专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2326664A2 A GAMMACARBOXYGLUTAMATE-RICH PROTEIN, METHODS AND ASSAYS FOR ITS DETECTION, PURIFICATION AND QUANTIFICATION AND USES THEREOF 审中-公开
标题翻译： FOR ITS，其纯化及其量化AND A GAMMACARBOXYGLUTAMATREICHES蛋白质，方法和检测方法及其用途
公开(公告)号：EP2326664A2
公开(公告)日：2011-06-01
申请号：EP09737193.4
申请日：2009-08-27
申请人： Universidade Do Algarve
发明人： FERNANDES RODRIGUES DA COSTA SIMES, Dina Cristina , SÃO BENTO VIEGAS, Carla Alexandra , QUINTAIS CANCELA DA FONSECA, Maria Leonor
IPC分类号： C07K14/435
CPC分类号： C07K14/461 , C07K14/46 , C07K14/78 , C07K16/18 , G01N33/68 , G01N33/6893
摘要： The present invention refers to a gammacarboxyglutamate -rich protein that shows in vivo a high capacity to bind calcium through specific gamma carboxylated glutamic acid residues (Gla). It includes a description of the referred protein, purification procedures, protein detection and quantification tools and methods.. This invention also refers to a kit for the detection and quantification of said protein in samples. This kit includes the use of one or more antibodies produced against the homologous sequence of the target species to be analyzed, and thus, methods for the production of such antibodies are disclosed as well. In another aspect of the invention, the methods and tools described hereby are used as biomarkers for evaluation of presence or risk to develop certain diseases. In another aspect of this invention, available complete GRP cDNA and gene sequences obtained from several species also enable the in vitro production of antigens, the quantification of GRP expression, the screening of GRP polymorphisms to access the predisposition for certain diseases and the screening for GRP mutations.
摘要翻译：当前盘游离缺失的主题是指富gammacarboxyglutamate蛋白确实显示了在体内通过特定的γ羧化谷氨酸残基（GLA）结合钙的高容量。它包括由蛋白质，纯化方法，蛋白检测和定量的工具和方法的称为的描述。一种用于所述蛋白质的样品中检测和定量试剂盒是预期的。该试剂盒可以包括使用对目标物种的同源序列产生的一种或多种抗体被分析，并且因此，用于生产检测抗体的方法是游离缺失盘以及。在另一个方面中，所述方法和在此所描述的工具可以被用作生物标志物的存在或风险评估开发某些疾病。在游离缺失的主题的光盘的另一个方面中，从几个物种中获得可用的完整GRP cDNA和基因序列从而能够在体外生产抗原，GRP表达的定量，GRP多态性的筛选以访问某些疾病和筛选易感性 GRP的突变。

IPRDB

热门服务

关于我们

友情链接

联系方式