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1. 发明公开

EP3355899A1 ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE 审中-公开
公开(公告)号：EP3355899A1
公开(公告)日：2018-08-08
申请号：EP16850516.2
申请日：2016-09-29
申请人： Ramot at Tel-Aviv University Ltd. , Yeda Research and Development Co. Ltd , Synvaccine Ltd.
发明人： TULLER, Tamir , GOZ, Eli , ATAR, Shimshi , ZUR, Hadas
IPC分类号： A61K35/76 , C12N7/04 , G06F19/10
CPC分类号： C12N7/00 , A61K35/76 , A61K39/12 , A61K2039/5254 , C12N2770/24121 , C12N2770/24162 , G06F19/10 , Y02A50/385 , Y02A50/387 , Y02A50/391 , Y02A50/465
摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

2. 发明授权

EP2917735B1 METHOD FOR PREDICTION OF AN IMMUNE RESPONSE AGAINST MISMATCHED HUMAN LEUKOCYTE ANTIGENS 有权
公开(公告)号：EP2917735B1
公开(公告)日：2018-07-18
申请号：EP13788993.7
申请日：2013-11-08
申请人： UMC Utrecht Holding B.V.
发明人： SPIERINGS, Hendrikus Theodorus
IPC分类号： G01N33/68 , C12Q1/6881 , G06F19/18 , G06F19/10 , G16H50/20 , G16H50/30
CPC分类号： G06F19/18 , C12Q1/6881 , C12Q2600/106 , G01N33/6878 , G01N2333/70539 , G01N2800/245 , G06F19/10 , G16H50/20 , G16H50/30
摘要： Disclosed is a method for prediction of an immune response against human leukocyte antigens (HLA) after transplantation, said method comprising HLA-typing of the donor and/or donor material and recipient to determine HLA-mismatches and determination of the number of predicted indirectly recognized HLA epitopes (PIRCHES). In particular, methods for selecting and/or screening donor material for allogeneic transplantation, for example for selecting donor material with permissible mismatches from mismatched unrelated donors and pre-transplantation prediction of an unwanted alloreactivity that could occur after transplantation of hematopoietic stem cells, cord blood, kidneys and/or other cells, tissues or organs are disclosed.

3. 发明公开

EP3294902A1 GENETIC MARKERS FOR SUICIDE RISK AND RELATED METHODS 审中-公开
公开(公告)号：EP3294902A1
公开(公告)日：2018-03-21
申请号：EP15892076
申请日：2015-11-19
申请人： CAMH
发明人： ZAI CLEMENT C , KENNEDY JAMES L
IPC分类号： C12Q1/68 , G01N33/48 , G06F19/10 , G06F19/12
CPC分类号： C12Q1/6883 , C12Q2600/156 , G01N2800/30 , G06F19/10 , G06F19/18
摘要： The invention provides genetic markers of severe suicidal behavior, related compositions, computer systems, and methods.

4. 发明公开

EP3285193A1 METHOD FOR PREDICTING ORGAN TRANSPLANT REJECTION USING NEXT-GENERATION SEQUENCING 审中-公开
标题翻译：使用下一代测序预测器官移植排斥的方法
公开(公告)号：EP3285193A1
公开(公告)日：2018-02-21
申请号：EP15889288.5
申请日：2015-06-11
申请人： Eone Diagnomics Genome Center Co., Ltd.
发明人： LEE, Min Seob , KWON, Sun Jae
IPC分类号： G06F19/22 , G06F19/10 , C12Q1/68
CPC分类号： C12Q1/68 , G06F19/10 , G06F19/22
摘要： The present invention relates to a method for non-invasively predicting an organ transplant rejection by measuring the ratio between an organ-donor-specific nucleic acid sequence and a recipient-specific nucleic acid sequence in a biological sample of an organ transplant recipient and, more specifically, to a method for predicting an organ transplant rejection by measuring the ratio of a donor-derived marker sequence and a recipient-derived marker sequence regarding three or more markers selected in Tables 1 to 10 by testing a biological sample (e.g. blood) of an organ transplant recipient and predicting the organ transplant rejection based on the measurement. The method for predicting an organ transplant rejection using next-generation sequencing (NGS) according to the present invention or a digital base amplification technique can apply even to a very small amount of sample, is faster and inexpensive, is fast in the rate of data analysis, can apply to all organ transplants of all races in the word, and can simultaneously detect error probability of a sequence analysis, and thus is useful to non-invasively predict the organ transplant rejection.
摘要翻译：本发明涉及通过测量器官移植接受者的生物样品中器官供体特异性核酸序列和受体特异性核酸序列之间的比率来非侵入性地预测器官移植排斥的方法，具体而言，涉及通过测定表1〜10中选择的3种以上的标记物的供体来源的标记物序列与来自受体来源的标记物序列的比例，通过对生物样品（例如血液）进行检测来预测器官移植排斥反应的生物学样品基于测量结果预测器官移植排斥反应。使用根据本发明的下一代测序（NGS）或数字基础扩增技术预测器官移植排斥的方法甚至可以应用于非常少量的样本，更快且更便宜，数据速率快分析可适用于所有种族的器官移植，并可同时检测出序列分析的错误概率，因此有助于非侵入性预测器官移植排斥反应。

5. 发明授权

EP2947461B1 METHODS FOR MASS SPECTROMETRIC BIOPOLYMER ANALYSIS USING OPTIMIZED OLIGOMER SCHEDULING 有权
标题翻译：利用优化的OLIGOMER SCHEDULING方法进行质谱生物多样性分析
公开(公告)号：EP2947461B1
公开(公告)日：2018-01-31
申请号：EP15168027.9
申请日：2015-05-18
申请人： Thermo Finnigan LLC
发明人： GROTHE Jr., Robert A. , MOHTASHEMI, Iman
IPC分类号： G01N33/68 , G06F19/00
CPC分类号： G01N33/6848 , G06F19/10
摘要： A method for detecting a list of known biopolymer molecules comprises: calculating, for each biopolymer, a respective list of oligomer molecules predicted to be produced by chemical processing; calculating, for each oligomer molecule, a respective predicted chromatographic elution time period; assigning, for each biopolymer molecule, one or more selected oligomer molecules to be detected, wherein the selecting is performed using weighted selection probabilities determined from the predicted elution times; scheduling a plurality of oligomer detection events of a detection system, wherein each oligomer detection event corresponds to a respective one of the predicted elution time periods; performing the chemical reaction or processing of the sample to generate a processed sample; introducing the processed sample into a chromatographic system; introducing any eluting oligomers into the detection system; and operating the detection system so as to search for each of the selected oligomer molecules in accordance with the scheduled detection events.

6. 发明授权

EP2763590B1 AUTOMATED TOTAL BODY ALBUMIN ANALYZER 有权
标题翻译：自动化总体白蛋白分析仪
公开(公告)号：EP2763590B1
公开(公告)日：2017-12-27
申请号：EP12841583.3
申请日：2012-10-17
申请人： Daxor Corporation
发明人： FELDSCHUH, Joseph , FELDSCHUH, Jonathan
IPC分类号： A61B5/1455 , G01N33/68 , G06F19/00
CPC分类号： A61B5/02755 , A61B5/1427 , A61B5/14546 , A61B5/15003 , A61B5/155 , A61B5/157 , G01N33/6827 , G01N2333/76 , G06F19/00 , G06F19/10
摘要： A computer-based method for automatically determining total body albumin of a living being based on the calculated intravascular albumin, the calculated observed ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time, and the baseline of expected ratio of amount of albumin in the intravascular system to amount of albumin in the extravascular system at the first time.

7. 发明公开

EP2619545A4 METHOD AND DEVICE FOR HIGH THROUGHPUT CELL DEFORMABILITY MEASUREMENTS 有权
公开(公告)号：EP2619545A4
公开(公告)日：2017-12-27
申请号：EP11827272
申请日：2011-09-16
申请人： UNIV CALIFORNIA
发明人： DI CARLO DINO , GOSSETT DANIEL R , TSE HENRY T K
IPC分类号： G01N15/14 , G01N33/48
CPC分类号： G01N15/1463 , B01L3/502715 , B01L3/50273 , B01L3/502776 , B01L2200/0605 , B01L2200/0647 , B01L2200/0652 , B01L2300/0654 , B01L2300/0864 , C12Q1/02 , G01N15/1404 , G01N15/1459 , G01N15/1484 , G01N33/487 , G01N33/574 , G01N2015/0065 , G01N2015/1006 , G01N2015/1415 , G01N2015/149 , G01N2015/1495 , G01N2015/1497 , G01N2800/7028 , G06F19/10
摘要： A system is disclosed that enables the automated measurement of cellular mechanical parameters at high throughputs. The microfluidic device uses intersecting flows to create an extensional flow region where the cells undergo controlled stretching. Cells are focused into streamlines prior to entering the extensional flow region. In the extensional region, each cell's deformation is measured with an imaging device. Automated image analysis extracts a range of independent biomechanical parameters from the images. These may include cell size, deformability, and circularity. The single cell data that is obtained may then be used to in a variety of ways. Scatter density plots of deformability and circularity may be developed and displayed for the user. Mechanical parameters such as deformability and circularity may be gated or thresholded to identify certain cells of interest or sub-populations of interest. Similarly, the mechanical data obtained using the device may be used as cell signatures.

8. 发明公开

EP3234173A1 PROCÉDÉ ET DISPOSITIF DE CARACTÉRISATION DU POUVOIR INHIBITEUR D'UNE MOLÉCULE SUR UN MICROORGANISME 有权
标题翻译： PROCÉDÉET DISPOSITIF DECARACTÉRISATIONDU POUVOIR INHIBITEUR D'UNEMOLÉCULESUR UN MICROORGANISME
公开(公告)号：EP3234173A1
公开(公告)日：2017-10-25
申请号：EP15808767.6
申请日：2015-11-30
申请人： bioMérieux
发明人： TOURNOUD, Maud , MAHE, Pierre
IPC分类号： C12Q1/18 , C12Q1/04 , G06F19/10 , C12Q1/06 , G01N33/569
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q1/06 , G01N33/569 , G06F19/10
摘要： A method for estimating a magnitude G
inhib quantifying the inhibitory capacity of a molecule on a type of microorganism comprises: the preparation (50) of a plurality of samples, comprising microorganisms of said type, a nutritive medium for the microorganisms and an initial quantity of the molecule per microorganism, which increases in a range [Q
min , Q
max ] as a function of a classification of the samples; the measurement (50) of the growth of the microorganisms in the samples as a function of time; and the determination (52) of the magnitude G
inhib as a function of the growth measurements. The determination (52) of the magnitude G
inhib comprises: - for each sample, the calculation (66) of a value reflecting the growth of the microorganism of said type on the basis of growth measurements; the classification (68) of the values calculated for the samples as a function of the classification of the samples; and the determination (70) of the magnitude G
inhib as a function of the change in the values classified.
摘要翻译：用于估计量值G抑制分子对一类微生物的抑制能力的方法包括：多种样品的制备（50），所述样品包含所述类型的微生物，微生物的营养培养基和初始量的作为样品分类的函数，每个微生物的分子增加[Q min，Q max] 样品中微生物生长的测量（50）作为时间的函数; 以及幅度G的确定（52）作为生长测量的函数来抑制。 G大小抑制的确定（52）包括： - 对于每个样品，基于生长测量结果计算（66）反映所述类型微生物生长的值; 作为样本分类的函数的针对样本计算的值的分类（68）以及幅度G的确定（70）作为所分类的值的变化的函数来进行抑制。

9. 发明公开

EP3218715A1 Système pour l'évaluation d'au moins un analyte susceptible d'être contenu dans un échantillon liquide déposé sur un dispositif immunochromatographique 有权
标题翻译： Systèmepour l'évaluationd'au moins un analyte susceptible d'étrecontenu dans unéchantillonliquidedéposésur un dispositif immunochromatographique
公开(公告)号：EP3218715A1
公开(公告)日：2017-09-20
申请号：EP15801916.6
申请日：2015-11-10
申请人： NG Biotech
发明人： STANKOV, Milovan , STANKOV-PUGES, Milovan
IPC分类号： G01N33/53 , G06F19/00 , A61B5/00 , G01N33/558
CPC分类号： G01N33/558 , A61B5/0022 , G06F19/00 , G06F19/10 , G16H10/40
摘要： The present invention relates to a system for the qualitative and/or quantitative evaluation of at least one analyte likely to be contained in a liquid sample deposited on an immunochromatographic device (2). The evaluation system (1) comprises a reading device (3) and an analysis device (5) that are structurally separate from one another. The reading device (3) comprises means (31) for receiving said immunochromatographic device (2), and means (32) for acquiring at least one digital image of its display area (24). The analysis device (5) comprises means (51) for processing the at least one digital image, which are suitable for the qualitative and/or quantitative evaluation of the at least one analyte likely to be contained in the liquid sample, and means for outputting the result of the evaluation. The evaluation system (1) comprises means (4, 33) for transmitting, via a telecommunications network (R), the at least one digital image acquired from the reading device (3) to the remote analysis device (5).
摘要翻译：本发明涉及用于定性和/或定量评估可能包含在沉积在免疫色谱装置（2）上的液体样品中的至少一种分析物的系统。评估系统（1）包括在结构上彼此分离的读取装置（3）和分析装置（5）。读取装置（3）包括用于接收所述免疫色谱装置（2）的装置（31）和用于获取其显示区域（24）的至少一个数字图像的装置（32）。分析装置（5）包括用于处理至少一个数字图像的装置（51），其适于定性和/或定量评估可能包含在液体样品中的至少一种分析物，以及用于输出评估的结果。评估系统（1）包括用于经由电信网络（R）将从读取设备（3）获取的至少一个数字图像发送到远程分析设备（5）的装置（4,33）。

10. 发明授权

EP2859395B1 SYSTEM, METHOD, AND DEVICE FOR DETERMINING A FOCAL POSITION OF AN OBJECTIVE IN A MICROSCOPY IMAGING SYSTEM 有权
标题翻译：用于在显微成像系统中确定目标的焦点位置的系统，方法和装置
公开(公告)号：EP2859395B1
公开(公告)日：2017-09-06
申请号：EP13801119.2
申请日：2013-06-05
申请人： Molecular Devices LLC
发明人： COHEN, Avrum I.
IPC分类号： G02B21/24 , G01B9/04 , G01M11/02
CPC分类号： G01M11/0228 , G01B9/04 , G02B21/006 , G02B21/245 , G06F19/10

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