专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP0394991B1 1-Azabicyclo(3.2.0)Hept-2-Ene-2-carboxylic acid compounds 失效
标题翻译：的1-氮杂双环（3.2.0）庚-2-烯-2-羧酸的化合物。
公开(公告)号：EP0394991B1
公开(公告)日：1994-08-17
申请号：EP90107824.6
申请日：1990-04-25
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Murata, Masayoshi , Chiba, Toshiyuki , Tsutsumi, Hideo , Hattori, Kohji , Kuroda, Satoru , Ohtake, Hiroaki , Shirai, Fumiyuki
IPC分类号： C07D477/00 , C07D519/00 , C07F7/18 , A61K31/40 , C07F9/568
CPC分类号： C07D477/14 , C07F7/186 , Y02P20/55

2. 发明公开

EP0304019A3 Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) 失效
标题翻译：新型结晶7-（2-（2-氨基苯甲酰基-4-基）-2-羟基亚氨基乙酰胺基）-3-乙烯基-3-甲基-4-羧酸（SYN异构体）
公开(公告)号：EP0304019A3
公开(公告)日：1990-12-27
申请号：EP88113311.0
申请日：1988-08-17
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Takaya, Takao , Shirai, Fumiyuki , Nakamura, Hitoshi , Inaba, Yasunobu
IPC分类号： A61K31/545 , C07D501/22
CPC分类号： A61K31/545
摘要： Crystalline 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) which is obtainable by acidifying a solution containing 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) at room temperature or under warming. Such crystalline compound shows a characteristic X-ray diffraction pattern. The invention comprises also processes for preparing such crystalline compound and pharmaceutical compositions containing it as active ingredient.
摘要翻译：通过将含有7- [2-（2-氨基噻唑-4-基）-2-羟基亚氨基乙酰氨基] -3-乙烯基-3-头孢烯-4-羧酸（顺式异构体） - （2-氨基噻唑-4-基）-2-羟基亚氨基乙酰氨基-3-乙烯基-3-头孢烯-4-羧酸（顺式异构体）。这种结晶化合物显示特征X射线衍射图。本发明还包括制备这种结晶化合物的方法和含有它作为活性成分的药物组合物。

3. 发明公开

EP0239853A1 3,4-Disubstituted-2-azetidinone derivatives and processes for the preparation thereof 失效
标题翻译： 3,4-Disubstituierte-2-azetidinon-Derivate und Verfahren zu ihrer Herstellung。
公开(公告)号：EP0239853A1
公开(公告)日：1987-10-07
申请号：EP87103715.6
申请日：1987-03-14
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Nakai, Takeshi , Shirai, Fumiyuki , Chiba, Toshiyuki , Ohtake, Hiroaki
IPC分类号： C07F7/18 , C07D417/06 , C07D205/08
CPC分类号： C07D417/06 , C07D205/08 , C07F7/186 , Y02P20/55
摘要： 3,4-Disubstituted-2-azetidinone derivatives of the formula:

in which R' is hydrogen or imino-protective group,
R 2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl
R 3 is lower alkyl, and
R 4 is 1-(lower)alkyl-1-hydroxy(C 2 -C 6 )alkyl, 1-(lower)alkyl-1-(protected hydroxy)(C 2 -C 6 )alkyl or 2-thioxothiazolidin-3-yl,
and salts thereof and processes for the preparation therof.
摘要翻译：下式的3,4-二取代-2-氮杂环丁酮衍生物：其中R 1是氢或亚氨基保护基，其中R 2是羟基（低级）烷基或被保护的羟基（低级）烷基R' 3低级烷基，R 4为1-（低级）烷基-1-羟基（C 2 -C 6）烷基，1-（低级）烷基-1-（被保护的羟基）（C 2 -C 6）烷基或2 - 硫代噻唑烷-3-基及其盐及其制备方法。

4. 发明授权

EP0304019B1 Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) 失效
标题翻译： Kristalline 7-（2-（2-氨基噻唑-4-基）-2-羟基亚氨基乙酰氨基）-3-乙烯基-3-头孢烯-4-羧基-Säure（顺式异构体）。
公开(公告)号：EP0304019B1
公开(公告)日：1995-05-31
申请号：EP88113311.0
申请日：1988-08-17
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Takaya, Takao , Shirai, Fumiyuki , Nakamura, Hitoshi , Inaba, Yasunobu
IPC分类号： A61K31/545 , C07D501/22
CPC分类号： A61K31/545

5. 发明公开

EP0421283A2 A new process for preparing optically active 3-substituted azetidinones 失效
标题翻译： Verfahren zur Herstellung von optisch wirkenden 3-substitutionierten Azetidinonen。
公开(公告)号：EP0421283A2
公开(公告)日：1991-04-10
申请号：EP90118625.4
申请日：1990-09-28
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Murata, Masayoshi , Chiba, Toshiyuki , Shirai, Fumiyuki , Washizuka, Kenichi , Hino, Motohiro
IPC分类号： C07D205/08 , C12P7/42 , C12N9/18
CPC分类号： C12R1/07 , C07D205/08 , C12P7/42 , C12P41/004 , Y02P20/55
摘要： A process for preparing optically active 3-substituted azetidinones of the formula

in which R¹ is hydroxy-protective group by a multi-step process. The invention also comprises a process for preparing optically active compound of the formula

in which R² is protected carboxy,
by enzymatic hydrolysis, preferably using esterase, preferably derived from microorganism belonging to genus Pimelobacter or Bacillus like FERM BP-3086 and FERM BP-3087. The invention also comprises biologically pure cultures of such microorganism and compounds of the formula

and process for their preparation.
摘要翻译：制备式（CHEM）的光学活性3-取代氮杂环丁酮的方法，其中R 1为多步法的羟基保护基。本发明还包括通过酶水解，优选使用酯酶，优选衍生自属于嗜血杆菌属或芽孢杆菌属如FERM BP-3086的微生物的制备式的光学活性化合物，其中R 2为保护的羧基的方法和FERM BP-3087。本发明还包括这种微生物的生物纯培养物和式CHEM的化合物及其制备方法。 Ë

6. 发明公开

EP0394991A1 1-Azabicyclo(3.2.0)Hept-2-Ene-2-carboxylic acid compounds 失效
标题翻译：（3.2.0）庚-2-烯-2-碳辛烷基。
公开(公告)号：EP0394991A1
公开(公告)日：1990-10-31
申请号：EP90107824.6
申请日：1990-04-25
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Murata, Masayoshi , Chiba, Toshiyuki , Tsutsumi, Hideo , Hattori, Kohji , Kuroda, Satoru , Ohtake, Hiroaki , Shirai, Fumiyuki
IPC分类号： C07D477/00 , C07D519/00 , C07F7/18 , A61K31/40 , C07F9/568
CPC分类号： C07D477/14 , C07F7/186 , Y02P20/55
摘要： A compound of the formula :
in which

R 1 is carboxy, protected carboxy or carboxylato,
R 2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,
R 3 is hydrogen or lower alkyl,
A is a group of the formula:
wherein
is N-containing aliphatic heterocyclic group optionally containing additional hetero atom(s),
R 4 is hydrogen, hydroxy, protected hydroxy, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, lower alkyl, lower alkoxy(lower)alkyl, halogen, carbamoyl, mono- or di(lower)alkylcarbamoyl or imino-protective group,
R 5 is hydrogen, lower alkenyl, carbamoyl, mono- or di(lower)alkylcarbamoyl, imino-protective group, or a group of the formula :
wherein
R 6 is hydrogen or lower alkyl optionally substituted by suitable substituent(s),
R 7 is hydrogen, lower alkyl, cyano, hydroxy(lower)alkoxy(lower)alkyl or heterocyclic group,
R 8 is lower alkyl, or
R 7 is combined with R 6 or R 8 to form lower alkylene, and
m and n are each an integer of 0 to 3, or pharmaceutically acceptable salts thereof,
processes for their preparation and pharmaceutical compositions comprising them as active ingredient in association with a pharmaceutically acceptable carrier or excipient.
摘要翻译：下式的化合物：其中R 1是羧基，保护的羧基或羧基，R 2是羟基（低级）烷基或被保护的羟基（低级）烷基，R 3是氢或低级烷基 A是下式的基团：其中CHEM是任选含有另外的杂原子的含N脂肪族杂环基，R 4是氢，羟基，被保护的羟基，羟基（低级）烷基，保护的羟基（低级）烷基，低级烷基，低级烷氧基（低级）烷基，卤素，氨基甲酰基，一或二（低级）烷基氨基甲酰基或亚氨基保护基，R 5是氢，低级烯基，氨基甲酰基，二（低级）烷基氨基甲酰基，亚氨基保护基或下式基团：其中R 6为氢或任选被合适的取代基取代的低级烷基，R 7为氢，低级烷基，氰基，羟基（低级）烷氧基（低级）烷基或杂环基，R 8为低级烷基，或R 7与R 6或R 8结合形成低级亚烷基，m和n为各为0〜3的整数，或其药学上可接受的盐，其制备方法和包含它们作为活性成分与药学上可接受的载体或赋形剂的药物组合物。

7. 发明授权

EP0239853B1 3,4-Disubstituted-2-azetidinone derivatives and processes for the preparation thereof 失效
标题翻译： 3,4-取代的2-氮杂环丁酮衍生物及其制备方法
公开(公告)号：EP0239853B1
公开(公告)日：1993-05-19
申请号：EP87103715.6
申请日：1987-03-14
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Nakai, Takeshi , Shirai, Fumiyuki , Chiba, Toshiyuki , Ohtake, Hiroaki
IPC分类号： C07F7/18 , C07D417/06 , C07D205/08
CPC分类号： C07D417/06 , C07D205/08 , C07F7/186 , Y02P20/55

8. 发明公开

EP0421283A3 A new process for preparing optically active 3-substituted azetidinones 失效
标题翻译：一种新的制备光学活性3-取代的亚硫酸氢盐的方法
公开(公告)号：EP0421283A3
公开(公告)日：1992-04-08
申请号：EP90118625.4
申请日：1990-09-28
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Murata, Masayoshi , Chiba, Toshiyuki , Shirai, Fumiyuki , Washizuka, Kenichi , Hino, Motohiro
IPC分类号： C07D205/08 , C12P7/42 , C12N9/18
CPC分类号： C12R1/07 , C07D205/08 , C12P7/42 , C12P41/004 , Y02P20/55
摘要： A process for preparing optically active 3-substituted azetidinones of the formula

in which R¹ is hydroxy-protective group by a multi-step process. The invention also comprises a process for preparing optically active compound of the formula

in which R² is protected carboxy,
by enzymatic hydrolysis, preferably using esterase, preferably derived from microorganism belonging to genus Pimelobacter or Bacillus like FERM BP-3086 and FERM BP-3087. The invention also comprises biologically pure cultures of such microorganism and compounds of the formula

and process for their preparation.

9. 发明公开

EP0304019A2 Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) 失效
标题翻译： Kristalline 7-（2-（2-氨基噻吩醇-4-基）-2-羟基亚氨基乙酰氨基）-3-乙烯基-3-头孢烯-4-羧基-Säure（顺式异构体）。
公开(公告)号：EP0304019A2
公开(公告)日：1989-02-22
申请号：EP88113311.0
申请日：1988-08-17
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： Takaya, Takao , Shirai, Fumiyuki , Nakamura, Hitoshi , Inaba, Yasunobu
IPC分类号： A61K31/545 , C07D501/22
CPC分类号： A61K31/545
摘要： Crystalline 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) which is obtainable by acidifying a solution containing 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) at room temperature or under warming. Such crystalline compound shows a characteristic X-ray diffraction pattern. The invention comprises also processes for preparing such crystalline compound and pharmaceutical compositions containing it as active ingredient.
摘要翻译：通过将含有7- [2-（2-氨基噻唑-4-基）-2-羟基亚氨基乙酰氨基] -3-乙烯基-3-头孢烯-4-羧酸（顺式异构体） - （2-氨基噻唑-4-基）-2-羟基亚氨基乙酰氨基-3-乙烯基-3-头孢烯-4-羧酸（顺式异构体）。这种结晶化合物显示特征X射线衍射图。本发明还包括制备这种结晶化合物的方法和含有它作为活性成分的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式