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1. 发明授权

EP2316962B1 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译： Adolasen，核酸编码这些，以及它们的制备和使用处理
公开(公告)号：EP2316962B1
公开(公告)日：2014-07-09
申请号：EP11000305.0
申请日：2007-03-07
申请人： Cargill, Incorporated
发明人： Burke, Ellen , Gort, Steven John , Hicks, Paula M. , Luginbuhl, Peter , Mc Farlan, Sara C. , Richardson, Toby , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12P17/10 , C07D209/20 , C12N9/88 , A23L1/22 , C12P13/00
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52

2. 发明公开

EP2112227A1 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛缩酶，核酸，其编码和它们的制备方法和用途
公开(公告)号：EP2112227A1
公开(公告)日：2009-10-28
申请号：EP09009627.2
申请日：2007-03-07
申请人： Cargill, Incorporated
发明人： Burke, Ellen , Gort, Steven John , Hicks, Paula M. , Luginbuhl, Peter , McFarlan, Sara C. , Richardson, Toby , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12P17/00 , C07D209/20 , C12N9/88 , A23L1/22
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R3R and S5R configurations, and salts thereof.
摘要翻译：本发明涉及所述多肽具有醛缩酶活性，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，多核苷酸编码所述多肽的合成，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性，以多肽，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，包括热电表和耐热活性，多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和多肽。在与本发明雅舞蹈的多肽可以在多种药物，农业和工业环境中使用。在一些实施方案中，本发明提供的多肽和生物合成途径也都在生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的有用：如R ，R和S，R莫纳甜，以及它们的盐，以及莫纳甜衍生物，：如R3R和S5R配置，以及它们的盐的某些立体异构体。

3. 发明公开

EP2361976A2 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译： Polypeptide und Biosynthesewege zur Herstellung von Stereoisomeren von Monatin und ihrenVorläufern
公开(公告)号：EP2361976A2
公开(公告)日：2011-08-31
申请号：EP11000670.7
申请日：2006-04-26
申请人： Cargill, Incorporated
发明人： Brazeau, Brian, J. , Burke, Ellen , De Souza, Mervyn , Gort, Steven, J. , Hicks, Paula, M. , Kollman, Sherry, R. , Luginbuhl, Peter , McFarlan, Sara, C. , Richardson, Toby , Sanchez-Riera, Fernando, A. , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12N9/10 , C12P13/22 , C07H21/04
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜，以及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

4. 发明公开

EP3168299A3 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PRECURSORS 无效
标题翻译：用于生产MONATIN立体异构体及其前体的多肽和生物合成途径
公开(公告)号：EP3168299A3
公开(公告)日：2017-07-05
申请号：EP16001105.2
申请日：2006-04-26
申请人： Cargill, Incorporated
发明人： Brazeau, Brian J. , Burke, Ellen , De Souza, Mervyn , Gort, Steven J. , Hicks, Paula M. , Kollman, Sherry R. , Luginbuhl, Peter , McFarlan, Sara C. , Richardson, Toby , Sanchez-Riera, Fernando A. , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12N9/10 , C12P13/22 , C07H21/04 , C12N9/90 , C12P17/10
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸，一种在某些monatin合成途径（包括一些生物合成途径）中形成的中间体。

5. 发明授权

EP2361976B1 Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors 有权
标题翻译：多肽和生物合成途径生产莫纳甜的立体异构体及其前体的
公开(公告)号：EP2361976B1
公开(公告)日：2016-05-25
申请号：EP11000670.7
申请日：2006-04-26
申请人： Cargill, Incorporated
发明人： Brazeau, Brian, J. , Burke, Ellen , De Souza, Mervyn , Gort, Steven, J. , Hicks, Paula, M. , Kollman, Sherry, R. , Luginbuhl, Peter , McFarlan, Sara, C. , Richardson, Toby , Sanchez-Riera, Fernando, A. , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12N9/10 , C12P13/22 , C07H21/04 , C12N9/90 , C12P17/10
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10

6. 发明公开

EP2090173A1 Monatin tabletop sweetener compositions and methods of making same 审中-公开
标题翻译： Monatin-Süßstoffzusammensetzungund deren Herstellungsverfahren
公开(公告)号：EP2090173A1
公开(公告)日：2009-08-19
申请号：EP09000968.9
申请日：2004-08-02
申请人： Cargill, Incorporated
发明人： Hicks, Paula, M. , Abraham, Timothy, W. , Cameron, Douglas, C. , Goulson, Melanie, J. , Lindley, Michael, G. , McFarlan, Sara, C. , Millis, James, R. , Rosazza, John , Zhao, Lishan , Weiner, David, P.
IPC分类号： A21D13/08 , A23C9/154 , A23F3/00 , A23F3/30 , A23F5/00 , A23G1/00 , A23G3/00 , A23L1/187 , A23L1/236 , A23L2/02 , A23L2/60 , C12P17/10
CPC分类号： A23C9/1544 , A21D13/80 , A23F3/30 , A23G1/56 , A23L2/60 , A23L27/31 , A23L27/32 , A23G2200/06
摘要： The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific blends of monatin stereoisomers, and /or monatin produced via a biosynthetic pathway in vivo (e.g., inside cells) or in vitro.
摘要翻译：本发明涉及包含莫纳甜的新型甜味剂组合物和制备这种组合物的方法。本发明还涉及包含特定莫纳甜立体异构体，莫纳甜立体异构体的特异性共混物和/或通过体内生物合成途径（例如细胞内）或体外产生的莫纳甜的甜味剂组合物。

7. 发明公开

EP3168299A2 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PRECURSORS 无效
标题翻译：多羟基琥珀酰亚胺基琥珀酰亚胺基维生素A维生素A维生素
公开(公告)号：EP3168299A2
公开(公告)日：2017-05-17
申请号：EP16001105.2
申请日：2006-04-26
申请人： Cargill, Incorporated
发明人： Brazeau, Brian J. , Burke, Ellen , De Souza, Mervyn , Gort, Steven J. , Hicks, Paula M. , Kollman, Sherry R. , Luginbuhl, Peter , McFarlan, Sara C. , Richardson, Toby , Sanchez-Riera, Fernando A. , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12N9/10 , C12P13/22 , C07H21/04 , C12N9/90 , C12P17/10
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜，以及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

8. 发明公开

EP2354240A1 Polypeptides and biosynthetic pathways 有权
标题翻译：多肽和生物合成Pfade
公开(公告)号：EP2354240A1
公开(公告)日：2011-08-10
申请号：EP10010240.9
申请日：2003-04-23
申请人： CARGILL, INCORPORATED
发明人： Abraham, Timothy W. , Cameron, Douglas C. , Dalluge, Joseph , Hicks, Paula M. , Hobson, Russell J. , McFarlan, Sara C. , Millis, Jim , Rosazza, Jack , Weiner, David P. , Zhao, Lishan
IPC分类号： C12P17/10 , C07D209/18 , C12N1/00 , C12N9/10 , C12N9/88 , C12N9/02 , C12N15/52 , C12N15/63
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10
摘要： Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
摘要翻译：提供可用于从葡萄糖，色氨酸，吲哚-3-乳酸，吲哚-3-丙酮酸和2-羟基2-（环烯醇-3-基甲基）-4-酮戊二酸制备莫纳甜的方法和组合物。还公开了制备吲哚-3-丙酮酸和2-羟基2-（吲哚基-3-甲基）-4-酮戊二酸中间体的方法。提供的组合物包括核酸分子，多肽，化学结构和细胞。方法包括体外和体内过程，体外方法包括化学反应。

9. 发明公开

EP2322643A1 Aldolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：醛醇缩酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP2322643A1
公开(公告)日：2011-05-18
申请号：EP11000304.3
申请日：2007-03-07
申请人： Cargill, Incorporated
发明人： Burke, Ellen , Gort, Steven John , Hicks, Paula M. , Luginbuhl, Peter , Mc Farlan, Sara C. , Richardson, Toby , Solheid, Christopher , Weiner, David , Zhao, Lishan
IPC分类号： C12P17/00 , C07D209/20 , C12N9/88 , A23L1/22
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R3R and S5R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种制药，农业和工业环境中。在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径，R和S，R莫纳甜及其盐，以及monatin衍生物的某些立体异构体，如R3R和S5R构型及其盐。

10. 发明授权

EP2354240B1 Polypeptides and biosynthetic pathways 有权
标题翻译：多肽和生物合成途径
公开(公告)号：EP2354240B1
公开(公告)日：2016-07-06
申请号：EP10010240.9
申请日：2003-04-23
申请人： CARGILL, INCORPORATED
发明人： Abraham, Timothy W. , Cameron, Douglas C. , Dalluge, Joseph , Hicks, Paula M. , Hobson, Russell J. , McFarlan, Sara C. , Millis, Jim , Rosazza, Jack , Weiner, David P. , Zhao, Lishan
IPC分类号： C12P17/10 , C07D209/18 , C12N1/00 , C12N9/10 , C12N9/88 , C12N9/02 , C12N15/52 , C12N15/63
CPC分类号： C12N15/52 , C12N9/0006 , C12N9/0014 , C12N9/0016 , C12N9/1096 , C12P17/10

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