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1. 发明公开

EP2676962A1 Derivatives of 1-aminoalkylphosphonate diaryl esters, method of 1-aminoalkylphosphonate diaryl ester derivatives preparation and their application 审中-公开
标题翻译： 1-氨基烷基膦酸酯 - 二芳基酯衍生物，1-芳基膦酸二芳基酯 - 衍生物和Anwendung davon
公开(公告)号：EP2676962A1
公开(公告)日：2013-12-25
申请号：EP13172944.4
申请日：2013-06-20
申请人： Universität Ulm , Wroclaw University of Technology
发明人： Sienczyk, Marcin , Grzywa, Renata , Pietrusewicz, Ewa , Oleksyszyn, Józef , Winiarski, Lukasz , Burster, Timo , Böhm, Otto
IPC分类号： C07F9/40 , C12Q1/37 , G01N33/573
CPC分类号： C07F9/405 , C12Q1/37 , G01N33/573 , G01N2333/96433 , Y02P20/55
摘要： The subject of the invention relates to 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl, and their use as inhibitors of serine proteases, and the low molecular weight molecular probes to detect the catalytically active forms of the enzymes.
A process for preparing 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl relies on application of triaryl phosphite, obtained from the phenol substituted at para position phosphorus (III) chloride in refluxing acetonitrile and is subjected to amidoalkylation reaction with benzyl carbamate and an aldehyde such as acetaldehyde, propionic aldehyde, iso -butyric aldehyde, phenylacetic aldehyde, p-nitrobenzoic aldehyde and isovaleric aldehyde, followed by the synthesis of hydrobromide salts of 1-aminoalkylphosphonate diaryl esters, in which the benzyloxycarbonyl (Cbz) protective group is removed, and in the next step is reacted with an amino acid containing protected α-amino group in the presence of a coupling reagent. The resulting phosphonic dipeptide containing tert-butoxycarbonyl (t-Boc) protective group is subjected to deprotection of α-amino group and obtained dipeptidyl 1-aminoalkylphosphonate diaryl ester is coupled with another amino acid with protected α-amino group, biotin or a derivative thereof in a manner analogous to that described above.
摘要翻译：本发明的主题涉及式I的1-氨基烷基膦酸二芳基酯，其中Bt表示生物素，W是5至10个碳原子的烃连接体，Y是0-4的氨基酸残基，R 是对应于缬氨酸，丙氨酸，亮氨酸，苯丙氨酸，4-胍基苯基甘氨酸或2-氨基丁酸（Abu）的侧链的取代基，X是氢或选自巯基甲基（S-甲基），甲氧基（O-甲基）或羧甲基，以及它们作为丝氨酸蛋白酶抑制剂的用途，以及用于检测酶的催化活性形式的低分子量分子探针。制备式I的1-氨基烷基膦酸二芳基酯的方法，其中Bt表示生物素，W是5至10个碳原子的烃连接体，Y是0-4的氨基酸残基，R是取代基对应于缬氨酸，丙氨酸，亮氨酸，苯丙氨酸，4-胍基苯基甘氨酸或2-氨基丁酸（Abu）的侧链，X是氢或选自巯基甲基（S-甲基），甲氧基（O - 甲基）或羧甲基取代于亚磷酸三芳基酯，由在对位位置上的氯取代的苯酚在回流的乙腈中得到，并与氨基甲酸苄酯和醛如乙醛，丙醛，异 - 丁醛，苯乙醛，对硝基苯甲醛和异戊醛，然后合成1-氨基烷基膦酸二芳基酯的氢溴酸盐，其中苄氧羰基（Cbz）p 除去脱水基团，并在下一步骤中与偶联剂存在下与含有保护的±氨基的氨基酸反应。将所得到的含有叔丁氧基羰基（t-Boc）保护基的膦酸二肽进行± - 氨基脱保护，得到了具有保护的± - 氨基，生物素或其衍生物的另一个氨基酸的二氨基苯基-1-氨基烷基膦酸二芳基酯以类似于上述方式。

2. 发明公开

EP2502102A1 BIREFRINGENT MICRO-STRUCTURED OPTICAL FIBER FOR SENSOR APPLICATION 有权转让
标题翻译：双断路结构光纤传感器微型应用
公开(公告)号：EP2502102A1
公开(公告)日：2012-09-26
申请号：EP10803451.3
申请日：2010-11-19
申请人： Vrije Universiteit Brussel , Uniwersytet Marii Curie Sklodowskiej , Politechnika Wroclawska (Wroclaw University Of Technology)
发明人： GEERNAERT, Thomas , BERGHMANS, Francis , NASILOWSKI, Tomasz , THIENPONT, Hugo , MAKARA, Mariusz , MERGO, Pawel , POTURAJ, Krzysztof, Grzegorz , URBANCZYK, Waclaw , MARTYNKIEN, Tadeusz , OLSZEWSKI, Jacek Marek , WOJCIK, Jan Jozef
IPC分类号： G02B6/02 , G01D5/353 , G01L11/02
CPC分类号： G02B6/105 , G01D5/35316 , G01D5/3538 , G02B6/02109 , G02B6/02338 , G02B6/02357 , G02B6/02371
摘要： The invention relates to the field of fiber structures, preferably adapted for use with fiber Bragg gratings in sensors. The fiber structure comprises a core and a cladding surrounding the core, a central micro structure (1) comprising a first plurality of longitudinal holes, wherein the central microstructure (1) is adapted for guiding optical radiation and for birefringence in the core, a side microstructure (2) comprising a second plurality of longitudinal holes, wherein the side microstructure (2) is at least partly surrounding the central microstructure (1) and is adapted for providing a predetermined mechanical anisotropy (anisotropic response to mechanical strain, or as anisotropic mechanical stiffness), a pressure responsive unit adapted for converting an isotropic pressure force to birefringence changes on the core, a lateral force responsive unit adapted for converting a directional pressure force to birefringence changes on the core, a temperature responsive unit adapted for converting temperature to birefringence changes on the core, and a birefringence responsive unit adapted for converting birefringence in the core to wavelength information. In this way, a fiber structure is provided that allows increasing the ratio of mechanical to thermal sensitivity up to several orders of magnitude with similar sized mode areas.

3. 发明公开

EP2686475A1 EMBEDDING NANOPARTICLES IN THERMOPLASTIC POLYMERS 有权
标题翻译：热塑性聚氨酯中的EINGEBETTETE NANOPARTIKEL
公开(公告)号：EP2686475A1
公开(公告)日：2014-01-22
申请号：EP12726170.9
申请日：2012-03-16
申请人： University of Limerick , Wroclaw Medical University , Wroclaw University of Technology
发明人： TOFAIL, Syed , ZEGLINSKI, Jacek , CRONIN, Patrick , PODBIELSKA, Halina , DWORNICZEK, Ewa , TIERNAN, Peter , FRANICZEK, Roman , BUZALEWICZ, Igor , WAWRZYNSKA, Magdalena
IPC分类号： D06M11/42 , D06M11/44 , D06M11/46 , D06M11/49 , D06M11/79 , D06M16/00 , B22F1/00 , B82Y30/00
CPC分类号： D06M11/46 , B22F1/0018 , B22F7/04 , B82Y30/00 , C22C5/02 , C22C5/06 , D06M11/42 , D06M11/44 , D06M11/49 , D06M11/79 , D06M16/00 , D06M23/08
摘要： The present invention relates to a polymeric material having one or more nanoparticles embedded within the surface layer of a single side of the material. In some embodiments, the nanoparticles are microbiocidal nanoparticles which impart antimicrobial characteristics to the polymeric material within which they sprayed and pushed by are embedded.
摘要翻译：本发明涉及一种具有一个或多个纳米颗粒的聚合物材料，该纳米颗粒嵌入材料的单面的表面层内。在一些实施方案中，纳米颗粒是将抗微生物特征赋予聚合物材料的杀微生物纳米颗粒，其中它们被嵌入其中被喷射和推动。

4. 发明授权

EP2686475B1 EMBEDDING NANOPARTICLES IN THERMOPLASTIC POLYMERS 有权
公开(公告)号：EP2686475B1
公开(公告)日：2018-08-22
申请号：EP12726170.9
申请日：2012-03-16
申请人： University of Limerick , Wroclaw Medical University , Wroclaw University of Technology
发明人： TOFAIL, Syed , ZEGLINSKI, Jacek , CRONIN, Patrick , PODBIELSKA, Halina , DWORNICZEK, Ewa , TIERNAN, Peter , FRANICZEK, Roman , BUZALEWICZ, Igor , WAWRZYNSKA, Magdalena
IPC分类号： D06M11/42 , D06M11/44 , D06M11/46 , D06M11/49 , D06M11/79 , D06M16/00 , B22F1/00 , B82Y30/00 , B22F7/04 , C22C5/06 , C22C5/02 , D06M23/08
CPC分类号： D06M11/46 , B22F1/0018 , B22F7/04 , B82Y30/00 , C22C5/02 , C22C5/06 , D06M11/42 , D06M11/44 , D06M11/49 , D06M11/79 , D06M16/00 , D06M23/08
摘要： The present invention relates to a polymeric material having one or more nanoparticles embedded within the surface layer of a single side of the material. In some embodiments, the nanoparticles are microbiocidal nanoparticles which impart antimicrobial characteristics to the polymeric material within which they sprayed and pushed by are embedded.

5. 发明授权

EP2912475B1 PROCEDE DE DETECTION DE CONDITIONS DE TURBULENCE UTILISANT L'INTERACTION D'UN FAISCEAU LASER AVEC UN FILM MINCE PHOTOCHROMIQUE ET DISPOSITIF METTANT EN OEUVRE LEDIT PROCEDE 有权
标题翻译：检测方法的湍流能用于利用激光束的薄膜PHOTO色烯和交互设备用于实施过程
公开(公告)号：EP2912475B1
公开(公告)日：2016-09-07
申请号：EP13779888.0
申请日：2013-10-23
申请人： Centre National de la Recherche Scientifique , Université d'Angers , Wroclaw University of Technology
发明人： BARILLE, Régis
IPC分类号： G01P5/00 , G01P5/26 , G03H1/00 , G06T3/00
CPC分类号： G01P5/001 , G01P5/26 , G06T3/0056

6. 发明公开

EP2912475A1 PROCEDE DE DETECTION DE CONDITIONS DE TURBULENCE UTILISANT L'INTERACTION D'UN FAISCEAU LASER AVEC UN FILM MINCE PHOTOCHROMIQUE ET DISPOSITIF METTANT EN UVRE LEDIT PROCEDE 有权
标题翻译：检测方法的湍流能用于利用激光束的薄膜PHOTO色烯和交互设备用于实施过程
公开(公告)号：EP2912475A1
公开(公告)日：2015-09-02
申请号：EP13779888.0
申请日：2013-10-23
申请人： Centre National de la Recherche Scientifique (CNRS) , Université d'Angers , Wroclaw University of Technology
发明人： BARILLE, Régis
IPC分类号： G01P5/00 , G01P5/26 , G03H1/00
CPC分类号： G01P5/001 , G01P5/26 , G06T3/0056
摘要： The invention relates to a method for assessing the turbulence parameters of a medium, characterized in that said method includes the following steps: illuminating, by means of a laser beam propagating in said medium, a film made of a photochromic organic material that may include azobenzene, spyropyrane, stylbene, coumarin, or fulgide molecules, said illumination creating a surface array in which the film comprises streaks having deformations based on turbulence parameters; acquiring images containing elementary areas of structures related to said streaks, more or less reduced and representative of the turbulence parameters of said medium; and processing said images to assess the turbulence parameters of said medium. The invention also relates to a device for implementing said method.

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