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1. 发明授权

EP1161989B1 Device for packaging a chip shaped carrier and process for assembling a plurality of such carriers 有权
标题翻译：用于包装切片状载体的装置和用于组装多个这种载体的过程
公开(公告)号：EP1161989B1
公开(公告)日：2007-08-01
申请号：EP01202144.0
申请日：2001-06-01
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Lehmann, Thomas , Vischer, Peter
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , C40B40/06 , G01N2035/00158

2. 发明公开

EP1226863A1 Method for processing a nucleic acid sample by swinging a segment of a cartridge wall, a system and a cartridge for performing such a method 有权
标题翻译：由筒壁的一部分的振动的手段治疗Nukleinsaüreproben的相同的方法，和盒系统，用于执行
公开(公告)号：EP1226863A1
公开(公告)日：2002-07-31
申请号：EP00811252.6
申请日：2000-12-28
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Aeschlimann, Marcel , Vischer, Peter
IPC分类号： B01F11/00 , B01F13/00
CPC分类号： B01F11/0042 , B01F13/0059 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L2300/0636 , B01L2300/0809 , B01L2300/0877 , B01L2400/0436 , B01L2400/0475 , G01N2035/00158 , G01N2035/00534
摘要： A method for processing a nucleic acid sample contained in a liquid comprises:

(a) introducing said liquid into a chamber (41) of a cartridge (42) which contains a chip shaped carrier (44) having an active surface (45) which carries an array of oligonucleotides, said active surface (45) facing the inner surface of a wall (46) of said cartridge,
said chamber (41) having a narrow interior and including a channel (43), a portion of said channel lying between said active surface (45) of said chip shaped carrier (44) and the inner surface of said wall (46),
a rigid segment (47) of said wall (46) being adapted to be swung of a predetermined angle back and forth about a torsion bar (59), swinging of that segment (47) in one sense moving one end thereof towards said active surface (45), and
swinging of that segment (47) in the opposite sense moving said one end of that segment (47) away from said active surface (45),
(b) positioning said cartridge (42) into a cartridge holder (56) which holds said cartridge, said positioning being effected before or after introduction of said liquid containing a sample into said chamber (41), and
(c) swinging said rigid segment (47) of said wall (46) of said predetermined angle back and forth about said torsion bar (59) in order to cause relative motion of the liquid contained in said channel (43) with respect to said active surface (45) of said chip shaped carrier (44).
摘要翻译：一种用于处理包含在液体中的核酸样品的方法包括：（a）将所述液体成盒的腔室（41）（42），其包含携带的芯片形载体（44）具有在有源表面（45）在寡核苷酸的阵列，面向所述盒的壁（46）的内表面有效表面（45），所述腔室（41）具有窄的内部并且包括一通道（43），所述信道之间的所述躺在部所述芯片形载体的活性表面（45）（44）和所述壁的内表面（46），所述壁的刚性链段（47）（46）是angepasst到摆动一个预定的角度的左右来回一个扭杆（59），确实在一个意义上的部段（47）移动其一端朝向所述有效面（45）和没有在相反的意义上的部段（47）移动做了段的所述一端的摆动的摆动（47）从所述有源表面（45）的距离，（b）定位所述盒（42）插入盒保持器（56）保持有所述盒，所述定位被之前或引入所述液体含有样品到所述腔室（41）的后实现的，和（c）摆动所述预定角度的所述壁（46）的刚性链段（47）来回绕所述为了相对于所述芯片形载体（44）的所述有效面（45）以引起包含在所述信道（43）的液体的相对运动扭杆（59）。

3. 发明公开

EP1623762A3 Cartridge for processing a nucleic acid sample 审中-公开
标题翻译：盒用于处理核酸样品
公开(公告)号：EP1623762A3
公开(公告)日：2014-05-21
申请号：EP05022568.9
申请日：2000-12-28
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , G01N35/00 , B01F11/00 , B01L9/00
CPC分类号： B01L3/502 , B01F11/0002 , B01F11/0008 , B01L3/5027 , B01L9/527 , B01L2300/0636 , B01L2300/0816 , B01L2400/0457 , G01N2035/00158 , G01N2035/00524 , Y10S977/924
摘要： A cartridge for processing a nucleic acid sample contained in a liquid. The cartridge comprises a chip shaped carrier (14) having an active surface (15) which carries an array of oligonucleotides. The active surface (15) faces an inner surface (24) of a part (21) of the cartridge (12). The cartridge also comprises a chamber (11) which has a narrow interior and includes a curved channel (13). A portion of the channel (13) lies between the active surface (15) and the inner surface (24).

4. 发明公开

EP1955769A3 Method for positioning and fastening a second object in a first object 有权
标题翻译：一种用于定位和固定一个对象到另一对象的过程
公开(公告)号：EP1955769A3
公开(公告)日：2008-08-20
申请号：EP08003958.9
申请日：2002-07-09
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/68 , B01J19/00 , G01N21/00
CPC分类号： H01L21/67144 , B01J2219/00274 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/508 , B01L9/52 , B01L9/527 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , B01L2400/0677 , C40B40/06 , H01L21/67121 , Y10S435/809
摘要： A method for positioning and fastening a second object (21) in a first object (14), the first object being provided with a seat for said at least one second object, both objects being made of a non-metallic materials. The method comprises forming at least part of the walls of the seat, preferably the circumferential rim, from a liquidifiable solid material (26) which is at least once reversibly liquidifiable by heating it, said solid material being other than said non-metallic materials, placing the second objects into the seat, liquidifying said solid material by heating it so that the latter material attaches the first object to the second object, and allowing said liquidifiable material to cool and resolidify, said liquidifiable material thereby forming a bond between the first object and the second object.

5. 发明公开

EP1161989A1 Device for packaging a chip shaped carrier and process for assembling a plurality of such carriers 有权
标题翻译：设备用于包装芯片形载体和处理用于组装多个这种载体的
公开(公告)号：EP1161989A1
公开(公告)日：2001-12-12
申请号：EP01202144.0
申请日：2001-06-01
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Lehmann, Thomas , Vischer, Peter
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , C40B40/06 , G01N2035/00158
摘要： A device for packaging a chip shaped carrier having an active surface which is adapted to be read by an electro-optical reading device, e.g. a surface which carries an array of DNA oligonucleids. The device comprises: a cartridge (12) having an opening (13) for receiving a liquid sample and including casing parts (14, 15); a casing part (14) having an inner surface (16) and outer surface (17), a first cavity (18) for receiving a chip shaped carrier (21), and means (22) which provide visual access to that first cavity and thereby to the active surface of the chip shaped carrier; a sealing frame (26) which is part of a casing part (14) and which is made of a compressible material, sealing frame (26) being connected to said bottom surface (23) of the first cavity (18); and a locking frame (31); the shape and dimensions of first cavity (18), chip shaped carrier (21), sealing frame (26), and locking frame (31) being so chosen that chip shaped carrier (21) fits into the space delimited by sealing frame (26)and a gap (27) which exists between sealing frame (26)and inclined side wall surfaces (24) of first cavity (18), and locking frame (31) is larger than gap (27), but locking frame (31) is however insertable into gap (27) by exerting pressure on locking frame (31) against casing part (14), that pressure causing a compression of sealing frame (26) and a corresponding pressure on a substantial part of the outer surface of the lateral periphery of chip shaped carrier (21), which outer surface is in contact with sealing frame (26) .
摘要翻译：一种用于在电光学读取装置，E.G.包装具有活性表面上的所有其angepasst由读取的芯片形载体设备一个表面上的DNA oligonucleids的阵列携带。该装置包括：用于接收液体样品并包括壳体部分（14，15）的盒（12），其具有上开口（13）; 具有内表面（16）和外表面（17）上，用于接收芯片形载体（21），以及装置（22），其提供视觉访问做第一空腔的外壳部件（14），第一空腔（18）和从而将芯片形载体的活性表面; 这是由可压缩材料制成的密封框（26），所有这些是一个壳体部分（14）的一部分和所有的，密封框（26）被连接到所述第一腔体（18）的所述底表面（23）; 和锁定框架（31）; 的形状和第一空腔的尺寸（18），芯片形载体（21），密封框架（26），以及锁定框架（31）被这样选择，没有芯片形载体（21）装配到由密封框架限定的空间（26 ）和密封第一空腔（18）的框架（26）和倾斜的侧壁面（24），以及锁定框架之间所存在的间隙（27）（31）比间隙（27）较大，但锁定框架（31）是通过对锁定框架（31）相对于壳体部件（14）施加压力无论其插入间隙（27），确实压力发生卷侧的外表面的主要部分的密封框架（26）和一个相应的压力的压缩芯片成形载体（21），该外表面与密封框（26）接触的外周。

6. 发明授权

EP1955769B1 Method for positioning and fastening a second object in a first object 有权
标题翻译：一种用于定位和固定一个对象到另一对象的过程
公开(公告)号：EP1955769B1
公开(公告)日：2011-09-07
申请号：EP08003958.9
申请日：2002-07-09
申请人： F.Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/68 , B01J19/00 , G01N21/00
CPC分类号： H01L21/67144 , B01J2219/00274 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/508 , B01L9/52 , B01L9/527 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , B01L2400/0677 , C40B40/06 , H01L21/67121 , Y10S435/809

7. 发明公开

EP1955769A2 Method for positioning and fastening a second object in a first object 有权
标题翻译：用于将第二物体定位和紧固在第一物体中的方法
公开(公告)号：EP1955769A2
公开(公告)日：2008-08-13
申请号：EP08003958.9
申请日：2002-07-09
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00 , B01L9/00 , C12Q1/68 , B01J19/00 , G01N21/00
CPC分类号： H01L21/67144 , B01J2219/00274 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/508 , B01L9/52 , B01L9/527 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , B01L2400/0677 , C40B40/06 , H01L21/67121 , Y10S435/809
摘要： A method for positioning and fastening a second object (21) in a first object (14), the first object being provided with a seat for said at least one second object, both objects being made of a non-metallic materials. The method comprises forming at least part of the walls of the seat, preferably the circumferential rim, from a liquidifiable solid material (26) which is at least once reversibly liquidifiable by heating it, said solid material being other than said non-metallic materials, placing the second objects into the seat, liquidifying said solid material by heating it so that the latter material attaches the first object to the second object, and allowing said liquidifiable material to cool and resolidify, said liquidifiable material thereby forming a bond between the first object and the second object.
摘要翻译：一种用于将第二物体（21）定位和固定在第一物体（14）中的方法，第一物体设置有用于所述至少一个第二物体的底座，两个物体均由非金属材料制成。该方法包括由可加热的可液化固体材料（26）形成座的至少部分壁，优选圆周边缘，所述可液化固体材料通过加热至少一次可逆地液化，所述固体材料不同于所述非金属材料，将第二物体放入座中，通过加热使所述固体材料加热而使所述固体材料液化，使得所述固体材料将第一物体附着到第二物体上，并且使所述可液化物质冷却并重新固化，由此在第一物体和第二个对象。

8. 发明授权

EP1161989B8 Device for packaging a chip shaped carrier and process for assembling a plurality of such carriers 有权
标题翻译：设备用于包装芯片形载体和处理用于组装多个这种载体的
公开(公告)号：EP1161989B8
公开(公告)日：2007-11-07
申请号：EP01202144.0
申请日：2001-06-01
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Lehmann, Thomas , Vischer, Peter
IPC分类号： B01J19/00 , B01L3/00
CPC分类号： B01L3/5027 , B01J19/0046 , B01J2219/00608 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0809 , C40B40/06 , G01N2035/00158

9. 发明公开

EP1623762A2 Cartridge for processing a nucleic acid sample 审中-公开
标题翻译： Patrone zur Verarbeitung einerNukleinsäure-Probe
公开(公告)号：EP1623762A2
公开(公告)日：2006-02-08
申请号：EP05022568.9
申请日：2000-12-28
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Vischer, Peter
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01F11/0002 , B01F11/0008 , B01L3/5027 , B01L9/527 , B01L2300/0636 , B01L2300/0816 , B01L2400/0457 , G01N2035/00158 , G01N2035/00524 , Y10S977/924
摘要： A cartridge for processing a nucleic acid sample contained in a liquid. The cartridge comprises a chip shaped carrier (14) having an active surface (15) which carries an array of oligonucleotides. The active surface (15) faces an inner surface (24) of a part (21) of the cartridge (12). The cartridge also comprises a chamber (11) which has a narrow interior and includes a curved channel (13). A portion of the channel (13) lies between the active surface (15) and the inner surface (24).
摘要翻译：用于处理包含在液体中的核酸样品的筒。盒包括具有携带寡核苷酸阵列的活性表面（15）的芯片状载体（14）。活性表面（15）面向盒（12）的部分（21）的内表面（24）。盒还包括具有窄内部并包括弯曲通道（13）的腔室（11）。通道（13）的一部分位于活性表面（15）和内表面（24）之间。

10. 发明授权

EP1226863B1 Method for processing a nucleic acid sample by swinging a segment of a cartridge wall, a system and a cartridge for performing such a method 有权
标题翻译：由筒壁的一部分的振动的手段治疗Nukleinsaüreproben的相同的方法，和盒系统，用于执行
公开(公告)号：EP1226863B1
公开(公告)日：2004-11-03
申请号：EP00811252.6
申请日：2000-12-28
申请人： F.HOFFMANN-LA ROCHE AG , Roche Diagnostics GmbH
发明人： Aeschlimann, Marcel , Vischer, Peter
IPC分类号： B01F11/00 , B01F13/00
CPC分类号： B01F11/0042 , B01F13/0059 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L3/502715 , B01L3/508 , B01L9/52 , B01L2300/0636 , B01L2300/0809 , B01L2300/0877 , B01L2400/0436 , B01L2400/0475 , G01N2035/00158 , G01N2035/00534

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