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1. 发明公开

EP4110045A1 CANNABINOID COMPOSITIONS 审中-实审
公开(公告)号：EP4110045A1
公开(公告)日：2023-01-04
申请号：EP21760253.1
申请日：2021-02-24
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , NEUPANE, Ram P. , SUZUKI, Sayuri , FAOUZI, Malika
IPC分类号： A01H6/28 , C12P7/42 , B01D11/02 , A61K31/352 , C12N15/82 , A61P29/00

2. 发明公开

EP3117768A1 MOTION TRACKING SYSTEM FOR REAL TIME ADAPTIVE IMAGING AND SPECTROSCOPY 有权
标题翻译：运动跟踪系统的实时自适应图像和光谱
公开(公告)号：EP3117768A1
公开(公告)日：2017-01-18
申请号：EP15202598.7
申请日：2007-05-18
申请人： The Queen's Medical Center , The University of Hawaii , The Medical College of Wisconsin, Inc. , UWM Research Foundation, Inc.
发明人： ERNST, Thomas, Michael , ARMSTRONG, Brian, Stewart, Randall , PRIETO, Thomas, Edmund
IPC分类号： A61B5/055 , G01R33/00 , A61B6/03 , A61B5/00 , A61B6/04 , A61B6/00 , A61B5/11 , G01R33/28 , G01R33/565 , G06K9/00 , G06T7/00 , H04N7/18 , G06K9/32 , G06K17/00
摘要： This invention relates to a system that adaptively compensates for subject motion in real-time in an imaging system. An object orientation marker (30), preferably a retro-grate reflector (RGR), is placed on the head or other body organ of interest of a patient (P) during a scan, such as an MRI scan. The marker (30) makes it possible to measure the six degrees of freedom (x, y, and z-translations, and pitch, yaw, and roll), or 'pose', required to track motion of the organ of interest. A detector, preferably a camera (40), observes the marker (30) and continuously extracts its pose. The pose from the camera (40) is sent to the scanner (120) via an RGR processing computer (50) and a scanner control and processing computer (100), allowing for continuous correction of scan planes and position (in real-time) for motion of the patient (P). This invention also provides for internal calibration and for co-registration over time of the scanner's and tracking system's reference frames to compensate for drift and other inaccuracies that may arise over time.

3. 发明公开

EP2950714A1 MOTION TRACKING SYSTEM FOR REAL TIME ADAPTIVE MOTION COMPENSATION IN BIOMEDICAL IMAGING 审中-公开
标题翻译： BEWEGUNGSVERFOLGUNGSSYSTEMFÜRECHTZEIT-ADAPTIVE BEWEGUNGSKOMPENSATION IN DER BIOMEDIZINISCHEN BILDGEBUNG
公开(公告)号：EP2950714A1
公开(公告)日：2015-12-09
申请号：EP14745503.4
申请日：2014-01-29
申请人： Kineticor, Inc. , The University of Hawaii , The Queen's Medical Center
发明人： YU, Jeffrey N. , ERNST, Thomas Michael
IPC分类号： A61B5/055 , A61B6/00
CPC分类号： A61B6/527 , A61B5/055 , A61B5/721 , A61B6/032 , A61B6/037 , A61B6/0492 , G01R33/283 , G01R33/5608 , G01R33/56509 , G06F19/00 , G06T7/0012 , G06T7/207 , G06T7/73 , G06T2200/04 , G06T2207/10072 , G06T2207/30004 , G06T2211/428
摘要： The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion. The detector processing interface is configured to send the tracking data to a scanner controller to enable adjustment of scanning parameters in real-time in response to the patient's motion.
摘要翻译：本文的公开内容提供用于在生物医学成像期间跟踪患者或感兴趣对象的运动并用于补偿生物医学成像扫描仪中的该运动和/或所得到的图像以减少或消除运动伪影的方法，系统和装置。在一个实施例中，运动跟踪系统被配置为在生物医学成像数据上覆盖跟踪数据，以便显示跟踪数据及其相关联的图像数据。在一个实施例中，运动跟踪系统被配置为在生物医学成像数据上覆盖跟踪数据，以便显示跟踪数据及其相关联的图像数据。在一个实施例中，一个或多个检测器被配置为检测患者的图像，并且检测器处理界面被配置为分析图像以估计患者的运动或移动并产生描述患者运动的跟踪数据。检测器处理接口被配置为将跟踪数据发送到扫描仪控制器，以便能够响应于患者的运动实时地调整扫描参数。

4. 发明授权

EP2021798B1 METHODS OF SCREENING FOR TRPM4 MODULATORS OF INSULIN SECRETION 有权
标题翻译： FOR TRPM4筛选方法调节剂的胰岛素分泌
公开(公告)号：EP2021798B1
公开(公告)日：2013-04-24
申请号：EP07762333.8
申请日：2007-05-25
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , FLEIG, Andrea
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/507 , G01N33/6872 , G01N2333/62 , G01N2333/705 , G01N2800/042

5. 发明公开

EP1337635A2 HUMAN LTRPC7 PROTEINS, NUCLEIC ACID MOLECULES ENCODING THEM, AND USES THEREOF 有权
标题翻译：人文LTRPC7蛋白质，核酸编码及其用途
公开(公告)号：EP1337635A2
公开(公告)日：2003-08-27
申请号：EP01270129.8
申请日：2001-11-13
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , FLEIG, Andrea
IPC分类号： C12N15/12 , C07K14/705 , G01N33/53
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04
摘要： The present invention relates to the identification and isolation of a novel family of ATP regulated calcium transmembrane channel polypeptides designated herein as 'LTRPC7' (Long Transient Receptor Potential Channel). Channels comprising these polypeptides close in response to concentrations of cytoplasmic ATP in the millimolar range, are subject to inhibition by high intracellular levels of calcium and/or magnesium, and do not respond to depletion or reduction in intracellular calcium stores. The invention further relates to the methods of utilizing LTRPC7 for binding, and the methods for modulating LTRPC7 activity and for measuring LTRPC2 permeability. The invention further relates to the methods of modulating expression of LTRPC7.

6. 发明授权

EP2135076B1 FUNCTIONAL IDENTIFICATION OF PROTEINS UNDERLYING ICRAC ACTIVITY IN A CELL 有权
标题翻译：在细胞中ICRAC活性的功能识别是基于蛋白
公开(公告)号：EP2135076B1
公开(公告)日：2016-09-28
申请号：EP08732683.1
申请日：2008-03-21
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , FLEIG, Andrea
IPC分类号： G01N33/50
CPC分类号： G01N33/6872 , G01N2500/10

7. 发明授权

EP1573322B1 METHODS OF SCREENING FOR TRPM4b MODULATORS 有权
标题翻译：筛选方法，TRPM4b调节剂
公开(公告)号：EP1573322B1
公开(公告)日：2015-12-23
申请号：EP03808373.9
申请日：2003-05-02
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , FLEIG, Andrea
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , C40B30/06 , G01N2500/00

8. 发明公开

EP1573322A2 METHODS OF SCREENING FOR TRPM4b MODULATORS 有权
标题翻译：筛选方法，TRPM4b调节剂
公开(公告)号：EP1573322A2
公开(公告)日：2005-09-14
申请号：EP03808373.9
申请日：2003-05-02
申请人： The Queen's Medical Center
发明人： PENNER, Reinhold , FLEIG, Andrea
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , C40B30/06 , G01N2500/00
摘要： The invention relates, in part, to methods useful in identifying molecules, that bind TRPM4b, which modulate TRPM4b ion channel activity, and/or which alter expression of TRPM4b within cells. The TRPM4b channels as described herein comprise TRPM4b polypeptides, which are in turn encoded by TRPM4b nucleic acids. The ion channels described herein are preferably formed in HEK-293 cells and comprise one or more novel TRPM4b polypeptides, which exhibit one or more of the unique TRPM4b properties described herein.

9. 发明公开

EP2950714A4 MOTION TRACKING SYSTEM FOR REAL TIME ADAPTIVE MOTION COMPENSATION IN BIOMEDICAL IMAGING 审中-公开
标题翻译： BEWEGUNGSVERFOLGUNGSSYSTEMFÜRECHTZEIT-适应BEWEGUNGSKOMPENSATION DER DER BIOMEDIZINISCHEN BILDGEBUNG
公开(公告)号：EP2950714A4
公开(公告)日：2017-08-16
申请号：EP14745503
申请日：2014-01-29
申请人： KINETICOR INC , THE UNIV OF HAWAII , THE QUEEN'S MEDICAL CENTER
发明人： YU JEFFREY N , ERNST THOMAS MICHAEL
IPC分类号： G01R33/28 , A61B5/055 , A61B6/00 , G01R33/565
CPC分类号： A61B6/527 , A61B5/055 , A61B5/721 , A61B6/032 , A61B6/037 , A61B6/0492 , G01R33/283 , G01R33/5608 , G01R33/56509 , G06T7/0012 , G06T7/207 , G06T7/73 , G06T2200/04 , G06T2207/10072 , G06T2207/30004 , G06T2211/428
摘要： The disclosure herein provides methods, systems, and devices for tracking motion of a patient or object of interest during biomedical imaging and for compensating for that motion in the biomedical imaging scanner and/or the resulting images to reduce or eliminate motion artifacts. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, a motion tracking system is configured to overlay tracking data over biomedical imaging data in order to display the tracking data along with its associated image data. In an embodiment, one or more detectors are configured to detect images of a patient, and a detector processing interface is configured to analyze the images to estimate motion or movement of the patient and to generate tracking data describing the patient's motion. The detector processing interface is configured to send the tracking data to a scanner controller to enable adjustment of scanning parameters in real-time in response to the patient's motion.
摘要翻译：本文的公开内容提供了用于在生物医学成像期间跟踪患者或感兴趣对象的运动并用于补偿生物医学成像扫描仪中的运动和/或所得图像以减少或消除运动伪影的方法，系统和设备。在一个实施例中，运动跟踪系统被配置为在生物医学成像数据上覆盖跟踪数据以显示跟踪数据及其相关联的图像数据。在一个实施例中，运动跟踪系统被配置为在生物医学成像数据上覆盖跟踪数据以显示跟踪数据及其相关联的图像数据。在一个实施例中，一个或多个检测器被配置成检测患者的图像，并且检测器处理接口被配置为分析图像以估计患者的运动或运动并生成描述患者运动的追踪数据。检测器处理接口被配置为将跟踪数据发送到扫描仪控制器以实现响应于患者的运动而实时调整扫描参数。

10. 发明公开

EP2013627A2 CRAC MODULATORS AND USE OF SAME FOR DRUG DISCOVERY 审中-公开
标题翻译： CRAC调节剂及其用于药物发现的用途
公开(公告)号：EP2013627A2
公开(公告)日：2009-01-14
申请号：EP07760408.0
申请日：2007-04-10
申请人： The Queen's Medical Center
发明人： FLEIG, Andrea , PENNER, Reinhold , KINET, Jean-Pierre , VIG, Monika
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , C12N15/113 , C12N2310/11 , C12N2310/14 , G01N33/5038
摘要： The invention relates to use of a calcium release activated Ca+2 (CRAC) channel (CRACM) such as CRACM1 and CRACM2 to identify bioactive agents which can modulate store operated calcium entry and CRAC channel activity. The invention further relates to the use of recombinant nucleic acids that encode CRACM. One aspect of the invention includes methods of determining binding of candidate bioactive agents to a CRACM polypeptide and for determining modulation of CRACM polypeptide activity as it affects CRAC channel permeability. The invention further relates to methods and compositions modulating the cellular expression of the nucleic acids that encode CRACM.
摘要翻译：本发明涉及钙释放活化的Ca +2（CRAC）通道（CRACM）如CRACM1和CRACM2的用途，以鉴定可调节存储操作的钙进入和CRAC通道活性的生物活性剂。本发明进一步涉及编码CRACM的重组核酸的用途。本发明的一个方面包括确定候选生物活性剂与CRACM多肽的结合和确定CRACM多肽活性的调节因为其影响CRAC通道渗透性的方法。本发明进一步涉及调节编码CRACM的核酸的细胞表达的方法和组合物。

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