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1. 发明公开

EP4251745A1 GENETICALLY ENGINEERED BACTERIUM CAPABLE OF PRODUCING CYTOKININS WITH ISOPRENOID SIDE CHAINS 审中-实审
公开(公告)号：EP4251745A1
公开(公告)日：2023-10-04
申请号：EP21819848.9
申请日：2021-11-26
申请人： Acies Bio d.o.o.
发明人： KOGEJ, Tina , KOSEC, Gregor , FUJS, Stefan , BLAZIC, Marko , HORVAT, Jaka
IPC分类号： C12N9/00

3. 发明公开

EP4389874A1 GENETICALLY MODIFIED MICROORGANISMS FOR THE MANUFACTURE OF COMPOUNDS DERIVED FROM DIHYDROXYACETONE PHOSPHATE 审中-公开
公开(公告)号：EP4389874A1
公开(公告)日：2024-06-26
申请号：EP22215949.3
申请日：2022-12-22
申请人： Acies Bio d.o.o.
发明人： KOSEC, Gregor , VIRANT, David , FUJS, Stefan , KRUIS, Aleksander, Johannes
IPC分类号： C12N1/20 , C12N15/09 , C12P5/02 , C12P7/04 , C12P7/20 , C12P7/24 , C12P7/26
CPC分类号： C12P7/04 , C12P7/20 , C12P7/24 , C12N1/20 , C12N15/74 , C12N15/52 , C12R2001/0120210501 , C12N9/0006 , C12N9/16 , C12Y101/01008 , C12Y301/03021 , C12R2001/86520210501 , C12R2001/64520210501 , C12P7/18 , C12P7/56 , C12P7/42 , C12Y101/01049 , C12Y101/01044 , C12Y102/01046 , C12Y117/01
摘要： The present invention generally relates to the biotechnology engineering, and specifically to genetically engineered microorganisms, e.g. of the genus Methylobacillus, which have improved properties making them particularly useful in large scale methanol fermentations. More specifically, the present invention provides a genetically engineered microorganism which is methylotrophic and can generate reducing power by methanol dissimilation, and which microorganism being modified to enable the synthesis of at least one DHAP-derived compound. The present invention further provides a method for producing a biochemical compound using a genetically modified bacterium of the present invention.

4. 发明公开

EP3236958A1 PHOSPHOPANTETHEINE COMPOUNDS ALONE OR IN COMBINATION WITH HMG-COA REDUCTASE INHIBITORS FOR LOWERING SERUM CHOLESTEROL AND SERUM TRIGLICERIDES 审中-实审转让
标题翻译：单独或与HMG-COA还原酶抑制剂结合用于降低血清胆固醇和血清三酰甘油的磷酸苯丙胺化合物
公开(公告)号：EP3236958A1
公开(公告)日：2017-11-01
申请号：EP15816199.2
申请日：2015-12-23
申请人： Acies Bio d.o.o. , Rijksuniversiteit Groningen , Academisch Ziekenhuis Groningen
发明人： KOSEC, Gregor , FUJS, Stefan , PETKOVIC, Hrvoje , SIBON, Oda Cornelia Maria , SRINIVASAN, Balaji
IPC分类号： A61K31/345 , A61K31/661 , A61P3/06
CPC分类号： A61K31/661 , A61K31/345 , A61K2300/00
摘要： The invention relates to the use of phosphopantetheine compounds alone and in combination with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Preferred medical uses relate to the treatment or prevention of dyslipidemia.
摘要翻译：本发明涉及单独使用磷酸泛酰巯基乙胺化合物并且与3-羟基-3-甲基戊二酰基 - 辅酶A还原酶抑制剂组合使用。优选的医疗用途涉及血脂异常的治疗或预防。

6. 发明公开

EP3140416A1 CO-CULTIVATION OF PROPIONIBACTERIUM AND YEAST 有权
标题翻译： CO-KULTIVIERUNG AUS PROPIONIBACTERIUM UND HEFE
公开(公告)号：EP3140416A1
公开(公告)日：2017-03-15
申请号：EP15723471.7
申请日：2015-05-08
申请人： Acies Bio d.o.o. , Arima d.o.o.
发明人： SVAGELJ, Mirjan , FUJS, Stefan , KOSEC, Gregor , PETKOVIC, Hrvoje
IPC分类号： C12P39/00 , C12R1/645 , C12R1/01
CPC分类号： C12P39/00 , C12N1/16 , C12P19/42 , C12R1/72
摘要： The invention provides a fungal cell, such as a yeast cell, capable of growing in co-cultivation with Propionibacterium. Also provided are methods of producing such cells and fermentation processes using the fungal cell of the invention and Propionibacterium in co-cultivation. Such co-cultivation significantly reduces the chemical oxygen demand load of the waste fermentation broth.
摘要翻译：本发明提供了能够与丙酸杆菌共培养生长的真菌细胞，例如酵母细胞。还提供了使用本发明的真菌细胞和丙酸杆菌共培养的生产这种细胞的方法和发酵方法。这种共培养显着降低废发酵液的化学需氧量。

7. 发明公开

EP3066106A1 STABLE PANTETHEINE DERIVATIVES FOR THE TREATMENT OF PANTOTHENATE KINASE ASSOCIATED NEURODEGENERATION (PKAN) AND METHODS FOR THE SYNTHESIS OF SUCH COMPOUNDS 有权转让
标题翻译：稳定PANTETHEINDERIVATE与泛酸激酶相关性神经变性（PKAN）和方法请客合成等环节
公开(公告)号：EP3066106A1
公开(公告)日：2016-09-14
申请号：EP14790616.8
申请日：2014-10-29
申请人： Acies Bio d.o.o. , Rijksuniversiteit te Groningen , Academisch Ziekenhuis Groningen
发明人： JENKO, Branko , KOSEC, Gregor , PETKOVIC, Hrvoje , PODGORSEK BERKE, Ajda , PAHOR, Jerca , CUSAK, Alen , SIBON, Oda Cornelia Maria , SRINIVASAN, Balaji
IPC分类号： C07F9/09 , A61K31/661 , A61P25/28
CPC分类号： C07F9/091
摘要： The invention relates to (S)-acyl-4'-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment ofneurodegenerative diseases, such as PKAN.
摘要翻译：本发明涉及（S）酰基-4'-磷酸泛酰衍生物，它们的合成的方法，以及测试化合物相关的医疗用途。优选的医疗用途涉及治疗疾病ofneurodegenerative ,:如PKAN。

8. 发明公开

EP4352073A1 NOVEL SPINOSYN COMPOUNDS 审中-实审
公开(公告)号：EP4352073A1
公开(公告)日：2024-04-17
申请号：EP22733018.0
申请日：2022-06-08
申请人： Acies Bio d.o.o.
发明人： KRAJNC, Nika Lendero , KOSEC, Gregor , KRALJ, Petra , FUJS, Stefan , SVAGELJ, Mirjan , CAMP, Nicholas
IPC分类号： C07H17/08 , A01N43/22
CPC分类号： C07H17/08 , A01N43/22

9. 发明公开

EP4309500A1 PEROXIDASE BASED BIOCONTROL AGENTS 审中-实审
公开(公告)号：EP4309500A1
公开(公告)日：2024-01-24
申请号：EP22213605.3
申请日：2022-12-14
申请人： Acies Bio d.o.o.
发明人： KOSEC, Gregor , MAGDEVSKA, Vasilka , FUJS, Stefan , KLANCNIK, Bor , KOZLEVCAR, Monika , JALSOVEC, Helena
IPC分类号： A01N37/46 , A01N63/22 , A01N59/00 , A01N59/12 , A01P1/00 , A01P3/00
摘要： The present invention relates to means and methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for medical and non-medical use in preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. The present invention thus relates to novel medical and non-medical uses of a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or on the human or animal body. Furthermore, the present invention relates to corresponding methods comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants or on or in the human or animal body comprising applying a sufficient amount of the bacterial heme peroxidase and/or a functional fragment thereof on said food, plants, or on mucosae, skin, in particular epidermal skin like scalp or facial skin and/or teeth to reduce the number of cells of said pathogen. In addition, the invention relates to specific heme peroxidases that have been identified to have desired properties. The invention also relates to fragments of or small heme peroxidases that have particularly advantageous properties. Moreover, the present invention further relates to corresponding compositions comprising a bacterial heme peroxidase and/or a functional fragment thereof for preventing and/or controlling a pathogen on food, plants, or in or on the human or animal body. Kits comprising components used in the methods and compositions of the invention are also provided herein. Furthermore, provided is the use of a bacterial heme peroxidase and/or of a functional fragment thereof for the preparation of the compositions of the present invention. The present invention finally also relates to a method for producing a bacterial heme peroxidase protein and/or a functional fragment thereof in an engineered Bacillus subtilis strain. The inventive use of the bacterial heme peroxidase of the present invention and/or a functional fragment thereof for preventing and/or controlling a pathogen is, without being limiting, particularly useful in ecologically compatible commercial plant/crop protection campaigns as well as in daily personal care products such as toothpaste for example.

10. 发明授权

EP3140416B1 CO-CULTIVATION OF PROPIONIBACTERIUM AND YEAST 有权
公开(公告)号：EP3140416B1
公开(公告)日：2018-08-01
申请号：EP15723471.7
申请日：2015-05-08
申请人： Acies Bio d.o.o. , Arima d.o.o.
发明人： SVAGELJ, Mirjan , FUJS, Stefan , KOSEC, Gregor , PETKOVIC, Hrvoje
IPC分类号： C12P39/00 , C12R1/645 , C12R1/01
CPC分类号： C12P39/00 , C12N1/16 , C12P19/42 , C12R1/72
摘要： The invention provides a fungal cell, such as a yeast cell, capable of growing in co-cultivation with Propionibacterium. Also provided are methods of producing such cells and fermentation processes using the fungal cell of the invention and Propionibacterium in co-cultivation. Such co-cultivation significantly reduces the chemical oxygen demand load of the waste fermentation broth.

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