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1. 发明公开

EP3283517A2 ANTI-PACAP ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗PACAP抗体及其用途
公开(公告)号：EP3283517A2
公开(公告)日：2018-02-21
申请号：EP16780954.0
申请日：2016-04-15
申请人： Alder Biopharmaceuticals, Inc.
发明人： ALLISON, Daniel, S. , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey, T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , HENDRIX, Katherine Lee , RUBIN, Vanessa Lisbeth , BILLGREN, Jens,J. , LOOMIS, Maria-Cristina , DUTZAR, Benjamin, H. , GARCIA-MARTINEZ, Leon
IPC分类号： C07K16/18 , A61P25/06 , A61K38/00
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

2. 发明公开

EP2972330A4 PROTOCOL FOR IDENTIFYING AND ISOLATING ANTIGEN-SPECIFIC B CELLS AND PRODUCING ANTIBODIES TO DESIRED ANTIGENS 审中-公开
标题翻译：协议鉴别和分离抗原特异性B细胞和抗体的所需抗原的制造
公开(公告)号：EP2972330A4
公开(公告)日：2016-10-26
申请号：EP14764593
申请日：2014-03-18
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： ALLISON DANIEL S , DUTZAR BENJAMIN H , GARCIA-MARTINEZ LEON F , ANDERSON KATIE , OJALA ETHAN W , LATHAM JOHN A , BILLGREN JENS , JENSEN ANNE ELISABETH CARVALHO
IPC分类号： G01N33/50 , C07K16/18 , C07K16/22 , C07K16/40 , G01N33/569
CPC分类号： G01N33/56972 , C07K16/18 , C07K16/22 , C07K16/40 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/5052

3. 发明公开

EP1678314A1 METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY 有权
标题翻译：法合成异源二聚体多肽利用酵母一个HAPLOIDPAARUNGSSTRATEGIE
公开(公告)号：EP1678314A1
公开(公告)日：2006-07-12
申请号：EP04796313.7
申请日：2004-10-22
申请人： Keck Graduate Institute , ALDER BIOPHARMACEUTICALS, INC.
发明人： CREGG, James M. , LATHAM, John , LITTON, Mark , SCHATZMAN, Randall , TOLSTORUKOV, Ilya I.
IPC分类号： C12P21/04 , C12N15/74
CPC分类号： C07K16/2896 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K2317/24 , C12N15/81 , C12N15/815
摘要： Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.

5. 发明公开

EP3233916A4 HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF 审中-公开
公开(公告)号：EP3233916A4
公开(公告)日：2018-06-06
申请号：EP15871177
申请日：2015-12-18
申请人： ALDER BIOPHARMACEUTICALS INC
发明人： FELDHAUS ANDREW L , GARCIA-MARTINEZ LEON F , DUTZAR BENJAMIN H , ALLISON DANIEL S , ANDERSON KATIE , OJALA ETHAN W , FAN PEI , KARASEK CHARLIE , MULLIGAN JENNY , MITCHELL DANIELLE , MCNEILL PATRICIA DIANNE , SCALLEY-KIM MICHELLE , STEWART ERICA , SMITH JEFFREY T L , LATHAM JOHN
IPC分类号： C07K16/26 , A61K39/00 , A61K39/395 , A61K45/06 , C07K16/42
CPC分类号： C07K16/26 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/4241 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2317/92
摘要： The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as CAH, FGD, Cushing's Disease, Cushing's Syndrome, Parkinson's disease, obesity, diabetes, sleep disorders, depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer's disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.

6. 发明公开

EP2972330A2 PROTOCOL FOR IDENTIFYING AND ISOLATING ANTIGEN-SPECIFIC B CELLS AND PRODUCING ANTIBODIES TO DESIRED ANTIGENS 审中-公开
标题翻译：协议鉴别和分离抗原特异性B细胞和抗体的所需抗原的制造
公开(公告)号：EP2972330A2
公开(公告)日：2016-01-20
申请号：EP14764593.1
申请日：2014-03-18
申请人： ALDER BIOPHARMACEUTICALS, INC.
发明人： ALLISON, Daniel, S. , DUTZAR, Benjamin, H. , GARCIA-MARTINEZ, Leon, F. , ANDERSON, Katie , OJALA, Ethan, W. , LATHAM, John, A. , BILLGREN, Jens , JENSEN, Anne, Elisabeth Carvalho
IPC分类号： G01N33/50
CPC分类号： G01N33/56972 , C07K16/18 , C07K16/22 , C07K16/40 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/5052
摘要： Methods of identifying antigen-specific antibody-secreting and antibody-forming cells, such as antigen-specific B cells, and methods for cloning the antigen-specific antibody sequences of the antibody produced by these cells are provided. In particular, the methods include enriching B cells for antigen-specific B cells, culturing the antigen-specific B cells to generate clonal B cell populations, detecting clonal B cells that produce a single antigen-specific antibody, optionally screening the clonal B cell populations for functional activity, staining and sorting the cells to isolate the antigen-specific B cells, sequencing the nucleic acids encoding the antigen-specific antibody sequences, expressing the sequences to produce an antibody, isolating the antibody and screening the antibody for antigen recognition. The methods provide improved enrichment and selection of antigen-specific antibody-secreting and antibody-forming cells, which enhances recovery of antigen-specific antibodies.

7. 发明公开

EP2970865A1 ANTIBODY PURIFICATION AND PURITY MONITORING 有权转让
标题翻译：抗体纯化和纯度监测
公开(公告)号：EP2970865A1
公开(公告)日：2016-01-20
申请号：EP14763076.8
申请日：2014-03-17
申请人： Alder Biopharmaceuticals, Inc.
发明人： LATHAM, John, A. , GARCIA-MARTINEZ, Leon, F. , ALLISON, Daniel, S. , DAVIN, Steven, D. , DO, Hoa, Binh , LEE, Geoffrey, F. , OJALA, Ethan, W. , YOUNG, Mark
IPC分类号： C12N1/19
摘要： Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as Pichia pastoris, and the glycosylated impurity is a glycovariant of the desired recombinant polypeptide, such as an N-linked and/or O-linked glycovariant.
摘要翻译：公开了生产和纯化重组蛋白的方法。特别地，本公开提供了产生和纯化在酵母或丝状真菌细胞中表达的多亚基蛋白质的方法。监测这些蛋白质的杂质的产生和/或纯化，优选使用凝集素结合分析，以便可以调整一个或多个工艺参数以最大化所需重组蛋白的量并使糖基化杂质的量最小化。还可以监测过程中是否有其他不需要的产品相关杂质，例如聚集体和核酸。在示例性实施方案中，重组蛋白质是多亚基蛋白质，例如抗体，宿主细胞是酵母，例如巴斯德毕赤酵母（Pichia pastoris），并且糖基化杂质是所需重组多肽的糖变体，例如N-连接的和/ 或O-连接的糖变体。

8. 发明授权

EP1678314B1 METHODS OF SYNTHESIZING HETEROMULTIMERIC POLYPEPTIDES IN YEAST USING A HAPLOID MATING STRATEGY 有权
标题翻译： VERFAHREN ZUR合成HETERMULTIMERER多肽在HEFE UNTER VERWENDUNG EINER HAPLOIDPAARUNGSSTRATEGIE
公开(公告)号：EP1678314B1
公开(公告)日：2012-09-05
申请号：EP04796313.7
申请日：2004-10-22
申请人： Keck Graduate Institute , ALDER BIOPHARMACEUTICALS, INC.
发明人： CREGG, James M. , LATHAM, John , LITTON, Mark , SCHATZMAN, Randall , TOLSTORUKOV, Ilya I.
IPC分类号： C12N15/81 , C07K16/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K2317/24 , C12N15/81 , C12N15/815
摘要： Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.
摘要翻译：提供了用于合成和分泌交配感受态酵母中重组异源多聚体蛋白的方法。将第一表达载体转化为第一单倍体细胞; 并将第二表达载体转化成第二单倍体细胞。鉴定转化的单倍体细胞，每个细胞各自合成不相同的多肽，然后遗传交叉或融合。所得的二倍体菌株用于产生和分泌完全组装和生物功能的杂多聚体蛋白。

9. 发明公开

EP2330201A1 Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy 有权
标题翻译：法合成异源二聚体多肽利用酵母一个HAPLOIDPAARUNGSSTRATEGIE
公开(公告)号：EP2330201A1
公开(公告)日：2011-06-08
申请号：EP10183188.1
申请日：2004-10-22
申请人： Keck Graduate Institute , ALDER BIOPHARMACEUTICALS, INC.
发明人： Cregg, James M. , Latham, John , Litton, Mark , Schatzman, Randall , Tolstorukov, IIya I.
IPC分类号： C12N15/81 , C07K16/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K16/18 , C07K16/2809 , C07K2317/24 , C12N15/81 , C12N15/815
摘要： Methods are provided for the synthesis and secretion of recombinant hetero-multimeric proteins in mating competent yeast. A first expression vector is transformed into a first haploid cell; and a second expression vector is transformed into a second haploid cell. The transformed haploid cells, each individually synthesizing a non-identical polypeptide, are identified and then genetically crossed or fused. The resulting diploid strains are utilized to produce and secrete fully assembled and biologically functional hetero-multimeric protein.

10. 发明公开

EP2021463A1 CULTURE METHOD FOR OBTAINING A CLONAL POPULATION OF ANTIGEN-SPECIFIC B CELLS 有权
标题翻译：安装步骤OBTAINING抗原特异性B细胞的克隆群体
公开(公告)号：EP2021463A1
公开(公告)日：2009-02-11
申请号：EP07861311.4
申请日：2007-05-21
申请人： ALDER BIOPHARMACEUTICALS, INC.
发明人： GARCIA, Leon , JENSEN, Anne, Elisabeth, Carvalho , OJALA, Ethan , LATHAM, John
IPC分类号： C12N5/06 , C12N5/16
CPC分类号： C12Q1/6881 , C07K16/00 , C07K16/241 , C07K16/248 , C12N5/0635 , C12N2502/11
摘要： The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.

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