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1. 发明公开

EP3076766A1 METHOD AND APPARATUS FOR ELECTROSTATICALLY DISCHARGING A PRIMARY PACKAGING CONTAINER MADE OF PLASTICS 审中-公开
标题翻译：方法和装置一个一级包装容器塑料静电放电
公开(公告)号：EP3076766A1
公开(公告)日：2016-10-05
申请号：EP15161877.4
申请日：2015-03-31
申请人： F. Hoffmann-La Roche AG
发明人： BUERKER, Tatjana , HAASE, Christian , REICHERT, Klaus
IPC分类号： H05F3/06
CPC分类号： H05F3/06
摘要： A method and an apparatus (100) for electrostatically discharging a primary packaging container (102) made of plastics are disclosed. The method comprises moving a primary packaging container (102) to be electrostatically discharged so as to pass at least one electrode (104, 106, 108), applying an alternating voltage to the electrode (104, 106, 108) so as to generate ionized air in a vicinity of the electrode (104, 106, 108), and rotating the primary packaging container (102) in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air. The apparatus (100) comprises at least one electrode (104, 106, 108) adapted to generate ionized air in a vicinity of the electrode (104, 106, 108) and a moving path (128) for moving a primary packaging container (102) to be electrostatically discharged, wherein the moving path (128) is formed such that the primary packaging container (102) is adapted to pass the electrode (104, 106, 108) and to be rotated in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air.
摘要翻译：甲装置（100），用于静电放电由塑料制成的初级包装容器（102）的方法和光盘是游离缺失。该方法包括：移动一个初级包装容器（102）被静电放电以便通过至少一个电极（104，106，108），适用于交流电压到所述电极（104，106，108），以便产生离子化空气在电极（104，106，108）的附近，并在旋转电极（104，106，108），以便部附近的主包装容器（102），以由所述电离空气接触。的装置（100）包括至少一个电极（104，106，108）angepasst在电极（104，106，108）和用于移动一个初级包装容器的移动路径（128）的附近，以产生电离空气（102 ）是静电放电，worin移动路径（128）形成检查做了初级包装容器（102）是angepasst传递电极（104，106，108）和在所述电极附近（104旋转， 106，108），以便通过电离空气接触。

2. 发明授权

EP2178900B1 PURIFICATION OF PEGYLATED POLYPEPTIDES 有权
标题翻译：清洁聚乙二醇化多肽
公开(公告)号：EP2178900B1
公开(公告)日：2012-05-02
申请号：EP08784775.2
申请日：2008-07-15
申请人： F. Hoffmann-La Roche AG
发明人： BURG, Josef , REICHERT, Klaus , SCHROTH, Axel , SCHURIG, Hartmut , WESSNER, Axel
IPC分类号： C07K1/18 , A61K38/18 , A61K47/48
CPC分类号： C07K1/18 , A61K47/60 , C07K14/505
摘要： The current invention comprises a method for the purification of mono-PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

3. 发明公开

EP1402050A2 METHODS FOR THE RECOMBINANT PRODUCTION OF PEPTIDIC ANTIVIRAL FUSION INHIBITORS, AND ACETYLATION OF GP41 FRAGMENTS 有权
标题翻译：重组生产的病毒融合的肽抑制剂的
公开(公告)号：EP1402050A2
公开(公告)日：2004-03-31
申请号：EP02740652.9
申请日：2002-05-27
申请人： F. HOFFMANN-LA ROCHE AG
发明人： HOESS, Eva , MEIER, Thomas , PESTLIN, Gabriele , POPP, Friedrich , REICHERT, Klaus , SCHMUCK, Rainer , SCHNEIDINGER, Bernd , SEIDEL, Christoph , TISCHER, Wilhelm
IPC分类号： C12P21/02 , C12N15/62 , C07K14/16 , C07K14/155
CPC分类号： C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12P21/02
摘要： A process for the production of an antifusogenic peptide of a length of about 10 to 50 amino acids in a prokaryotic host cell, characterized in that, under such conditions that inclusion bodies of said non-fusion antifusogenic peptide or said fusion peptide are formed, a) in said host cell there is expressed a nucleic acid encoding said antifusogenic peptide as a non-fusion peptide or encoding a fusion peptide of a length of about 14 to 70 amino acids consisting of said antifusogenic peptide N-terminally linked to a further peptide of a length of about 4 to 30 amino acids; b) said host cell is cultivated; c) said inclusion bodies are recovered and solubilized; d) in the case of said fusion peptide said antifusogenic peptide is cleaved off from said further peptide; and e) said antifusogenic peptide is isolated.

4. 发明授权

EP2173450B1 METHOD FOR THE REGENERATION OF A CHROMATOGRAPHY COLUMN 有权
公开(公告)号：EP2173450B1
公开(公告)日：2018-10-31
申请号：EP08784776.0
申请日：2008-07-15
申请人： F. Hoffmann-La Roche AG
发明人： BURG, Josef , REICHERT, Klaus , SCHROTH, Axel , SCHURIG, Hartmut , WESSNER, Axel
IPC分类号： B01D15/36 , B01D15/20 , C07K1/18 , B01J49/00
CPC分类号： B01D15/203 , B01D15/362 , B01J49/53 , B01J49/60 , C07K1/18 , C07K14/505
摘要： The current invention comprises a method for the regeneration of a cation exchange chromatography column.

5. 发明公开

EP3278635A1 METHOD AND APPARATUS FOR ELECTROSTATICALLY DISCHARGING A PRIMARY PACKAGING CONTAINER MADE OF PLASTICS 失效
标题翻译：用于静电放电由塑料制成的一次包装容器的方法和设备
公开(公告)号：EP3278635A1
公开(公告)日：2018-02-07
申请号：EP16713379.2
申请日：2016-03-24
申请人： F. Hoffmann-La Roche AG
发明人： BUERKER, Tatjana , HAASE, Christian , REICHERT, Klaus
IPC分类号： H05F3/06
CPC分类号： H05F3/06
摘要： A method and an apparatus (100) for electrostatically discharging a primary packaging container (102) made of plastics are disclosed. The method comprises moving a primary packaging container (102) to be electrostatically discharged so as to pass at least one electrode (104, 106, 108), applying an alternating voltage to the electrode (104, 106, 108) so as to generate ionized air in a vicinity of the electrode (104, 106, 108), and rotating the primary packaging container (102) in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air. The apparatus (100) comprises at least one electrode (104, 106, 108) adapted to generate ionized air in a vicinity of the electrode (104, 106, 108) and a moving path (128) for moving a primary packaging container (102) to be electrostatically discharged, wherein the moving path (128) is formed such that the primary packaging container (102) is adapted to pass the electrode (104, 106, 108) and to be rotated in the vicinity of the electrode (104, 106, 108) so as to be contacted by the ionized air.

6. 发明授权

EP1402050B1 Recombinant production of peptidic antiviral fusion inhibitors 有权
标题翻译：重组生产的病毒融合的肽抑制剂的
公开(公告)号：EP1402050B1
公开(公告)日：2014-10-29
申请号：EP02740652.9
申请日：2002-05-27
申请人： F. Hoffmann-La Roche AG
发明人： HOESS, Eva , MEIER, Thomas , PESTLIN, Gabriele , POPP, Friedrich , REICHERT, Klaus , SCHMUCK, Rainer , SCHNEIDINGER, Bernd , SEIDEL, Christoph , TISCHER, Wilhelm
IPC分类号： C12P21/02 , C12N15/62 , C07K14/12 , C07K14/135 , C07K14/16
CPC分类号： C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12P21/02

7. 发明公开

EP2178900A2 PURIFICATION OF PEGYLATED POLYPEPTIDES 有权
标题翻译：清洁聚乙二醇化多肽
公开(公告)号：EP2178900A2
公开(公告)日：2010-04-28
申请号：EP08784775.2
申请日：2008-07-15
申请人： F. Hoffmann-La Roche AG
发明人： BURG, Josef , REICHERT, Klaus , SCHROTH, Axel , SCHURIG, Hartmut , WESSNER, Axel
IPC分类号： C07K1/18 , A61K38/18 , A61K47/48
CPC分类号： C07K1/18 , A61K47/60 , C07K14/505
摘要： The current invention comprises a method for the purification of mono-PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.

8. 发明公开

EP2173450A2 CHROMATOGRAPHIC METHODS 有权
标题翻译：色谱仪VERFAHREN
公开(公告)号：EP2173450A2
公开(公告)日：2010-04-14
申请号：EP08784776.0
申请日：2008-07-15
申请人： F. Hoffmann-La Roche AG
发明人： BURG, Josef , REICHERT, Klaus , SCHROTH, Axel , SCHURIG, Hartmut , WESSNER, Axel
IPC分类号： B01D15/36 , B01D15/20 , C07K1/18 , B01J49/00
CPC分类号： B01D15/203 , B01D15/362 , B01J49/53 , B01J49/60 , C07K1/18 , C07K14/505
摘要： The current invention comprises a method for the regeneration of a cation exchange chromatography column.
摘要翻译：本发明包括一种用于再生阳离子交换色谱柱的方法。

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