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1. 发明公开

EP3363903A1 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING GRNAS 有权转让
公开(公告)号：EP3363903A1
公开(公告)日：2018-08-22
申请号：EP18159400.3
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/902 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/1137 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

2. 发明授权

EP0772619B2 IMMUNOMODULATORY OLIGONUCLEOTIDES 失效
标题翻译：免疫组织化学寡核苷酸
公开(公告)号：EP0772619B2
公开(公告)日：2010-12-08
申请号：EP95911630.2
申请日：1995-02-07
申请人： The University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
发明人： KRIEG, Arthur, M. , KLINMAN, Dennis , STEINBERG, Alfred D.
IPC分类号： C07H21/00 , C12Q1/68 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Oligonucleotides containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for treating diseases associated with immune system activation that are initiated by unmethylated CpG dinucleotides in a subject comprising administering to the subject oligonucleotides that do not contain unmethylated CpG sequences (i.e. methylated CpG sequences or no CpG sequence) to outcompete unmethylated CpG nucleic acids for binding. Further disclosed are methylated CpG containing dinucleotides for use in antisense therapies or as in vivo hybridization probes, and immunoinhibitory oligonucleotides for use as antiviral therapeutics.
摘要翻译：含有至少一种未甲基化的CpG二核苷酸用于药用的稳定的免疫刺激性寡核苷酸。

3. 发明公开

EP1167377A3 Immunomodulatory oligonucleotides 失效
标题翻译：免疫调节寡核苷酸
公开(公告)号：EP1167377A3
公开(公告)日：2004-09-08
申请号：EP01202811.4
申请日：1995-02-07
申请人： THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
发明人： Krieg, Arthur, M. , Klinman, Dennis , Steinberg, Alfred D.
IPC分类号： C07H21/00 , C12Q1/68 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Immunostimulatory phosphodiester oligonucleotides, which contain at least one unmethylated CpG dinucleotide, do not contain a six base palindrome and include more than eight, but no more than 100 nucleotides, for medicinal use.

4. 发明公开

EP4372090A3 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING GRNAS 审中-实审
公开(公告)号：EP4372090A3
公开(公告)日：2024-08-07
申请号：EP23219520.6
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63 , C12N15/11 , C12N9/22
CPC分类号： C12N15/63 , C12N15/111 , C12N15/1137 , C12N2310/1020130101 , C12N2310/2020170501 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

5. 发明公开

EP3283168A1 USE OF ANTI-PACAP ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR TREATMENT, PREVENTION, OR INHIBITION OF PHOTOPHOBIA 审中-公开
标题翻译：使用抗PACAP抗体和其抗原结合片段治疗，预防或抑制PHOTOPHOBIA
公开(公告)号：EP3283168A1
公开(公告)日：2018-02-21
申请号：EP16780943.3
申请日：2016-04-15
申请人： Alder Biopharmaceuticals, Inc. , The University of Iowa Research Foundation
发明人： ALLISON, Daniel S. , HENDRIX, Katherine Lee , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , RUBIN, Vanessa Lisbeth , BILLGREN, Jens J. , KUBURAS, Adisa , MASON, Bianca , SOWERS, Levi P. , RUSSO, Andrew F. , LOOMIS, Maria-Cristina , DUTZAR, Benjamin H. , GARCIA-MARTINEZ, Leon
IPC分类号： A61P25/06 , A61K39/395
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

6. 发明授权

EP0772619B1 IMMUNOMODULATORY OLIGONUCLEOTIDES 失效
标题翻译：免疫调节寡核苷酸
公开(公告)号：EP0772619B1
公开(公告)日：2006-06-07
申请号：EP95911630.2
申请日：1995-02-07
申请人： The University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
发明人： KRIEG, Arthur, M. , KLINMAN, Dennis , STEINBERG, Alfred D.
IPC分类号： C07H21/00 , C12Q1/68 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68

7. 发明授权

EP3066201B1 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING GRNAS 有权转让
标题翻译： CRISPR相关方法和具有治疗GRNA的组合物
公开(公告)号：EP3066201B1
公开(公告)日：2018-03-07
申请号：EP14802772.5
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/902 , C12N9/22 , C12N15/11 , C12N15/111 , C12N15/1137 , C12N15/63 , C12N2310/10 , C12N2310/20 , C12N2800/80
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

8. 发明公开

EP3062717A1 PERCUTANEOUS TRANSVERSE CONNECTOR SYSTEM 有权
标题翻译： PERKUTANES QUERVERBINDERSYSTEM
公开(公告)号：EP3062717A1
公开(公告)日：2016-09-07
申请号：EP14858273.7
申请日：2014-10-30
申请人： The University of Iowa Research Foundation
发明人： VILJOEN, Stephanus, V. , GROSSBACH, Andrew
IPC分类号： A61B17/70 , A61B17/80 , A61B17/88
CPC分类号： A61B17/7089 , A61B17/7043 , A61B17/7049 , A61B17/7052 , A61B17/7076 , A61B17/7083 , A61B17/7085
摘要： A system and method for stabilizing a spine of an animal subject involving a transverse rod installation instrument assembly for inserting a transverse rod on the spine of a subject percutaneously comprising: a first rod clamp extender mounted on a ipsilateral rod clamp and a second rod clamp extender mounted on a contralateral rod clamp wherein the ipsilateral rod clamp and the contralateral rod clamp are secured to a vertebra at the ipsilateral and contralateral pedicle; and a pivoting installation instrument pivotab!y mounted to the first rod clamp extender and the second rod clamp extender to pass a transverse rod percutaneously through a head portion of the ipsilateral side rod clamp and to the head portion of the contralateral rod clamp after passing through a spinous process of the vertebra through pivot axis "A" such that the transverse rod Is secured at the head portion of the ipsilateral rod clamp and the head portion of the contralateral rod clamp.
摘要翻译：一种用于稳定涉及横杆安装仪器组件的动物受试者的脊柱的系统和方法，用于将横向杆经皮经皮插入到脊柱上，包括：安装在同侧杆夹上的第一杆夹持器和第二杆夹持器安装在对侧杆夹上，其中同侧杆夹和对侧杆夹固定在同侧和对侧椎弓根的椎骨上; 以及枢转安装装置，其可枢转地安装到第一杆夹具延伸器和第二杆夹持器延伸器，以使穿过横向杆经由同侧侧杆夹的头部部分穿过横向杆并穿过棘突后的对侧杆夹的头部椎骨通过枢转轴线“A”的过程，使得横杆固定在同侧杆夹的头部和对侧杆夹的头部。

9. 发明公开

EP1167377A2 Immunomodulatory oligonucleotides 失效
标题翻译：免疫调节剂寡核苷酸
公开(公告)号：EP1167377A2
公开(公告)日：2002-01-02
申请号：EP01202811.4
申请日：1995-02-07
申请人： THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
发明人： Krieg, Arthur, M.
IPC分类号： C07H21/00 , C12Q1/68 , A61K31/70
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Immunostimulatory phosphodiester oligonucleotides, which contain at least one unmethylated CpG dinucleotide, do not contain a six base palindrome and include more than eight, but no more than 100 nucleotides, for medicinal use.
摘要翻译：含有至少一个未甲基化的CpG二核苷酸的免疫刺激磷酸二酯寡核苷酸不含有六碱基回文，并且包括用于药用的多于八个，但不超过100个核苷酸。

10. 发明公开

EP4372090A2 CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING GRNAS 审中-实审
公开(公告)号：EP4372090A2
公开(公告)日：2024-05-22
申请号：EP23219520.6
申请日：2014-11-07
申请人： Editas Medicine, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology , The University of Iowa Research Foundation
发明人： PALESTRANT, Deborah , MATA-FINK, Jordi , BORISY, Alexis , ZHANG, Feng , DAVIDSON, Beverly , RODRIGUEZ, Edgardo
IPC分类号： C12N15/63
CPC分类号： C12N15/63 , C12N15/111 , C12N15/1137 , C12N2310/1020130101 , C12N2310/2020170501 , C12N9/22
摘要： Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.

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