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1. 发明公开

EP3052609A1 ASSEMBLY FOR FORMING MICROCHAMBER FOR INVERTED SUBSTRATE 有权
标题翻译： ÜATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE ATE
公开(公告)号：EP3052609A1
公开(公告)日：2016-08-10
申请号：EP14851065.4
申请日：2014-10-03
申请人： BioGenex Laboratories, Inc.
发明人： KALRA, Krishan, L. , KUMAR, Y.N., Siva
IPC分类号： C12M1/24 , C12M1/34 , G01N35/08
CPC分类号： G01N1/312 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L7/52 , B01L9/50 , B01L9/52 , B01L2200/027 , B01L2200/028 , B01L2200/0684 , B01L2200/142 , B01L2300/043 , B01L2300/045 , B01L2300/06 , B01L2300/0609 , B01L2300/0822 , B01L2300/14 , B01L2300/16 , B01L2300/18 , B01L2300/1805 , B01L2400/0406 , G01N1/30
摘要： An assembly for forming a microchamber for an inverted substrate is disclosed. The assembly can include a body having a chamber formed therein. A dispensing cavity can be provided to supply a reagent to the chamber. A slide support structure can be configured to support the slide such that the tissue sample faces the chamber when the slide is mounted to the slide support structure. The chamber and the slide support structure can be dimensioned such that, when the reagent is supplied to the dispensing cavity, the reagent is drawn to the chamber by way of capillary forces acting on the reagent.
摘要翻译：公开了一种用于形成用于倒置衬底的微室的组件。组件可以包括其中形成有腔室的主体。可以提供分配腔以将试剂供应到腔室。滑动支撑结构可以构造成支撑滑块，使得当滑块安装到滑动支撑结构时，组织样本面向腔室。腔室和滑动支撑结构的尺寸可以确定为当将试剂供应到分配腔时，试剂通过作用在试剂上的毛细管力被吸引到腔室。

2. 发明公开

EP1066502A1 AUTOMATED STAINING APPARATUS 失效
标题翻译：自动染色机
公开(公告)号：EP1066502A1
公开(公告)日：2001-01-10
申请号：EP98915168.3
申请日：1998-03-24
申请人： BIOGENEX LABORATORIES
发明人： KALRA, Krishan, L. , ZHANG, Jason, Z. , CHANG, Zhi-Weng , SHUI, Jianghong
IPC分类号： G01N1/30 , G01N35/10
CPC分类号： G01N1/312 , G01N35/109 , G01N2001/317
摘要： Disclosed is an automated staining apparatus including an arm (30) moveable in three dimensions, and a hollow tip head (70) located on the arm including integral reagent tip head (40), wash tip (41) and blow tip (42) for selectively dispensing gas and liquid onto microscope slides. Also disclosed are various sub-components of the apparatus that are specifically adapted to the processing of specimens on slides.

3. 发明公开

EP0698118A1 DEPARAFFINIZATION COMPOSITIONS AND METHODS FOR THEIR USE 失效
标题翻译： DEPARAFFINISIERUNGS组合物及使用方法
公开(公告)号：EP0698118A1
公开(公告)日：1996-02-28
申请号：EP95913592.0
申请日：1995-03-07
申请人： BIOGENEX LABORATORIES
发明人： ZHANG, Guangrong , YU, Cheng-Zhi , SU, Sheng-Hui , KALRA, Krishan, L. , ZHOU, Ding
IPC分类号： G01N33 , C08L91 , G01N1
CPC分类号： C11D1/143 , C11D1/62 , C11D1/72 , C11D3/187 , C11D3/188 , C11D3/201 , C11D3/2044 , G01N1/30 , G01N1/36 , Y10S435/975
摘要： Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis. The method can comprise the further step of washing the dewaxed specimen immediately after dewaxing with an aqueous wash composition comprising a detergent to remove residual dewaxing composition. Also provided is a kit for dewaxing a wax-embedded specimen, which comprises a dewaxing composition and can further comprise a second composition of (1) an immunostaining reagent or (2) an aqueous wash solution comprising a detergent for removing residual dewaxing solution.

4. 发明公开

EP1671117A2 SAMPLE PROCESSING SYSTEM 审中-公开
标题翻译：样本处理系统
公开(公告)号：EP1671117A2
公开(公告)日：2006-06-21
申请号：EP04783590.5
申请日：2004-09-09
申请人： BIOGENEX LABORATORIES
发明人： KALRA, Krishan, L. , CHANG, Wallace , MELKOTE, Ravishankar , IQBAL, Shahzi
IPC分类号： G01N31/00
CPC分类号： B01L3/50853 , B01L3/508 , B01L3/5085 , B01L3/545 , B01L7/52 , B01L2200/0689 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/041 , B01L2300/0822 , B01L2300/089 , B01L2300/161 , G01N1/30 , G01N1/312 , G01N33/5302 , G01N35/0099 , G01N35/109 , G01N2001/317 , G01N2035/00138 , G01N2035/00752
摘要： In accordance with an embodiment of a system for handling and processing chemical and/or biological samples, a MicroChamber comprises a substrate, a reservoir formed on the substrate for receiving a chemical and/or biological sample, and an encoder such as a barcode or other suitable device. The encoder encodes information describing at least one characteristic of the substrate and/or reservoir.

5. 发明公开

EP1325300A1 ENHANCEMENT OF i IN SITU /i HYBRIDIZATION 审中-公开
标题翻译：提高原位杂交
公开(公告)号：EP1325300A1
公开(公告)日：2003-07-09
申请号：EP01971284.3
申请日：2001-09-17
申请人： BIOGENEX LABORATORIES
发明人： KALRA, Krishan, L. , WANG, Qian-Shu , JIN, Jian, Kuan
IPC分类号： G01N1/30 , G01N33/48
CPC分类号： G01N1/30 , C12Q1/6841
摘要： Methods and compositions for improving in situ hybridization analysis of aldehyde fixed tissue are described.

6. 发明公开

EP0954606A1 NON-NUCLEOTIDE LINKING REAGENTS 失效
标题翻译：非核苷酸连接试剂
公开(公告)号：EP0954606A1
公开(公告)日：1999-11-10
申请号：EP97926780.0
申请日：1997-05-15
申请人： Biogenex Laboratories
发明人： SHENG-HUI SU, George , IYER, Rajkumar, Siva , AGGARWAL, Sunil, K. , KALRA, Krishan, L.
IPC分类号： C12Q1 , C07F9 , C07H21
CPC分类号： C07H21/00 , C07F9/2416 , C07F9/6561
摘要： Non-nucleotide reagents capable of forming oligomers with nucleotide units are disclosed, together with intermediates for synthesizing such non-nucleotide reagents, oligomers incorporating such reagents, kits containing such reagents and methods for their use in forming oligomers with nucleotide units.

7. 发明授权

EP0698118B1 DEPARAFFINIZATION COMPOSITIONS AND METHODS FOR THEIR USE 失效
标题翻译： DEPARAFFINISIERUNGS组合物及使用方法
公开(公告)号：EP0698118B1
公开(公告)日：2003-12-03
申请号：EP95913592.2
申请日：1995-03-07
申请人： BIOGENEX LABORATORIES
发明人： ZHANG, Guangrong , YU, Cheng-Zhi , SU, Sheng-Hui , KALRA, Krishan, L. , ZHOU, Ding
IPC分类号： C12Q1/00 , C07G17/00 , G01N1/28 , G01N1/34
CPC分类号： C11D1/143 , C11D1/62 , C11D1/72 , C11D3/187 , C11D3/188 , C11D3/201 , C11D3/2044 , G01N1/30 , G01N1/36 , Y10S435/975
摘要： Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis. The method can comprise the further step of washing the dewaxed specimen immediately after dewaxing with an aqueous wash composition comprising a detergent to remove residual dewaxing composition. Also provided is a kit for dewaxing a wax-embedded specimen, which comprises a dewaxing composition and can further comprise a second composition of (1) an immunostaining reagent or (2) an aqueous wash solution comprising a detergent for removing residual dewaxing solution.

8. 发明公开

EP1284823A1 AUTOMATED SPECIMEN PROCESSING APPARATUS WITH FLUID DETECTION 审中-公开
标题翻译：与流体检测自动样品处理设备
公开(公告)号：EP1284823A1
公开(公告)日：2003-02-26
申请号：EP01922413.8
申请日：2001-03-15
申请人： BIOGENEX LABORATORIES
发明人： KALRA, Krishan, L. , ZHANG, Jason , BAHL, Suneet
IPC分类号： B01L3/02 , G01N21/00 , G01N31/00 , G01N33/00 , B32B27/04 , B32B27/12 , B32B5/02
CPC分类号： G01N1/312 , G01N2001/317
摘要： An automated specimen processing apparatus (10) for dispensing a reagent onto a mounted specimen comprising a support framework (20), at least one reagent vial holder (120) movable arm (30), multifunction Z head (70). The device also includes a dispensing means that comprises at least one reagent tip head (90), first control means for positioning the tip head, means for withdrawing fluid from the vial, and a second control means to detect the fluid level in the reagent vial.

9. 发明授权

EP0722363B1 AUTOMATED STAINING APPARATUS AND METHOD 失效
标题翻译：自动和着色方法 - DEVICE
公开(公告)号：EP0722363B1
公开(公告)日：1999-04-14
申请号：EP94929964.8
申请日：1994-09-29
申请人： BIOGENEX LABORATORIES
发明人： TSEUNG, Ken , WONG, Wai, Bun , JONES, Christopher, Michael , KALRA, Krishan, L.
IPC分类号： B01L11/00
CPC分类号： B01L3/0275 , G01N1/312 , G01N35/0099 , G01N35/109 , G01N2001/282 , G01N2001/317 , G01N2035/103 , G02B21/34
摘要： An automated microscope-slide-staining apparatus, comprising a supporting framework; an arm moveable in three dimensions attached to the framework; means for moving the arm; a hollow tip head located on the arm; means for alternatively supplying positive or negative gas pressure to the hollow tip head; a removable wash/blow tip having an exit slit, the wash/blow tip being adapted to be removably attached to the hollow tip head by a preselected movement of the arm; a wash/blow tip holder at a first fixed location on the framework; a reagent application tip holder at a second fixed location on the framework for holding a reagent application tip, the reagent application tip being adapted to be removably attached to the hollow tip head by a preselected movement of the arm; a reagent container holder at a third fixed location on the framework; a microscope slide holder at a fourth fixed location on the framework, the microscope slide holder being adapted to removably contain the microscope slide; and control means for controlling movement of the arm between the locations, whereby the tip head picks up the wash/blow tip or the reagent application tip in response to movement of the arm under control of the control means and moves to one or more of the loations to pick up a reagent in the reagent container or dispense the reagent on the slide or to dispense a gas through the wash/blow tip over the slide. Components of the apparatus and methods of staining are also part of the invention.

10. 发明公开

EP0607422A1 ENHANCEMENT OF IMMUNOCHEMICAL STAINING IN ALDEHYDE-FIXED TISSUES 失效
标题翻译：改善免疫组织化学染色醛固定组织。
公开(公告)号：EP0607422A1
公开(公告)日：1994-07-27
申请号：EP93919972.0
申请日：1993-08-12
申请人： BIOGENEX LABORATORIES
发明人： SHI, Shan-Rong , TANDON, Atul, K. , KALRA, Krishan, L. , MALHOTRA, Nagesh , SU, Sheng-Hui , YU, Cheng-Zhi
IPC分类号： G01N33 , G01N1
CPC分类号： G01N1/30 , G01N33/5306
摘要： L'invention se rapporte à un procédé visant à rétablir l'immunoréactivité d'un tissu, notamment d'un tissu décalcifié, fixé par un agent fixateur aldéhyde et incorporé dans un liquide d'inclusion comprenant généralement de la celloïdine. Le procédé consiste à mettre en contact le tissu avec une solution d'un réactif libérant de l'aldéhyde comprenant un solvant et un réactif libérant de l'aldéhyde, à retirer l'aldéhyde libéré par le réactif libérant l'aldéhyde du contact avec le tissu, à faire réagir l'aldéhyde de manière pratiquement irréversible pour former un dérivé non-aldéhyde, et à retirer la base excédentaire du tissu. Une solution préférée d'un tissu décalcifié incorporé dans la celloïdine comprend de la soude caustique méthanolique au tiers environ du niveau de saturation.

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