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2. 发明公开

EP2686068A1 STUDYING DOSIMETRIC IMPACT OF MOTION TO GENERATE ADAPTIVE PATIENT-SPECIFIC MARGINS IN EBRT PLANNING 有权
标题翻译：运动的剂量测定效应用于在规划EBRT，生成自适应患者特异性LIMITS研究
公开(公告)号：EP2686068A1
公开(公告)日：2014-01-22
申请号：EP12713339.5
申请日：2012-03-13
申请人： Koninklijke Philips N.V. , Washington University in St. Louis
发明人： BHARAT, Shyam , BZDUSEK, Karl, Antonin , PARIKH, Parag, Jitendra , NOEL, Camille, Elizabeth
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1031 , A61N2005/1072
摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.
摘要翻译：治疗计划系统（106），用于生成患者特异性治疗的利润率。该系统（106）包括一个或多个处理器（142）。处理器（142）被编程以接收一个辐射处置计划（RTP）用于通过一个或多个处理级分的过程上辐照靶（122）。目标（122）和用于所述目标（122）有计划的剂量分布围绕RTP包括一个或多个处理空间。处理器（142）还被编程使用运动数据来接收的运动数据用于从一个或多个目标替代物（124），计算所述目标（122）的运动补偿的剂量分布的RTP的治疗组分中的至少一个和计划的剂量分布，比较经运动补偿的剂量分布与计划的剂量分布，以及调整基于所述经运动补偿的剂量分布和所计划的剂量分布之间的差异剂量学治疗边距。

3. 发明公开

EP2317915A1 SYSTEMS AND METHODS FOR ON-SITE AND REAL-TIME ELECTROCARDIOGRAPHIC IMAGING (ECGI) 审中-公开
标题翻译：系统和原生境和心电图IMAGING REAL-TIME方法（ECGI）
公开(公告)号：EP2317915A1
公开(公告)日：2011-05-11
申请号：EP09807119.4
申请日：2009-08-10
申请人： Washington University in St. Louis
发明人： RUDY, Yoram , WANG, Yong
IPC分类号： A61B5/04
CPC分类号： A61B5/04085 , A61B5/04012 , A61B5/6805 , A61B6/503 , A61B6/5247 , A61B8/0883 , A61B8/5261 , A61B2018/00839
摘要： A computer-implemented method for electrocardiographic imaging (ECGI) is provided. The method includes computing a transfer matrix, measuring a plurality of electrical potentials, and computing an estimation of electrical potentials on a surface of interest based at least in part on the measured potentials and the computed transfer matrix. The transfer matrix computing step is performed prior to the measuring step.

4. 发明公开

EP2203733A2 CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION 有权
标题翻译：具有光学横向分辨率共焦光声显微镜
公开(公告)号：EP2203733A2
公开(公告)日：2010-07-07
申请号：EP08842292.8
申请日：2008-10-24
申请人： Washington University in St. Louis
发明人： WANG, Lihong , MASLOV, Konstantin
IPC分类号： G01N21/00 , G01N29/00 , G02B27/30 , A61B8/00 , A61B5/1455
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/0068 , A61B5/0082 , A61B5/02007 , A61B5/14542 , A61B5/14546 , A61B5/444 , A61B5/4848 , A61B8/485 , A61B2090/306 , G01N21/1702 , G01N29/0681 , G01N29/2418 , G01N2291/02836 , G01N2291/02872 , G02B21/0028 , G02B21/008
摘要： A confocal photoacoustic microscopy system includes a laser configured to emit a light pulse, a focusing assembly configured to receive the light pulse and to focus the light pulse into an area inside an object, an ultrasonic transducer configured to receive acoustic waves emitted by the object in response to the light pulse, and an electronic system configured to process the acoustic waves and to generate an image of the area inside the object. The focusing assembly is further configured to focus the light pulse on the object in such a way that a focal point of the focusing assembly coincides with a focal point of the at least one ultrasonic transducer.

5. 发明公开

EP1827493A2 USE OF ANTI-ABETA ANTIBODY TO TREAT TRAUMATIC BRAIN INJURY 审中-公开
标题翻译：抗Aβ抗体的脑外伤治疗中的应用
公开(公告)号：EP1827493A2
公开(公告)日：2007-09-05
申请号：EP05854855.3
申请日：2005-12-21
申请人： Washington University in St. Louis
发明人： BRODY, David, Lozoff , HOLTZMAN, David, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505
摘要： A method of effectively treating traumatic brain injury is described. The method comprises administering an effective amount of an anti-Aβ antibody to a living mammalian biosystem such as to a human. An antibody useful in such treating includes an antibody that therapeutically attenuates the toxic effects of the Aβ peptide in a living mammal in relation to traumatic brain injury.

6. 发明公开

EP1660137A2 SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS 审中-公开
标题翻译： SIGMA-2受体的放射性示踪成像实体瘤增殖情况
公开(公告)号：EP1660137A2
公开(公告)日：2006-05-31
申请号：EP04817745.5
申请日：2004-07-30
申请人： Washington University in St. Louis
发明人： MACH, Robert, H. , WELCH, Michael, J. , ROWLAND, Douglas, J., Jr. , TU, Zhude
IPC分类号： A61K51/00 , C07D217/04
CPC分类号： C07D295/13 , A61K31/47 , A61K31/495 , A61K51/04 , A61K51/0497 , C07C323/41 , C07D217/04 , C07D257/02
摘要： Novel benzamide compounds of Formula (I), Formula (II) and Formula (III, salts, water soluble salts, analogs and radiolabeled counterparts thereof as sigma-2 receptor radiotracers for imaging the proliferative status of solid tumors. A method for diagnosing a mammal for the presence of a mammalian tumor therein comprises administering to the mammal a diagnostic imaging detectable effective amount of a benzamide compound having a structure illustrated in Formula (I), Formula (III) and Formula (III) and detecting binding of the compound to a tumor in the mammal. A method for diagnostic imaging of a mammalian tissue having cell surface sigma-2 receptors comprising administering to a mammal a diagnostic imaging amount of a compound having a structure illustrated in Formula (I) Formula (II) and Formula (III) and detecting an image of a tissue having an ample cells with sigma-2 receptors.

7. 发明公开

EP1654206A2 AUTOMATED SEPARATION, PURIFICATION AND LABELING SYSTEMS FOR 60CU ,61CU and 64CU RADIONUCLIDES AND RECOVERY THEREOF 审中-公开
标题翻译：自动切割，净化和MARK系统60CU-，61CU-和64Cu，放射性核素和其恢复
公开(公告)号：EP1654206A2
公开(公告)日：2006-05-10
申请号：EP04786479.8
申请日：2004-08-09
申请人： Washington University in St. Louis
发明人： WELCH, Michael, John , TANG, Lucie, Li, Wa , GAEHLE, Gregory, Glen , LEWIS, Jason, Stuart
IPC分类号： C07C1/00
CPC分类号： G05B19/418 , A61K51/1282 , B01D15/10 , B01D15/361 , B01D15/363 , G21G1/001 , G21G4/08 , G21G2001/0094
摘要： A novel method for separating an irradiated 60CU or 61CU or 64CU respectively from a composition containing 60Ni or 61Ni or 64Ni respectively therein comprises dissolving the irradiated 60CU or 61CU or 64CU in a solvent acid to form an acidic solubilized composition, feeding the acidic solubilized composition onto an ion exchange column and removing an eluent comprising 60Ni or 61Ni or 64Ni ions. In an aspect the eluent is further processed for 60Ni or 61Ni or 64Ni recovery and recycling to prepare future targets. In an aspect 60CU or 61CU or 64CU respectively is temporarily trapped into the ion exchange column resin and held for subsequent recovery by addition of 0.5 N HCl to elute out the 60CU or 61CU or 64CU for further use or labeling. An enhanced process for labeling compounds with highly 60CU or 61CU or 64CU comprises loading 60CU, 61CU and 64CU elute onto a concentrating cartridge, collecting the 0.5N HCl eluent and admixing therewith 10-µL of ligand and 3N HCl solution in a reaction line to form a 60 or 61 or 64CU labeled product. In an aspect a further purification step comprises loading 10-mL sterile water into the reaction line and through the C18 Sep-Pak cartridge to further purify the labeled product which is adherent in the cartridge and 60CU, 61CU and 64CU each as a separate and independent purified product.

8. 发明公开

EP1542792A2 CHARGING AND CAPTURE OF PARTICLES IN CORONAS IRRADIATED BY IN-SITU X-RAYS 审中-公开
标题翻译： LOADING并捕获粒子在具有在线照射X射线日冕
公开(公告)号：EP1542792A2
公开(公告)日：2005-06-22
申请号：EP03749138.8
申请日：2003-08-28
申请人： Washington University in St. Louis
发明人： BISWAS, Pratim , NAMIKI, Norikazu , KULKARNI, Pramod
IPC分类号： B01J19/08 , B03C3/011
CPC分类号： B01J19/125 , B01J19/088 , B01J2219/0809 , B01J2219/0828 , B01J2219/083 , B01J2219/0841 , B01J2219/0849 , B01J2219/0869 , B01J2219/0871 , B01J2219/0886 , B01J2219/0892 , G21K5/02
摘要： An improved method for charging ultrafine particles in coronas (e.g., unipolar or bipolar corona discharges) by exposing the particles to X-ray irradiation. Experimental tests have verified that positive corona in the presence of X-ray irradiation results in maximum or optimum charging efficiency, followed by a negative corona in the presence of X-ray irradiation, X-ray radiation only (without corona), negative corona only (without X-ray irradiation), and finally positive corona only (without X-ray irradiation). This method and system is particularly well suited for use with bioaerosol particles wherein exposure to the corona discharge and X-ray irradiation serves to both capture and inactivate the bioaerosol particles using a single device.

9. 发明公开

EP3229010A2 CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION 审中-公开
公开(公告)号：EP3229010A2
公开(公告)日：2017-10-11
申请号：EP17159220.7
申请日：2008-10-24
申请人： Washington University in St. Louis
发明人： WANG, Lihong , MASLOV, Konstantin
IPC分类号： G01N21/17 , G01N29/06 , A61B8/08 , A61B5/1455 , G01N29/24 , G02B21/00 , A61B5/00 , A61B5/08 , A61B5/02 , A61B5/145 , A61B90/30
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/0068 , A61B5/0082 , A61B5/02007 , A61B5/14542 , A61B5/14546 , A61B5/444 , A61B5/4848 , A61B8/485 , A61B2090/306 , G01N21/1702 , G01N29/0681 , G01N29/2418 , G01N2291/02836 , G01N2291/02872 , G02B21/0028 , G02B21/008
摘要： A confocal photoacoustic microscopy system includes a laser configured to emit a light pulse, a focusing assembly configured to receive the light pulse and to focus the light pulse into an area inside an object, an ultrasonic transducer configured to receive acoustic waves emitted by the object in response to the light pulse, and an electronic system configured to process the acoustic waves and to generate an image of the area inside the object. The focusing assembly is further configured to focus the light pulse on the object in such a way that a focal point of the focusing assembly coincides with a focal point of the at least one ultrasonic transducer.

10. 发明公开

EP2786289A2 AUTOMATED ALGORITHM AND FRAMEWORK FOR MULTI-PATIENT TREATMENT PLAN ACCESS IN RADIATION THERAPY 审中-公开
标题翻译：自动算法和框架获得了治疗方案针对多个患者放射治疗
公开(公告)号：EP2786289A2
公开(公告)日：2014-10-08
申请号：EP12808510.7
申请日：2012-11-30
申请人： Koninklijke Philips N.V. , Washington University in St. Louis
发明人： BHARAT, Shyam , BAL, Matthieu Frédéric , PARIKH, Parag Jitendra , MOORE, Kevin Lawrence
IPC分类号： G06F19/00
CPC分类号： G06F19/3487 , A61N5/103 , G06F19/00 , G06F19/3481 , G06Q50/22 , G16H10/60 , G16H15/00
摘要： A method for reviewing a treatment plan including displaying list of at least one of a selected plurality of patients, institutions, and treatment plans associated with a treatment planning system, selecting at least one of the one or more patients, institutions, and treatment plans, querying treatment plan parameters associated with the selected one or more patients, institutions, and treatment plans, and generating a report file of the queried treatment plan parameters

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