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1. 发明授权

EP2971160B1 DIGITAL ASSAYS FOR MUTATION DETECTION 有权
公开(公告)号：EP2971160B1
公开(公告)日：2018-05-30
申请号：EP14770183.3
申请日：2014-03-13
申请人： Bio-Rad Laboratories, Inc.
发明人： REGAN, John , COOPER, Samantha , SO, Austin , KOEHLER, Ryan , MONTESCLAROS, Luz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2545/114 , C12Q2561/101 , C12Q2563/159
摘要： Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.

2. 发明公开

EP3271849A1 DETECTION OF GENOME EDITING 有权转让
公开(公告)号：EP3271849A1
公开(公告)日：2018-01-24
申请号：EP16765783.2
申请日：2016-03-17
申请人： Bio-Rad Laboratories, Inc.
发明人： JOUVENOT, Yann , HEREDIA, Nick , PATEL, Viresh , COOPER, Samantha , BERMAN, Jen , HEFNER, Eli
IPC分类号： G06F19/18 , C12N15/09 , C12N15/11 , C12N15/85 , C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q2521/313 , C12Q2531/125
摘要： Methods, compositions, and kits are provided for quantifying a number or frequency of double stranded breaks in the genome of a cell or in the genomes of a population of cells.

3. 发明公开

EP3242938A1 DETECTION OF GENOME EDITING 有权
标题翻译：检测基因组编辑
公开(公告)号：EP3242938A1
公开(公告)日：2017-11-15
申请号：EP16735521.3
申请日：2016-01-08
申请人： Bio-Rad Laboratories, Inc. , The J. David Gladstone Institutes
发明人： BERMAN, Jennifer , COOPER, Samantha , KARLIN-NEUMANN, George , MIYAOKA, Yuichiro , CONKLIN, Bruce , SCHINOFF, Josh
IPC分类号： C12N15/00
摘要： Methods, compositions, and kits are provided for quantification of genome editing.

4. 发明公开

EP3307911A1 AMPLIFICATION ASSAY WITH A PROBE COMPETITOR 有权转让
标题翻译：带探针竞争者的放大测定
公开(公告)号：EP3307911A1
公开(公告)日：2018-04-18
申请号：EP16808529.8
申请日：2016-06-13
申请人： Bio-Rad Laboratories, Inc.
发明人： COOPER, Samantha , YANG, Wei , BERMAN, Jennifer
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6827 , C12Q2563/159 , G06F19/22 , C12Q2537/16 , C12Q2545/107
摘要： Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.

5. 发明公开

EP3161157A1 DIGITAL PCR BARCODING 有权转让
标题翻译：数字PCR条形码
公开(公告)号：EP3161157A1
公开(公告)日：2017-05-03
申请号：EP15790435.0
申请日：2015-06-24
申请人： Bio-Rad Laboratories, Inc.
发明人： AGRESTI, Jeremy , COOPER, Samantha , KARLIN-NEUMANN, George , HEREDIA, Nick , LEBOFSKY, Ronald
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , C12Q1/6806 , C12Q1/6853 , C12Q2521/531 , C12Q2525/161 , C12Q2525/204 , C12Q2535/122 , C12Q2565/629 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/514
摘要： Methods, compositions, and kits are provided for nucleic acid analysis, including single cell analysis.
摘要翻译：提供了用于核酸分析的方法，组合物和试剂盒，包括单细胞分析。

6. 发明授权

EP3242938B1 DETECTION OF GENOME EDITING 有权
公开(公告)号：EP3242938B1
公开(公告)日：2020-01-08
申请号：EP16735521.3
申请日：2016-01-08
申请人： Bio-Rad Laboratories, Inc. , The J. David Gladstone Institutes
发明人： BERMAN, Jennifer , COOPER, Samantha , KARLIN-NEUMANN, George , MIYAOKA, Yuichiro , CONKLIN, Bruce , SCHINOFF, Josh
IPC分类号： C12Q1/6809 , C12Q1/6827

7. 发明授权

EP3033445B1 AMPLIFICATION REPORTER WITH BASE-PAIRING OLIGOMERS 有权
公开(公告)号：EP3033445B1
公开(公告)日：2020-01-01
申请号：EP14836787.3
申请日：2014-08-12
申请人： Bio-Rad Laboratories, Inc.
发明人： REGAN, John F. , MAAR, Dianna , SHELTON, Dawne N. , LEGLER, Tina C. , COOPER, Samantha , YANG, Wei , HEFNER, Eli A. , KLITGORD, Niels
IPC分类号： C12Q1/6818 , C12Q1/6823

8. 发明公开

EP3259373A1 SMALL NUCLEIC ACID QUANTIFICATION USING SPLIT CYCLE AMPLIFICATION 有权转让
标题翻译：使用分裂循环放大的小核酸量化
公开(公告)号：EP3259373A1
公开(公告)日：2017-12-27
申请号：EP16753003.9
申请日：2016-02-17
申请人： Bio-Rad Laboratories, Inc.
发明人： MAAR, Dianna , COOPER, Samantha , YANG, Wei
IPC分类号： C12Q1/68 , C12N15/00 , C12N15/11
CPC分类号： C12Q1/6851 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q2525/161 , C12Q2525/204 , C12Q2525/207 , C12Q2527/107 , C12Q2563/159 , C12Q2531/113
摘要： Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.

9. 发明公开

EP3033445A1 AMPLIFICATION REPORTER WITH BASE-PAIRING OLIGOMERS 有权
标题翻译：具有基本配对的OLIGOM的放大报告器
公开(公告)号：EP3033445A1
公开(公告)日：2016-06-22
申请号：EP14836787.3
申请日：2014-08-12
申请人： Bio-Rad Laboratories, Inc.
发明人： REGAN, John F. , MAAR, Dianna , SHELTON, Dawn N. , LEGLER, Tina C. , COOPER, Samantha , YANG, Wei , HEFNER, Eli A. , KLITGORD, Niels
IPC分类号： C40B30/04
摘要： System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
摘要翻译：用扩增报道分子进行扩增测定的系统，包括能够在报道分子的解链温度以下彼此碱基配对的第一寡聚物和第二寡聚物。报道分子可能具有可检测的光致发光，其通过第一和第二寡聚体彼此碱基配对而受到影响，例如减少。诸如核酸靶序列之类的靶可以在熔解温度以上的至少一个体积（诸如多个分区）中被扩增，并且报道子的光致发光可以从低于解链温度的至少一个体积中被检测到。可以基于检测到的光致发光来确定目标的属性，诸如目标的浓度。

10. 发明公开

EP2971160A1 DIGITAL ASSAYS FOR MUTATION DETECTION 有权
标题翻译：数字测定的突变的检测
公开(公告)号：EP2971160A1
公开(公告)日：2016-01-20
申请号：EP14770183.3
申请日：2014-03-13
申请人： Bio-Rad Laboratories, Inc.
发明人： REGAN, John , COOPER, Samantha , SO, Austin , KOEHLER, Ryan , MONTESCLAROS, Luz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2545/114 , C12Q2561/101 , C12Q2563/159
摘要： Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.

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