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1. 发明公开

EP2122352A2 A METHOD AND A MICRODEVICE FOR THE IDENTIFICATION AND/OR QUANTIFICATION OF AN ANALYTE IN A BIOLOGICAL SAMPLE 有权
标题翻译：方法和微器件的识别和/或分析的量化在生物样品
公开(公告)号：EP2122352A2
公开(公告)日：2009-11-25
申请号：EP07849492.9
申请日：2007-12-14
申请人： Consiglio Nazionale delle Ricerche - INFM Istituto Nazionale per la Fisica della Materia , Fondazione Istituto Italiano Di Tecnologia
发明人： POMPA, Pier Paolo , SABELLA, Stefania , RINALDI, Rosaria , CINGOLANI, Roberto , CALABI, Franco
IPC分类号： G01N33/542 , C12Q1/68
CPC分类号： C12Q1/6818 , B82Y5/00 , C12Q1/6825 , C12Q1/6834 , G01N33/542 , C12Q2565/101 , C12Q2565/519 , C12Q2565/601
摘要： A method and device, based on a film of a luminescent substance, such as colloidal semiconductor nanocrystals dispersed in a polymer matrix, for conducting quantitative and real-time analyses of PCR processes or of biomolecular interactions in genomics and/or proteomics. The optical detection system is based on FRET processes between the luminescent substance (which acts as the donor in the FRET process) and a suitable fluorophore (which acts as the acceptor species) with which the DNA or other biomolecule is marked. The device is essentially composed of a reaction microchamber with a wall formed by a thin film made of polymer material, in which the nanocrystals are uniformly dispersed, or made of a photoluminescent or electroluminescent polymer. Molecular probes are chemically immobilized on the surface of the polymer film for the specific recognition of the analyte which is to be determined in real time. The film of nanocrystals is excited by radiation at low wavelength (for example, UV/blue), and the radiation in the spectral emission window characteristic of the fluorescent marker of the biomolecule is detected. The specific photophysical characteristics of FRET processes make it possible to monitor in a selective way, in real time and in quantitative mode, the biomolecular interactions, which take place in the close proximity of the surface of the film (typically at distances of

3. 发明授权

EP2885622B1 DEVICE AND METHOD FOR DETERMINING THE DISSOLUTION KINETICS OF COLLOIDAL NANOPARTICLES 有权
标题翻译：确定胶体纳米颗粒溶解动力学的装置和方法
公开(公告)号：EP2885622B1
公开(公告)日：2017-10-04
申请号：EP13779375.8
申请日：2013-08-14
申请人： Fondazione Istituto Italiano Di Tecnologia
发明人： POMPA, Pier Paolo , SABELLA, Stefania , CINGOLANI, Roberto
IPC分类号： G01N13/00
CPC分类号： G01N13/00 , G01N2013/006

4. 发明公开

EP2885622A1 DEVICE AND METHOD FOR DETERMINING THE DISSOLUTION KINETICS OF COLLOIDAL NANOPARTICLES 有权
标题翻译：装置和方法用于确定KOLLOIDNANOTEILCHEN解散
公开(公告)号：EP2885622A1
公开(公告)日：2015-06-24
申请号：EP13779375.8
申请日：2013-08-14
申请人： Fondazione Istituto Italiano Di Tecnologia
发明人： POMPA, Pier Paolo , SABELLA, Stefania , CINGOLANI, Roberto
IPC分类号： G01N13/00
CPC分类号： G01N13/00 , G01N2013/006
摘要： A device (1) is described for determining the dissolution kinetics of colloidal nanoparticles (2) in respective derivation ions (3) in a solution (4), which comprises a dissolution compartment (5) containing the solution (4), and feedable with nhe colloidal nanoparticles (2); an analysis compartment (6) separate from the dissolution compartment (5); a fixed filtering membrane (7) which separates the dissolution compartment (5) from the analysis compartment (6), is selectively permeable to the derivation ion (3) and is adapted to filter the solution (4),· compressing means (8) to induce passage of the solution (4) from the dissolution compartment (5) to the analysis compartment (6) through the filtering membrane (7); a determination device (9) for determining the quantity of the derivation ion (3); the device furthermore comprises mixing means (io) associated to the dissolution compartment (5) and distinct from the compressing means (8) and the filtering membrane (7) has pores of size smaller than 10 nm. Relative determination methods for determining the dissolution kinetics and the toxicity of colloidal nanoparticles (2) are also described.
摘要翻译：一种装置是在溶液中，其包括溶解隔室装有溶液描述了用于确定性的采矿胶体纳米颗粒的溶解动力学在respectivement推导离子，和饲料能够与胶体纳米粒子; 上隔室分析从溶解分离隔室; 固定过滤膜哪个溶解隔室从所述分析室隔开，是选择性地渗透的推导离子和是angepasst过滤溶液; 压缩装置，以诱导从溶解隔室通过过滤膜的分析室的溶液的通道; 确定性采矿推导离子的量的确定装置; 该装置进一步包括多个混合装置相关联，以溶解隔室和从所述压缩装置不同的和过滤膜具有大小为确定性采矿溶解动力学和胶体纳米颗粒的毒性被如此描述纳米小于10种相对判定方法的孔..

5. 发明公开

EP3233135A1 ALBUMIN NANOPARTICLES ENCAPSULATING GADOLINIUM AND METHOD OF SYNTHESIS THEREOF 有权
标题翻译：包埋钆的白蛋白纳米颗粒及其合成方法
公开(公告)号：EP3233135A1
公开(公告)日：2017-10-25
申请号：EP15825836.8
申请日：2015-12-14
申请人： Fondazione Istituto Italiano di Tecnologia
发明人： SABELLA, Stefania , MALVINDI, Maria Ada , TORINO, Enza , POMPA, Pier Paolo , CINGOLANI, Roberto , NETTI, Paolo
IPC分类号： A61K49/14 , A61K49/18 , B82Y15/00
CPC分类号： A61K49/143 , A61K49/1818
摘要： The invention relates to cross-linked albumin nanoparticles loaded with gadolinium, for example with GdCl3 or Gd-DTPA, characterized in that they have a controlled size comprised between 50 nm and 80 nm, and that the gadolinium molecules are encapsulated by albumin, without the presence of covalent or electrostatic bonds. The gadolinium thus encapsulated has a relaxivity value greater than the reference molecules currently used for MRI diagnostics. The method of synthesis of the nanoparticles of the invention is also described.
摘要翻译：本发明涉及负载有钆的交联白蛋白纳米颗粒，例如GdCl 3或Gd-DTPA，其特征在于它们具有包括在50nm和80nm之间的受控尺寸，并且钆分子被白蛋白包封，没有共价键或静电键的存在。如此封装的钆具有比当前用于MRI诊断的参考分子更大的弛豫值。还描述了合成本发明纳米颗粒的方法。

6. 发明公开

EP2827912A1 POLYMERIC COMPOSITE MATERIALS WITH ANTIMICROBIAL AND BIODEGRADABLE PROPERTIES AND USES THEREOF 有权
标题翻译：高分子复合材料具有抗微生物和生物可降解性能及其应用
公开(公告)号：EP2827912A1
公开(公告)日：2015-01-28
申请号：EP13721090.2
申请日：2013-03-21
申请人： Fondazione Istituto Italiano Di Tecnologia
发明人： ATHANASIOU, Athanasia , BAYER, Ilker S. , LIAKOS, Ioannis , RIZZELLO, Loris , CINGOLANI, Roberto , SABELLA, Stefania , POMPA, Pier Paolo
IPC分类号： A61L15/46 , A61L17/00 , A61L24/00 , A61L26/00 , A61L27/54
摘要： A composite material for the production of a medical device having an antiseptic action includes a matrix of alginate in which the complex of iodopovidone is dispersed. The composite material is used particularly for the production of films, micro-capsules, and suture threads with iodine controlled release.

7. 发明授权

EP2122352B1 A METHOD AND A MICRODEVICE FOR THE IDENTIFICATION AND/OR QUANTIFICATION OF AN ANALYTE IN A BIOLOGICAL SAMPLE 有权
标题翻译：方法和微器件的识别和/或分析的量化在生物样品
公开(公告)号：EP2122352B1
公开(公告)日：2012-05-02
申请号：EP07849492.9
申请日：2007-12-14
申请人： Consiglio Nazionale Delle Ricerche , Fondazione Istituto Italiano Di Tecnologia
发明人： POMPA, Pier Paolo , SABELLA, Stefania , RINALDI, Rosaria , CINGOLANI, Roberto , CALABI, Franco
IPC分类号： B82Y5/00 , B82Y10/00 , G01N33/542 , C12Q1/68
CPC分类号： C12Q1/6818 , B82Y5/00 , C12Q1/6825 , C12Q1/6834 , G01N33/542 , C12Q2565/101 , C12Q2565/519 , C12Q2565/601
摘要： A method and device, based on a film of a luminescent substance, such as colloidal semiconductor nanocrystals dispersed in a polymer matrix, for conducting quantitative and real-time analyses of PCR processes or of biomolecular interactions in genomics and/or proteomics. The optical detection system is based on FRET processes between the luminescent substance (which acts as the donor in the FRET process) and a suitable fluorophore (which acts as the acceptor species) with which the DNA or other biomolecule is marked. The device is essentially composed of a reaction microchamber with a wall formed by a thin film made of polymer material, in which the nanocrystals are uniformly dispersed, or made of a photoluminescent or electroluminescent polymer. Molecular probes are chemically immobilized on the surface of the polymer film for the specific recognition of the analyte which is to be determined in real time. The film of nanocrystals is excited by radiation at low wavelength (for example, UV/blue), and the radiation in the spectral emission window characteristic of the fluorescent marker of the biomolecule is detected. The specific photophysical characteristics of FRET processes make it possible to monitor in a selective way, in real time and in quantitative mode, the biomolecular interactions, which take place in the close proximity of the surface of the film (typically at distances of

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