专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2079758B1 METHOD FOR THE PURIFICATION OF DNAK 有权
标题翻译：方法纯化的DnaK的
公开(公告)号：EP2079758B1
公开(公告)日：2014-07-30
申请号：EP07821242.0
申请日：2007-10-12
申请人： Biotech Tools S.A.
发明人： HENOT, Frédéric , LEGON, Thierry , PIROTTON, Sabine , PLACIER, Gael
IPC分类号： C07K14/47 , C07K14/245
CPC分类号： C07K14/245 , A61K38/00 , Y02A50/473
摘要： Recombinant purified DnaK - having a ATPase activity without the addition of an other chaperone protein - essentially free of T-cell stimulating impurities.

2. 发明公开

EP2224953A1 PHARMACEUTICAL FORMULATION FOR ALLERGEN PREPARATION 审中-公开
标题翻译： PHARMAZEUTISCHE FORMULIERUNG ZUR HERSTELLUNG VON ALLERGENEN
公开(公告)号：EP2224953A1
公开(公告)日：2010-09-08
申请号：EP08866892.6
申请日：2008-12-30
申请人： BIOTECH TOOLS S.A.
发明人： LEGON, Thierry , PIROTTON, Sabine , PLACIER, Gael , KERGOAT, Gilles
IPC分类号： A61K39/35 , A61K39/36
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/542 , A61K2039/6087
摘要： Method for the production of a purified extract of natural allergens comprising the steps of extracting a natural source of allergens comprising allergenic proteins, purifying of said extract to remove non-protein components denaturating said purified extract, said purified denaturated extract comprising proteins, wherein the most abundant (w/w) proteins, forming together at least 60% (w/w) of all proteins, are at least two proteins, and all proteins represent at least 60% (w/w) of the dry weight of the purified denaturated extract or a method for the production of a purified extract of natural allergens comprising the steps of hydrolysing a denaturated allergen purifying said allergen hydrolysate to remove peptides with a molecular weight above 10,000 Da and below 1,000 Da in order to obtain a purified hydrolysate where 70%, more preferably 80% of the peptides are between 10,000 Da and 1,000 Da, in the form of an starch based pellet.
摘要翻译：用于生产天然过敏原纯化提取物的方法，包括以下步骤：提取包含过敏原蛋白质的天然过敏原来源，纯化所述提取物以除去使所述纯化提取物变性的非蛋白质组分，所述纯化的变性提取物包含蛋白质，其中最多含有至少60％（w / w）的蛋白质的丰富的（w / w）蛋白质是至少两种蛋白质，所有蛋白质代表纯化变性的干重至少60％（w / w）提取物或生产纯化的天然过敏原提取物的方法，包括以下步骤：将纯化所述变应原水解产物的变性过氧化物水解以除去分子量高于10,000Da且低于1,000Da的肽，以获得纯化的水解产物，其中70％更优选80％的肽在10,000Da和1,000Da之间，以淀粉基丸的形式。

3. 发明公开

EP2043684A1 A METHOD FOR THE PRODUCTION OF HYDROLYZED ALLERGEN 失效转让
标题翻译： VERFAHREN ZUR HERSTELLUNG VON HYDROLYSIERTEM ALLERGEN
公开(公告)号：EP2043684A1
公开(公告)日：2009-04-08
申请号：EP07730314.7
申请日：2007-06-28
申请人： BIOTECH TOOLS S.A.
发明人： LEGON, Thierry , PIROTTON, Sabine , PLACIER, Gael , KERGOAT, Gilles
IPC分类号： A61K39/35 , A61K39/36
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/542 , C07K14/415 , C12P21/06
摘要： A method for the production of a purified extract of natural allergens comprising the steps of a) extracting a natural source of allergens comprising allergenic proteins to form an extract, b) purifying of said extract to remove non-protein components to form a purified extract c) denaturating said purified extract to form a purified denaturated extract, said purified denaturated extract comprising proteins, wherein the most abundant (w/w) proteins, forming together at least 60% (w/w) of all proteins, are at least two proteins, and all proteins represent at least 60% (w/w) of the dry weight of the purified denaturated extract and a method for the production of a purified extract of natural allergens comprising the steps of a) hydrolysing a denaturated allergen to form an allergen hydrolysate, b) purifying said allergen hydrolysate to remove peptides with a molecular weight above 10,000 Da and below 1,000 Da in order to obtain a purified hydrolysate where 70%, more preferably 80% of the peptides are between 10,000 Da and 1,000 Da.
摘要翻译：一种用于生产天然过敏原纯化提取物的方法，包括以下步骤：a）提取包含过敏原蛋白质的天然过敏原来源以形成提取物，b）纯化所述提取物以除去非蛋白质组分以形成纯化的提取物c ）使所述纯化的提取物变性以形成纯化的变性提取物，所述纯化的变性提取物包含蛋白质，其中形成至少60％（w / w）的所有蛋白质的最丰富的（w / w）蛋白质是至少两种蛋白质，并且所有蛋白质代表纯化的变性提取物的干重的至少60％（w / w），以及用于生产天然过敏原纯化提取物的方法，包括以下步骤：a）水解变性变应原以形成变应原水解物，b）纯化所述变应原水解产物以除去分子量高于10,000Da且低于1,000Da的肽，以获得纯化的水解产物，其中70％，更优选80％肽在10,000Da和1,000Da之间。

4. 发明公开

EP2721051A1 A METHOD FOR THE PRODUCTION OF HYDROLYZED ALLERGENS 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON HYDROLISIERTEN ALLERGENEN
公开(公告)号：EP2721051A1
公开(公告)日：2014-04-23
申请号：EP12728495.8
申请日：2012-06-15
申请人： Biotech Tools S.A.
发明人： PLACIER, Gael , FRISCH, Laetitia , LEGON, Thierry , BENOIT, Marie-Ange
IPC分类号： C07K1/14 , C07K1/18 , C07K1/30 , C07K1/36 , A61K39/00 , C07K14/415 , A61K39/35 , C12P21/06
CPC分类号： A61K45/06 , A61K39/00 , A61K39/35 , C07K14/415 , C07K14/43531 , C12P21/06
摘要： A method for the production of hydrolyzed allergens from allergens comprising the steps of: a) extracting a source of allergens comprising allergenic proteins to form an extract, b) purifying the extract to remove non-protein components to form a purified extract, c) denaturing the purified extract with a first denaturing agent to form a purified denatured extract, d) refining the purified denatured extract to remove impurities to form a refined denatured extract, e) denaturing the refined denatured extract with a second denaturing agent to form denatured allergen mixture, and f) hydrolyzing the denatured allergen mixture to form the hydrolyzed allergens.
摘要翻译：一种用于从变应原产生水解过敏原的方法，包括以下步骤：a）提取包含变应原蛋白质的变应原源以形成提取物，b）纯化提取物以除去非蛋白质组分以形成纯化的提取物，c）变性所述纯化的提取物用第一变性剂形成纯化的变性提取物，d）精制所述纯化的变性提取物以除去杂质以形成精制变性提取物，e）用第二变性剂变性所述精制变性提取物以形成变性过敏原混合物，和f）水解变性过敏原混合物以形成水解的变应原。

5. 发明公开

EP2079758A1 METHOD FOR THE PURIFICATION OF DNAK 有权
标题翻译：方法纯化的DnaK的
公开(公告)号：EP2079758A1
公开(公告)日：2009-07-22
申请号：EP07821242.0
申请日：2007-10-12
申请人： Biotech Tools S.A.
发明人： HENOT, Frédéric , LEGON, Thierry , PIROTTON, Sabine , PLACIER, Gael
IPC分类号： C07K14/47 , C07K14/245
CPC分类号： C07K14/245 , A61K38/00 , Y02A50/473
摘要： Recombinant purified DnaK - having a ATPase activity without the addition of an other chaperone protein - essentially free of T-cell stimulating impurities.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式