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1. 发明授权

EP3006044B1 COMBINATION OF ANTI-ACID-FAST BACTERIAL AGENTS 有权
公开(公告)号：EP3006044B1
公开(公告)日：2020-07-15
申请号：EP14807892.6
申请日：2014-06-03
申请人： Microbial Chemistry Research Foundation , THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： ISHIZAKI, Yoshimasa , IGARASHI, Masayuki , BRENNAN, Patrick Joseph , CRICK, Dean Calvin
IPC分类号： A61K31/7072 , A61K31/496 , A61P31/04 , C12Q1/04 , A61K45/06 , A61K31/551 , C07H19/067

2. 发明公开

EP2305272A1 Use of equol for treating skin diseases 审中-公开
标题翻译： Verwendung von Equol zur Behandlung von Hauterkrankungen
公开(公告)号：EP2305272A1
公开(公告)日：2011-04-06
申请号：EP10194495.7
申请日：2005-02-17
申请人： Brigham Young University , Children's Hospital Medical Center , THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： Lephart, Edwin Douglas , Lund, Trent D , Setchell, Kenneth David Reginald , Handa, Robert J
IPC分类号： A61K31/7048 , A61K31/353 , A61K47/00 , A61P17/00
CPC分类号： A61K31/353 , A61K8/498 , A61Q7/00 , A61Q15/00 , A61Q19/00 , A61Q19/08
摘要： Equol (7-hydroxy-3(4'hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5adihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies of skin and hair. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes affecting skin and hair.
摘要翻译：洋甘菊（7-羟基-3（4'-羟基苯基） - 苯并二氢吡喃）是植物雌激素黄豆苷原的主要代谢物，特异性结合并阻断了5位氢睾酮（DHT）在体外和体内的激素作用。 Equol可以结合循环免费的DHT并从雄激素受体中隔离，从而改变由雄激素调节的生长和生理激素反应。这些数据表明了一种解释牛尿酚生物学特性的新模型。雌激素特异性结合并从雄激素受体中螯合DHT的能力的意义在健康和疾病中具有重要的影响，并且可能表明在治疗和预防雄激素介导的皮肤和头发病理学中对牛尿酚具有广泛和重要的用途。因此，雌马酚可以特异性结合DHT并防止DHT在影响皮肤和头发的生理和病理生理过程中的生物学作用。

3. 发明授权

EP1094744B1 RETINAL VASCULATURE IMAGE ACQUISITION APPARATUS AND METHOD 有权
标题翻译：设备和方法，用于记录NETZHAUTVASKULATUR
公开(公告)号：EP1094744B1
公开(公告)日：2011-02-16
申请号：EP99932319.9
申请日：1999-07-07
申请人： THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： GOLDEN, Bruce, L. , ROLLIN, Bernard, E. , SWITZER, Ralph, V., Jr. , COMSTOCK, Carlton, R., Jr.
IPC分类号： A61B3/14 , A61B5/117 , A01K11/00
CPC分类号： A01K11/008 , A61B3/145 , A61B5/117 , A61B5/1171 , A61B5/411 , G06K9/00597 , G06K2009/00932
摘要： The present invention creates a permanent record of an animal through a series of steps including, preliminarily acquiring an image of the retinal vasculature of the animal of interest; digitizing that image if the image is not a digital image; analyzing the image to determine if the image is satisfactory for further analysis; storing the image; and analyzing the image for unique anatomical landmarks. The image and data gathered therefrom may be stored in a database for later retrieval and comparison against other images. The data gathered from the image may be compared against other stored data in the database to determine the identity of the animal. Preferably, the system would also include a global positioning system ("GPS") device which would simultaneously time and date stamp the acquired image as well as stamp the image with the location where the imaging took place by recording the latitude and longitude of that location.

4. 发明公开

EP1718149A2 SYSTEM IMMUNE ACTIVATION METHOD USING NON CpG NUCLEIC ACIDS 审中-公开
标题翻译：使用CPG NUCLEIC系统免疫激活技术
公开(公告)号：EP1718149A2
公开(公告)日：2006-11-08
申请号：EP05723350.4
申请日：2005-02-17
申请人： Juvaris Biotherapeutics, Inc. , THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： DOW, Steven, W. , FAIRMAN, Jeffery
IPC分类号： A01N43/04 , A61K31/70 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
CPC分类号： A61K9/1272
摘要： This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such method.

5. 发明公开

EP1740191A1 USE OF EQUOL FOR TREATING SKIN DISEASES 审中-公开
标题翻译：雌马酚的皮肤疾病治疗中的应用
公开(公告)号：EP1740191A1
公开(公告)日：2007-01-10
申请号：EP05723182.1
申请日：2005-02-17
申请人： Brigham Young University , Children's Hospital Medical Center , THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： LEPHART, Edwin, Douglas , LUND, Trent, D. , SETCHELL, Kenneth, David, Reginald , HANDA, Robert, J.
IPC分类号： A61K31/7048 , A61K31/353 , A61K47/00
CPC分类号： A61K31/353 , A61K8/498 , A61Q7/00 , A61Q15/00 , A61Q19/00 , A61Q19/08
摘要： [0177] Equol (7-hydroxy-3(4'hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5adihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies of skin and hair. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes affecting skin and hair.

6. 发明公开

EP1094744A1 RETINAL VASCULATURE IMAGE ACQUISITION APPARATUS AND METHOD 有权
标题翻译： GERÄTUND VERFAHREN ZUR BILDAUFNAHME DER NETZHAUTVASKULATUR
公开(公告)号：EP1094744A1
公开(公告)日：2001-05-02
申请号：EP99932319.9
申请日：1999-07-07
申请人： THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： GOLDEN, Bruce, L. , ROLLIN, Bernard, E. , SWITZER, Ralph, V., Jr. , COMSTOCK, Carlton, R., Jr.
IPC分类号： A61B3/14 , A61B5/117 , A01K11/00
CPC分类号： A01K11/008 , A61B3/145 , A61B5/117 , A61B5/1171 , A61B5/411 , G06K9/00597 , G06K2009/00932
摘要： The present invention creates a permanent record of an animal through a series of steps including, preliminarily acquiring an image of the retinal vasculature of the animal of interest; digitizing that image if the image is not a digital image; analyzing the image to determine if the image is satisfactory for further analysis; storing the image; and analyzing the image for unique anatomical landmarks. The image and data gathered therefrom may be stored in a database for later retrieval and comparison against other images. The data gathered from the image may be compared against other stored data in the database to determine the identity of the animal. Preferably, the system would also include a global positioning system ("GPS") device which would simultaneously time and date stamp the acquired image as well as stamp the image with the location where the imaging took place by recording the latitude and longitude of that location.
摘要翻译：本发明通过一系列步骤创建动物的永久记录，包括初步获取感兴趣的动物的视网膜脉管系统的图像; 如果图像不是数字图像，则对该图像进行数字化; 分析图像以确定图像是否令人满意进一步分析; 存储图像; 并分析图像的独特解剖标志。从其收集的图像和数据可以存储在数据库中，以便稍后检索和与其他图像进行比较。从图像收集的数据可以与数据库中的其他存储数据进行比较，以确定动物的身份。优选地，该系统还将包括一个全球定位系统（“GPS”）装置，其将同时对所获取的图像进行时间和日期压缩，并且通过记录该位置的纬度和经度将图像与成像所在的位置进行印记。

7. 发明公开

EP1060391A1 MEAT COLOR IMAGING SYSTEM FOR PALATABILITY AND YIELD PREDICTION 有权
标题翻译：肉的颜色IMAGING预报系统的口感和产量
公开(公告)号：EP1060391A1
公开(公告)日：2000-12-20
申请号：EP99908231.6
申请日：1999-02-18
申请人： THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： BELK, Keith, E. , TATUM, J., Daryl , SMITH, Gary, C.
IPC分类号： G01N33/12
CPC分类号： A22C17/008 , A22B5/007 , G01N33/12 , G06T7/11 , G06T7/90 , G06T2207/10016 , G06T2207/10024 , G06T2207/30128
摘要： Herein is disclosed a video image analysis (VIA) system for scoring characteristics predictive of palatability and yield of a meat animal carcass or cut. The VIA system provides for a video camera, a data processing unit for processing video image data, and an output device for output of processed data to the user. Also disclosed is a method for using the VIA system in predicting palatability and yield of a meat animal carcass or cut.

8. 发明公开

EP0635058A1 PROTEASE VACCINE AGAINST HEARTWORM 失效
标题翻译：蛋白酶疫苗丝虫。
公开(公告)号：EP0635058A1
公开(公告)日：1995-01-25
申请号：EP92924400.0
申请日：1992-11-12
申请人： THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： GRIEVE, Robert, B. , RICHER, Jennifer , FRANK, Glenn, R. , SAKANARI, Judy
IPC分类号： A61K38 , A61K39 , A61P33 , C12N9 , C12N15
CPC分类号： C12N9/641 , A61K39/00 , C07K2319/00 , C12N9/6402 , G01N2333/4353 , G01N2333/95 , G01N2333/96402 , Y02A50/396
摘要： The transition between the L3 and L4 larval stages of the nematode filarial parasites such as Dirofilaria immitis occurs after introduction into the animal host and is mediated by at least one metalloprotease and/or cysteine protease unique to the L3 or L4 larval stage. Methods to prevent and treat filarial infection are provided by vaccines comprised of the immunogenic determinants of the characteristic L3 or L4 proteases and by administration of inhibitors of these proteases.

9. 发明公开

EP4114456A1 PRODUCTION OF VACCINES COMPRISING INACTIVATED SARS-COV-2 VIRAL PARTICLES 审中-实审转让
公开(公告)号：EP4114456A1
公开(公告)日：2023-01-11
申请号：EP21715375.8
申请日：2021-03-05
申请人： THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： GOODRICH, Raymond P. , BOWEN, Richard
IPC分类号： A61K39/12 , A61M1/36 , A61P31/14 , G01N33/00

10. 发明公开

EP3006044A1 COMBINED ANTI-ACID-FAST BACTERIAL AGENT, SCREENING METHOD FOR ANTI-ACID-FAST BACTERIAL AGENTS, AND ACTIVITY INHIBITOR OF WecA OR ORTHOLOG THEREOF 有权
标题翻译：联合快速防酸菌，筛选方法，快速防酸菌和作用WECA抑制剂或直系同源物
公开(公告)号：EP3006044A1
公开(公告)日：2016-04-13
申请号：EP14807892.6
申请日：2014-06-03
申请人： Microbial Chemistry Research Foundation , THE COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： ISHIZAKI, Yoshimasa , IGARASHI, Masayuki , BRENNAN, Patrick Joseph , CRICK, Dean Calvin
IPC分类号： A61K45/00 , A61K31/7072 , A61P31/04
摘要： A drug combination against acid-fast bacillus, including: an inhibitor for WecA or an ortholog thereof; and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor, wherein the inhibitor for WecA or an ortholog thereof is used in combination with the at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor; a screening method for a drug against acid-fast bacillus; and an inhibitor for WecA or an ortholog thereof.

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