专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2303245A2 DEGRADABLE MICROCAPSULES 有权转让
标题翻译： ABBAUBARE MIKROKAPSELN
公开(公告)号：EP2303245A2
公开(公告)日：2011-04-06
申请号：EP09780410.8
申请日：2009-07-10
申请人： ETH Zurich , Swissgenetics
发明人： KEMMER, Christian , FLURI, David , WITSCHI, Ulrich , WEBER, Wilfried , FUSSENEGGER, Martin
IPC分类号： A61K9/50
CPC分类号： A61K35/52 , A61K9/5042 , A61K9/5068
摘要： The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.
摘要翻译：本发明涉及由可由可包含药物或目的的其它化合物的多肽降解的聚合物和响应于引发化合物表达所述多肽的遗传工程改造的细胞组成的微胶囊以及目的化合物的定向释放方法。优选的聚合物是任选改性的硫酸纤维素/聚二烯丙基二甲基氯化铵。这样的微胶囊是无毒的，不引起免疫应答并且在哺乳动物中具有延长的半衰期。纤维素酶的表达系统例如是基于TET和多西环素，或E.REX和红霉素。在另一个实例中，纤维素酶的表达是由黄体生成激素引发的，其可用于携带精子的微胶囊的人工授精。

2. 发明授权

EP2303245B1 DEGRADABLE MICROCAPSULES 有权转让
标题翻译：生物可降解微囊
公开(公告)号：EP2303245B1
公开(公告)日：2016-12-28
申请号：EP09780410.8
申请日：2009-07-10
申请人： ETH Zurich , Swissgenetics
发明人： KEMMER, Christian , FLURI, David , WITSCHI, Ulrich , WEBER, Wilfried , FUSSENEGGER, Martin
IPC分类号： A61K9/50
CPC分类号： A61K35/52 , A61K9/5042 , A61K9/5068
摘要： The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.

3. 发明公开

EP3485040A1 B-CELL-MIMETIC CELLS 有权
公开(公告)号：EP3485040A1
公开(公告)日：2019-05-22
申请号：EP17749378.0
申请日：2017-07-17
申请人： ETH Zurich
发明人： FUSSENEGGER, Martin , XIE, Mingqi
IPC分类号： C12Q1/68 , A61K48/00 , C12N15/63

4. 发明公开

EP3184638A1 PROGRAMMABLE DIFFERENTIATION CONTROL NETWORK 审中-公开
标题翻译：可编程的差分控制网络
公开(公告)号：EP3184638A1
公开(公告)日：2017-06-28
申请号：EP15202677.9
申请日：2015-12-24
申请人： ETH Zurich
发明人： FUSSENEGGER, Martin , SAXENA, Pratik , ZULEWSKI, Henryk
IPC分类号： C12N15/63 , C12N15/85 , C12N5/071
CPC分类号： C12N15/85 , C12N5/0676 , C12N15/63 , C12N2501/60 , C12N2506/45 , C12N2830/002 , C12N2830/005
摘要： The present invention relates to expression system for establishing a transgenic differentiation-control network useful for controlling cell differentiation.
摘要翻译：本发明涉及建立用于控制细胞分化的转基因分化控制网络的表达系统。

5. 发明公开

EP2954057A1 DESIGNER PH SENSOR AS UNIVERSAL TRANSGENE CONTROLLER 有权
标题翻译：设计师 - PH传感器ALS UNIVERSELLER TRANSGENREGLER
公开(公告)号：EP2954057A1
公开(公告)日：2015-12-16
申请号：EP14705028.0
申请日：2014-02-10
申请人： ETH Zurich
发明人： AUSLAENDER, David , AUSLAENDER, Simon , FUSSENEGGER, Martin
IPC分类号： C12N15/63
CPC分类号： C12N15/85 , A61K35/22 , A61K35/28 , C07K16/2887 , C07K2317/24 , C12N9/16 , C12N15/63 , C12N2840/002 , C12Y301/03001
摘要： The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to pH and gaseous carbon dioxide, taking advantage of signal transduction of the human proton-activated cell-surface receptor TDAG8, OGR1 and/or GPR4 and related receptors to chimeric promoters containing cAMP-response elements. The systems according to the invention can be used to precisely monitor culture pH within the physiologic range, or also to adjust expression by gaseous CO 2 which shifts the CO 2 -bicarbonate balance towards hydrogen ions. Production of biopharmaceuticals of engineered cells cultivated in a bioreactor setup can be induced by gaseous CO2. Also, implanting engineered cells provide novel treatment strategies for acidosis-related disorders and type 1 diabetes.
摘要翻译：本发明涉及利用人质子激活的细胞表面受体TDAG8，OGR1和/或（或）的信号转导，可用于开启或关闭响应于pH和气态二氧化碳的基因表达的系统中的载体和哺乳动物细胞 GPR4和含有cAMP反应元件的嵌合启动子的相关受体。根据本发明的系统可以用于精确地监测生理范围内的培养pH，或者也可以通过将CO 2 - 碳酸酯平衡向氢离子转移的气态CO 2来调节表达。在生物反应器装置中培养的工程细胞的生物药物的生产可以由气态CO 2诱导。此外，植入工程细胞为酸中毒相关疾病和1型糖尿病提供新的治疗策略。

6. 发明公开

EP2285418A1 STIMULI-RESPONSIVE HYDROGEL 审中-公开
标题翻译： ON REIZE反应性水凝胶
公开(公告)号：EP2285418A1
公开(公告)日：2011-02-23
申请号：EP09757312.5
申请日：2009-06-05
申请人： ETH Zurich
发明人： WEBER, Wilfried , FUSSENEGGER, Martin , SCHOENMAKERS, Ronald
IPC分类号： A61K47/48 , A61K38/19 , A61K47/42 , A61K9/06
CPC分类号： A61K38/52 , A61K38/1866 , A61K47/549 , A61K47/552 , A61K47/58 , A61K47/60 , A61K47/62 , A61K47/6903
摘要： The present invention relates to a hydrogel comprising a polymer, a first polypeptide and a polypeptide binding partner, wherein the polypeptide binding partner is a second polypeptide, a nucleic acid or a small molecule, and wherein the interaction between the first polypeptide and the polypeptide binding partner stabilizes the hydrogel and is modulated by the addition of a modulating compound. A drug may be physically entrapped in the hydrogel, bound to the polymer forming the hydrogel structure, or bound to the first polypeptide or the polypeptide binding partner, and then be set free on addition of the modulating compound. Such a hydrogel comprising a drug may be injected into a patient, and drug release modulated by orally administering the modulating compound.

7. 发明公开

EP3394267A1 PROGRAMMABLE DIFFERENTIATION CONTROL NETWORK 有权
公开(公告)号：EP3394267A1
公开(公告)日：2018-10-31
申请号：EP16816292.3
申请日：2016-12-21
申请人： ETH Zurich
发明人： FUSSENEGGER, Martin , SAXENA, Pratik , ZULEWSKI, Henryk
IPC分类号： C12N15/63 , C12N15/85 , C12N5/071
摘要： The present invention relates to expression system for establishing a transgenic differentiation-control network useful for controlling cell differentiation.

8. 发明公开

EP2473606A1 CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN 有权
标题翻译：通过皮肤的转基因表达的控制
公开(公告)号：EP2473606A1
公开(公告)日：2012-07-11
申请号：EP10713570.9
申请日：2010-04-01
申请人： ETH Zurich
发明人： FUSSENEGGER, Martin , GITZINGER, Marc
IPC分类号： C12N15/09
CPC分类号： C12N15/8509 , A61K9/0014 , A61K47/10 , C12N2820/55 , C12N2830/002 , C12N2830/005
摘要： The invention relates to the use of a skin permeating compound such as phloretin for controlling transgene expression under control of the
Pseudomonas putida DOT-T1E- derived bacterial repressor TtgR, to a vector comprising the genetic code for the repressor TtgR fused to a transactivation or a transrepressor domain, to a vector comprising a TtgR- specific operator sequence (O
TtgR ), a promoter and a polynucleotide coding for an endogenous or exogenous protein, and to a mammalian cell transiently or constitutively transfected with the mentioned vectors, and to mammals comprising such cells in nano- or microcontainers.

9. 发明公开

EP2432496A1 CONTROL OF URIC ACID HOMEOSTASIS 失效
标题翻译： KONTROLLE VON HARNSUREURE-HOMÖOSTASE
公开(公告)号：EP2432496A1
公开(公告)日：2012-03-28
申请号：EP10722931.2
申请日：2010-05-06
申请人： ETH Zurich
发明人： KEMMER, Christian , WEBER, Wilfried , FUSSENEGGER, Martin
IPC分类号： A61K38/44 , C12N9/06 , C12N15/63 , C12Q1/68
CPC分类号： C12N15/85 , C07K14/195 , C12N9/0046 , C12N9/16 , C12N15/63 , C12N15/635
摘要： The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to uric acid. In a particular embodiment the invention relates to a mammalian cell useful in detecting and/or degrading a harmful excess of uric acid comprising (a) a vector comprising a genetic code for the uricase sensor-regulator HucR from Deinococcus radiodurans R1 fused to a transactivation domain or a transrepressor domain; and (b) a vector comprising the corresponding operator sequence hucO from Deinococcus radiodurans R1 specifically binding the bacterial uric acid sensor-regulator HucR, a promoter and a polynucleotide coding for an endogenous or exogenous protein, e.g. a protein interacting with uric acid.
摘要翻译：本发明涉及用于开启或关闭响应于尿酸的基因表达的系统中的载体和哺乳动物细胞。在一个具体实施方案中，本发明涉及可用于检测和/或降解有害过量的尿酸的哺乳动物细胞，其包含（a）载体，所述载体包含与转录激活结构域融合的放线杆菌R1的尿酸酶传感器调节物HucR的遗传密码或转录因子结构域; 和（b）包含来自放线杆菌属R1的相应的操作序列hucO的载体特异性结合细菌尿酸传感器调节剂HucR，启动子和编码内源或外源蛋白的多核苷酸，例如。与尿酸相互作用的蛋白质。

10. 发明公开

EP2234643A2 COMPOSITION FOR TREATMENT OF TUBERCULOSIS 有权
标题翻译：组合物技术治疗肺结核
公开(公告)号：EP2234643A2
公开(公告)日：2010-10-06
申请号：EP08865866.1
申请日：2008-11-25
申请人： ETH Zurich
发明人： FUSSENEGGER, Martin , WEBER, Wilfried , SCHOENMAKERS, Ronald
IPC分类号： A61K45/06 , A61K31/4409 , A61P31/06
CPC分类号： A61K31/17 , A61K31/4409 , A61K45/06 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition comprising a compound preventing EthR from binding to the
ethA promoter, for example a compound of formula 1 wherein R
1 is optionally substituted phenyl or optionally substituted pyridyl; R
2 is (CH
2 )
n wherein n is 1, 2, 3 or 4; R
3 is CH
3 (CH
2 )
m wherein m is 0, 1, 2 or 3; X
1 is O, S, NH, N(CH
3 ) or CH
2 ; and X
2 is O, S or NH; in particular 2-phenylethyl butyrate, and a thioamide or thiourea of formula 2 wherein R
4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, -NR
7 R
8 ; or -NH-N=CH-R
9 ; and substituents R
5 to R
9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式