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1. 发明授权

EP2978008B1 FILAMENT FOR MASS SPECTROMETRIC ELECTRON IMPACT ION SOURCE 有权转让
公开(公告)号：EP2978008B1
公开(公告)日：2018-10-03
申请号：EP15175379.5
申请日：2015-07-06
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy P. , Muntean, Felician , Splendore, Maurizio
IPC分类号： H01J27/20 , H01J49/14
CPC分类号： H01J49/147 , H01J27/205
摘要： The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.

2. 发明公开

EP3185276A1 TRIPLE QUADRUPOLE MASS SPECTROMETRY COUPLED TO TRAPPED ION MOBILITY SEPARATION 有权转让
标题翻译：三重四极杆质谱联用法用于陷阱离子迁移率分离
公开(公告)号：EP3185276A1
公开(公告)日：2017-06-28
申请号：EP16195564.6
申请日：2016-10-25
申请人： Bruker Daltonics, Inc.
发明人： Kaplan, Desmond Allen , Muntean, Felician , Park, Mel , Ridgeway, Mark
IPC分类号： H01J49/06 , H01J49/00 , G01N27/62
CPC分类号： H01J49/4225 , G01N27/622 , H01J49/0045 , H01J49/066 , H01J49/10
摘要： The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer ("TIMS") is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.
摘要翻译：本发明提供了一种用于获取复杂物质混合物中物质的碎片离子谱的方法，其中捕获的离子迁移谱仪（“TIMS”）被用作耦合到三重四极杆质量过滤器组件的离子迁移率分离装置。碎片离子谱可以用于在具有上游物质分离器的质谱仪中通过碎片离子质谱来鉴定复杂混合物中的大量蛋白质，或用于安全定量某些物质。 TIMS，特别是配备了平行积累，提供了独特的可能性，以延长离子积累时间，以找到更多可检测的离子种类，而不会降低碎片离子质谱的测量能力。碎片离子质谱的高测量容量允许重复测量低丰度离子种类以提高碎片离子谱的质量。

3. 发明公开

EP2688087A2 Assembly for an electrospray ion source 审中-公开
标题翻译： AnordnungfüreineElektrosprühionenquelle
公开(公告)号：EP2688087A2
公开(公告)日：2014-01-22
申请号：EP13003393.9
申请日：2013-07-04
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy P. , Thakur, Rohan , Muntean, Felician , Splendore, Maurizio A. , Zanon, Stephen
IPC分类号： H01J49/16
CPC分类号： H01J49/10 , H01J49/165 , H01J49/167
摘要： An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.
摘要翻译：用于电喷雾离子源的组件包括毛细管，用于引导通常含有目标分析物的液体流，所述分析物将被电喷雾到电离室中，第一管至少部分地包封毛细管，使得第一在毛细管附近产生用于引导第一可加热气体的导管，以及具有内部抽真空空间并位于毛细管外周的中空构件，使得从毛细管附近流过的第一可加热气体到液体中的热传递毛细管受阻。该组件提供了一种简单且精益/紧凑的方式来防止电喷雾离子源的毛细管中的液体过度传热。

4. 发明公开

EP2822021A2 Reduction of cross-talk between RF components in a mass spectrometer 有权转让
标题翻译：减少质谱仪中RF组件之间的串扰
公开(公告)号：EP2822021A2
公开(公告)日：2015-01-07
申请号：EP14000940.8
申请日：2014-03-14
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy , Muntean, Felician , Zanon, Stephen
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/06 , H01J49/063 , H01J49/4215
摘要： The invention generally relates to an assembly of a first RF component and a second RF component in a mass spectrometer, the first RF component comprising a first set of electrodes and the second RF component comprising a second set of electrodes, wherein the RF components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce RF electric field cross-talk between the electrodes of the first set and those of the second set. The invention affords for technically simple and economic means to reduce cross-talk or capacitive coupling between adjacent RF components in a mass spectrometer.
摘要翻译：本发明总体上涉及质谱仪中的第一RF部件和第二RF部件的组件，第一RF部件包括第一组电极并且第二RF部件包括第二组电极，其中RF部件位于并且端对端彼此对齐，并且其中第一组电极的横向尺寸小于第二组电极的横向尺寸。该组件进一步包括位于第一组电极的外周边并且面对第二组电极的导电电场屏幕，以减少第一组电极和第二组电极之间的RF电场串扰。本发明提供了用于减少质谱仪中的相邻RF部件之间的串扰或电容耦合的技术上简单且经济的手段。

5. 发明公开

EP2688087A3 Assembly for an electrospray ion source 审中-公开
标题翻译：组件，用于电喷雾离子源
公开(公告)号：EP2688087A3
公开(公告)日：2016-03-23
申请号：EP13003393.9
申请日：2013-07-04
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy P. , Thakur, Rohan , Muntean, Felician , Splendore, Maurizio A. , Zanon, Stephen
IPC分类号： H01J49/16 , F16L59/065
CPC分类号： H01J49/10 , H01J49/165 , H01J49/167
摘要： An assembly for use in an electrospray ion source includes a capillary for guiding a flow of liquid generally containing analyte(s) of interest, which is to be electrosprayed into an ionization chamber, a first tube at least partially encasing the capillary such that a first conduit for guiding a first heatable gas is created proximate the capillary and a hollow member that has an internal evacuated space and is located at the outer circumference of the capillary such that heat transfer from the first heatable gas flowing proximate the capillary to the liquid in the capillary is impeded. The assembly provides a simple and lean/compact way of preventing excessive heat transfer to the liquid in the capillary of an electrospray ion source.

6. 发明公开

EP2822021A3 Reduction of cross-talk between RF components in a mass spectrometer 有权转让
标题翻译：在质谱仪中的RF组件之间的串扰的降低
公开(公告)号：EP2822021A3
公开(公告)日：2015-04-01
申请号：EP14000940.8
申请日：2014-03-14
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy , Muntean, Felician , Zanon, Stephen
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/06 , H01J49/063 , H01J49/4215
摘要： The invention generally relates to an assembly of a first RF component and a second RF component in a mass spectrometer, the first RF component comprising a first set of electrodes and the second RF component comprising a second set of electrodes, wherein the RF components are located and aligned end-to-end to one another, and wherein a transverse dimension of the electrodes of the first set is smaller than that of the electrodes of the second set. The assembly further comprises a conductive electric field screen located at an outer periphery of the first set of electrodes and facing the electrodes of the second set as to reduce RF electric field cross-talk between the electrodes of the first set and those of the second set. The invention affords for technically simple and economic means to reduce cross-talk or capacitive coupling between adjacent RF components in a mass spectrometer.

7. 发明授权

EP3032569B1 CONTAMINATION-PROOF ION GUIDE FOR MASS SPECTROMETRY 有权转让
公开(公告)号：EP3032569B1
公开(公告)日：2018-10-17
申请号：EP15195298.3
申请日：2015-11-19
申请人： Bruker Daltonics, Inc.
发明人： Kaplan, Desmond Allen , Muntean, Felician , Zanon, Stephen
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/421
摘要： The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.

8. 发明公开

EP3032569A1 CONTAMINATION-PROOF ION GUIDE FOR MASS SPECTROMETRY 有权转让
标题翻译： KONTAMINATIONSSICHEREIONENFÜHRUNGFÜRMASSENSPEKTROMETRIE
公开(公告)号：EP3032569A1
公开(公告)日：2016-06-15
申请号：EP15195298.3
申请日：2015-11-19
申请人： Bruker Daltonics, Inc.
发明人： Kaplan, Desmond Allen , Muntean, Felician , Zanon, Stephen
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/421
摘要： The invention relates to a radio frequency ion guide construction for use in mass spectrometry that minimizes contamination by allowing ions rejected by the RF confinement field to fly through and away from the ion guide electrodes and preventing them from hitting the sensitive electric potential defining surfaces of the ion guide electrodes. At the entrance end of the ion guide, each electrode of the plurality of electrodes has a front end that is forked or that contains a recessed feature facing an interior of the ion guide. For an electrode that is forked, the teeth of the forked end may have different shapes or tapers, and a conductive mesh may be used to cover a gap between the teeth. Similarly, for an electrode that has a recessed feature, a conductive mesh may cover the recessed feature.
摘要翻译：本发明涉及一种用于质谱分析的射频离子导向结构，其通过允许由RF限制场所排斥的离子飞过和离开离子导向电极并使其不受打击敏感电位限定表面的影响而使污染最小化离子导向电极。在离子导向器的入口端处，多个电极的每个电极具有分叉的前端或包含面向离子导向件内部的凹陷特征。对于分叉的电极，叉形端部的齿可以具有不同的形状或锥度，并且可以使用导电网来覆盖齿之间的间隙。类似地，对于具有凹陷特征的电极，导电网可以覆盖凹陷特征。

9. 发明公开

EP2978008A1 FILAMENT FOR MASS SPECTROMETRIC ELECTRON IMPACT ION SOURCE 有权转让
标题翻译： FILAMENTFÜRMASSENSPEKTROMETRISCHE ELEKTRONENSTOSSIONENQUELLE
公开(公告)号：EP2978008A1
公开(公告)日：2016-01-27
申请号：EP15175379.5
申请日：2015-07-06
申请人： Bruker Daltonics, Inc.
发明人： Moeller, Roy P. , Muntean, Felician , Splendore, Maurizio
IPC分类号： H01J27/20 , H01J49/14
CPC分类号： H01J49/147 , H01J27/205
摘要： The invention provides a cathode system for an Electron Ionization (EI) source comprising a filament and current supply posts, the current supply posts dividing the filament into segments and each current supply post supplying or returning the current for at least two segments of the filament. Each filament segment is connected, for instance by spot welding, to the supply posts delivering the heating current. The filament segments may be arranged in a row, or substantially parallel to each other. Filament segments arranged in a row may form a closed loop, for instance, a ring. Other embodiments encompass the filament shape of a helical coil.
摘要翻译：本发明提供了一种用于电离电离（EI）源的阴极系统，其包括灯丝和电流供应柱，电流供应柱将灯丝分成段，每个电流供应柱供应或返回灯丝的至少两个段的电流。每个细丝部分例如通过点焊连接到供给点，从而传递加热电流。灯丝段可以排列成一排或基本上彼此平行。排列成一行的细丝片可以形成闭环，例如环。其他实施例包括螺旋线圈的丝的形状。

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