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1. 发明公开

EP1376135A2 Automated method and reagent therefor for assaying body fluid samples such as cerebrospinal fluid 有权
标题翻译：该自动方法和试剂用于体液样品，如脑脊液的测量
公开(公告)号：EP1376135A2
公开(公告)日：2004-01-02
申请号：EP03076454.2
申请日：2003-05-15
申请人： BAYER CORPORATION
发明人： Ornstein, Leonard , Fischer, Gena , Zelmanovic, David , Elsins, Pamela , Kunicka, Jolanta E. , Malin, Michael J.
IPC分类号： G01N33/68 , G01N33/50
CPC分类号： G01N33/96 , A01N1/00 , G01N15/1459 , G01N2015/0073 , G01N2015/1486 , Y10T436/10 , Y10T436/11 , Y10T436/2525
摘要： The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid (CSF) samples. The reagent compositions sphere and fix all cells in the sample in suspension. Reported results can include red blood cell (RBC) and white blood cell (WBC) counts, WBC differential values, cell-by-cell volumes and dry-mass concentrations.
摘要翻译：本发明描述了为此用于测定和体液样品，特别是非血液样品的分析半和全自动化的方法和试剂。的方法和试剂是爱脑脊髓液（CSF）样品的测定和分析特别有用。所述试剂组合物领域和修复所有细胞悬浮于样品中。报告的结果可以包括红血细胞（RBC），白血细胞（WBC）计数，白细胞分类值，细胞通过细胞体积和干质量浓度。

2. 发明授权

EP0878715B1 Cyanide-containing hemoglobin reagent composition and method providing acceptable precision, accuracy and freedom from white cell interference on automated hematology analyzers 失效
标题翻译：血红蛋白试剂和方法，其自动上血液分析仪通过白细胞提供可接受的准确度，正确性和免于干扰含氰化物的
公开(公告)号：EP0878715B1
公开(公告)日：2002-07-31
申请号：EP98108384.3
申请日：1998-05-08
申请人： Bayer Corporation
发明人： Malin, Michael J.
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/5094 , Y10T436/10 , Y10T436/107497 , Y10T436/108331 , Y10T436/25125

3. 发明公开

EP1162461A3 Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum 有权
标题翻译：用于定量测定和全血中监测外源血红蛋白，血浆和血清自动方法
公开(公告)号：EP1162461A3
公开(公告)日：2002-03-06
申请号：EP01112904.6
申请日：2001-06-05
申请人： Bayer Corporation
发明人： Malin, Michael J. , Shapiro, Phyllis
IPC分类号： G01N33/72 , G01N33/49
CPC分类号： G01N33/721 , G01N33/726
摘要： The invention provides a new method and system for detecting and monitoring extracellular or exogenously added hemoglobin, i.e., a cell-free hemoglobin substitute or derivative, in a blood, plasma, or serum sample of an individual, particularly a whole blood sample. The invention further describes the use of automated hematlogy analyzers to determine and quantify at the same time the concentration of total, cellular and exogenous hemoglobin in a blood, plasma, or serum sample, and is particularly advantageous for medical use during or after patient trauma or surgery, as well as for monitoring hemoglobin levels during patient recovery.

4. 发明公开

EP0214613A3 Method for determination of a differential white blood cell count 失效
标题翻译：用于确定差异白细胞计数的方法
公开(公告)号：EP0214613A3
公开(公告)日：1989-07-26
申请号：EP86112197.8
申请日：1986-09-03
申请人： Bayer Corporation
发明人： Cremins, John F. , Kim, Young Ran , Malin, Michael J. , Sclafani, Louis D. IV
IPC分类号： G01N1/30 , G01N15/14 , G01N33/48
CPC分类号： G01N33/5094 , G01N2001/305
摘要： This invention relates to a method and composition for the rapid determination of a differential white blood cell count in a sample, which method comprises:
a) preparing a reagent solution comprising
formaldehyde or paraformaldehyde;
a surfactant;
a sugar or sugar alcohol; and
a buffer; and b) rapidly mixing said reagent solution with the sample to be analyzed to form a reaction mixture, wherein both said reagent solution and said sample are initially at room temperature; and c) rapidly heating said reaction mixture to a temperature of from about 62°C to about 72°C in order to lyse the red blood cells in said sample and fix the white blood cells in said sample.

5. 发明授权

EP0743356B1 Universal rinse reagent composition for use in hematological analyses of whole blood samples 失效
标题翻译：在全血样本的血液分析中使用通用Reagenzspülmittel
公开(公告)号：EP0743356B1
公开(公告)日：2002-10-09
申请号：EP96106953.1
申请日：1996-05-03
申请人： Bayer Corporation
发明人： Malin, Michael J. , Shapiro, Phyllis
IPC分类号： C11D1/722 , C11D3/37
CPC分类号： C11D3/3707 , C11D1/722 , Y10S435/962 , Y10T436/10 , Y10T436/114998

6. 发明公开

EP0878715A1 Cyanide-containing hemoglobin reagent composition and method providing acceptable precision, accuracy and freedom from white cell interference on automated hematology analyzers 失效
标题翻译：血红蛋白试剂和方法，其自动上血液分析仪通过白细胞提供可接受的准确度，正确性和免于干扰含氰化物的
公开(公告)号：EP0878715A1
公开(公告)日：1998-11-18
申请号：EP98108384.3
申请日：1998-05-08
申请人： Bayer Corporation
发明人： Malin, Michael J.
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/5094 , Y10T436/10 , Y10T436/107497 , Y10T436/108331 , Y10T436/25125
摘要： The invention describes an improved stable reagent composition and method for the determination of hemoglobin (Hb) using whole blood samples and automated hematology analyzers, for example, the TECHNICON H*™ series of instruments as sold by the assignee hereof. The Hb reagent comprises an inorganic cyanide salt, at least one surfactant and a base and has a final pH of about 10.0 to about 11.2, preferably about 10.4 to about 11.2 or less and more preferably about 10.8 to about 11.2 or less. This reagent is intended for use as a universal Hb determination reagent for all of the instruments in the aforementioned series and will provide accurate and precise results without accompanying interference from elevated numbers of white blood cells, especially as found in abnormal blood specimens, and without system-to-system variation in the results obtained.
摘要翻译：本发明描述了改进的稳定试剂组合物和方法，用于血红蛋白的使用全血样品和自动血液分析仪，例如，TECHNICON H * TM系列仪器如由本受让人销售的判定（HB）。无机氰化物盐的血红蛋白试剂包含，至少一种表面活性剂和碱，并且具有约10.0至约11.2的最终pH，优选约10.4至约11.2或更小，更优选约8.10至约2.11或更小。这种试剂的目的是用作所有在上述系列仪器的普遍血红蛋白检测试剂，并希望没有伴随从白细胞升高数字干扰，从而提供准确和精确的结果，爱情尤其是在血液样本异常发现，并没有系统在结果-to-系统变化得到。

7. 发明公开

EP0743356A1 Universal rinse reagent composition for use in hematological analyses of whole blood samples 失效
标题翻译：分析von Vollblutproben verwendetes universalesReagenzspülmittel
公开(公告)号：EP0743356A1
公开(公告)日：1996-11-20
申请号：EP96106953.1
申请日：1996-05-03
申请人： Bayer Corporation
发明人： Malin, Michael J. , Shapiro, Phyllis
IPC分类号： C11D1/722 , C11D3/37
CPC分类号： C11D3/3707 , C11D1/722 , Y10S435/962 , Y10T436/10 , Y10T436/114998
摘要： The present invention provides a heretofore unknown use for a aqueous reagent composition that serves as a universal rinse for performing and/or improving a variety of hematological analyses on automated analyzers. The universal rinse reagent comprises a phosphate buffer to maintain the rinse solution pH at from about 7.0 to about 7.6; a nonhemolytic nonionic surfactant, such as a Pluronic; an alkali metal salt, such as NaCl; antimicrobial and anti-oxidant compounds; and has an osmolality of about 285 to 305 mOsmol/kg. The universal rinse reagent composition is highly suitable for use in the rinse phases or cycles of all types of blood cell analysis methods and processes performed on semi- and fully-automated systems. The invention allows the replacement of mutiple and specific rinse solutions with the disclosed universal rinse to obtain accurate and acceptable results, independent of the types of blood cell analyses that are performed. The universal rinse is most particularly useful for automated systems having intricate hardware and a number of different input and output channels. The universal rinse composition serves to economize, streamline, and simplify the design and operation of such systems.
摘要翻译：本发明提供了用于水性试剂组合物的迄今为止未知的用途，其用作在自动分析仪上进行和/或改进各种血液学分析的通用冲洗液。通用冲洗试剂包含磷酸盐缓冲液，以将漂洗溶液的pH保持在约7.0至约7.6; 非溶解性非离子表面活性剂，例如Pluronic; 碱金属盐，如NaCl; 抗菌和抗氧化剂; 并且具有约285至305mOsmol / kg的重量克分子渗透压浓度。通用冲洗试剂组合物非常适合用于在半自动和全自动化系统中进行的所有类型血细胞分析方法和过程的漂洗阶段或循环。本发明允许用所公开的通用冲洗液替换多种和特定的漂洗溶液，以获得准确和可接受的结果，而与执行的血细胞分析的类型无关。通用冲洗对于具有复杂硬件和多个不同输入和输出通道的自动化系统最为特别有用。通用冲洗组合物用于节约，简化和简化这些系统的设计和操作。

8. 发明授权

EP1162461B1 Automated method for detecting, quantifying and monitoring exogenous hemoglobin in whole blood, plasma and serum 有权
标题翻译：用于定量测定和全血中监测外源血红蛋白，血浆和血清自动方法
公开(公告)号：EP1162461B1
公开(公告)日：2008-04-09
申请号：EP01112904.6
申请日：2001-06-05
申请人： BAYER CORPORATION
发明人： Malin, Michael J. , Shapiro, Phyllis
IPC分类号： G01N33/72 , G01N33/49
CPC分类号： G01N33/721 , G01N33/726

9. 发明授权

EP0743519B1 Improved method and reagent composition for performing leukocyte differential counts on fresh and aged whole blood samples, based on intrinsic peroxidase activity of leukocytes 失效
标题翻译：用于执行新鲜和gealteren全血样品中分化Leukocytzählungen，白细胞的现有过氧化物酶活性的基础上，所述的方法和试剂组合物
公开(公告)号：EP0743519B1
公开(公告)日：2002-08-28
申请号：EP96106957.2
申请日：1996-05-03
申请人： Bayer Corporation
发明人： Malin, Michael J. , Shapiro, Phyllis , Cremins, John F.
IPC分类号： G01N33/50 , C12Q1/28 , G01N1/30
CPC分类号： G01N33/5094 , Y10T436/106664 , Y10T436/107497

10. 发明授权

EP0214613B1 Method for determination of a differential white blood cell count 失效
标题翻译：一种用于有区别的确定白血细胞的过程。
公开(公告)号：EP0214613B1
公开(公告)日：1993-10-27
申请号：EP86112197.8
申请日：1986-09-03
申请人： Bayer Corporation
发明人： Cremins, John F. , Kim, Young Ran , Malin, Michael J. , Sclafani, Louis D. IV
IPC分类号： G01N1/30 , G01N15/14 , G01N33/48
CPC分类号： G01N33/5094 , G01N2001/305

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