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1. 发明公开

EP4126972A1 MASKED IL12 FUSION PROTEINS AND METHODS OF USE THEREOF 审中-实审转让
公开(公告)号：EP4126972A1
公开(公告)日：2023-02-08
申请号：EP21776799.5
申请日：2021-03-23
申请人： Zymeworks Inc.
发明人： VOLKERS, Gesa , SPRETER VON KREUDENSTEIN, Thomas , AFACAN, Nicole , DESJARDINS, Genevieve , DOUDA, David , BLACKLER, Ryan
IPC分类号： C07K19/00 , A61K47/68 , A61P35/00 , C07K14/54 , C07K16/00 , C07K7/06 , C12N15/62 , C12P21/02

3. 发明授权

EP2994164B1 BISPECIFIC HER2 AND HER3 ANTIGEN BINDING CONSTRUCTS 有权转让
公开(公告)号：EP2994164B1
公开(公告)日：2020-08-05
申请号：EP14794897.0
申请日：2014-05-08
申请人： Zymeworks Inc.
发明人： NG, Gordon, Yiu Kon , CHAN, Peter, Wing Yiu , WICKMAN, Grant, Raymond
IPC分类号： A61K39/395 , A61K45/06 , C07K16/32

4. 发明公开

EP3601368A1 TUMOR ANTIGEN PRESENTATION INDUCER CONSTRUCTS AND USES THEREOF 审中-公开
公开(公告)号：EP3601368A1
公开(公告)日：2020-02-05
申请号：EP18777747.9
申请日：2018-03-29
申请人： Zymeworks Inc.
发明人： MILLS, David M. , ESCOBAR-CABRERA, Eric
IPC分类号： C07K19/00 , A61K39/00 , A61P35/00 , A61P37/04 , C07K14/705 , C12N15/62 , C12N5/0783 , C12N5/10 , C12P21/02 , C12Q1/02 , C40B30/04 , C40B30/06 , G01N33/48 , G01N33/50

5. 发明授权

EP2828779B1 SYSTEMS AND METHODS FOR MAKING TWO DIMENSIONAL GRAPHS OF MACROMOLECULES 有权
公开(公告)号：EP2828779B1
公开(公告)日：2019-05-08
申请号：EP13763804.5
申请日：2013-03-12
申请人： Zymeworks Inc.
发明人： OHRN, Anders , MACDONALD, Scott Paul
IPC分类号： G06F19/00 , G06F19/26

6. 发明授权

EP2619700B1 SYSTEM FOR MOLECULAR PACKING CALCULATIONS 有权转让
公开(公告)号：EP2619700B1
公开(公告)日：2019-05-08
申请号：EP11826255.9
申请日：2011-09-22
申请人： Zymeworks, Inc.
发明人： OHRN, Anders
IPC分类号： G06F19/12 , G06F19/10 , G01N33/68
CPC分类号： G16B5/00 , G01N33/531 , G01N33/68 , G01N2500/00 , G16B15/00
摘要： The invention provides a computer implemented method of quantifying the quality of packing for a residue comprising one or more residue atoms in a first protein in a first conformation, the method comprising: (a) calculating one or more close contact potentials based on a distance between the one or more residue atoms and one or more environment atoms, (b) calculating a contact area of the one or more residue atoms that is exposed to the one or more environment atoms and (c) calculating a close contact surface density (CCSD) by dividing the sum of the one or more close contact potentials by the contact area.

7. 发明公开

EP3443014A1 MULTI-SPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING IMMUNOTHERAPEUTICS 审中-公开
公开(公告)号：EP3443014A1
公开(公告)日：2019-02-20
申请号：EP17781690.7
申请日：2017-04-13
申请人： Zymeworks Inc.
发明人： MILLS, David M.
IPC分类号： C07K16/46 , A61K35/17 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , C12N15/13 , C12N5/0783 , C12N5/10

8. 发明公开

EP3208281A1 ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION 审中-公开
标题翻译：具有增强或抑制效应功能的抗体
公开(公告)号：EP3208281A1
公开(公告)日：2017-08-23
申请号：EP17163630.1
申请日：2011-03-28
申请人： Zymeworks, Inc.
发明人： D'ANGELO, Igor , BLEILE, Dustin , TOM-YEW, Stacey A. L. , ESCOBAR-CABRERA, Eric , LARIO, Paola, I. , OHRN, Anders , POON, David K. Y. , DIXIT, Surjit, B.
IPC分类号： C07K16/00 , A61K39/395 , A61P35/00 , A61P37/00 , C07K19/00 , C12N15/13 , G06F19/10 , C07K14/735 , C07K16/28 , C07K16/46 , G06F19/16 , C07K16/08 , C07K16/32
CPC分类号： C07K16/32 , C07K14/70535 , C07K16/00 , C07K16/082 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2851 , C07K16/2887 , C07K16/464 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G06F19/16
摘要： Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
摘要翻译：提供了包含多个Fc区氨基酸取代的合理设计的抗体和多肽，其协同地提供对靶Fc受体的增强的选择性和结合亲和力。当将多肽掺入抗体治疗剂中时，这些多肽在多个位置发生突变，使它们比具有野生型Fc组分的抗体治疗剂更有效。

9. 发明公开

EP2973132A4 SYSTEMS AND METHODS FOR IDENTIFYING THERMODYNAMIC EFFECTS OF ATOMIC CHANGES TO POLYMERS 有权
标题翻译：系统和用于鉴定的原子更改THERMO动态效应在聚合物中
公开(公告)号：EP2973132A4
公开(公告)日：2017-01-25
申请号：EP14762610
申请日：2014-03-13
申请人： ZYMEWORKS INC
发明人： LAKATOS GREGORY , MCWHIRTER JAMES LIAM
IPC分类号： G06F19/10 , C07K1/00 , C12P21/00
CPC分类号： G06F17/5009 , G06F17/10 , G06F19/16
摘要： Systems and methods for evaluating thermodynamics of atomic changes in a polymer include using a first portion of a refined derived set of three-dimensional coordinates for a derivation of the polymer, which incorporates the atomic change under study, to compute a first effective atomistic Hessian. A second effective atomistic Hessian is computed using a second portion of a refined native set of three-dimensional coordinates for the native polymer. Atoms in the first and second portions are identical. A thermodynamic property of the first portion is determined using the refined derived set of three-dimensional coordinates and the first effective atomistic Hessian. A thermodynamic property of the second portion of the native polymer is determined using the refined native set of three-dimensional coordinates and the second effective atomistic Hessian. The effect of the atomic changes is quantified by taking the difference between the calculated thermodynamic properties of the first and second portions.
摘要翻译：系统和用于评价的在聚合物原子更改热力学方法包括使用一个精制衍生集的三维坐标中的第一部分，用于聚合物，结合有原子变更替补的推导，来计算的第一有效原子论Hessian矩阵。第二有效原子论的Hessian使用精制天然组用于天然聚合物的三维坐标中的第二部分来计算。在第一和第二部分的原子是相同的。所述第一部分的热力学性质是使用三维坐标的精衍生的集合和所述第一有效原子论海森确定性开采。天然聚合物的第二部分的热力学性质是使用三维坐标的精制天然集合和第二有效原子论海森确定性开采。的原子变化的影响是通过取第一和第二部分的计算的热力学性质之间的差异进行量化。

10. 发明公开

EP3087185A1 ANTIBODIES COMPRISING C-TERMINAL LIGHT CHAIN POLYPEPTIDE EXTENSIONS AND CONJUGATES AND METHODS OF USE THEREOF 无效
标题翻译：有使用C端LEICHTKETTEPOLYPEPTIDERWEITERUNGEN和结合物及其方法抗体
公开(公告)号：EP3087185A1
公开(公告)日：2016-11-02
申请号：EP14874786.8
申请日：2014-12-23
申请人： Zymeworks Inc.
发明人： BABCOOK, John , RICH, James , BERGQVIST, Jan Peter , BARNSCHER, Stuart Daniel
IPC分类号： C12N15/13 , C07K16/00 , C07K16/28 , C07K16/46
CPC分类号： C07K16/32 , A61K47/6835 , A61K47/6851 , A61K49/0039 , A61K49/0058 , A61K2039/505 , C07K16/00 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/522 , C07K2317/53 , C07K2317/56 , C07K2317/73 , C07K2317/92
摘要： The present disclosure provides light chain polypeptides that include a C-terminal extension, as well as antibodies and antibody conjugates containing such modified light chain polypeptides, where the C-terminal extension includes one or more cysteine residues. Conjugates that include an antibody of the present disclosure conjugated to an agent via the cysteine residue of the C-terminal amino acid extension are also provided. The present disclosure further provides nucleic acids encoding an antibody light chain polypeptide that includes a C-terminal amino acid extension including a cysteine residue. Pharmaceutical compositions including the antibodies or conjugates of the present disclosure are also provided, as are methods of making and use of the modified antibodies and conjugates of the present disclosure.
摘要翻译：本发明提供轻链多肽都包含C-末端延伸，以及抗体和含改性求轻链多肽，其中所述C-末端延伸包含一个或多个半胱氨酸残基标记抗体。偶联物也包括在经由C-末端氨基酸延伸的半胱氨酸残基缀合至剂的本公开内容的抗体因此提供。本公开内容进一步提供了核酸的抗体轻链多肽的编码做包括C-末端氨基酸延伸部包括一个半胱氨酸残基。被设置成药物组合物包括抗体或本发明的缀合物，如了制备和使用所述修饰的抗体和本发明的缀合物的方法。

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