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1. 发明公开

EP3583858A1 COMPOSITIONS FOR TREATING OR PREVENTING GUT BARRIER DYSFUNCTION 无效
公开(公告)号：EP3583858A1
公开(公告)日：2019-12-25
申请号：EP18178806.8
申请日：2018-06-20
申请人： DuPont Nutrition Biosciences ApS
发明人： HIRVONEN, Johanna , LATVALA, Sinikka Anneli , MARTTINEN, Maija Emilia , SALLI, Krista , PUTAALA, Heli , TIIHONEN, Kirsti , OUWEHAND, Arthur , YDE, Christian Clement , HONORÉ, Anders Hans , MARCUSSEN, Jørn , JENSEN, Henrik Max
IPC分类号： A23L33/125 , A23L33/135
摘要： This specification relates to compositions for maintaining or improving gut barrier integrity. In particular, such compositions may be useful for treating or preventing gut barrier dysfunction. The compositions comprise 2'-fucosyllactose and Bifidobacterium longum ssp. infantis.

2. 发明授权

EP2704704B1 PROBIOTIC BACTERIA FOR THE TOPICAL TREATMENT OF SKIN DISORDERS 有权转让
公开(公告)号：EP2704704B1
公开(公告)日：2018-09-26
申请号：EP12730161.2
申请日：2012-05-02
申请人： DuPont Nutrition Biosciences ApS
发明人： PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , RAUTONEN, Nina
IPC分类号： A61K35/74 , A61K35/747 , A61K35/745 , A61K35/744 , A61P17/00 , A61P17/18 , A61P37/00
CPC分类号： A61K35/741 , A61K31/205 , A61K35/744 , A61K35/745 , A61K35/747
摘要： The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.

3. 发明公开

EP3209774A1 USE OF PROLINE TOLERANT TRIPEPTIDYL PEPTIDASES IN FEED ADDITIVE COMPOSITIONS 审中-公开
标题翻译：脯氨酸耐受性三磷酸肽在饲料添加剂组合物中的应用
公开(公告)号：EP3209774A1
公开(公告)日：2017-08-30
申请号：EP15794483.6
申请日：2015-10-23
申请人： DuPont Nutrition Biosciences ApS
发明人： HAANING, Svend , KRAGH, Karsten Matthias , SHIPOVSKOV, Stepan , MIASNIKOV, Andrei , MA, Maria , MILLAN, Luis Fernando Romero , BARNARD, Luke , YU, Shukun , MEINJOHANNS, Ernst , BAK, Steffen Yde , NURMINEN, Paivi , PUTAALA, Heli
IPC分类号： C12N9/48 , A23J3/34 , C12P21/06
摘要： A method of preparing a feed additive composition comprising: (a) admixing at least one proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having (i) (A) Proline at P1; and (B) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids at P1; or (ii) (a′) Proline at P1′; and (b′) An amino acid selected from alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, serine, threonine, tryptophan, tyrosine, valine or synthetic amino acids or amines at P1′; and one or more ingredients selected from the group consisting of a salt, polyol including sorbitol and glycerol, wheat or a wheat component, sodium acetate, sodium acetate trihydrate, potassium sorbate Talc, polyvinyl alcohol (PVA), benzoate, sorbiate, 1,3-propane diol, glucose, parabens, sodium chloride, citrate, metabisulfite, formate or a combination thereof; and (b) optionally packaging as well as uses of such proline tolerant tripeptidyl peptidases, feed additive compositions, feed additive kits, feeds or feedstuffs and/or premixes.
摘要翻译：一种制备饲料添加剂组合物的方法，包括：（a）混合至少一种主要具有外肽酶活性的脯氨酸耐受性三肽肽酶，其中所述脯氨酸耐受性三肽肽酶能够从具有（i）（ A）P1处的脯氨酸; （B）选自丙氨酸，精氨酸，天冬酰胺，天冬氨酸，半胱氨酸，谷氨酰胺，谷氨酸，甘氨酸，组氨酸，异亮氨酸，亮氨酸，赖氨酸，甲硫氨酸，苯丙氨酸，丝氨酸，苏氨酸，色氨酸，酪氨酸，缬氨酸或合成的氨基酸 P1处的氨基酸; 或（ii）（a'）PV处的脯氨酸; 和（b'）选自丙氨酸，精氨酸，天冬酰胺，天冬氨酸，半胱氨酸，谷氨酰胺，谷氨酸，甘氨酸，组氨酸，异亮氨酸，亮氨酸，赖氨酸，甲硫氨酸，苯丙氨酸，丝氨酸，苏氨酸，色氨酸，酪氨酸，缬氨酸或 PV处的合成氨基酸或胺; 以及一种或多种选自盐，包括山梨醇和甘油的多元醇，小麦或小麦组分，乙酸钠，乙酸钠三水合物，山梨酸钾滑石，聚乙烯醇（PVA），苯甲酸酯，山梨酸酯，1,3 丙二醇，葡萄糖，对羟基苯甲酸酯，氯化钠，柠檬酸盐，偏亚硫酸氢盐，甲酸盐或其组合; 和（b）任选地包装以及这种耐受脯氨酸的三肽肽酶，饲料添加剂组合物，饲料添加剂药盒，饲料或饲料和/或预混合物的用途。

5. 发明公开

EP3512532A1 BACTERIA 审中-实审转让
公开(公告)号：EP3512532A1
公开(公告)日：2019-07-24
申请号：EP17791942.0
申请日：2017-09-12
申请人： DuPont Nutrition Biosciences ApS
发明人： PUTAALA, Heli , FORSSTEN, Sofia , LAHTINEN, Sampo , OUWEHAND, Arthur , MÄTTÖ, Jaana , MÄKIVUOKKO, Harri , MATTSBY-BALTZER, Inger , ANDERSCH, Björn
IPC分类号： A61K35/747 , A61K35/741 , A61K35/745 , C12R1/00 , A61P31/00 , C12Q1/00 , G01N33/00

6. 发明授权

EP2459203B1 LACTIC ACID BACTERIA AND BIFIDOBACTERIA FOR TREATING ENDOTOXEMIA 有权转让
公开(公告)号：EP2459203B1
公开(公告)日：2018-10-31
申请号：EP10747076.7
申请日：2010-07-30
申请人： DuPont Nutrition Biosciences ApS
发明人： BURCELIN, Rémy , CARCANO, Didier , DESREUMAUX, Pierre , LAHTINEN, Sampo , RAUTONEN, Nina , PUTAALA, Heli , TIIHONEN, Kirsti , BARRANGOU, Rodolphe
IPC分类号： A61P29/00 , A61K35/745 , A61K35/747 , A61P5/50
CPC分类号： A61K35/747 , A61K35/74 , A61K35/745 , A61K2035/115 , A61P5/50 , A61P29/00 , A61K2300/00
摘要： The invention relates to use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal.

8. 发明公开

EP3512966A1 BACTERIA 审中-实审转让
公开(公告)号：EP3512966A1
公开(公告)日：2019-07-24
申请号：EP17764827.6
申请日：2017-09-12
申请人： DuPont Nutrition Biosciences ApS
发明人： PUTAALA, Heli , FORSSTEN, Sofia , LAHTINEN, Sampo , OUWEHAND, Arthur , MÄTTÖ, Jaana , MÄKIVUOKKO, Harri , NIKKILÄ, Janne
IPC分类号： C12R1/23 , C12R1/24 , C12R1/225

9. 发明授权

EP1981516B1 USE OF PROBIOTIC MICROORGANISMS FOR THE TREATMENT AND PREVENTION OF OBESITY AND RELATED DISORDERS 有权转让
公开(公告)号：EP1981516B1
公开(公告)日：2018-08-08
申请号：EP07734501.5
申请日：2007-01-26
申请人： DuPont Nutrition Biosciences ApS
发明人： RAUTONEN, Nina , PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , KORCZYNSKA, Marta, Zdzislawa , NOORDMAN, Wouter Herman
IPC分类号： A61K35/745 , A61K35/747 , A23K10/18 , A23K50/75 , A23L33/00 , A23L33/135 , A61P3/04 , A23K50/40
CPC分类号： A61K35/747 , A23K10/18 , A23K50/40 , A23K50/75 , A23L33/135 , A23L33/30 , A61K35/745
摘要： Use of at least one strain of a microorganism and/or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and/or a metabolite thereof may be administered to the subject for the treatment and/or prevention of excess weight and/or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and/or a metabolite thereof is administered to the subject for the treatment and/or prevention of obesity and/or a caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain of Lactobacillus spp. and/or Bifidobacterium spp., for example a strain of Lactobacillus acidophilus, L. curvatus, L. salivarius and/or B. lactis.

10. 发明公开

EP2704704A1 PROBIOTIC BACTERIA FOR THE TOPICAL TREATMENT OF SKIN DISORDERS 有权转让
标题翻译： PROBIOTISCHE BAKTERIEN ZUR TOPISCHEN BEHANDLUNG VON HAUTERKRANKUNGEN
公开(公告)号：EP2704704A1
公开(公告)日：2014-03-12
申请号：EP12730161.2
申请日：2012-05-02
申请人： DuPont Nutrition Biosciences ApS
发明人： PUTAALA, Heli , OUWEHAND, Arthur , TIIHONEN, Kirsti , RAUTONEN, Nina
IPC分类号： A61K31/205 , A61K35/74 , A61P17/06 , A61P17/16
CPC分类号： A61K35/741 , A61K31/205 , A61K35/744 , A61K35/745 , A61K35/747
摘要： The present invention relates to a probiotic bacteria, and/or soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria for use in the treatment of a disorder associated with Tight Junction function, characterised in that the probiotic bacteria, soluble metabolite of a probiotic bacteria and/or a cell lysate of a probiotic bacteria is formulated for topical administration.
摘要翻译：本发明涉及用于治疗与紧结功能相关的病症的益生菌和/或益生菌的细胞裂解物的益生菌和/或可溶性代谢物，其特征在于益生菌，可溶性将益生菌和/或益生菌的细胞裂解液的代谢物配制成局部给药。

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