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1. 发明公开

EP3392663A1 METALLIC DEVICE FOR SCANNING PROBE MICROSCOPY AND METHOD FOR MANUFACTURING SAME 审中-公开
公开(公告)号：EP3392663A1
公开(公告)日：2018-10-24
申请号：EP16875011.5
申请日：2016-12-13
申请人： Universidade Federal De Minas Gerais - UFMG , Instituto Nacional de Metrologia Qualidade e Tecnologia - Inmetro
发明人： DE LOURENÇO E VASCONCELOS, Thiago , SANTOS DE OLIVEIRA, Bruno , ALBERTO ACHETE, Carlos , SOARES ARCHANJO, Bráulio , JORIO DE VASCONCELOS, Ado , DE OLIVEIRA LOPES CANÇADO, Luiz Gustavo , NUNES RODRIGUES, Wagner , ARANTES DA SILVA WETZSTEIN, Caroline , VALASKI, Rogerio , RABELO E SILVA, Cassiano
IPC分类号： G01Q70/16 , G01Q60/38 , G01R1/067
CPC分类号： G01Q60/22 , G01Q70/10 , G01R1/067
摘要： The present invention relates to a device for uses in scanning probe microscopy and to a method for manufacturing same. The metallic device comprises a single body (1) with two parts (2) and (3), wherein the second part (3) has a submicrometric point (4) that defines a nanoscale apex (7). The present invention also provides a method for manufacturing a high optical efficiency probe for scanning probe microscopy.

2. 发明公开

EP2899198A1 SYNTHETIC PNTX(19) PEPTIDE, PHARMACEUTICAL COMPOSITIONS AND USE 有权
标题翻译： SYNTHETISCHES PNTX（19）-PEPTIDE，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN UND VERWENDUNG
公开(公告)号：EP2899198A1
公开(公告)日：2015-07-29
申请号：EP13831141.0
申请日：2013-08-20
申请人： Universidade Federal de Minas Gerais - UFMG
发明人： DE LIMA PEREZ GARCIA, Maria Elena , NUNES DA SILVA, Carolina , DE MARCO ALMEIDA, Flávia , DA SILVA LOMEO, Rosangela , LACERDA BEIRÃO, Paulo Sérgio , SILVA TORRES, Fernanda , MONTEIRO DE CASTRO PIMENTA, Adriano
IPC分类号： C07K7/08 , A61K38/10 , A61P15/10
CPC分类号： C07K14/43518 , A61K38/00 , A61K38/10 , C07K7/08
摘要： The present invention relates to a synthetic peptide of 19 amino acids, called PnTx(19), constituted from the sequence of the native toxin PnTx2-6 of the Phoneutria nigriventer spider. It also relates to pharmaceutical compositions containing such a peptide and to the use thereof in the treatment of erectile dysfunction and/or in potentiating the erectile function.
摘要翻译：本发明涉及由Phoneutria nigriventer蜘蛛的天然毒素PnTx2-6的序列构成的称为PnTx（19）的19个氨基酸的合成肽。它还涉及含有这种肽的药物组合物及其在治疗勃起功能障碍和/或增强勃起功能中的用途。

3. 发明公开

EP2499981A1 ELECTROCAUTERY DEVICE SPECIFIC TO HEPATOTOMY ENHANCED WITH IONIC SOLUTION 审中-公开
标题翻译：与离子溶液尤其是对增强HEPATOTOMIEN SUITABLE电灼
公开(公告)号：EP2499981A1
公开(公告)日：2012-09-19
申请号：EP10829389.5
申请日：2010-11-10
申请人： Universidade Federal De Minas Gerais - UFMG
发明人： DE REZENDE NETO, João Baptista
IPC分类号： A61B18/12
CPC分类号： A61B18/1477 , A61B2018/00029 , A61B2018/00529 , A61B2018/00595 , A61B2018/1425 , A61B2018/1472 , A61B2218/002
摘要： The present invention deals with a device capable of cauterizing tissues, especially of the liver. The electrocautery device can reach variable depths for cauterization, through its elongated stems (5). To improve the cauterizing capacity of the device, it uses an ionic solution that passes through a tube (6), inside the handle (2) of the device, which results in a significant reduction of the surgical time and of the perioperative bleeding. Despite being invasive, the invention proposed here did not alter significantly the hepatic transaminase levels which correspond to the preservation of the hepatic tissue adjacent to the area of the removal of the liver.
摘要翻译：与设备能够烧灼组织的本发明的交易，爱的尤其是肝脏。电烙器装置可用于烧灼达到可变的深度通过其细长杆（5）。为了提高烧灼装置的容量时，它使用离子溶液来处理确实穿过管（6）内的（2）的装置，这导致和围手术期出血的显著减少的手术时间的。尽管是侵入性的，这里提出的发明并没有明显的对应于肝组织毗邻切除肝脏的面积保存改变肝转氨酶水平。

4. 发明公开

EP2335711A2 EXTRACT OF HANCORNIA SPECIOSA AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：药物津巴布韦大学
公开(公告)号：EP2335711A2
公开(公告)日：2011-06-22
申请号：EP09749353.0
申请日：2009-05-19
申请人： Universidade Federal de Minas Gerais-UFMG
发明人： CASTRO BRAGA, Fernão , DE FRANÇA CÔRTES, Steyner , CAROLINE DA SILVA, Grazielle , COUTINHO ENDRINGER, Denise
IPC分类号： A61K36/24 , A61K31/047 , A61K31/7048
CPC分类号： A61K36/24 , A61K31/047 , A61K31/351
摘要： The present invention describes a standardized extract obtained from the leaves of Hancornia speciosa Gomes (EHS), popularly known as "mangaba" in Brazil, as well as a standardized fraction with inhibiting activity on the angiotensin converting enzyme (ACE), and vasodilating, anti-hypertensive and antioxidant properties. The invention further relates to the preparation of pharmaceutical compositions that contain said extract or fractions derived from the extract of Hancornia speciosa Gomes leaves rich in cyclitols and flavonoids, as well as the use of same for the treatment of cardiovascular diseases such as arterial hypertension, atherosclerosis, stenosis, and non-limiting cardiac or cerebral ischaemia.
摘要翻译：本发明描述了从巴西通俗称为“mangaba”的Hancornia speciosa Gomes（EHS）的叶子获得的标准化提取物，以及对血管紧张素转换酶（ACE）具有抑制活性的标准化部分，以及血管扩张，抗 - 高血压和抗氧化性能。本发明进一步涉及药物组合物的制备，所述药物组合物含有所述提取物或衍生自富含星形醇和黄酮的Hancornia speciosa Gomes叶的提取物的级分，以及其用于治疗心血管疾病如动脉高血压，动脉粥样硬化，狭窄和非限制性心脏或脑缺血。

5. 发明公开

EP2305343A2 DEVICE FOR CONTROLLING AND MONITORING VACUUM PRESSURE IN SYSTEMS FOR THE SUCTION OF BIOLOGICAL SECRETIONS 审中-公开
标题翻译：设备技术控制和监控真空系统中的压力，恢复生物分泌物
公开(公告)号：EP2305343A2
公开(公告)日：2011-04-06
申请号：EP09731759.8
申请日：2009-04-17
申请人： Universidade Federal de Minas Gerais-Ufmg
发明人： PINOTTI BARBOSA, Marcos , LIMA CAMPOS, Shirley , CARVALHO SOARES, Fabrício , BARBOSA DE DEUS, José Renato
IPC分类号： A61M39/22 , A61M1/00 , A61M27/00 , A61M16/04
CPC分类号： A61M1/0031 , A61M1/0027 , A61M39/22 , A61M2210/1032
摘要： The present invention concerns a vacuum pressure control and monitoring device for aspiration of biological secretions from respiratory routes, as well as of other biological fluids. The proposed device consists of a vacuum pressure regulating valve integrated to a monitoring system, which can be coupled together a hospital vacuum network and portable aspiration apparatus in ambulatory and household environments. The said device is designed to control and monitor maximum vacuum aspiration pressures, in this way preventing injuries during aspiration procedures.
摘要翻译：本发明涉及一种真空压力控制和用于从呼吸途径生物分泌物抽吸监视装置，以及作为其他生物流体。所提出的装置的真空压力调节阀集成到一个监控系统，其可以被耦合在一起的医院真空网络和便携式抽吸装置在门诊和家庭环境中的besteht。所述装置被设计成控制和监视在这种方式中抽吸程序防止受伤最大真空抽吸压力。

6. 发明公开

EP2201391A2 METHOD AND DEVICE FOR MEASURING AND MONITORING 无效
标题翻译： VERFAHREN UND EINRICHTUNG ZUR MESSUNG UNDÜBERWACHUNG
公开(公告)号：EP2201391A2
公开(公告)日：2010-06-30
申请号：EP08800214.2
申请日：2008-09-11
申请人： Universidade Federal de Minas Gerais-Ufmg , Centro Federal De Educação Tecnológica De Minas Gerais- Cefet , Cemig Distribuição S.a.
发明人： GONÇALVES JOTA, Fabio , ROMEIRO DA SILVA JOTA, Patrícia , CARVALHAES NOBRE, Eduardo
IPC分类号： G01R22/00 , G01R21/133 , G01D4/00 , G05B13/00
CPC分类号： G01D4/004 , G01R22/063 , G01R22/10 , Y02B90/242 , Y02B90/246 , Y04S20/322 , Y04S20/42
摘要： A method and device for remotely measuring, monitoring and controlling physical quantities over digital communication networks is provided. The measured quantities are grouped by energy end-uses or type of energy produced. The present patent describes the hardware and software used to perform these measurements, monitoring and control actions. The method and associated devices provide the means to sub-divide the building energy consumption by its end-uses or into cost centers, so as to determine the “specific energy consumption” of each cost center, in terms of kWh/produced unit, kWh/m2, kWh/employee, for example. The system comprises four hierarchically interconnected layers. The first layer includes all the equipments and technologies involved in data acquisition (or actuation) in the monitored building. The second layer contains the equipments and the software for grouping the measurements gathered at each sampling instant by their end-use consumption or type of energy produced, which are responsible for storing the acquired data and sending them to a remote database server, via the Internet. The third layer is responsible for the authentication of each connection to the database server coming from the Web-Servers of the monitored buildings. The fourth layer incorporates the equipments and associated functions responsible for the reception, processing and storage of the data coming from all the monitored loads and for the control of the on-line access to these data (given to users with special privileges). The stored data are analyzed and processed by an application program in order to extract from them the relevant information.
摘要翻译：提供了一种通过数字通信网络远程测量，监控和控制物理量的方法和设备。测量的数量按能源最终用途或所产生的能量类型分组。本专利描述了用于执行这些测量，监视和控制动作的硬件和软件。方法和相关设备提供了通过其最终用途或成本中心对建筑物能耗进行细分的手段，以千瓦时/生产单位（kWh / kWh）来确定每个成本中心的“具体能源消耗” / m2，千瓦时/员工。该系统包括四个分层互连的层。第一层包括监控建筑物中数据采集（或启动）涉及的所有设备和技术。第二层包含设备和软件，用于将在每个采样时刻收集的测量值按其最终用途消耗或所产生的能量类型进行分组，负责通过互联网将所获取的数据存储并发送到远程数据库服务器。第三层负责对来自受监视建筑物的Web服务器的数据库服务器的每个连接的身份验证。第四层结合了负责接收，处理和存储来自所有监控负载的数据的设备和相关功能，以及用于控制对这些数据的在线访问（给予具有特权的用户）。存储的数据由应用程序分析和处理，以从中提取相关信息。

7. 发明公开

EP1389106A1 PREPARATION OF FORMULATIONS OF ANGIOTENSIN II AT1 RECEPTORS ANTAGONISTS FOR THE TREATMENT OF ARTERIAL HYPERTENSION, OTHER CARDIOVASCULAR ILLNESSES AND ITS COMPLICATIONS 审中-公开
标题翻译：血管紧张素II AT1受体拮抗剂的制造配方的动脉性高血压的治疗中，其他心血管疾病及其并发症
公开(公告)号：EP1389106A1
公开(公告)日：2004-02-18
申请号：EP02713951.8
申请日：2002-04-09
申请人： Universidade Federal de Minas Gerais-Ufmg
发明人： MILLAN, Rubén Dario Sinisterra , DOS SANTOS, Robson Algusto Souza , FREZARD, Frédéric Jean Georges , DE PAULA, Washington Xavier
IPC分类号： A61K31/4155 , A61K47/40 , A61P9/12
CPC分类号： A61K9/0002 , A61K9/1652 , A61K9/19 , A61K9/5036 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K38/085
摘要： Preparation of AT1 receptors antagonists formulations using the cyclodextrins, their derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular disease and their complications. Until now, no applications using the AT11 receptor antagonists and cyclodextrins or derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular diseases and their complications, was found in the technical state of art. The present invention is characterized by the combination of two different technologies: one is the molecular encapsulation of AT11 receptor antagonists in cyclodextrins and the other is the microencapsulation in biodegradable polymers. It also comprises the increase of the effectiveness of the AT11 receptor antagonists as well as an increase in their bio-availability. The present invention comprises a new more effective alternative for the treatment of arterial hypertension, other cardiovascular diseases and their complications.

8. 发明公开

EP4190305A1 TOOTH-WHITENING GEL COMPRISING MODIFIED NIOBIUM COMPOUNDS, METHOD AND USE 审中-实审
公开(公告)号：EP4190305A1
公开(公告)日：2023-06-07
申请号：EP21849693.3
申请日：2021-07-08
申请人： Universidade Federal De Minas Gerais - UFMG , Ondonto Tech Pesquisa e Inovação, Ltda
发明人： HEITMANN RODRIGUES, Ana Pacheli , ALVES DE OLIVEIRA, Luiz Carlos , BELCHIOR, Jadson Claudio , MORGAN DOS SANTOS ALVES, Luis Fernando , MAUAD DE ABREU, Fernando Antonio
IPC分类号： A61K6/00 , A61K6/17
摘要： The present technology relates to a product applied for teeth whitening based on the generation of active oxygen in the form of oxygen radical species in situ. The whitening gel comprises modified niobium compounds and its activity is maximized mainly if it is applied with hydrogen peroxide in low concentrations, from 1 to 10% (preferably 3% by mass), with stabilization by a thickener, preferably carbopol. The whitening gel can be used in teeth whitening without the need for additional light to the treatment, which allows its use in teeth whitening with greater efficiency than commercial products and with a significant potential to reduce side effects (hypersensitivity and inflammation). The developed product did not show cytotoxicity, and no significant inflammatory effect was observed in the pulp tissue. The present technology also describes a method for producing the whitening gel.

9. 发明公开

EP3362038A1 COSMETIC COMPOSITION HAVING PROBIOTIC BACTERIA 审中-公开
公开(公告)号：EP3362038A1
公开(公告)日：2018-08-22
申请号：EP16854666.1
申请日：2016-10-17
申请人： Natura Cosméticos S.A. , Universidade Federal De Minas Gerais - UFMG
发明人： DE MIRANDA CHAVES VASQUEZ PINTO, Luciana , DOMENES PALMIERI RODRIGUEZ, Débora , NICOLI, Jacques Robert , DOS SANTOS MARTINS, Flaviano , SOARES SILVA, Anna Karolina , DA SILVA, Simone Helena
IPC分类号： A61K8/99 , A61Q19/08 , A61Q19/00
CPC分类号： A61K8/99 , A61Q17/005 , A61Q19/08 , A61Q19/10
摘要： The present invention relates to a probiotic cosmetic formulation for the cosmetic treatment of the skin, comprising a microbiota and a cosmetically acceptable carrier. Preferably, betaines and/or prebiotic agents may be incorporated into said formulation. The invention also relates to the use of a microbiota in preparing said probiotic cosmetic formulation of the invention, and a method for the cosmetic treatment of the skin, which comprises administering to the skin of an individual the probiotic cosmetic formulation of the invention.

10. 发明授权

EP2899198B1 SYNTHETIC PNTX(19) PEPTIDE, PHARMACEUTICAL COMPOSITIONS AND USE 有权
标题翻译：合成PNTX（19）肽，药物组合物和用途
公开(公告)号：EP2899198B1
公开(公告)日：2018-05-02
申请号：EP13831141.0
申请日：2013-08-20
申请人： Universidade Federal De Minas Gerais - UFMG
发明人： DE LIMA PEREZ GARCIA, Maria Elena , NUNES DA SILVA, Carolina , DE MARCO ALMEIDA, Flávia , DA SILVA LOMEO, Rosangela , LACERDA BEIRÃO, Paulo Sérgio , SILVA TORRES, Fernanda , MONTEIRO DE CASTRO PIMENTA, Adriano
IPC分类号： C07K7/08 , A61K38/10 , A61P15/10 , A61K38/00 , C07K14/435
CPC分类号： C07K14/43518 , A61K38/00 , A61K38/10 , C07K7/08
摘要： The present invention relates to a synthetic peptide of 19 amino acids, called PnTx(19), constituted from the sequence of the native toxin PnTx2-6 of the Phoneutria nigriventer spider. It also relates to pharmaceutical compositions containing such a peptide and to the use thereof in the treatment of erectile dysfunction and/or in potentiating the erectile function.

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