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1. 发明公开

EP2303245A2 DEGRADABLE MICROCAPSULES 有权转让
标题翻译： ABBAUBARE MIKROKAPSELN
公开(公告)号：EP2303245A2
公开(公告)日：2011-04-06
申请号：EP09780410.8
申请日：2009-07-10
申请人： ETH Zurich , Swissgenetics
发明人： KEMMER, Christian , FLURI, David , WITSCHI, Ulrich , WEBER, Wilfried , FUSSENEGGER, Martin
IPC分类号： A61K9/50
CPC分类号： A61K35/52 , A61K9/5042 , A61K9/5068
摘要： The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.
摘要翻译：本发明涉及由可由可包含药物或目的的其它化合物的多肽降解的聚合物和响应于引发化合物表达所述多肽的遗传工程改造的细胞组成的微胶囊以及目的化合物的定向释放方法。优选的聚合物是任选改性的硫酸纤维素/聚二烯丙基二甲基氯化铵。这样的微胶囊是无毒的，不引起免疫应答并且在哺乳动物中具有延长的半衰期。纤维素酶的表达系统例如是基于TET和多西环素，或E.REX和红霉素。在另一个实例中，纤维素酶的表达是由黄体生成激素引发的，其可用于携带精子的微胶囊的人工授精。

2. 发明公开

EP4183252A1 METHOD FOR INCREASING THE LIFESPAN AND MOTILITY OF ANIMAL SPERM USING AN INHIBITOR OF SLO3 POTASSIUM CHANNEL 审中-实审
公开(公告)号：EP4183252A1
公开(公告)日：2023-05-24
申请号：EP22217303.1
申请日：2018-12-18
申请人： IMV Technologies , Université Grenoble Alpes , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Swissgenetics
发明人： ARNOULT, Christophe , SCHMITT, Eric , MARTINEZ, Guillaume , ESCOFFIER, Jessica
IPC分类号： A01N1/02 , G01N33/50
摘要： The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of SIo3 potassium channel. The invention also relates to a use of an inhibitor of SIo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of SIo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of SIo3 potassium channel.
The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument.
Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of SIo3 potassium channel; then artificially inseminating said animal with said sperm.

4. 发明公开

EP3498096A1 METHOD FOR INCREASING THE LIFESPAN AND MOTILITY OF ANIMAL SPERM USING AN INHIBITOR OF SLO3 POTASSIUM CHANNEL 审中-公开
公开(公告)号：EP3498096A1
公开(公告)日：2019-06-19
申请号：EP17306818.0
申请日：2017-12-18
申请人： IMV Technologies , Université Grenoble Alpes , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Swissgenetics
发明人： ARNOULT, Christophe , SCHMITT, Eric , MARTINEZ, Guillaume , ESCOFFIER, Jessica
IPC分类号： A01N1/02 , G01N33/50
摘要： The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel. The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel.
The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument.
Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

5. 发明授权

EP2303245B1 DEGRADABLE MICROCAPSULES 有权转让
标题翻译：生物可降解微囊
公开(公告)号：EP2303245B1
公开(公告)日：2016-12-28
申请号：EP09780410.8
申请日：2009-07-10
申请人： ETH Zurich , Swissgenetics
发明人： KEMMER, Christian , FLURI, David , WITSCHI, Ulrich , WEBER, Wilfried , FUSSENEGGER, Martin
IPC分类号： A61K9/50
CPC分类号： A61K35/52 , A61K9/5042 , A61K9/5068
摘要： The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate/poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.

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