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1. 发明公开

EP1210923A3 Control system for corneal laser surgery 有权
标题翻译：用于角膜激光手术控制系统
公开(公告)号：EP1210923A3
公开(公告)日：2003-08-27
申请号：EP01308220.1
申请日：2001-09-27
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/01 , A61F9/08 , A61B3/107
CPC分类号： A61B3/1015 , A61B2017/00017 , A61F9/00806 , A61F2009/00844 , A61F2009/00848 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088
摘要： The present invention provides a closed-loop control system for superficial photoablation of tissue from an exposed stromal surface of an eye wherein the exposed surface introduces mechanically induced optical aberrations, said system comprising a source for generating an incising laser beam for photoablation of tissue from the exposed surface, a source for generating a diagnostic laser beam, a deformable mirror for directing said diagnostic laser beam through the exposed stromal surface to a focal spot on the retina of the eye, a detector for using light from said diagnostic beam reflected from the retina through the exposed stromal surface to generate an induced wavefront having characteristics of the mechanically induced optical aberrations, together with a distorted wavefront having actual real-time characteristics of the cornea, a compensator for altering a predetermined desired wavefront by incorporating said induced wavefront therewith to create a rectified wavefront, a comparator for comparing said rectified wavefront with said distorted wavefront to create an error signal, a means for reconfiguring said deformable mirror in accordance with said error signal to maintain a focal spot on the retina, and a means for ceasing generation of said incising laser beam when said error signal is a null. The present invention also provides a method for preparing a system for photoablation of a mechanically exposed stromal surface of an eye comprising providing the system with a distorted wavefront that has been determined by previous diagnosis of the eye and a desired wavefront.

2. 发明公开

EP1210923A2 Control system for corneal laser surgery 有权
标题翻译： Hornhaut-Laser-Chirurgie的Steuerungssystemfürdie
公开(公告)号：EP1210923A2
公开(公告)日：2002-06-05
申请号：EP01308220.1
申请日：2001-09-27
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/01
CPC分类号： A61B3/1015 , A61B2017/00017 , A61F9/00806 , A61F2009/00844 , A61F2009/00848 , A61F2009/00855 , A61F2009/00872 , A61F2009/0088
摘要： The present invention provides a closed-loop control system for superficial photoablation of tissue from an exposed stromal surface of an eye wherein the exposed surface introduces mechanically induced optical aberrations, said system comprising a source for generating an incising laser beam for photoablation of tissue from the exposed surface, a source for generating a diagnostic laser beam, a deformable mirror for directing said diagnostic laser beam through the exposed stromal surface to a focal spot on the retina of the eye, a detector for using light from said diagnostic beam reflected from the retina through the exposed stromal surface to generate an induced wavefront having characteristics of the mechanically induced optical aberrations, together with a distorted wavefront having actual real-time characteristics of the cornea, a compensator for altering a predetermined desired wavefront by incorporating said induced wavefront therewith to create a rectified wavefront, a comparator for comparing said rectified wavefront with said distorted wavefront to create an error signal, a means for reconfiguring said deformable mirror in accordance with said error signal to maintain a focal spot on the retina, and a means for ceasing generation of said incising laser beam when said error signal is a null.
The present invention also provides a method for preparing a system for photoablation of a mechanically exposed stromal surface of an eye comprising providing the system with a distorted wavefront that has been determined by previous diagnosis of the eye and a desired wavefront.
摘要翻译：本发明提供了一种闭环控制系统，用于从眼睛的暴露的基质表面的组织表面光消融，其中暴露表面引入机械感应的光学像差，所述系统包括用于产生切割激光束的源，用于从暴露表面，用于产生诊断激光束的源，用于将所述诊断激光束通过暴露的基质表面引导到眼睛的视网膜上的焦斑的可变形反射镜，用于使用来自视网膜反射的所述诊断光的光的检测器通过暴露的基质表面产生具有机械感应的光学像差的特征的感应波阵面，以及具有角膜的实际实时特性的失真波阵面，用于通过将所述感应波前并入而改变预定的所需波前的补偿器，以产生一个纠正的波前，一个比较或用于将所述经整流的波前与所述畸变波阵面进行比较以产生误差信号;根据所述误差信号重新配置所述可变形反射镜以在视网膜上保持焦点的装置，以及用于停止产生所述切割激光束的装置，所述错误信号为空。本发明还提供了一种用于制备眼睛的机械暴露的基质表面的光消融的系统的方法，包括向所述系统提供由先前的眼睛诊断和期望的波前确定的失真的波前。

3. 发明公开

EP1059061A3 Method and apparatus for measurement of the refractive properties of the human eye 有权
$Method and apparatus for measurement of the refractive properties of the human eye$
标题翻译： Verfahren und Vorrichtung zur Messung von Refraktionseigenschaften des menschlichen Auges
公开(公告)号：EP1059061A3
公开(公告)日：2002-06-05
申请号：EP00301118.6
申请日：2000-02-14
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef , Loesel, Frieder
IPC分类号： A61B3/103 , A61B3/107 , A61B3/10
CPC分类号： A61B3/103
摘要： A system, and its method, for measuring the optical properties of an eye employs optical components for detecting both the reflection of a first light beam from the anterior surface of the eye, and the reflection of a second light beam from the retina of the eye. Sensors are included to receive and separate each of these reflected light beams into a plurality of individual beams, each having its own specific optical path length. The optical path lengths of individual beams reflected from the cornea are collectively used to create a topographical map of the cornea's anterior surface and the optical path lengths of individual beams reflected from the retina are collectively used to create an acuity map of the entire eye. Further, there are additional optical components which respectively determine the position of the eye, a length for the eye and an aberration for the relaxed lens of the eye. A computer is then used to compare the topographical map with the acuity map, while compensating for the lens aberration, to construct a topography for the posterior surface of the cornea.
摘要翻译：用于测量眼睛的光学性质的系统及其方法使用光学部件来检测来自眼睛的前表面的第一光束的反射和来自眼睛的视网膜的第二光束的反射。包括传感器以将这些反射光束中的每一个接收并分离成多个单独的光束，每个光束具有其自己的特定光程长度。从角膜反射的单个光束的光路长度被统一用于创建角膜前表面的形貌图，并且从视网膜反射的各个光束的光路长度被统一用于创建整个眼睛的视力图。此外，还有另外的光学部件分别确定眼睛的位置，眼睛的长度和眼睛松弛的眼镜的像差。然后使用计算机来比较地形图与视力映射，同时补偿透镜像差，以构造角膜后表面的形貌。

4. 发明公开

EP1473006A1 Apparatus for intrastromal refractive surgery 审中-公开
$Apparatus for intrastromal refractive surgery$
标题翻译： Einrichtung zur intrastromalen，refraktiven Chirurgie
公开(公告)号：EP1473006A1
公开(公告)日：2004-11-03
申请号：EP04075241.2
申请日：2004-01-28
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/01
CPC分类号： A61F9/008 , A61F9/00829 , A61F9/00836 , A61F9/013 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： A method and apparatus for intrastromal refractive surgery is disclosed wherein tissue at selected locations within the stroma of the cornea is photoablated using a pulsed laser beam. The apparatus includes an optical system for forming a shaped laser beam having a waist at a predetermined distance from the optical system. The pulse duration and pulse energy of the laser beam are selected to cause ablation to occur in front of the waist (i.e. between the waist and the optical system). To achieve this, a pulse energy is used that exceeds the minimum pulse energy required for ablation at the waist. By ablating in front of the waist, a relatively large ablation zone (per pulse) is created (compared to ablation at the waist). Furthermore, while the laser is scanned through the cornea to effectuate a refractive change, the optical system maintains a uniform waist for the laser beam.
摘要翻译：公开了一种用于脉管内屈光手术的方法和装置，其中使用脉冲激光束将角膜基质内选定位置的组织照相。该装置包括用于形成具有与光学系统预定距离的腰围的成形激光束的光学系统。选择激光束的脉冲持续时间和脉冲能量，使得在腰部（即在腰部和光学系统之间）发生消融。为了实现这一点，使用超过腰部消融所需的最小脉冲能量的脉冲能量。通过在腰部前面消融，产生相对较大的消融区（每脉冲）（与腰部消融相比）。此外，当激光被扫描穿过角膜以实现折射变化时，光学系统为激光束保持均匀的腰部。

5. 发明公开

EP1199026A3 Aberration-free delivery system 有权
标题翻译：无像差输送系统
公开(公告)号：EP1199026A3
公开(公告)日：2003-07-02
申请号：EP01304460.7
申请日：2001-05-21
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef , Loesel, Frieder
IPC分类号： A61B3/10 , G02B26/06
CPC分类号： A61B3/10
摘要： A device and method for establishing an aberration-free delivery system for use in evaluating an optical specimen includes a light source for directing light through the system and along a beam path toward the specimen. A first beam splitter is positioned on the beam path to direct light radiated from the system toward a detector for creation of a first wavefront, and for generation of a signal. In turn, the signal is used to program an active mirror that is also positioned on the beam path, to thereafter establish an aberration-free wavefront for light incident on the optical specimen. Further, a second beam splitter is positioned on the beam path for directing light reflected from the specimen toward the detector for the creation of a second wavefront having characteristics of optical aberrations in the specimen. The second wavefront is then used to further program the active mirror for analysis and evaluation of the optical specimen.

6. 发明公开

EP1252872A1 Apparatus for creating a corneal reference mark 有权
标题翻译： Vorrichtung zur Erstellung einer Bezugsmarke auf der Hornhaut
公开(公告)号：EP1252872A1
公开(公告)日：2002-10-30
申请号：EP02075523.7
申请日：2002-02-07
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef , Loesel, Frieder
IPC分类号： A61F9/01
CPC分类号： A61B3/113 , A61B2090/3937 , A61B2090/3983 , A61F9/00825 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872
摘要： Apparatus for increasing the accuracy of an ocular laser procedure by detecting and compensating for small eye movements includes means for establishing a corneal reference plane. To create the corneal reference plane, a laser beam is first used to photoablate stromal tissue at three different locations in cornea. Bubbles that are created upon photoablation define the plane and can be imaged to determine the position of the plane as the eye moves. A pair of cameras and a processor are provided to image the cornea and triangulate the position of the reference plane. The updated position of the corneal reference plane is then used to guide the path of the laser beam during the course of the ocular procedure.
摘要翻译：用于通过检测和补偿小眼睛运动来增加眼睛激光程序的精度的装置包括用于建立角膜参考平面的装置。为了创建角膜参考平面，首先使用激光束在角膜的三个不同位置照射基质组织。通过光消融产生的气泡限定了平面，并且可以被成像以确定当眼睛移动时平面的位置。提供一对相机和处理器以对角膜成像并对参考平面的位置进行三角测量。然后角膜参考平面的更新位置用于在眼睛过程的过程中引导激光束的路径。

7. 发明公开

EP1232734A1 Apparatus and device for separating lamellae 有权
标题翻译： Apparat undGerätzur Separation von Lamellen
公开(公告)号：EP1232734A1
公开(公告)日：2002-08-21
申请号：EP01204167.9
申请日：2001-10-29
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/013
CPC分类号： A61F9/00836 , A61B2018/00642 , A61F9/008 , A61F9/00827 , A61F9/013 , A61F2009/00848 , A61F2009/00872 , A61F2009/00897
摘要： An apparatus (10) for separating lamellae (50, 50a, 50b, 50c) in the stroma (34) of an eye (26) includes means (12, 14, 16, 20) for finding a focal depth at an interface layer between lamellae (50, 50a, 50b, 50c) in the stroma (34).
Means are provided (12, 18, 20) for sequentially focusing a laser beam (22) to a plurality of focal points (73) in the stroma (34) to photodisrupt stromal tissue, separate the lamellae (50, 50a, 50b, 50c) and create a photodisruptive response thereto. The photodisruptive response is indicative of a diameter of a gas bubble (60, 62) created in the stroma (34) during photodisruption of the stromal tissue.
The apparatus includes further means (14) for alternating from a first energy level to a second energy level when the photodisruptive response is less than a reference value, and from the second energy level to said first energy level when the photodisruptive response is greater than the reference value. Maintenance of a proper focal depth can be periodically verified by maintaining a birefringent reference using an ellipsometer (14). Once the lamellae (50, 50a, 50b, 50c) are separated, a flap of corneal tissue is be created that can be lifted to expose underlying stromal tissue for further surgical photodisruption.
摘要翻译：一种用于分离眼睛（26）的基质（34）中的薄片（50,50a，50b，50c）的装置（10）包括用于找到在眼睛（26）之间的界面层处的焦点深度的装置（12,14,16,20）在基质（34）中的薄片（50,50a，50b，50c）。提供了用于将激光束（22）顺序地聚焦到基质（34）中的多个焦点（73）上以对光子破坏基质组织（12,18,20）的装置，将薄片（50,50a，50b，50c ）并对其产生光破坏性响应。光致破坏性反应指示在基质组织的光破坏期间在基质（34）中产生的气泡（60,62）的直径。该装置包括另外的装置（14），用于当光致破坏性响应小于参考值时从第一能级交替到第二能量级，并且当光致破坏性响应大于参考值时，从第二能级到第一能级参考值。可以通过使用椭偏仪（14）维持双折射基准来周期性地验证适当焦深的维持。一旦薄片（50,50a，50b，50c）被分离，就可以产生角膜组织瓣，其可被提升以暴露下面的基质组织以进一步手术中断。

8. 发明公开

EP1199026A2 Aberration-free delivery system 有权
标题翻译： Aberrationsfreies Auslieferungssystem
公开(公告)号：EP1199026A2
公开(公告)日：2002-04-24
申请号：EP01304460.7
申请日：2001-05-21
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef , Loesel, Frieder
IPC分类号： A61B3/10
CPC分类号： A61B3/10
摘要： A device and method for establishing an aberration-free delivery system for use in evaluating an optical specimen includes a light source for directing light through the system and along a beam path toward the specimen. A first beam splitter is positioned on the beam path to direct light radiated from the system toward a detector for creation of a first wavefront, and for generation of a signal. In turn, the signal is used to program an active mirror that is also positioned on the beam path, to thereafter establish an aberration-free wavefront for light incident on the optical specimen. Further, a second beam splitter is positioned on the beam path for directing light reflected from the specimen toward the detector for the creation of a second wavefront having characteristics of optical aberrations in the specimen. The second wavefront is then used to further program the active mirror for analysis and evaluation of the optical specimen.
摘要翻译：用于建立用于评估光学试样的无像差的传送系统的装置和方法包括用于引导光通过系统并沿着朝向样本的光束路径的光源。第一分束器被定位在光束路径上以将从系统辐射的光引向检测器以产生第一波前，并产生信号。反过来，该信号用于对同时位于光束路径上的有源反射镜进行编程，然后为入射在光学标本上的光线建立无像差波前。此外，第二分束器位于光束路径上，用于将从样本反射的光引导到检测器，以产生具有样品中的光学像差特征的第二波前。然后，第二波前用于进一步编程主动镜，用于光学样本的分析和评估。

9. 发明公开

EP1302186A3 A device for performing refractive surgery 审中-公开
$A device for performing refractive surgery$
标题翻译：一种用于执行屈光手术
公开(公告)号：EP1302186A3
公开(公告)日：2005-02-02
申请号：EP02078480.7
申请日：2002-08-22
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/008 , A61F9/013
CPC分类号： A61F9/013 , A61F9/00829 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： A device for altering the refractive properties of the cornea (24) by photodisrupting stromal lamellae involves focusing a laser beam (22) within the stroma. To effectuate tissue alteration with minimal laser energies, the focal point of the laser beam (22) is maintained inside the stromal lamella, rather than on an interface between layers of lamellae. To maintain the focal point inside the lamella, the bubbles that result from the photodisruption are measured using a wavefront detector (16). When a large bubble is observed, indicating photodisruption on an interface between layers of lamellae, the depth of the focal point, measured from the anterior surface, is adjusted to thereby resume photodisruption inside a lamella. A wavefront detector (16) can be used to track the progress of the photodisruption procedure, providing information that can be used to update the amounts and locations of stromal tissue that must be removed to obtain the desired refractive correction.

10. 发明授权

EP1232734B1 Apparatus and device for separating lamellae 有权
标题翻译：装置和设备，用于散热片的分离
公开(公告)号：EP1232734B1
公开(公告)日：2005-02-02
申请号：EP01204167.9
申请日：2001-10-29
申请人： 20/10 Perfect Vision Optische Geraete GmbH
发明人： Bille, Josef
IPC分类号： A61F9/013
CPC分类号： A61F9/00836 , A61B2018/00642 , A61F9/008 , A61F9/00827 , A61F9/013 , A61F2009/00848 , A61F2009/00872 , A61F2009/00897

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