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1. 发明公开

EP2045244A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS 有权
标题翻译：尼日利亚革命联盟
公开(公告)号：EP2045244A1
公开(公告)日：2009-04-08
申请号：EP07790690.7
申请日：2007-07-12
申请人： Asahi Kasei Pharma Corporation
发明人： ARIMOTO, Yuichi , ISHII, Naoyuki , SHODA, Motoshi
IPC分类号： C07D231/56 , A61K31/416 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00
CPC分类号： C07D231/56
摘要： [Object] In the case of using 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, or methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate as a medicine, more preferable aspects or improved methods are provided.
[Means] Crystals of any compound among 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionic acid, methyl 3-[4-(indan-2-yloxy)-3-(1-methyl-1H-indazol-5-yl)-5-nitrophenyl]propionate, and methyl 3-[3-amino-4-(indan-2-yloxy)-5-(1-methyl-1H-indazol-5-yl)phenyl]propionate, and methods of producing the same are provided.
摘要翻译：在使用3- [3-氨基-4-（茚满-2-基氧基）-5-（1-甲基-1H-吲唑-5-基）苯基]丙酸的情况下，将3- [4 - （茚满-2-基氧基）-3-（1-甲基-1H-吲唑-5-基）-5-硝基苯基]丙酸酯，或3- [3-氨基-4-（茚满-2-基氧基） 5-（1-甲基-1H-吲唑-5-基）苯基]丙酸乙酯作为药物，提供了更优选的方面或改进的方法。 [装置] 3- [3-氨基-4-（茚满-2-基氧基）-5-（1-甲基-1H-吲唑-5-基）苯基]丙酸3- [4 - （茚满-2-基氧基）-3-（1-甲基-1H-吲唑-5-基）-5-硝基苯基]丙酸乙酯和3- [3-氨基-4-（茚满-2-基氧基） - 5-（1-甲基-1H-吲唑-5-基）苯基]丙酸乙酯及其制备方法。

2. 发明公开

EP1847533A1 SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF 有权
标题翻译： 6-GLIEDRIGE HETEROCYCLISCHE VERBINDUNG UND ANWENDUNG DAVON
公开(公告)号：EP1847533A1
公开(公告)日：2007-10-24
申请号：EP06712288.7
申请日：2006-01-25
申请人： Asahi Kasei Pharma Corporation
发明人： SHODA, Motoshi , ISHIZUYA, Toshinori
IPC分类号： C07D237/04 , A61K31/50 , A61P1/02 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00
CPC分类号： C07D237/04
摘要： A compound represented by the general formula (I) or a salt thereof:

[T represents oxygen atom and the like; V represents CH 2 and the like; R O1 to R O4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents -CH(OH)- group and the like; and W represent -U 1 -(R W1 )(R W2 )-U 2 -U 3 group (U 1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; R W1 and R W2 represent hydrogen atom and the like; U 2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U 3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.
摘要翻译：由通式（I）表示的化合物或其盐：[T表示氧原子等; V表示CH 2等; R O1〜R O4表示氢原子等; A表示直链亚烷基或碳原子数2〜8的直链亚烯基等; D表示羧基等; X表示亚乙基，三亚甲基等; E表示-CH（OH） - 基等; W表示-U 1 - （R W1）（R W2）-U 2 -U 3基（U 1表示单键，碳原子数1〜4的亚烷基等; R W1，R W2表示氢原子等; U 2表示单键，碳原子数1〜4的亚烷基等; U 3表示碳原子数为1〜8的烷基等）或碳环的残基或杂环化合物]，其可以用作有效预防和/或治疗骨质疏松症和骨折性疾病如青光眼，溃疡性结肠炎等的有效成分。

3. 发明授权

EP2045244B1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS 有权
标题翻译：取代苯基链和方法新的晶体
公开(公告)号：EP2045244B1
公开(公告)日：2013-04-03
申请号：EP07790690.7
申请日：2007-07-12
申请人： Asahi Kasei Pharma Corporation
发明人： ARIMOTO, Yuichi , ISHII, Naoyuki , SHODA, Motoshi
IPC分类号： C07D231/56 , A61K31/416 , A61P25/04 , A61P29/00 , A61P37/00 , A61P37/08 , A61P43/00
CPC分类号： C07D231/56

4. 发明公开

EP2006271A9 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：取代双环导数及其使用
公开(公告)号：EP2006271A9
公开(公告)日：2009-07-29
申请号：EP07740229.5
申请日：2007-03-29
申请人： Asahi Kasei Pharma Corporation
发明人： MATSUMOTO, Akiko , SHODA, Motoshi , KURIYAMA, Hiroshi
IPC分类号： C07C69/616 , A61K31/216 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/4184 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/451 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/5375
CPC分类号： C07D209/18 , C07C59/64 , C07C59/68 , C07C59/72 , C07C69/616 , C07C69/618 , C07C69/732 , C07C69/736 , C07C2601/14 , C07C2602/10 , C07C2602/22 , C07D211/14 , C07D213/30 , C07D213/55 , C07D215/14 , C07D217/00 , C07D231/54 , C07D265/30 , C07D277/62 , C07D295/14 , C07D307/54 , C07D307/80 , C07D319/20 , C07D333/24 , C07D333/60 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/10
摘要： [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action.
[Means for solution] A compound represented by the formula (I):

[In the formula, ---- represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V 1 and V 2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.

5. 发明授权

EP1847533B1 SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF 有权
标题翻译： 6元杂环化合物及其用途
公开(公告)号：EP1847533B1
公开(公告)日：2013-08-14
申请号：EP06712288.7
申请日：2006-01-25
申请人： Asahi Kasei Pharma Corporation
发明人： SHODA, Motoshi , ISHIZUYA, Toshinori
IPC分类号： C07D237/04 , A61K31/50 , A61P1/02 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00
CPC分类号： C07D237/04

6. 发明授权

EP1477472B1 SUBSTITUTED PHENYLALKANOIC ACID DERIVATIVE AND USE THEREOF 有权
标题翻译：取代苯基链及其用途
公开(公告)号：EP1477472B1
公开(公告)日：2009-01-14
申请号：EP03706983.8
申请日：2003-02-20
申请人： Asahi Kasei Pharma Corporation
发明人： SHODA, Motoshi , KURIYAMA, Hiroshi
IPC分类号： C07C69/734 , C07C59/62 , C07C59/68 , C07C229/42 , C07C205/56 , C07C233/54 , C07C235/06 , C07C235/16 , C07C235/20 , C07C237/20 , C07C275/42 , C07D209/18 , C07D215/14 , C07D215/22 , C07D231/56 , C07D307/68 , C07D307/79 , C07D277/64 , C07D277/82 , C07D333/60 , C07D409/12 , A61K31/19 , A61K31/215 , A61K31/405 , A61K31/425 , A61K31/41 , A61P25/04 , A61P37/00
CPC分类号： C07C59/58 , C07C59/68 , C07C59/72 , C07C69/734 , C07C229/42 , C07C307/10 , C07C2601/08 , C07D209/08 , C07D209/18
摘要： A compound represented by the general formula (I):[wherein n is an integer of 1 to 3; R represents C3-8 alkyl, a group represented by R1(CH2)k- (k is an integer of 0 to 3; and R1 represents C3-7 saturated cycloalkyl or C6-8 fused-ring saturated alkyl, provided that R1 may be substituted by C1-4 alkyl), etc.; and Ar represents a bicyclic fused-ring group, e.g., naphthalen-1-yl] or a salt of the compound. The compound or salt has prostaglandin and leukotriene production inhibitory activity. It is useful for the prevention of and treatments for, e.g., various inflammatory diseases attributable to the lipid mediator.

7. 发明公开

EP2006271A2 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：替代品BISYCLISCHES DERIVAT UND DESSEN VERWENDUNG
公开(公告)号：EP2006271A2
公开(公告)日：2008-12-24
申请号：EP07740229.5
申请日：2007-03-29
申请人： Asahi Kasei Pharma Corporation
发明人： MATSUMOTO, Akiko , SHODA, Motoshi , KURIYAMA, Hiroshi
IPC分类号： C07C1/00
CPC分类号： C07D209/18 , C07C59/64 , C07C59/68 , C07C59/72 , C07C69/616 , C07C69/618 , C07C69/732 , C07C69/736 , C07C2601/14 , C07C2602/10 , C07C2602/22 , C07D211/14 , C07D213/30 , C07D213/55 , C07D215/14 , C07D217/00 , C07D231/54 , C07D265/30 , C07D277/62 , C07D295/14 , C07D307/54 , C07D307/80 , C07D319/20 , C07D333/24 , C07D333/60 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/10
摘要： [Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action.
[Means for solution] A compound represented by the formula (I):

[In the formula, ---- represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V 1 and V 2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.
摘要翻译：本发明提供具有前列腺素生产抑制作用的化合物和白三烯生产抑制作用。 [解决方案]由式（I）表示的化合物：[式中，----表示单键或双键，Link表示单键，或具有1或以上的饱和或不饱和直链烃） 2个碳原子，W表示单键，氧原子，硫原子，N（Rw）等，Rw表示氢原子，碳原子数为1〜8的烷基等，Rs表示-D-Rx等，D表示单键，氧原子，硫原子等，Rx表示碳原子数为3〜8的直链或支链饱和烷基等，V 1和V 2中的一个表示Z x，另一个表示AR，Z x表示氢原子具有1至4个碳原子的直链或支链饱和烷基等，AR表示部分不饱和或完全不饱和的稠合双环碳环或杂环，Y表示氢原子，具有1至4个碳原子的低级烷基等。]，或其盐。

8. 发明公开

EP1660427A1 SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：取代的芳基卡诺酸衍生物及其用途
公开(公告)号：EP1660427A1
公开(公告)日：2006-05-31
申请号：EP04771913.3
申请日：2004-08-13
申请人： Asahi Kasei Pharma Corporation
发明人： SHODA, Motoshi , KURIYAMA, Hiroshi
IPC分类号： C07C59/64 , C07C59/68 , C07C59/72 , C07C69/734 , C07C205/44 , C07C205/56 , C07C217/18 , C07C217/76 , C07C229/42
CPC分类号： C04B35/632 , C07C45/68 , C07C45/71 , C07C47/575 , C07C59/64 , C07C59/66 , C07C59/68 , C07C59/72 , C07C69/616 , C07C69/734 , C07C205/44 , C07C205/56 , C07C217/18 , C07C217/76 , C07C229/42 , C07C307/10 , C07C309/65 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/12 , C07C323/62 , C07C335/16 , C07C335/22 , C07C2601/08 , C07C2601/14 , C07D207/323 , C07D209/08 , C07D209/12 , C07D209/46 , C07D213/64 , C07D213/68 , C07D213/74 , C07D215/04 , C07D215/14 , C07D215/227 , C07D217/02 , C07D217/24 , C07D233/02 , C07D233/54 , C07D233/64 , C07D235/06 , C07D235/08 , C07D235/26 , C07D235/28 , C07D235/30 , C07D239/74 , C07D241/42 , C07D249/04 , C07D249/18 , C07D261/08 , C07D263/56 , C07D263/58 , C07D275/04 , C07D277/24 , C07D277/62 , C07D277/68 , C07D277/70 , C07D277/82 , C07D285/14 , C07D295/155 , C07D307/68 , C07D307/79 , C07D307/80 , C07D317/54 , C07D319/18 , C07D333/32 , C07D333/54 , C07D333/56 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A compound represented by the formula (I)[In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic ring (E) independently represent a ring-constituting carbon atom, one of the ring-constituting carbon atoms may be replaced with V, V represents nitrogen atom, or carbon atom substituted with Zx, Zx represents a saturated alkyl group having 1 to 4 carbon atoms and the like, Rs represents -D-Rx etc., D represents a single bond, oxygen atom and the like, Rx represents a saturated alkyl group having 3 to 8 carbon atoms and the like, AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or a heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms and the like] or a salt thereof. A compound having prostaglandin production-suppressing action and leukotriene production-suppressing action is provided.
摘要翻译：式（I）所示的化合物[式中，Link表示碳原子数1〜3的饱和或不饱和直链状烃链，芳香族环（E）中的碳原子数2〜6独立地表示成环碳原子，成环碳原子可以被V替代，V代表氮原子或被Zx取代的碳原子，Zx代表具有1至4个碳原子的饱和烷基等，Rs代表-D-Rx等， D表示单键，氧原子等，Rx表示碳原子数3〜8的饱和烷基等，AR表示部分不饱和或完全不饱和的稠合双环碳环或杂环，Y表示氢原子，具有1至4个碳原子的低级烷基等]或其盐。提供具有前列腺素生成抑制作用和白三烯生成抑制作用的化合物。

9. 发明公开

EP1477472A1 SUBSTITUTED PHENYLALKANOIC ACID DERIVATIVE AND USE THEREOF 有权
标题翻译：替代品维多利亚
公开(公告)号：EP1477472A1
公开(公告)日：2004-11-17
申请号：EP03706983.8
申请日：2003-02-20
申请人： Asahi Kasei Pharma Corporation
发明人： SHODA, Motoshi , KURIYAMA, Hiroshi
IPC分类号： C07C69/734 , C07C59/62 , C07C59/68 , C07C229/42 , C07C205/56 , C07C233/54 , C07C235/06 , C07C235/16 , C07C235/20 , C07C237/20 , C07C275/42 , C07C311/08 , C07C311/29 , C07C317/46 , C07C307/10 , A61K31/192 , A61K31/216 , A61K31/235 , A61K31/255 , A61K31/341
CPC分类号： C07C59/58 , C07C59/68 , C07C59/72 , C07C69/734 , C07C229/42 , C07C307/10 , C07C2601/08 , C07D209/08 , C07D209/18
摘要： A compound represented by the formula (I) or a salt thereof
wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R 1 (CH 2 ) k - (wherein k represents 0 or an integer of 1 to 3; R 1 represents a saturated cyclic alkyl group having 3 to 7 carbon atoms or a saturated condensed cyclic alkyl group having 6 to 8 carbon atoms, and the group R 1 may be substituted with a lower alkyl group having 1 to 4 carbon atoms) and the like, and Ar represents a condensed bicyclic group such as naphthalen-1-yl group, which has suppressing action on prostaglandin and leukotriene production and is useful for prophylactic and/or therapeutic treatment of various inflammatory diseases and the like caused by these lipid mediators.
摘要翻译：由式（I）表示的化合物或其盐其中n表示1〜3的整数，R表示碳原子数为3〜8的烷基，由下式表示的基团：R 1，（CH 2）k - （其中k表示0或1〜3的整数; R 1表示碳原子数3〜7的饱和环状烷基或碳原子数6〜8的饱和稠环状烷基，基团R 1可以被具有1〜4个碳原子的低级烷基取代）等，Ar表示对前列腺素和白三烯生产具有抑制作用的萘-1-基等稠合双环，对于由这些脂质介质引起的各种炎性疾病等的预防和/或治疗有用。

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