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1. 发明授权

EP1105812B1 SYSTEM AND METHOD FOR FACILITATING CLINICAL DECISION MAKING 有权
标题翻译：系统和方法，以促进临床决策
公开(公告)号：EP1105812B1
公开(公告)日：2003-01-08
申请号：EP99942007.8
申请日：1999-08-04
申请人： Aspect Medical Systems, Inc.
发明人： CHAMOUN, Nassib, G. , DEVLIN, Philip, H.
IPC分类号： G06F17/00 , A61B5/00
CPC分类号： A61B5/4821 , A61B5/0476 , A61B5/0488 , G06F19/00
摘要： Disclosed is a system and method for providing information to the user of a medical monitoring or diagnostic device to aid in the clinical decision making process. The preferred embodiment uses two estimators or predictors of the same physiological quantity, with each of the estimators being designed to detect specific states or artifacts in the estimated parameter and thus operating at a different point on its respective ROC curve; one chosen to provide high sensitivity, the other chosen to provide high specificity. The divergence between the estimators is indicated by the use of a shaded region between their respective time trends. The use of 2 estimators of the same parameters with different performance characteristics allows the system and method of the present invention to derive additional information about the underlying physiologic process over and above that which would be available from a single estimator. The system and method of the present invention can derive information from not only the instantaneous values of the estimators and the difference between them, but also from the time trend of the difference.

2. 发明公开

EP0863719A1 ELECTRODE CONNECTOR SYSTEM 失效
标题翻译：电连接器系统FOR LEAD
公开(公告)号：EP0863719A1
公开(公告)日：1998-09-16
申请号：EP96937692.0
申请日：1996-10-18
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： DEVLIN, Philip, H. , CHAMOUN, Nassib, G. , SHAMBROOM, John, R. , BRUCKNER, Mark, E. , MARCUS, Todd, A.
IPC分类号： A61B5 , A61B18 , H01R29
CPC分类号： A61B18/14 , A61B5/0416 , A61B5/04286 , A61B5/0478 , A61B2018/00178 , A61B2560/045 , A61B2562/08 , A61B2562/227 , H01R29/00
摘要： Disclosed is a physiological electrical signal connector system (20) with one connector (20a) connected to an electrode set (24) and another connector (20b) connected to a digital signal convertor (14) which leads to a patient monitor (10). Each type of electrode set has a specific code identified with it and when connected to the digital signal convertor (14), the connector code is recognized by the digital signal convertor. The connector code is then relayed to the monitor (10) which will self-configure based on the identified code.

3. 发明授权

EP0764001B1 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：系统和方法分析生物电势脑
公开(公告)号：EP0764001B1
公开(公告)日：2003-05-14
申请号：EP95922265.4
申请日：1995-06-08
申请人： Aspect Medical Systems, Inc.
发明人： CHAMOUN, Nassib, G. , SIGL, Jeffrey, C. , SMITH, Charles, P.
IPC分类号： A61B5/04 , G06F17/00
CPC分类号： A61B5/048 , A61B5/16 , A61B5/4821 , A61B5/725 , A61B5/7253 , A61B5/7257 , G06F19/00 , G16H15/00
摘要： Disclosed is a system and method to derive a diagnostic index indicative of a selected cerebral phenomena which obtains 19 unipolar EEG signals from regions of interest on both the left and right hemispheres of a subject's brain. The system uses high-gain, low-noise amplifiers to maximize the dynamic range for low energy wave components of the signals. Band-pass filtering is used to reduce noise and to avoid aliasing. The system applies commonly used digital signal processing (DSP) techniques to digitize, to low-pass filter (100 Hz), and to decimate the signals. Power spectral, bispectral, and higher-order spectral processing is then performed. In a preferred embodiment, the system divides the most recent 63 seconds of digitized EEG data from each lead into 60 4-second intervals, each with 3 seconds of overlap with the previous interval. For a selected set of derived leads, the system produces auto power spectrum, autobispectrum, and auto higher-order spectrum variables, by using either a Fast Fourier Transform (FFT) based approach or a parametric approach. Any pair of leads can be combined to compute cross power spectrum, cross bispectrum, and cross higher-order spectrum variables. The spectral values are separated into bins and a value representative of the bin is selected or computed and then each value is multiplied by a predetermined coefficient. The resulting products are summed to arrive at the diagnostic index.

4. 发明公开

EP1105812A1 SYSTEM AND METHOD FOR FACILITATING CLINICAL DECISION MAKING 有权
标题翻译：系统和方法，以促进临床决策
公开(公告)号：EP1105812A1
公开(公告)日：2001-06-13
申请号：EP99942007.8
申请日：1999-08-04
申请人： Aspect Medical Systems, Inc.
发明人： CHAMOUN, Nassib, G. , DEVLIN, Philip, H.
IPC分类号： G06F17/00 , A61B5/00
CPC分类号： A61B5/4821 , A61B5/0476 , A61B5/0488 , G06F19/00
摘要： Disclosed is a system and method for providing information to the user of a medical monitoring or diagnostic device to aid in the clinical decision making process. The preferred embodiment uses two estimators or predictors of the same physiological quantity, with each of the estimators being designed to detect specific states or artifacts in the estimated parameter and thus operating at a different point on its respective ROC curve; one chosen to provide high sensitivity, the other chosen to provide high specificity. The divergence between the estimators is indicated by the use of a shaded region between their respective time trends. The use of 2 estimators of the same parameters with different performance characteristics allows the system and method of the present invention to derive additional information about the underlying physiologic process over and above that which would be available from a single estimator. The system and method of the present invention can derive information from not only the instantaneous values of the estimators and the difference between them, but also from the time trend of the difference.

5. 发明公开

EP0468999A1 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译： FOR GEHIRNBIOPOTENTIAL分析系统和方法。
公开(公告)号：EP0468999A1
公开(公告)日：1992-02-05
申请号：EP90905998.0
申请日：1990-03-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G.
IPC分类号： A61B5 , G01R23 , G06F17 , G06K9
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/1106 , A61B5/16 , A61B5/6814 , A61B5/7257 , A61B2505/05 , G06F19/00 , G06K9/00523
摘要： Disclosed is a real time cerebral diagnostic apparatus and method for quantitatively evaluating, in a noninvasive manner, cerebral phenomena such as the depth and adequacy of anesthesia pain responses during surgical stress, acute cerebral ischemia, level of consciousness, degree of intoxication and ongoing normal and abnormal cognitive processes. A suitable electrode and amplifier system is used to obtain high resolution biopotentials from the regions of interest. Surface electroencephalographic (EEG) signals are filtered to allow the acquisition of frequencies between 2 and 500 Hz, then digitized and transmitted over a high speed serial line to a host computer where a 32 second long signal is divided into 128 consecutive 0.25 second intervals. Digital EEG data from unipolar leads is normalized and the dynamic phase and density relations within the signal are then characterized by estimating the third-order autocorrelation function or autobispectrum using either a frequency domain, or parametric approach. Paired EEG data from corresponding left and right hemisphere leads is used to characterize the dynamic phase and density relations between hemispheres by estimating the third order crosscorrelation function or crossbispectrum using either frequency domain or parametric techniques. Under certain specific filtering circumstances the power spectrum and crosspower spectrum are also computed. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's autobicoherence, autobispectral density, autobiphase, crossbicoherence, crossbispectral density, and crossbiphase arrays. The ensemble of values for the particular diagnostic determination is used to compute an index which serves as the diagnostic criterion by which the patient's state is judged. Any diagnostic index can be continuously displayed on a graphics terminal for real-time diagnostic monitoring or can be sent to a hard copy device to generate reports for the medical record.

6. 发明授权

EP1182965B1 A SMART ELECTROPHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION 有权
标题翻译：具有真实性和验证智能ELECTRO生理传感器系统
公开(公告)号：EP1182965B1
公开(公告)日：2008-04-02
申请号：EP00970431.3
申请日：2000-06-09
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CORDERO, Rafael, M. , DEVLIN, Philip, H. , CHAMOUN, Nassib, G. , SHAMBROOM, John, R. , MERRICK, Edwin, B. , MELO, Joao
IPC分类号： A61B5/0408 , A61B5/0428
CPC分类号： A61B5/04085 , A61B5/04286 , A61B2560/028 , A61B2562/08 , G06F19/00
摘要： A sensor system which includes a biopotential signal monitor, a smart sensor and the accompanying hardware and software interface which authenticates the source and validity of the smart sensor and also verifies that the smart sensor meets various criteria for use.

7. 发明授权

EP0489010B1 CARDIAC BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：心脏生物分析系统与方法
公开(公告)号：EP0489010B1
公开(公告)日：1998-11-18
申请号：EP90905061.9
申请日：1990-03-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G.
IPC分类号： G06F17/18
CPC分类号： A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/0464 , A61B5/413 , A61B5/7257 , A61B5/7275 , G06F19/00
摘要： Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.

8. 发明授权

EP0863719B1 ELECTRICAL ELECTRODE CONNECTOR SYSTEM 失效
标题翻译：电连接器系统FOR LEAD
公开(公告)号：EP0863719B1
公开(公告)日：2004-08-04
申请号：EP96937692.0
申请日：1996-10-18
申请人： Aspect Medical Systems, Inc.
发明人： DEVLIN, Philip, H. , CHAMOUN, Nassib, G. , SHAMBROOM, John, R. , BRUCKNER, Mark, E. , MARCUS, Todd, A.
IPC分类号： A61B5/0428 , A61B5/0416 , A61B5/0478 , H01R29/00
CPC分类号： A61B18/14 , A61B5/0416 , A61B5/04286 , A61B5/0478 , A61B2018/00178 , A61B2560/045 , A61B2562/08 , A61B2562/227 , H01R29/00
摘要： Disclosed is a physiological electrical signal connector system (20) with one connector (20a) connected to an electrode set (24) and another connector (20b) connected to a digital signal convertor (14) which leads to a patient monitor (10). Each type of electrode set has a specific code identified with it and when connected to the digital signal convertor (14), the connector code is recognized by the digital signal convertor. The connector code is then relayed to the monitor (10) which will self-configure based on the identified code.

9. 发明公开

EP1182965A2 A SMART ELECTROPHYSIOLOGICAL SENSOR SYSTEM WITH AUTOMATIC AUTHENTICATION AND VALIDATION 有权
标题翻译：具有真实性和验证智能ELECTRO生理传感器系统
公开(公告)号：EP1182965A2
公开(公告)日：2002-03-06
申请号：EP00970431.3
申请日：2000-06-09
申请人： Aspect Medical Systems, Inc.
发明人： CORDERO, Rafael, M. , DEVLIN, Philip, H. , CHAMOUN, Nassib, G. , SHAMBROOM, John, R. , MERRICK, Edwin, B. , MELO, Joao
IPC分类号： A61B5/0408 , A61B5/0428
CPC分类号： A61B5/04085 , A61B5/04286 , A61B2560/028 , A61B2562/08 , G06F19/00
摘要： A sensor system which includes a biopotential signal monitor, a smart sensor and the accompanying hardware and software interface which authenticates the source and validity of the smart sensor and also verifies that the smart sensor meets various criteria for use.

10. 发明授权

EP0610365B1 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译： DEVICE AND METHOD FOR脑生物潜力研究
公开(公告)号：EP0610365B1
公开(公告)日：1999-03-31
申请号：EP92922952.4
申请日：1992-10-23
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G. , MEAD, Peter, A. , CHIANG, Hsing-Hsing , SAINI, Vikas
IPC分类号： A61B5/04 , G06F17/00
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/16 , A61B5/725 , A61B5/7253 , A61B5/7257 , G06F19/00 , G16H15/00
摘要： A method of generating a diagnostic index for quantifying the presence or absence of a phenomena which is represented by spectral values generated from acquired electrical signals of the phenomena, comprises the steps of: sorting said spectral values into predetermined bins of ranges of spectral values; summing all of the spectral values in each bin; multiplying the sum of spectral values in each bin by a predetermined coefficient to obtain a bin product; summing said bin products to obtain a diagnostic index which represents a degree of presence or absence of said phenomena.

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