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1. 发明公开

EP2847607A4 PULSE SEQUENCE METHOD FOR MRI 有权转让
标题翻译： PULSSEQUENZVERFAHRENFÜR地铁
公开(公告)号：EP2847607A4
公开(公告)日：2016-12-14
申请号：EP13785251
申请日：2013-05-03
申请人： CR DEV AB
发明人： TOPGAARD DANIEL , LASIC SAMO , NILSSON MARKUS
IPC分类号： G01R33/563 , G01R33/561 , G01R33/565
CPC分类号： G01R33/565 , G01R33/4818 , G01R33/5615 , G01R33/56341
摘要： The present invention describes a method for magnetic resonance (MR) and/or MR imaging, comprising acquisition of signals and MR images originating from a RF and gradient sequence causing isotropic diffusion weighting of signal attenuation, wherein the isotropic diffusion weighting is achieved by one time-dependent dephasing vector q(t) having an orientation, wherein the isotropic diffusion weighting is proportional to the trace of a diffusion tensor D, and wherein the orientation of the time-dependent dephasing vector q(t) is either varied discretely in more than three directions in total, or changed continuously, or changed in a combination of discretely and continuously during the gradient pulse sequence, 0≦t≦echo time, where t represents the time. The method may be performed during a single shot (single MR excitation).
摘要翻译：本发明描述了一种用于磁共振（MR）和/或MR成像的方法，包括获取源自RF的信号和MR图像和导致信号衰减的各向同性扩散加权的梯度序列，其中各向同性扩散加权一次实现具有取向的相关去相位向量q（t），其中各向同性扩散加权与扩散张量D的轨迹成比例，并且其中时间相关的去相位向量q（t）的取向离散地变化超过在梯度脉冲序列0＆nlE; t＆nlE;回波时间，其中t表示时间，总共三个方向，或连续变化，或者在离散和连续的组合中改变。该方法可以在单次射击（单次MR激发）期间执行。

2. 发明公开

EP2150828A4 METHOD AND SYSTEM FOR DIFFUSION MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：方法和系统扩散磁成像
公开(公告)号：EP2150828A4
公开(公告)日：2011-08-10
申请号：EP08779317
申请日：2008-05-30
申请人： CR DEV AB
发明人： BRYSKHE KARIN , TOPGAARD DANIEL , STENSTAM ANNA
IPC分类号： G01R33/20 , A61B5/055 , G01N24/08
CPC分类号： G01R33/4633 , A61B5/055 , G01R33/5605 , G01R33/56341 , Y10T436/24

3. 发明公开

EP2847606A4 ANALYSIS FOR QUANTIFYING MICROSCOPIC DIFFUSION ANISOTROPY 有权转让
标题翻译： ANALYZE ZUR QUANTIFIZIERUNG VON MIKROSKOPISCHER DIFFUSIONSANISOTROPIE
公开(公告)号：EP2847606A4
公开(公告)日：2016-07-27
申请号：EP13785201
申请日：2013-05-03
申请人： CR DEV AB
发明人： TOPGAARD DANIEL , LASIC SAMO , NILSSON MARKUS
IPC分类号： G01R33/563 , A61B5/055 , G01N24/08 , G01R33/56
CPC分类号： G01R33/56341 , G01N24/08 , G01N24/081 , G01R33/56 , G01R33/56308
摘要： The present invention describes a method for quantifying microscopic diffusion anisotropy and/or mean diffusivity in a material by analysis of echo attenuation curves acquired with two different gradient modulations schemes, wherein one gradient modulation scheme is based on isotropic diffusion weighting and the other gradient modulation scheme is based on non-isotropic diffusion weighting, and wherein the method comprises analyzing by comparing the signal decays of the two acquired echo attenuation curves.
摘要翻译：本发明描述了通过分析用两种不同的梯度调制方案获得的回波衰减曲线来量化材料中的微观扩散各向异性和/或平均扩散率的方法，其中一个梯度调制方案基于各向同性扩散加权和另一种梯度调制方案基于非各向同性扩散加权，并且其中所述方法包括通过比较两个所获得的回波衰减曲线的信号衰减进行分析。

4. 发明公开

EP2867690A4 QUANTIFICATION OF THE RELATIVE AMOUNT OF WATER IN THE TISSUE MICROCAPILLARY NETWORK 有权转让
标题翻译：水的相对量的微毛细管结构网络数量化
公开(公告)号：EP2867690A4
公开(公告)日：2017-01-25
申请号：EP13810505
申请日：2013-06-24
申请人： CR DEV AB
发明人： TOPGAARD DANIEL , LASIC SAMO
IPC分类号： G01R33/563 , A61B5/00 , A61B5/026 , A61B5/055 , G01R33/54 , G01R33/56 , G01R33/565
CPC分类号： G01R33/56341 , A61B5/0263 , A61B5/055 , A61B5/7207 , F04C2270/041 , G01R33/543 , G01R33/5608 , G01R33/5635 , G01R33/56366 , G01R33/56509

5. 发明公开

EP3105606A4 METHOD FOR QUANTIFYING ISOTROPIC DIFFUSION AND/OR ANISOTROPIC DIFFUSION IN A SAMPLE 有权转让
公开(公告)号：EP3105606A4
公开(公告)日：2018-06-20
申请号：EP15746618
申请日：2015-02-10
申请人： CR DEV AB
发明人： TOPGAARD DANIEL , LASIC SAMO , NILSSON MARKUS
IPC分类号： G01R33/563
CPC分类号： G01R33/56341 , A61B5/055 , G01N24/08 , G01R33/5608
摘要： According to an aspect of the present inventive concept there is provided a method for quantifying isotropic diffusion and/or anisotropic diffusion in a sample, the method comprising: performing diffusion weighted magnetic resonance measurements on the sample using diffusion encoding magnetic gradient pulse sequences Gi=1. . . m, wherein each magnetic gradient pulse sequence Gi is generated such that a diffusion encoding tensor bi for the magnetic gradient pulse sequence Gi has one to three non-zero eigenvalues, where bi=Formula (I), qi(t) is proportional to Formula (II) and t is an echo time. The method further comprises collecting data representing magnetic resonance echo signals resulting from the measurements on the sample, wherein at least a subset of the data represents echo signals being acquired with a set of magnetic gradient pulse sequences causing anisotropic diffusion weighting, and wherein the diffusion encoding tensor for each gradient pulse sequence of the set of magnetic gradient pulse sequences has three non-zero eigenvalues, at least one of the three eigenvalues being different from the other two eigenvalues. The method further comprises calculating a degree of isotropic diffusion and/or a degree of anisotropic diffusion using the data.

6. 发明公开

EP2438454A4 METHOD AND SYSTEM FOR MAGNETIC RESONANCE IMAGING, AND USE THEREOF 有权转让
公开(公告)号：EP2438454A4
公开(公告)日：2018-01-17
申请号：EP10778010
申请日：2010-04-22
申请人： CR DEV AB
发明人： TOPGAARD DANIEL
IPC分类号： G01R33/563 , A61B5/055 , G01R33/44 , G01R33/46 , G01R33/50 , G01R33/56
CPC分类号： G01R33/56341 , A61B5/055 , G01R33/448 , G01R33/46 , G01R33/4616 , G01R33/50 , G01R33/5608
摘要： The present invention refers to a method for magnetic resonance imaging or nuclear magnetic resonance spectroscopy comprising emitting a radio frequency and gradient pulse sequence towards an object being subjected to a magnetic field, wherein said object comprises a molecule having an atom with a nuclear spin differing from 0, encoding, detecting and acquiring a magnetic resonance signal from said object corresponding to said emitted radio frequency and gradient pulse sequence, wherein the radio frequency and gradient pulse sequence comprises a first weighting block, a mixing block with duration tm and a second weighting block, and wherein encoding, detecting and acquiring the magnetic resonance signal from said object is limited to initial decay of the signal intensity I with increasing strength of at least one of the first weighting block and the second weighting block, wherein the variation of the initial signal decay rate with tm is analysed to obtain the apparent exchange rate AXR.

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