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1. 发明公开

EP4055461A1 PRESSURE STABILIZER 无效
公开(公告)号：EP4055461A1
公开(公告)日：2022-09-14
申请号：EP20833982.0
申请日：2020-11-04
申请人： Universidade de Coimbra , Universidade Do Algarve
发明人： MENDES PEDROSO DE LIMA, João Luís , GUIEIRO PEREIRA ISIDORO, Jorge Manuel
IPC分类号： G05D16/04 , B05B12/08

2. 发明公开

EP2326664A2 A GAMMACARBOXYGLUTAMATE-RICH PROTEIN, METHODS AND ASSAYS FOR ITS DETECTION, PURIFICATION AND QUANTIFICATION AND USES THEREOF 审中-公开
标题翻译： FOR ITS，其纯化及其量化AND A GAMMACARBOXYGLUTAMATREICHES蛋白质，方法和检测方法及其用途
公开(公告)号：EP2326664A2
公开(公告)日：2011-06-01
申请号：EP09737193.4
申请日：2009-08-27
申请人： Universidade Do Algarve
发明人： FERNANDES RODRIGUES DA COSTA SIMES, Dina Cristina , SÃO BENTO VIEGAS, Carla Alexandra , QUINTAIS CANCELA DA FONSECA, Maria Leonor
IPC分类号： C07K14/435
CPC分类号： C07K14/461 , C07K14/46 , C07K14/78 , C07K16/18 , G01N33/68 , G01N33/6893
摘要： The present invention refers to a gammacarboxyglutamate -rich protein that shows in vivo a high capacity to bind calcium through specific gamma carboxylated glutamic acid residues (Gla). It includes a description of the referred protein, purification procedures, protein detection and quantification tools and methods.. This invention also refers to a kit for the detection and quantification of said protein in samples. This kit includes the use of one or more antibodies produced against the homologous sequence of the target species to be analyzed, and thus, methods for the production of such antibodies are disclosed as well. In another aspect of the invention, the methods and tools described hereby are used as biomarkers for evaluation of presence or risk to develop certain diseases. In another aspect of this invention, available complete GRP cDNA and gene sequences obtained from several species also enable the in vitro production of antigens, the quantification of GRP expression, the screening of GRP polymorphisms to access the predisposition for certain diseases and the screening for GRP mutations.
摘要翻译：当前盘游离缺失的主题是指富gammacarboxyglutamate蛋白确实显示了在体内通过特定的γ羧化谷氨酸残基（GLA）结合钙的高容量。它包括由蛋白质，纯化方法，蛋白检测和定量的工具和方法的称为的描述。一种用于所述蛋白质的样品中检测和定量试剂盒是预期的。该试剂盒可以包括使用对目标物种的同源序列产生的一种或多种抗体被分析，并且因此，用于生产检测抗体的方法是游离缺失盘以及。在另一个方面中，所述方法和在此所描述的工具可以被用作生物标志物的存在或风险评估开发某些疾病。在游离缺失的主题的光盘的另一个方面中，从几个物种中获得可用的完整GRP cDNA和基因序列从而能够在体外生产抗原，GRP表达的定量，GRP多态性的筛选以访问某些疾病和筛选易感性 GRP的突变。

4. 发明公开

EP3886190A1 FLEXIBLE AND LIGHTWEIGHT DIODE AND ITS PROCESS OF MANUFACTURING 审中-公开
公开(公告)号：EP3886190A1
公开(公告)日：2021-09-29
申请号：EP20382214.3
申请日：2020-03-23
申请人： Consejo Superior de Investigaciones Científicas (CSIC) , Universitat de Girona , Universidade Do Algarve , Instituto de Telecomunicações
发明人： MARTÍNEZ-DOMINGO, Carme , CONTI, Silvia , TERÉS TERÉS, Lluís , RAMON GARCIA, Eloi , VILASECA MORERA, Fabiola , LEONEL GOMES, Henrique
IPC分类号： H01L51/10
摘要： The invention relates to a flexible and lightweight diode susceptible of being processed by inkjet printing additive manufacturing which is based on conductive nanopaper. Furthermore, the invention relates to its process of manufacturing by means of an additive manufacturing technique and to an electronic component comprising said diode. Therefore, the present invention could be included in the field of paper-based green electronics.

6. 发明公开

EP4301876A1 METHODS OF ANALYSIS OF ALLELIC EXPRESSION OF PIK3CA IN CANCER AND USES THEREOF 审中-实审
公开(公告)号：EP4301876A1
公开(公告)日：2024-01-10
申请号：EP22714776.6
申请日：2022-03-04
申请人： Universidade Do Algarve
发明人： LUÍS LOPES MAIA, Ana Teresa , GONÇALVES DE GOUVEIA MAIA XAVIER, Joana , WINKELSTRÖTER CORREIA, Lizelle , MAGNO MORGADO, Ramiro Emanuel
IPC分类号： C12Q1/6886

7. 发明公开

EP3638429A1 HIGH FREQUENCY WIDEBAND WIDE BEAM ULTRASOUND EMITTER TRANSDUCER FOR UNDERWATER COMMUNICATIONS 有权
公开(公告)号：EP3638429A1
公开(公告)日：2020-04-22
申请号：EP18746282.5
申请日：2018-06-18
申请人： Universidade do Minho , Universidade Do Algarve
发明人： SILVA MARTINS, Marcos , VALENTE GONÇALVES, Luís Miguel , FREITAS GOMES DA SILVA, Ant nio Jo o , MACHADO JESUS, Sergio Manuel
IPC分类号： B06B1/06 , G10K11/00 , H04R1/44

8. 发明公开

EP2547369A1 A NANOPARTICLE COMPRISING A MICELLE FORMED BY AN AMPHIPHILIC BLOCK- COPOLYMER AND ENCAPSULATING A GADOLINIUM COMPLEX 有权
标题翻译： WITH A BASIS纳米颗粒的两亲性嵌段共聚物胶束MADE用于包囊的钆
公开(公告)号：EP2547369A1
公开(公告)日：2013-01-23
申请号：EP11709651.1
申请日：2011-03-21
申请人： King Saud University , Universidade do Algarve
发明人： MOUFFOUK, Fouzi , RODRIGUES DOS SANTOS, Nuno , ALROKAYAN, Salman, A., H. , DA COSTA, Ana M. Rosa
IPC分类号： A61K49/18 , A61K9/107 , A61P35/00 , B82Y5/00
CPC分类号： A61K49/1806 , A61K9/1075 , A61K9/5146 , A61K49/103
摘要： The present invention relates to a nanoparticle comprising a micelle formed by an amphophilic block-copolymer and an agent encapsulated within said micelle. The present invention also relates to a composition comprising such nanoparticle and to the use of such nanoparticle and/or of such composition. More particularly, in one embodiment, the invention describes a new class of polymeric nanoparticles as smart Tl contrast agent for MR imaging for breast cancer early detection. These nanoparticles contrast agents have the capability to remain switched off during circulation and then switch on their imaging capacity upon arrival at the target sites (tissue of interest). These smart nanoparticles contrast agent are self-assembled from pH sensitive amphiphilic polymer, loaded with Gadolinium (Gd
3+ ) complex based Tl agent and then fitted with targeting biomolecules such as antibody, small molecules or DNA to increase its specificity toward the target of interest.

9. 发明公开

EP4337245A1 ISOLATED OR ARTIFICIAL NUCLEOTIDE SEQUENCES FOR USE IN NEURODEGENERATIVE DISEASES 审中-实审
公开(公告)号：EP4337245A1
公开(公告)日：2024-03-20
申请号：EP22731306.1
申请日：2022-05-13
申请人： Universidade Do Algarve
发明人： RODRIGUES NÓBREGA, Clévio David , CAVACO KOPPENOL, Rebekah , DO VALE MARCELO, Adriana Isabel , VIEIRA DA CONCEIÇÃO, André Filipe
IPC分类号： A61K38/46 , A61K48/00 , A61K31/713 , A61P25/28

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