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1. 发明公开

EP3971282A1 ARRAY AND METHOD FOR DETECTING SPATIAL INFORMATION OF NUCLEIC ACIDS 审中-公开
公开(公告)号：EP3971282A1
公开(公告)日：2022-03-23
申请号：EP20806227.3
申请日：2020-05-14
申请人： BGI Shenzhen , MGI Tech Co., Ltd.
发明人： CHEN, Ao , XU, Xun , YANG, Jin , LIU, Longqi , WANG, Ou , LI, Yuxiang , LIAO, Sha , TANG, Guoxin , JIANG, Yuan , XU, Chongjun , NI, Ming , ZHANG, Wenwei , DRMANAC, Radoje , DRMANAC, Snezana
IPC分类号： C12M1/34 , C12Q1/68 , C40B40/06 , C40B20/02
摘要： Provided are a method for detecting spatial information of nucleic acids in a sample, as well as a nucleic acid array used in the method and a method for producing the nucleic acid array.

2. 发明公开

EP4353835A1 MICROPOROUS STRUCTURE, PREPARATION METHOD, AND CHIP 审中-公开
公开(公告)号：EP4353835A1
公开(公告)日：2024-04-17
申请号：EP21955427.6
申请日：2021-08-31
申请人： BGI Shenzhen
发明人： YUN, Quanxin , ZHANG, Yuning , LI, Yuxiang , ZHANG, Wenwei , XU, Xun
IPC分类号： C12Q1/6869 , H10N30/30
CPC分类号： C12Q1/6869
摘要： This application provides a microwell structure, a preparation method and a chip, which belongs to the field of biotechnology. The microwell structure provided in this application comprises a base and support structure layers having through holes and being provided over the base; the support structure layers and the through holes form a cavity with the base; from top to bottom, the support structure layers comprise at least two layers, and the diameter of the through hole in the support structure layer far away from the base is smaller than that of the through hole in the support structure layer provided over the base. With this structure, since the diameter of the through hole in the support structure layer at the top is smaller, it can achieve a better fixing effect on the membrane, thereby increasing the stability of the membrane; the through hole in the support structure layer over the base has a relatively large diameter and communicates with the through hole with a smaller diameter in the support structure layer at the top, thereby obtaining a structure similar to a hole with a smaller opening diameter but a larger volume, which fundamentally solves the stability problem of the membrane and problems of the applicability of a common membrane, the cost and the like , caused by the developing a suitable complex artificial membrane material.

3. 发明公开

EP3916386A1 MICROBEAD 审中-公开
公开(公告)号：EP3916386A1
公开(公告)日：2021-12-01
申请号：EP19911678.1
申请日：2019-01-23
申请人： BGI Shenzhen
发明人： ZHANG, Wenwei , CHEN, Wei , WANG, Weimao , LI, Mei , LI, Yuxiang , WANG, Jian
IPC分类号： G01N33/543 , G01N33/53
摘要： A microbead with a code engraved on an outside of the microbead. The microbead includes a central region and an edge region surrounding the central region. An outer contour of the edge region before and after engraving the code is non-circular. The edge region includes a plurality of coding positions. The code of the microbead is engraved on the plurality of coding positions. Each bit of the code corresponds to each of the plurality of coding positions. The present disclosure increases the utilization rate of the microbead.

4. 发明公开

EP4293568A3 MICROBEAD 审中-公开
公开(公告)号：EP4293568A3
公开(公告)日：2024-02-28
申请号：EP23207691.9
申请日：2019-01-23
申请人： BGI Shenzhen
发明人： ZHAN, Wenwei , CHEN, Wei , WANG, Weimao , LI, Mei , LI, Yuxiang , WANG, Jian
IPC分类号： G01N33/543 , G01N33/53 , G06K19/06
摘要： A microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) with a code engraved on an outside of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90). The microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) includes a central region (12, 52, 82) and an edge region (11, 51, 81) surrounding the central region (12, 52, 82). An outer contour of the edge region (11, 51, 81) before and after engraving the code is non-circular. The edge region (11, 51, 81) includes a plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The code of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) is engraved on the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). Each bit of the code corresponds to each of the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The present disclosure increases the utilization rate of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90).

5. 发明公开

EP4293568A2 MICROBEAD 审中-公开
公开(公告)号：EP4293568A2
公开(公告)日：2023-12-20
申请号：EP23207691.9
申请日：2019-01-23
申请人： BGI Shenzhen
发明人： ZHAN, Wenwei , CHEN, Wei , WANG, Weimao , LI, Mei , LI, Yuxiang , WANG, Jian
IPC分类号： G06K19/06
摘要： A microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) with a code engraved on an outside of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90). The microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) includes a central region (12, 52, 82) and an edge region (11, 51, 81) surrounding the central region (12, 52, 82). An outer contour of the edge region (11, 51, 81) before and after engraving the code is non-circular. The edge region (11, 51, 81) includes a plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The code of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90) is engraved on the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). Each bit of the code corresponds to each of the plurality of coding positions (141, 241, 341, 441, 541, 641, 731, 741, 831, 841). The present disclosure increases the utilization rate of the microbead (10, 20, 30, 40a, 40b, 50, 60, 70, 80, 90).

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