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1. 发明公开

EP2459727A2 BIOCATALYST FOR CATALYTIC HYDROAMINATION 审中-公开
标题翻译：生物催化剂催化氢胺化
公开(公告)号：EP2459727A2
公开(公告)日：2012-06-06
申请号：EP10737889.5
申请日：2010-07-27
申请人： BASF SE
发明人： HAUER, Bernhard , SCHNEIDER, Nina , DREW, Dejana , DITRICH, Klaus , TURNER, Nick , NESTL, Bettina, M.
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C07C211/27
摘要： The present invention relates to a method for the enzymatic hydroamination of C-C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.

2. 发明公开

EP1968960A2 RACEMATSPALTUNG VON 2,6-TRANS-DIMETHYLMORPHOLIN 有权
标题翻译： 2,6-TRANS二甲基决议
公开(公告)号：EP1968960A2
公开(公告)日：2008-09-17
申请号：EP06830698.4
申请日：2006-12-18
申请人： BASF SE
发明人： DITRICH, Klaus , HAESE, Frank
IPC分类号： C07D295/02
CPC分类号： C07D295/027
摘要： The invention relates to a method for producing optically active trans-2,6-dimethylmorpholine by (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid, (ii) separating the formed salt from D-mandelic acid and the one enantiomer of the trans-2,6-dimethylmorpholine from the other enantiomer of the trans-2,6-dimethylmorpholine and (iii) isolating the desired optically active trans-2,6-dimethylmorpholine.

3. 发明授权

EP2893026B1 PROCESS FOR PREPARING SEBACIC ACID 有权
公开(公告)号：EP2893026B1
公开(公告)日：2018-08-01
申请号：EP13758836.4
申请日：2013-09-03
申请人： BASF SE
发明人： PIATESI, Andrea , BALDENIUS, Kai-Uwe , DITRICH, Klaus , KINDLER, Alois , ZAJACZKOWSKI-FISCHER, Marta , BÖHLING, Ralf , REHFINGER, Alwin
IPC分类号： C12P7/64 , C07C55/20 , C07C59/147
CPC分类号： C12P7/6427 , C07C51/235 , C07C51/373 , C12P7/6409 , C12Y402/01053 , C07C59/147 , C07C55/20
摘要： A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form10- hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step(iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.

4. 发明公开

EP2888351A2 GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS 审中-公开
标题翻译：基因及其制造方法CLAVIN生物碱
公开(公告)号：EP2888351A2
公开(公告)日：2015-07-01
申请号：EP13831449.7
申请日：2013-08-13
申请人： BASF SE , Evolva SA
发明人： NAESBY, Michael , FOLLY, Christophe , NIELSEN, Curt Aimé Friis , HATSCH, Anaelle , SCHWAB, Markus , ZELDER, Oskar , HAEFNER, Stefan , SCHRÖDER, Hartwig , HOFF, Birgit , MOLT, Andrea , DITRICH, Klaus , BREUER, Michael , HARTMANN, Holger , KÖRBER, Karsten
IPC分类号： C12N1/21 , C12N1/15 , C12N1/16 , C12N15/80 , C12N15/81 , C12N15/31 , C12N15/52 , C12P1/00 , C12P17/10 , C07K14/195 , C07K14/37 , A61K31/48 , C07K16/00
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

5. 发明授权

EP1968960B1 RACEMATSPALTUNG VON 2,6-TRANS-DIMETHYLMORPHOLIN 有权
标题翻译： 2,6-TRANS二甲基决议
公开(公告)号：EP1968960B1
公开(公告)日：2010-05-26
申请号：EP06830698.4
申请日：2006-12-18
申请人： BASF SE
发明人： DITRICH, Klaus , HAESE, Frank
IPC分类号： C07D295/02
CPC分类号： C07D295/027
摘要： The invention relates to a method for producing optically active trans-2,6-dimethylmorpholine by (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid, (ii) separating the formed salt from D-mandelic acid and the one enantiomer of the trans-2,6-dimethylmorpholine from the other enantiomer of the trans-2,6-dimethylmorpholine and (iii) isolating the desired optically active trans-2,6-dimethylmorpholine.

6. 发明公开

EP2069517A1 VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEM 2-BENZYLOXYCYCLOHEXYLAMIN 有权
标题翻译：工艺生产光学有源2 benzyloxycyclohexylamine
公开(公告)号：EP2069517A1
公开(公告)日：2009-06-17
申请号：EP07803441.0
申请日：2007-09-12
申请人： BASF SE
发明人： DITRICH, Klaus , REUTHER, Ute , BARTSCH, Michael
IPC分类号： C12P13/02 , C12P41/00
CPC分类号： C12P13/001 , C12P41/007
摘要： The invention relates to a method for the enantioselective acylation of trans-2-benzyloxycyclohexylamine or cis-2-benzyloxycyclohexylamine, according to which an enantiomer mixture of 2-benzyloxycyclohexylamine is reacted with an acylation agent in the presence of a hydrolase. The invention also relates to a method for producing optically active trans-stereoisomers of 2-benzyloxycyclohexylamine.

7. 发明公开

EP1969129A1 VERFAHREN ZUR HERSTELLUNG VON (R) - UND (S) -4- (1-AMMONIUMETHYL) BENZOESÄUREMETHYLESTER-SULFAT AUS RACEMISCHEM 4-(l-AMIN0ETHYL)BENZ0ESÄUREMETHYLESTER DURCH LIPASE-KATALYSIERTE ENANTIOSELEKTIVE ACYLIERUNG UND ANSCHLIESSENDEM AUSFÄLLEN MIT SCHWEFELSÄURE 有权
标题翻译：用于生产（R） - 和（S）-4-（1-氨基甲基）从外消旋4-（1- AMIN0ETHYL）苯甲酸甲酯苯甲酸硫酸
公开(公告)号：EP1969129A1
公开(公告)日：2008-09-17
申请号：EP06830713.1
申请日：2006-12-19
申请人： BASF SE
发明人： DITRICH, Klaus , WINSEL, Harald , MOULIN, Dominique
IPC分类号： C12P13/02 , C12P41/00 , C07C211/03 , C07C235/00
CPC分类号： C07C229/38 , C07B2200/07 , C07C227/34 , C12P13/00 , C12P13/001 , C12P13/02 , C12P41/007
摘要： The invention relates to a method for producing optically active 4-(1-ammoniumethyl)-benzoic acid methylester-sulphate by reacting racemic 4-(1- aminoethyl)-benzoic acid methylester with an acylating agent in the presence of a lipase to form 4-(1-aminoethyl)benzoic acid methylester and subsequently, precipitation of 4-(1-ammoniumethyl)benzoic methylester-sulphate by adding sulphuric acid.

8. 发明公开

EP3191498A1 METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE 有权
标题翻译：制备2'-O-果糖基丙糖的方法
公开(公告)号：EP3191498A1
公开(公告)日：2017-07-19
申请号：EP15763307.4
申请日：2015-09-11
申请人： BASF SE
发明人： PUHL, Michael , DITRICH, Klaus , KELLER, Andreas , DIMITROVA, Pepa , WEINGARTEN, Melanie , SIEGEL, Wolfgang
IPC分类号： C07H3/06 , C07H15/26
摘要： The present invention relates to a method for preparing 2'-O-fucosyllactose, the 2'-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(=O)-R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6- alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4- alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.
摘要翻译：本发明涉及制备2'-O-岩藻糖基乳糖的方法，由该方法得到的2'-O-岩藻糖基乳糖及其用途。该方法包括使以下通式（I）的经过硅烷化的，被保护的岩藻糖衍生物与至少一种三（C1-C6-烷基）甲硅烷基碘化物反应，随后使如此获得的产物与通式（II）在一个基地的存在。在式（I）和（II）中，变量各自如下定义：RSi相同或不同，并且是式SiR a R b R c的残基; R 1为C（= O）-R 11残基或SiR 12 R 13 R 14残基，R 2相同或不同且为C 1 -C 8烷基或一起形成未取代或具有1至6个甲基的直链C 3 -C 6烷二基作为取代基; R3是相同或不同的并且是C1-C8-烷基或一起形成未取代的或具有1-6个甲基作为取代基的直链C1-C4-链烷二基。

9. 发明公开

EP2643467A1 VERFAHREN ZUR HERSTELLUNG N-HETEROZYKLISCHER OPTISCH AKTIVER ALKOHOLE 审中-公开
标题翻译： METHOD FOR PRODUCING N-杂环的光学活性醇
公开(公告)号：EP2643467A1
公开(公告)日：2013-10-02
申请号：EP11784705.3
申请日：2011-11-22
申请人： BASF SE
发明人： SCHNEIDER, Nina , BONNEKESSEL, Melanie , BREUER, Michael , DÄUWEL, Jürgen , DITRICH, Klaus , KARL, Ulrich , STÄB, Tobias
IPC分类号： C12P7/22 , C12N9/04
CPC分类号： C12N9/0006 , C07D211/22 , C07D213/30 , C12P7/22 , C12P17/10 , C12P17/12 , C12P41/002
摘要： Method for producing N-heterocyclic optically active alcohols of the formula (I), where R
1 represents alkyl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
3 , OH, OR
3 , NO
2 , CN, CO, COOR
3 , NR
3 R
4 or NR
3 R
3 R
5+ X
- , where R
3 , R
4 and R
5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
- is a counterion, R
2 is N-containing heteroaryl groups which in turn can be monosubstituted or polysubstituted by alkyl, halogen, SH.SR
3 , OH, OR
3 , NO
2 , CN, CO, COOR
3 , NR
3 R
4 or NR
3 R
3 R
5+ X
- , where R
3 , R
4 and R
5 independently of one another are H or a low-alkyl or low-alkoxy radical and X
- is a counterion, by reduction of the corresponding ketone, wherein the reduction is carried out using a dehydrogenase having the polypeptide sequence SEQ ID NO: 2 or NO: 4, or having a polypeptide sequence in which up to 25% of the amino acid radicals are modified in comparison with SEQ ID NO: 2 or NO: 4 by deletion, insertion, substitution or a combination thereof.

10. 发明公开

EP2643281A1 PREPARATION OF ISOMERICALLY PURE SUBSTITUTED CYCLOHEXANOLS 审中-公开
标题翻译：生产异构取代的环己
公开(公告)号：EP2643281A1
公开(公告)日：2013-10-02
申请号：EP11843794.6
申请日：2011-11-21
申请人： BASF SE
发明人： BONNEKESSEL, Melanie , DITRICH, Klaus , DÄUWEL, Jürgen , SORG, Achim , LADNER, Wolfgang , COOPER, Bryan , BACKES, Rene
IPC分类号： C07C35/08 , C12N11/14
CPC分类号： C12N11/14 , C12P7/02 , C12P41/004 , C12Y301/01003
摘要： Disclosed is a method for preparing isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols, which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated from the unreacted substituted cyclohexanol cis isomer.

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