准曲线的方法包括：制备多种含有不同已知浓度的甲状腺激素和环糊精或其衍生物的甲状腺激素在缓冲溶液中的标准溶液; 并根据甲状腺激素各标准溶液中所含的甲状腺激素浓度与免疫测定中的信号之间的关系制备标准曲线以制备甲状腺激素的每种标准溶液进行免疫测定。

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