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1. 发明授权

EP1399060B1 SYSTEM AND METHOD FOR THE DETECTION AND REMOVAL OF RADIO FREQUENCY NOISE ARTIFACT FROM BIOPOTENTIAL SIGNALS 有权
标题翻译：装置和方法检测和生物电势信号射频噪声的消除。
公开(公告)号：EP1399060B1
公开(公告)日：2011-04-20
申请号：EP02746642.4
申请日：2002-06-21
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： SHAMBROOM, John, R. , SMITH, Charles, P. , CAI, Hongmei , MERRICK, Edwin
IPC分类号： A61B5/04
CPC分类号： A61B5/0476 , A61B5/04004 , A61B5/04282 , A61B5/0478
摘要： A system and method of identifying and removing artifact from radio frequency noise from biopotentials identifies epochs contaminated with radio frequency noise. Contaminated epochs are then replaced with recent uncontaminated epochs stored in a buffer, depending on the current level of artifact and the availability of suitable data. Discontinuities arising at the beginning of the replaced epochs are smoothed by means of a windowing function.

2. 发明公开

EP1850742A1 SYSTEM AND METHOD OF PREDICTION OF RESPONSE TO NEUROLOGICAL TREATMENT USING THE ELECTROENCEPHALOGRAM 审中-公开
标题翻译：系统和方法预测对治疗的反应与神经系统脑电图
公开(公告)号：EP1850742A1
公开(公告)日：2007-11-07
申请号：EP06735429.0
申请日：2006-02-17
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： DEVLIN, Philip, R. , GREENWALD, Scott, D.
IPC分类号： A61B5/0476 , A61N1/36
CPC分类号： A61B5/0476 , A61B5/048 , A61N1/0534 , A61N1/0551 , A61N1/36025 , A61N1/36082
摘要： Disclosed is a system and method of assessing the efficacy of and predicting response to treatment of neurological or psychological disorders. The preferred embodiment uses at least two surface electrodes to acquire EEG signals from the surface of a patient’s body, a processor for computing from the EEG signals various features and indices that are representative of the patient’s neurological or psychological state. Pretreatment indices represent a patient’s neurological or psychological state and therefore may be used to predict the response to treatment. Changes in these parameters may be used to assess the efficacy of treatment and to modify the treatment to optimize the resultant patient state.

3. 发明公开

EP1411830A1 SYSTEM AND METHOD FOR MEASURING BIOELECTRIC IMPEDANCE IN THE PRESENCE OF INTERFERENCE 有权
标题翻译：系统和方法测量BIOELEKTRISCHEM抵抗的干扰的情况下
公开(公告)号：EP1411830A1
公开(公告)日：2004-04-28
申请号：EP02763228.0
申请日：2002-07-03
申请人： Aspect Medical Systems, Inc.
发明人： SHAMBROOM, John, R. , SMITH, Charles, P.
IPC分类号： A61B5/05 , A61B5/0476
CPC分类号： A61B5/0531 , A61B5/0424 , A61B5/0476 , A61B5/7257
摘要： A method for measuring bioelectric impedance in real time, in the presence of interference and noise is disclosed. A small electric current is injected into a biopotential electrode system, and then the measurement is tested for contamination by electrical interference or other noise sources.

4. 发明公开

EP1350462A1 Electrode array system for measuring electrophysical signals 失效
标题翻译： Elektrodenanordnung zur Messung elektrophysiologischer Signale
公开(公告)号：EP1350462A1
公开(公告)日：2003-10-08
申请号：EP03010436.8
申请日：1997-10-10
申请人： Aspect Medical Systems, Inc.
发明人： Devlin, Philip H. , Shambroom, John R. , Cordero, Rafael M. , Fendrock, Charles , Chamoun, Nassib B. , McDaniel, Terrie L.
IPC分类号： A61B5/0408 , A61B5/0428
CPC分类号： A61B5/04004 , A61B5/04085 , A61B5/0478 , A61B2560/045 , A61B2562/227
摘要： An array of electrodes is constructed to allow the user to easily adjust to the correct size of the patient's head. The array is self-adhesive, pre-gelled and disposable. The array fits easily over the temple and forehead areas where EEG signals can be acquired by specially designed monitors for purposes of monitoring a number of bodily phenomena, including but not limited to, depth of anesthesia, and/or ischemia, and burst suppression. The array is connected to the monitor via a tab connector that is integral to the disposable device. The tab connector is insertible into a reusable connector that is part of a monitoring system.
摘要翻译：电极阵列被构造成允许用户容易地适应患者头部的正确尺寸。该阵列是自粘的，预胶凝的和一次性的。该阵列容易地适合于通过专门设计的监视器可以获得EEG信号的寺庙和前额区域，用于监视许多身体现象，包括但不限于麻醉深度和/或局部缺血和突发抑制。阵列通过与一次性设备成一体的接头连接器连接到监视器。标签连接器可插入到可重复使用的连接器中，该连接器是监控系统的一部分。

5. 发明授权

EP0764001B1 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：系统和方法分析生物电势脑
公开(公告)号：EP0764001B1
公开(公告)日：2003-05-14
申请号：EP95922265.4
申请日：1995-06-08
申请人： Aspect Medical Systems, Inc.
发明人： CHAMOUN, Nassib, G. , SIGL, Jeffrey, C. , SMITH, Charles, P.
IPC分类号： A61B5/04 , G06F17/00
CPC分类号： A61B5/048 , A61B5/16 , A61B5/4821 , A61B5/725 , A61B5/7253 , A61B5/7257 , G06F19/00 , G16H15/00
摘要： Disclosed is a system and method to derive a diagnostic index indicative of a selected cerebral phenomena which obtains 19 unipolar EEG signals from regions of interest on both the left and right hemispheres of a subject's brain. The system uses high-gain, low-noise amplifiers to maximize the dynamic range for low energy wave components of the signals. Band-pass filtering is used to reduce noise and to avoid aliasing. The system applies commonly used digital signal processing (DSP) techniques to digitize, to low-pass filter (100 Hz), and to decimate the signals. Power spectral, bispectral, and higher-order spectral processing is then performed. In a preferred embodiment, the system divides the most recent 63 seconds of digitized EEG data from each lead into 60 4-second intervals, each with 3 seconds of overlap with the previous interval. For a selected set of derived leads, the system produces auto power spectrum, autobispectrum, and auto higher-order spectrum variables, by using either a Fast Fourier Transform (FFT) based approach or a parametric approach. Any pair of leads can be combined to compute cross power spectrum, cross bispectrum, and cross higher-order spectrum variables. The spectral values are separated into bins and a value representative of the bin is selected or computed and then each value is multiplied by a predetermined coefficient. The resulting products are summed to arrive at the diagnostic index.

6. 发明公开

EP1105812A1 SYSTEM AND METHOD FOR FACILITATING CLINICAL DECISION MAKING 有权
标题翻译：系统和方法，以促进临床决策
公开(公告)号：EP1105812A1
公开(公告)日：2001-06-13
申请号：EP99942007.8
申请日：1999-08-04
申请人： Aspect Medical Systems, Inc.
发明人： CHAMOUN, Nassib, G. , DEVLIN, Philip, H.
IPC分类号： G06F17/00 , A61B5/00
CPC分类号： A61B5/4821 , A61B5/0476 , A61B5/0488 , G06F19/00
摘要： Disclosed is a system and method for providing information to the user of a medical monitoring or diagnostic device to aid in the clinical decision making process. The preferred embodiment uses two estimators or predictors of the same physiological quantity, with each of the estimators being designed to detect specific states or artifacts in the estimated parameter and thus operating at a different point on its respective ROC curve; one chosen to provide high sensitivity, the other chosen to provide high specificity. The divergence between the estimators is indicated by the use of a shaded region between their respective time trends. The use of 2 estimators of the same parameters with different performance characteristics allows the system and method of the present invention to derive additional information about the underlying physiologic process over and above that which would be available from a single estimator. The system and method of the present invention can derive information from not only the instantaneous values of the estimators and the difference between them, but also from the time trend of the difference.

7. 发明公开

EP0665728A1 MONITOR AND METHOD FOR ACQUIRING AND PROCESSING ELECTRICAL SIGNALS RELATING TO BODILY FUNCTIONS 失效
标题翻译：监测设备和方法收集和处理生物电信号。
公开(公告)号：EP0665728A1
公开(公告)日：1995-08-09
申请号：EP93923860.0
申请日：1993-10-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： SHAMBROOM, John, R.
IPC分类号： A61B5 , G06F17 , G06F19
CPC分类号： A61B5/6843 , A61B5/0006 , A61B5/0476 , A61B5/7217 , G06F19/00 , G16H40/63 , Y10S128/901 , Y10S128/902
摘要： An EEG monitor utilizes a portable acquisition module (14) and a substantially stationary processing module (12). The EEG signals are acquired and converted to an oversampled stream of digital signals by a sigma-delta modulator (64) located in the data acquisition module. The signals are then filtered by a decimation filter (62) located in the processing module. Additional means are also provided to monitor the electrode leads to detect when the leads become unplugged. The monitor provides all power to the data acquisition module over a single twisted line (82) which transmits data as well.

8. 发明公开

EP0468999A1 CEREBRAL BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译： FOR GEHIRNBIOPOTENTIAL分析系统和方法。
公开(公告)号：EP0468999A1
公开(公告)日：1992-02-05
申请号：EP90905998.0
申请日：1990-03-13
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： CHAMOUN, Nassib, G.
IPC分类号： A61B5 , G01R23 , G06F17 , G06K9
CPC分类号： A61B5/4821 , A61B5/048 , A61B5/1106 , A61B5/16 , A61B5/6814 , A61B5/7257 , A61B2505/05 , G06F19/00 , G06K9/00523
摘要： Disclosed is a real time cerebral diagnostic apparatus and method for quantitatively evaluating, in a noninvasive manner, cerebral phenomena such as the depth and adequacy of anesthesia pain responses during surgical stress, acute cerebral ischemia, level of consciousness, degree of intoxication and ongoing normal and abnormal cognitive processes. A suitable electrode and amplifier system is used to obtain high resolution biopotentials from the regions of interest. Surface electroencephalographic (EEG) signals are filtered to allow the acquisition of frequencies between 2 and 500 Hz, then digitized and transmitted over a high speed serial line to a host computer where a 32 second long signal is divided into 128 consecutive 0.25 second intervals. Digital EEG data from unipolar leads is normalized and the dynamic phase and density relations within the signal are then characterized by estimating the third-order autocorrelation function or autobispectrum using either a frequency domain, or parametric approach. Paired EEG data from corresponding left and right hemisphere leads is used to characterize the dynamic phase and density relations between hemispheres by estimating the third order crosscorrelation function or crossbispectrum using either frequency domain or parametric techniques. Under certain specific filtering circumstances the power spectrum and crosspower spectrum are also computed. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's autobicoherence, autobispectral density, autobiphase, crossbicoherence, crossbispectral density, and crossbiphase arrays. The ensemble of values for the particular diagnostic determination is used to compute an index which serves as the diagnostic criterion by which the patient's state is judged. Any diagnostic index can be continuously displayed on a graphics terminal for real-time diagnostic monitoring or can be sent to a hard copy device to generate reports for the medical record.

9. 发明公开

EP2007279A4 SYSTEM AND METHOD OF ASSESSING ANALGESIC ADEQUACY USING BIOPOTENTAL VARIABILITY 有权
标题翻译：用于评估充足性镇痛系统和方法的部件BIOPOTENZIALSCHWANKUNGEN
公开(公告)号：EP2007279A4
公开(公告)日：2011-10-19
申请号：EP07759890
申请日：2007-03-30
申请人： ASPECT MEDICAL SYSTEMS INC
发明人： GREENWALD SCOTT D
IPC分类号： A61B5/048 , A61B5/0488
CPC分类号： A61B5/04012 , A61B5/048 , A61B5/0488 , A61B5/4821

10. 发明授权

EP1278564B1 System for adaptive drug delivery 有权
标题翻译：一种用于施用药物自适应系统
公开(公告)号：EP1278564B1
公开(公告)日：2006-07-26
申请号：EP01932895.4
申请日：2001-05-03
申请人： ASPECT MEDICAL SYSTEMS, INC.
发明人： STRUYS, Michel , DE SMET, Tom , VERSICHELEN, Linda
IPC分类号： A61M5/172 , A61M15/00 , A61M16/01 , A61B5/11
CPC分类号： A61M5/172 , G06F19/00
摘要： A system and method for controlling the administration of medication to a patient utilizes adaptive feedback to achieve and maintain a target effect in said patient. A sensor package having one or more sensors is used to sense an attribute of the patient and to provide a parameter indicating the attribute being sensed. A medication delivery controller accepts one or more parameters from the sensor package and uses these parameters to determine the effect of a medication on a patient and the concentration level of medication that will achieve a desired effect. The medication delivery controller controls the medication delivery unit to deliver the medication at a rate determined to achieve said target concentration level of said medication in said patient. If the patient's response to a given medication changes as a result of external stimuli, the medication delivery controller can detect this change and determine a new concentration level of medication which will achieve the desired effect. The medication delivery controller can steer the medication delivery unit to administer an amount of medication to reach this new concentration level.

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