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1. 发明公开

EP4108784A1 MARKER SELECTION METHOD USING METHYLATION DIFFERENCE BETWEEN NUCLEIC ACIDS, METHYLATED OR DEMETHYLATED MARKER, AND DIAGNOSTIC METHOD USING MARKER 审中-公开
公开(公告)号：EP4108784A1
公开(公告)日：2022-12-28
申请号：EP21757111.6
申请日：2021-02-19
申请人： Eone Diagnomics Genome Center Co., Ltd.
发明人： LEE, Sunghoon , MIN, Na Young , KWON, Hyukjung , BAE, Jin-Sik , LEE, Min Seob , SHIN, Shang Cheol
IPC分类号： C12Q1/6886 , C12Q1/6869 , C12Q1/6876
摘要： The present invention relates to a marker screening method using differences in methylation of nucleic acids, a demethylation marker and a diagnostic method using the marker, more specifically, a novel method for screening disease-specific demethylation markers using methylation differences in free nucleic acids, and relates to a new cancer diagnosis method by methylation detection for determining cancer by calculating the demethylation marker and the frequency of the marker screened by this method, and to a cancer-specific demethylation marker in the selected cfDNA.

2. 发明公开

EP3285193A1 METHOD FOR PREDICTING ORGAN TRANSPLANT REJECTION USING NEXT-GENERATION SEQUENCING 审中-公开
标题翻译：使用下一代测序预测器官移植排斥的方法
公开(公告)号：EP3285193A1
公开(公告)日：2018-02-21
申请号：EP15889288.5
申请日：2015-06-11
申请人： Eone Diagnomics Genome Center Co., Ltd.
发明人： LEE, Min Seob , KWON, Sun Jae
IPC分类号： G06F19/22 , G06F19/10 , C12Q1/68
CPC分类号： C12Q1/68 , G06F19/10 , G06F19/22
摘要： The present invention relates to a method for non-invasively predicting an organ transplant rejection by measuring the ratio between an organ-donor-specific nucleic acid sequence and a recipient-specific nucleic acid sequence in a biological sample of an organ transplant recipient and, more specifically, to a method for predicting an organ transplant rejection by measuring the ratio of a donor-derived marker sequence and a recipient-derived marker sequence regarding three or more markers selected in Tables 1 to 10 by testing a biological sample (e.g. blood) of an organ transplant recipient and predicting the organ transplant rejection based on the measurement. The method for predicting an organ transplant rejection using next-generation sequencing (NGS) according to the present invention or a digital base amplification technique can apply even to a very small amount of sample, is faster and inexpensive, is fast in the rate of data analysis, can apply to all organ transplants of all races in the word, and can simultaneously detect error probability of a sequence analysis, and thus is useful to non-invasively predict the organ transplant rejection.
摘要翻译：本发明涉及通过测量器官移植接受者的生物样品中器官供体特异性核酸序列和受体特异性核酸序列之间的比率来非侵入性地预测器官移植排斥的方法，具体而言，涉及通过测定表1〜10中选择的3种以上的标记物的供体来源的标记物序列与来自受体来源的标记物序列的比例，通过对生物样品（例如血液）进行检测来预测器官移植排斥反应的生物学样品基于测量结果预测器官移植排斥反应。使用根据本发明的下一代测序（NGS）或数字基础扩增技术预测器官移植排斥的方法甚至可以应用于非常少量的样本，更快且更便宜，数据速率快分析可适用于所有种族的器官移植，并可同时检测出序列分析的错误概率，因此有助于非侵入性预测器官移植排斥反应。

3. 发明公开

EP4083205A1 DOUBLE-STRANDED NUCLEIC ACID MOLECULES AND METHOD FOR REMOVING GLASS ADAPTOR IN DNA LIBRARY BY MEANS OF SAME 审中-实审
公开(公告)号：EP4083205A1
公开(公告)日：2022-11-02
申请号：EP20906126.6
申请日：2020-12-24
申请人： Eone Diagnomics Genome Center Co., Ltd.
发明人： MIN, Na Young , BAE, Jin-Sik , LEE, Min Seob , SHIN, Shang Cheol
IPC分类号： C12N15/11 , C12Q1/6869
摘要： The present invention relates to a method for removing free adapters in a DNA library using a double-stranded nucleic acid molecule and a restriction enzyme, and more specifically, to a method for removing free adapters in a DNA library for next generation sequencing (NGS) using a double-stranded nucleic acid molecule including a type IIs restriction enzyme recognition site and a complementary sequence thereof, and a type IIs restriction enzyme.

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