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1. 发明授权

EP2683364B1 STABLE FORMULATIONS FOR PARENTERAL INJECTION OF PEPTIDE DRUGS 有权
标题翻译：维生素BENTEENENENENEN ZEN PARENTERALEN INJEKTION VON PEPTIDWIRKSTOFFEN
公开(公告)号：EP2683364B1
公开(公告)日：2017-01-18
申请号：EP12711071.6
申请日：2012-03-09
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven , KINZELL, John
IPC分类号： A61K9/19 , A61K9/08 , A61K9/00 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/22 , A61K47/02 , A61K47/20 , A61K47/14 , A61K47/10 , A61K38/22 , A61K38/28 , A61K38/26
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/19 , A61K38/02 , A61K38/09 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/1816 , A61K38/22 , A61K38/2207 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/30 , A61K38/4893 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36

2. 发明公开

EP2773331A1 FORMULATIONS FOR THE TREATMENT OF DIABETES 有权
标题翻译：制剂治疗糖尿病
公开(公告)号：EP2773331A1
公开(公告)日：2014-09-10
申请号：EP12798470.6
申请日：2012-10-31
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven , SCOTT, Nancy
IPC分类号： A61K9/19 , A61K9/08 , A61K38/22 , A61K38/26 , A61K38/28 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/22
CPC分类号： A61K47/20 , A61K9/0019 , A61K9/145 , A61K9/19 , A61K38/22 , A61K38/28
摘要： Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.

4. 发明公开

EP4327804A3 METHODS FOR PRODUCING STABLE THERAPEUTIC GLUCAGON FORMULATIONS IN APROTIC POLAR SOLVENTS 审中-实审
公开(公告)号：EP4327804A3
公开(公告)日：2024-05-01
申请号：EP23218481.2
申请日：2016-09-25
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven , DONOVAN, Martin , SANDOVAL, Michael
IPC分类号： A61K38/26 , A61K38/00 , A61K9/00 , A61M5/142 , A61K47/26 , A61K47/00 , A61K47/20 , A61K9/08
CPC分类号： A61M5/142 , A61K47/12 , A61K9/08 , A61K47/183 , A61K47/186 , A61M5/32 , A61K9/0019 , A61K38/26 , A61K47/02 , A61K47/20 , A61P3/00 , A61P3/08
摘要： Certain embodiments are directed to a formulation of a therapeutic agent, as well as a method of making such a formulation, comprising at least one therapeutic agent dissolved in an aprotic polar solvent system comprising at least one ionization stabilizing excipient in a concentration sufficient to impart physical and chemical stability to the therapeutic agent.

5. 发明公开

EP3975993A1 STABLE THERAPEUTIC COMPOSITIONS IN APROTIC POLAR SOLVENTS AND METHODS OF MANUFACTURING THE SAME 审中-公开
公开(公告)号：EP3975993A1
公开(公告)日：2022-04-06
申请号：EP20733172.9
申请日：2020-05-29
申请人： Xeris Pharmaceuticals, Inc.
发明人： DONOVAN, Martin , HU, Wendy
IPC分类号： A61K9/00 , A61K38/26 , A61P3/10 , A61K9/08 , A61K47/02 , A61K47/20

6. 发明授权

EP2874599B1 STABLE FORMULATIONS FOR PARENTERAL INJECTION COMPRISING BENZODIAZEPINES 有权转让
公开(公告)号：EP2874599B1
公开(公告)日：2019-05-01
申请号：EP13736714.0
申请日：2013-06-27
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven, J. , SCOTT, Nancy
IPC分类号： A61K9/00 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/352 , A61K31/4045 , A61K31/4196 , A61K31/496 , A61K31/55 , A61K31/675 , A61K31/7036
CPC分类号： A61K31/5513 , A61K9/0019 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/352 , A61K31/4045 , A61K31/4196 , A61K31/496 , A61K31/55 , A61K31/675 , A61K31/7036 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22
摘要： Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 3 ml.

7. 发明公开

EP3185932A1 SYRINGES, KITS, AND METHODS FOR INTRACUTANEOUS AND/OR SUBCUTANEOUS INJECTION OF PASTES 审中-公开
标题翻译：用于皮内和/或皮下注射药膏的注射器，套件和方法
公开(公告)号：EP3185932A1
公开(公告)日：2017-07-05
申请号：EP15750582.7
申请日：2015-08-06
申请人： Xeris Pharmaceuticals, Inc.
发明人： DONOVAN, Martin
IPC分类号： A61M5/178 , A61M5/28 , A61M5/31
CPC分类号： A61M5/281 , A61M5/178 , A61M5/28 , A61M5/315 , A61M5/329 , A61M5/344 , A61M2202/06
摘要： This disclosure includes syringes, kits containing the same, and related methods. Some syringes are pre-loaded with paste and have a syringe body defining a reservoir having an internal first transverse dimension, a paste disposed within the reservoir, the paste having a solids concentration of greater than 50 mg/mL, a needle defining a lumen having an internal second transverse dimension that is smaller than the first transverse dimension, the needle configured to be in fluid communication with the reservoir to allow intracutaneous delivery of the paste, and a plunger and/or piston disposed within the reservoir and configured to be moved to dispense paste from the reservoir through the lumen. Some syringes include a fitting (e.g. Luer fitting) disposed on the syringe body and in fluid communication with the reservoir and a sealing cap disposed on the Luer fitting to seal the reservoir.
摘要翻译：本公开包括注射器，包含其的试剂盒和相关方法。一些注射器预装有糊剂并且具有限定具有内部第一横向尺寸的贮存器的注射器主体，设置在贮存器内的糊剂，糊剂具有大于50mg / mL的固体浓度，限定内腔的针小于所述第一横向尺寸的内部第二横向尺寸，所述针构造成与所述贮存器流体连通以允许所述糊剂的皮内递送，以及设置在所述贮存器内并且构造成移动到所述贮存器内的柱塞和/或活塞通过内腔从储液器分配膏剂。一些注射器包括布置在注射器本体上并与储液器流体连通的配件（例如鲁尔配件）以及布置在鲁尔配件上以密封储液器的密封帽。

8. 发明公开

EP2874599A1 STABLE FORMULATIONS FOR PARENTERAL INJECTION OF SMALL MOLECULE DRUGS 有权转让
标题翻译：稳定的制剂用于非肠道注射小分子药物CHINESE
公开(公告)号：EP2874599A1
公开(公告)日：2015-05-27
申请号：EP13736714.0
申请日：2013-06-27
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven, J. , SCOTT, Nancy
IPC分类号： A61K9/00 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/352 , A61K31/4045 , A61K31/4196 , A61K31/496 , A61K31/55 , A61K31/675 , A61K31/7036
CPC分类号： A61K31/5513 , A61K9/0019 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/352 , A61K31/4045 , A61K31/4196 , A61K31/496 , A61K31/55 , A61K31/675 , A61K31/7036 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/22
摘要： Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight residual water, and wherein the volume of the liquid formulation to be parenterally injected is from 0.1 μl to 3 ml.

9. 发明公开

EP2526996A1 Intracutaneous injection 有权转让
标题翻译： Intrakutane Injektion
公开(公告)号：EP2526996A1
公开(公告)日：2012-11-28
申请号：EP12180169.0
申请日：2003-12-22
申请人： Xeris Pharmaceuticals, Inc.
发明人： Prestrelski, Steven , Brodbeck, Kevin
IPC分类号： A61M37/00 , A61K9/00 , A61M5/315
CPC分类号： A61K9/0021 , A61K9/0014 , A61K9/127 , A61K9/16 , A61K9/1647 , A61K9/19 , A61K38/26 , A61K38/27 , A61K47/14 , A61K47/22 , A61M5/1782 , A61M5/19 , A61M5/2033 , A61M5/2053 , A61M5/31513 , A61M5/31531 , A61M5/31548 , A61M5/31563 , A61M5/3234 , A61M5/326 , A61M5/3286 , A61M5/329 , A61M5/42 , A61M5/46 , A61M5/5086 , A61M37/00 , A61M37/0069 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2205/59
摘要： The delivery of biopharmaceutical and other therapeutic agents parenterally to an animal via a minimally invasive, low pain administration is provided. The agents are delivered to the patient via, e.g., the epidermal, dermal, or subcutaneous layer of the skin in a concentrated form of injectable paste of slurry.
摘要翻译：提供了生物制药和其它治疗剂通过微创，低疼痛给药胃肠外递送给动物。药剂通过例如皮肤的表皮，皮肤或皮下层以浆液的可注射浆料的浓缩形式递送至患者。

10. 发明公开

EP4378463A3 PRECIPITATION RESISTANT SMALL MOLECULE DRUG FORMULATIONS 审中-实审
公开(公告)号：EP4378463A3
公开(公告)日：2024-10-23
申请号：EP24167722.8
申请日：2018-05-31
申请人： Xeris Pharmaceuticals, Inc.
发明人： PRESTRELSKI, Steven J. , SANDOVAL, Michael A. , SLOAT, Brian R.
IPC分类号： A61K9/00 , A61K47/14 , A61K47/16 , A61K47/20 , A61K47/22 , A61K9/08 , A61K31/5513 , A61K31/198 , A61K31/4045 , A61P25/08 , A61P25/14 , A61P25/22
CPC分类号： A61K9/0019 , A61K47/14 , A61K47/16 , A61K47/20 , A61K47/22 , A61K9/08 , A61K31/5513 , A61P25/14 , A61P25/22 , A61P25/08
摘要： Embodiments of the invention are directed to formulations that provide a solution to the problem of small molecule (e.g., diazepam) precipitation at the injection site when administered as a highly-concentrated formulation. In certain aspects the formulations include at least one surfactant in a non-aqueous formulation, which prevents small molecule precipitation and improves the bioavailability of the drug by enhancing absorption into the systemic circulation.

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