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1. 发明公开

EP1282713A2 MOSS GENES FROM PHYSCOMITRELLA PATENS ENCODING PROTEINS INVOLVED IN THE SYNTHESIS OF POLYUNSATURATED FATTY ACIDS AND LIPIDS 审中-公开
标题翻译：基因苔藓小立碗藓，蛋白质代码在多不饱和脂肪酸和脂质合成有关
公开(公告)号：EP1282713A2
公开(公告)日：2003-02-12
申请号：EP00979617.8
申请日：2000-11-22
申请人： BASF Plant Science GmbH
发明人： LERCHL, Jens , RENZ, Andreas , EHRHARDT, Thomas , REINDL, Andreas , CIRPUS, Petra , BISCHOFF, Friedrich , FRANK, Markus , FREUND, Annette , DUWENIG, Elke , SCHMIDT, Ralf-Michael , RESKI, Ralf
IPC分类号： C12N15/52 , C12N15/29 , C12N1/11 , C12N1/21 , C12N1/13 , C12N5/10 , C12N9/00
摘要： Isolated nucleic acid molecules, designated LMRP nucleic acid molecules, which encode novel LMRPs from e.g. Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing LMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated LMRPs, mutated LMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of LMRP genes in these organisms.

2. 发明公开

EP1599582A2 VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESÄTTIGTER FETTSÄUREN 有权
标题翻译：用于生产多不饱和脂肪酸
公开(公告)号：EP1599582A2
公开(公告)日：2005-11-30
申请号：EP04706146.0
申请日：2004-01-29
申请人： BASF Plant Science GmbH
发明人： RENZ, Andreas , HEINZ, Ernst , ABBADI, Amine , DOMERGUE, Frederic , ZANK, Thorsten
IPC分类号： C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing polyunsaturated fatty acids in an organism by introducing nucleic acids coding for polypeptides with acyl-CoA:lysophospholipid-acyl transferase activity into the organism. Advantageously, said nucleic acid sequences can optionally be expressed in the transgenic organism along with additional nucleic acid sequences coding for polypeptides of fatty acid metabolism or lipid metabolism biosynthesis. The invention also relates to the nucleic acid sequences, nucleic acid structures containing said nucleic acid sequences, vectors containing the inventive nucleic acid sequences, and/or the nucleic acid structures and transgenic organisms containing said nucleic acid sequences, nucleic acid structures, and/or vectors. The invention further relates to oils, lipids, and/or fatty acids that are produced according the inventive method, and the use thereof.

3. 发明授权

EP1506289B1 VERFAHREN ZUM ERHÖHEN DES ÖLGEHALTES IN PFLANZEN 有权
标题翻译：方法提高含油量在植物
公开(公告)号：EP1506289B1
公开(公告)日：2012-08-08
申请号：EP03737958.3
申请日：2003-05-06
申请人： BASF Plant Science GmbH
发明人： RENZ, Andreas , BAUER, Jörg , STITT NIGEL, Marc , ZRENNER, Rita, Maria , GEIGENBERGER, Peter , VIGEOLAS, Helene
IPC分类号： C12N9/02
CPC分类号： C12N9/0006 , C12N15/8247
摘要： The invention relates to methods for increasing the oil content in plants, preferably in the seeds of plants, by expression of glycerol-3-phosphatdehydrogenases (G3PDH) from yeast, preferably from Saccharomyces cerevisiae. The invention also relates to expression constructs for the expression of G3PDH yeast in plants, preferably in the seeds of plants, transgenic plants expressing G3PDH, and to the use of said transgenic plants in the production of foodstuffs, feed, seeds, pharmaceuticals or fine chemicals, especially in the production of oils.

4. 发明授权

EP1356067B1 VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESAETTIGTER FETTSAEUREN, NEUE BIOSYNTHESEGENE SOWIE NEUE PFLANZLICHE EXPRESSIONSKONSTRUKTE 有权
标题翻译：用于生产多不饱和脂肪酸，合成新的和新工厂的表达构建
公开(公告)号：EP1356067B1
公开(公告)日：2010-04-28
申请号：EP02704657.2
申请日：2002-01-18
申请人： BASF Plant Science GmbH
发明人： LERCHL, Jens , RENZ, Andreas , HEINZ, Ernst , DOMERGUE, Frederic , ZÄHRINGER, Ulrich
IPC分类号： C12N15/82 , C12N15/53 , C12N15/11 , C12N9/02 , C12P7/62 , C12P7/64 , C12Q1/68 , C07K16/40 , G01N33/573 , C11B1/00
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472

5. 发明公开

EP1527182A2 PROCESS FOR THE PRODUCTION OF UNSATURATED FATTY ACIDS 审中-公开
标题翻译：用于生产不饱和脂肪酸
公开(公告)号：EP1527182A2
公开(公告)日：2005-05-04
申请号：EP03716183.3
申请日：2003-02-27
申请人： BASF Plant Science GmbH
发明人： RENZ, Andreas , GIPMANS, Martijn , FEUSSNER, Ivo , ROSENFIELD, Claire-Lise , KNIPPLE, Douglas,C.
IPC分类号： C12N15/80 , C12N15/81 , C12N15/82
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6472
摘要： The invention relates to processes for the production of unsaturated fatty acids, preferably of conjugated polyunsaturated fatty acids such as conjugated linoleic acid (CLA), by the recombinant expression of desaturases from insects of the order Lepidoptera. Expression preferably takes place in an organism selected from the group of the plant organisms, yeasts, fungi and algae. Also according to the invention are recombinant expression cassettes for the recombinant expression of desaturases from insects of the order Lepidoptera, and the transgenic organisms transformed with these.

6. 发明公开

EP1501932A2 VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESÄTTIGTER FETTSÄUREN IN PFLANZEN 审中-公开
标题翻译：用于生产不饱和脂肪酸多植物
公开(公告)号：EP1501932A2
公开(公告)日：2005-02-02
申请号：EP03747357.6
申请日：2003-04-25
申请人： BASF Plant Science GmbH
发明人： CIRPUS, Petra , RENZ, Andreas , LERCHL, Jens , KUIJPERS, Anne-Marie
IPC分类号： C12N15/82 , C12P7/64
CPC分类号： C12P7/6427 , C12N9/0083 , C12N15/8247 , C12P7/6472 , C12P7/6481
摘要： The invention relates to a method for producing fatty acid esters which contain unsaturated fatty acids with at least three double-bonds, and free unsaturated fatty acids having a content of at least 1 wt.- %, in relation to the total amount of fatty acids contained in plants, by expression of at least one nucleic acid sequence which codes for a polypeptide having D-6-desaturase activity, and at least one nucleic acid sequence which codes for a polypeptide having D-6-elongase activity. Advantageously, said nucleic acid sequences can be expressed, optionally, together with a third nucleic acid sequence in the transgenic plant, which codes for a polypeptide having D-5-desaturase activity. The invention also relates to the use of defined nucleic acid sequences which code for polypeptides having a D-6-desaturase activity, D-6-elongase activity or D-5-desaturase activity, selected from a group of nucleic acid sequences, or to the use of nucleic acid structures containing the above-mentioned nucleic acid sequences.

7. 发明公开

EP1356067A2 VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESAETTIGTER FETTSAEUREN, NEUE BIOSYNTHESEGENE SOWIE NEUE PFLANZLICHE EXPRESSIONSKONSTRUKTE 有权
标题翻译：用于生产多不饱和脂肪酸，合成新的和新工厂的表达构建
公开(公告)号：EP1356067A2
公开(公告)日：2003-10-29
申请号：EP02704657.2
申请日：2002-01-18
申请人： BASF Plant Science GmbH
发明人： LERCHL, Jens , RENZ, Andreas , HEINZ, Ernst , DOMERGUE, Frederic , ZÄHRINGER, Ulrich
IPC分类号： C12N15/82 , C12N15/53 , C12N15/11 , C12N9/02 , C12P7/62 , C12P7/64 , C12Q1/68 , C07K16/40 , G01N33/573 , C11B1/00
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing unsaturated fatty acids comprising at least two double bonds, and a method for producing triglycerides having an increased content of polyunsaturated fatty acids comprising at least two double bonds. The invention also relates to the advantageous use of the nucleic acid sequences of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 18 in the inventive methods, and for producing a transgenic organism, preferably a transgenic plant or a transgenic micro-organism having an increased content of fatty acids, oils or lipids containing unsaturated C18, C20, or C22 fatty acids. The invention further relates to novel desaturases comprising the sequences of SEQ ID NO. 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11, or the homologues, derivatives or analogues thereof, and gene constructs comprising said genes or the homologues, derivatives or analogues thereof, in addition to the use of the same, either alone or combined with biosynthesis genes of polyunsaturated fatty acids, as advantageously represented in SEQ ID NO: 7 and SEQ ID NO: 9. Furthermore, the invention relates to isolated nucleic acid sequences, expression cassettes containing said nucleic acid sequences, vectors, and transgenic organisms containing at least one nucleic acid sequence or an expression cassette. The invention also relates to unsaturated fatty acids comprising at least two double bonds and triglycerides having an increased content of unsaturated fatty acids comprising at least two double bonds, and the use of the same. Finally, the invention relates to multi-expression cassettes for seed-specific expression, in addition to vectors or organisms comprising a desaturase gene, either alone or combined with other desaturases having the sequence of SEQ ID NO: 7 and/or elongase genes having the sequence of ID NO: 9 or the homologues, derivatives or analogues of the same, expressed by means of the above-mentioned expression cassettes.

8. 发明公开

EP1244696A2 MOSS GENES FROM PHYSCOMITRELLA PATENS ENCODING PROTEINS INVOLVED IN THE SYNTHESIS OF TOCOPHEROLS, CAROTENOIDS AND AROMATIC AMINO ACIDS 审中-公开
标题翻译： GENE MOSS小立碗藓在蛋白质生物合成维生素E，类胡萝卜素和生物合成芳香族氨基酸准则的的
公开(公告)号：EP1244696A2
公开(公告)日：2002-10-02
申请号：EP00983319.5
申请日：2000-12-14
申请人： BASF Plant Science GmbH
发明人： LERCHL, Jens , RENZ, Andreas , EHRHARDT, Thomas , REINDL, Andreas , CIRPUS, Petra , BISCHOFF, Friedrich , FRANK, Markus , FREUND, Annette , DUWENIG, Elke , SCHMIDT, Ralf-Michael , RESKI, Ralf , BADUR, Ralf
IPC分类号： C07K14/415 , C12N9/88 , C12N15/82 , C07K16/16
CPC分类号： C12N9/1007 , C12N15/52 , C12N15/8243 , C12N15/825
摘要： Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.

9. 发明授权

EP1599582B1 VERFAHREN ZUR HERSTELLUNG MEHRFACH UNGESÄTTIGTER FETTSÄUREN 有权
标题翻译：用于生产多不饱和脂肪酸
公开(公告)号：EP1599582B1
公开(公告)日：2011-07-27
申请号：EP04706146.0
申请日：2004-01-29
申请人： BASF Plant Science GmbH
发明人： RENZ, Andreas , HEINZ, Ernst , ABBADI, Amine , DOMERGUE, Frederic , ZANK, Thorsten
IPC分类号： C12N9/10 , C12N15/82 , C12P7/64
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing polyunsaturated fatty acids in an organism by introducing nucleic acids coding for polypeptides with acyl-CoA:lysophospholipid-acyl transferase activity into the organism. Advantageously, said nucleic acid sequences can optionally be expressed in the transgenic organism along with additional nucleic acid sequences coding for polypeptides of fatty acid metabolism or lipid metabolism biosynthesis. The invention also relates to the nucleic acid sequences, nucleic acid structures containing said nucleic acid sequences, vectors containing the inventive nucleic acid sequences, and/or the nucleic acid structures and transgenic organisms containing said nucleic acid sequences, nucleic acid structures, and/or vectors. The invention further relates to oils, lipids, and/or fatty acids that are produced according the inventive method, and the use thereof.

10. 发明公开

EP1506289A2 VERFAHREN ZUM ERHÖHEN DES ÖLGEHALTES IN PFLANZEN 有权
标题翻译：方法提高含油量在植物
公开(公告)号：EP1506289A2
公开(公告)日：2005-02-16
申请号：EP03737958.3
申请日：2003-05-06
申请人： BASF Plant Science GmbH
发明人： RENZ, Andreas , BAUER, Jörg , STITT NIGEL, Marc , ZRENNER, Rita, Maria , GEIGENBERGER, Peter , VIGEOLAS, Helene
IPC分类号： C12N9/02
CPC分类号： C12N9/0006 , C12N15/8247
摘要： The invention relates to methods for increasing the oil content in plants, preferably in the seeds of plants, by expression of glycerol-3-phosphatdehydrogenases (G3PDH) from yeast, preferably from Saccharomyces cerevisiae. The invention also relates to expression constructs for the expression of G3PDH yeast in plants, preferably in the seeds of plants, transgenic plants expressing G3PDH, and to the use of said transgenic plants in the production of foodstuffs, feed, seeds, pharmaceuticals or fine chemicals, especially in the production of oils.

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