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1. 发明公开

EP0747046A3 Permeable immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译：半透明Immunoisolationsmembranstrukturen用于细胞植入在宿主组织
公开(公告)号：EP0747046A3
公开(公告)日：1997-12-03
申请号：EP96303400.4
申请日：1996-05-14
申请人： BAXTER INTERNATIONAL INC.
发明人： Sternberg, Shmuel , Pauley, Robin G. , Boggs, Daniel R. , McLarty, Donna L. , Khare, Atul R. , Brauker, James H. , Martinson, Laura A.
IPC分类号： A61K9/22 , A61F2/02
CPC分类号： A61K9/0024 , A61F2/022 , A61F2/062 , A61L27/16 , A61L27/20 , A61L27/38 , C08L33/00 , C08L33/22 , C08L1/08
摘要： Permeable structures suited for implanting in host tissue include a first permeable region comprising a polymer solution formed-in-place in contact with a second permeable region. The structures provide enhanced immunoisolation, which promotes the survival of even xenogeneic cells implanted in host tissue.

2. 发明公开

EP2168605A1 Device for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
标题翻译：一种用于灭活存在于治疗性流体病原体用杀菌辐射装置
公开(公告)号：EP2168605A1
公开(公告)日：2010-03-31
申请号：EP09075485.4
申请日：2001-01-26
申请人： Baxter International Inc.
发明人： Breillatt, Julian , Woo, Lecon , Sandford, Craig , Boggs, Daniel R. , Khare, Atul , Sternberg, Shmuel
IPC分类号： A61L2/10 , A61L2/02 , A61M1/36
CPC分类号： A61L2/10 , A61L2/0011 , A61M1/0281 , A61M1/3681 , A61M2202/0415 , A61M2205/053
摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).
摘要翻译：一种用于灭活存在于治疗性流体病原体在连续流动装置消毒辐射，同时表现出的辐射剂量的均匀性和在装置内的流体的窄停留时间分布的装置和方法。的装置（10）包括具有设置于其中的同心圆筒状的转子（14），从而提供薄的间隙（16）之间有一个辐射透过的圆柱形管（12）。顶板（18），其具有一个流体出口（26）和具有流体入口（24）的底板（20），密封该圆柱形管（12）。所述入口（24）和出口（26）与两个薄间隙（16）流体连通。转子轴（36）穿过所述圆筒形转子（14）轴向diposed并且被连接到一个马达（30）。泵提供通过所述装置（10）的流体流动。辐射源提供通过圆筒形管（12）灭菌辐射到流体。当流体流动时，马达（30）驱动转子（14），以赋予泰勒旋涡的流体流动，这交换流体更靠近圆柱形管（12）与所述流体更靠近所述转子（14）。

3. 发明公开

EP1275410A3 A blood filter 失效
标题翻译：血液过滤器
公开(公告)号：EP1275410A3
公开(公告)日：2003-03-26
申请号：EP02078995.4
申请日：1994-12-20
申请人： BAXTER INTERNATIONAL INC.
发明人： Sternberg, Shmuel , Wons, Allen R. , Fisher, David P. , Lynn, Daniel R. , Minshall, Billy W.
IPC分类号： B01D29/01 , B01D39/16 , A61M1/36 , A61M5/165 , B29C65/04
CPC分类号： G01N15/08 , B29C65/04 , B29C65/08 , B29C66/1122 , B29C66/1312 , B29C66/24221 , B29C66/53261 , B29C66/53262 , B29C66/54 , B29C66/71 , B29C66/73921 , B29C66/81423 , B29C66/81431 , B29C66/8322 , B29C66/83221 , B29C66/9513 , B29K2027/06
摘要： In a method for processing audio signals composed audio signals (L+R) and (L-R) are derived from left (L) and right (R) audio signals. The energy content of the composed (L-R) audio signals above a predetermined frequency value is measured and compared with a predetermined threshold value. Then, when this energy content falls below said threshold value, a signal derived from and decorrelated with respect to the composed (L+R) audio signal is added to the composed (L-R) signal to obtain an improved composed (L-R) audio signal, and left (L) and right(R) audio signals are obtained back again from the composed (L+R) signal and the improved composed (L-R) audio signal.

4. 发明公开

EP0747046A2 Permeable immunoisolation membrane structures for implantation of cells in host tissue 失效
标题翻译： D be be be be be be be be be be be be be be be be be be be be be
公开(公告)号：EP0747046A2
公开(公告)日：1996-12-11
申请号：EP96303400.4
申请日：1996-05-14
申请人： BAXTER INTERNATIONAL INC.
发明人： Sternberg, Shmuel , Pauley, Robin G. , Boggs, Daniel R. , McLarty, Donna L. , Khare, Atul R. , Brauker, James H. , Martinson, Laura A.
IPC分类号： A61K9/22 , A61F2/02
CPC分类号： A61K9/0024 , A61F2/022 , A61F2/062 , A61L27/16 , A61L27/20 , A61L27/38 , C08L33/00 , C08L33/22 , C08L1/08
摘要： Permeable structures suited for implanting in host tissue include a first permeable region comprising a polymer solution formed-in-place in contact with a second permeable region. The structures provide enhanced immunoisolation, which promotes the survival of even xenogeneic cells implanted in host tissue.
摘要翻译：适于植入宿主组织的可渗透结构包括第一可渗透区域，其包含与第二可渗透区域接触形成的聚合物溶液。该结构提供增强的免疫隔离，其促进植入宿主组织的甚至异种细胞的存活。

5. 发明授权

EP2168605B1 Device for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
标题翻译：一种用于灭活存在于治疗性流体病原体用杀菌辐射装置
公开(公告)号：EP2168605B1
公开(公告)日：2014-04-16
申请号：EP09075485.4
申请日：2001-01-26
申请人： Baxter International Inc.
发明人： Breillatt, Julian , Woo, Lecon , Sandford, Craig , Boggs, Daniel R. , Khare, Atul , Sternberg, Shmuel
IPC分类号： A61L2/02 , A61M1/36 , A61L2/10 , A61L2/00 , A61M1/02
CPC分类号： A61L2/10 , A61L2/0011 , A61M1/0281 , A61M1/3681 , A61M2202/0415 , A61M2205/053

6. 发明公开

EP2016938A1 Preparation of submicron sized particles via dispersion and solevnt or liquid phase removal 审中-公开
标题翻译：通过分散的手段和溶剂或液相中移出生产亚微米尺寸的颗粒
公开(公告)号：EP2016938A1
公开(公告)日：2009-01-21
申请号：EP08075760.2
申请日：2002-09-25
申请人： Baxter International Inc.
发明人： Brynjelsen, Sean , Sternberg, Shmuel , Dunham, Andrew J. , Narayanan, Krishnaswamy , Doty, Mark J. , Kipp, James E , Jayswal, Nailesh
IPC分类号： A61K9/51
CPC分类号： A61K9/5169 , A61K9/5192
摘要： The present invention relates to a process for preparing submicron sized particles comprising the steps of: providing a crude dispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having a pharmaceutically active compound therein; providing energy to the crude dispersion to form a fine dispersion; freezing the fine dispersion; and lyophilizing the frozen dispersion to obtain particles having a mean particle size of less than 500nm.
摘要翻译：本发明涉及一种用于制备亚微米大小的颗粒，其包括的步骤：提供具有有机相和在wässrige相的多相系统的粗分散体，其中具有药学活性化合物的有机相; 到粗分散体提供能量以形成精细分散体; 冷冻细分散体; 和冻干冷冻的分散体，以获得具有小于500nm的平均颗粒尺寸的颗粒。

7. 发明公开

EP1275410A2 A blood filter 失效
标题翻译： Eine Filtervorrichtung zur Entfernung von Leukocyten
公开(公告)号：EP1275410A2
公开(公告)日：2003-01-15
申请号：EP02078995.4
申请日：1994-12-20
申请人： BAXTER INTERNATIONAL INC.
发明人： Sternberg, Shmuel , Wons, Allen R. , Fisher, David P. , Lynn, Daniel R. , Minshall, Billy W.
IPC分类号： A61M5/165
CPC分类号： G01N15/08 , B29C65/04 , B29C65/08 , B29C66/1122 , B29C66/1312 , B29C66/24221 , B29C66/53261 , B29C66/53262 , B29C66/54 , B29C66/71 , B29C66/73921 , B29C66/81423 , B29C66/81431 , B29C66/8322 , B29C66/83221 , B29C66/9513 , B29K2027/06
摘要： In a method for processing audio signals composed audio signals (L+R) and (L-R) are derived from left (L) and right (R) audio signals. The energy content of the composed (L-R) audio signals above a predetermined frequency value is measured and compared with a predetermined threshold value. Then, when this energy content falls below said threshold value, a signal derived from and decorrelated with respect to the composed (L+R) audio signal is added to the composed (L-R) signal to obtain an improved composed (L-R) audio signal, and left (L) and right(R) audio signals are obtained back again from the composed (L+R) signal and the improved composed (L-R) audio signal.
摘要翻译：在用于处理从左（L）和右（R）音频信号导出构成音频信号（L + R）和（L-R）的音频信号的方法中。测量高于预定频率值的组合（L-R）音频信号的能量含量并与预定阈值进行比较。然后，当该能量含量低于所述阈值时，从组合的（L + R）音频信号中导出和解相关的信号被添加到组合的（LR）信号中，以获得改进的组合（LR）音频信号，并且从组合的（L + R）信号和改进的组合（LR）音频信号中再次获得左（L）和右（R）音频信号。

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