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1. 发明公开

EP4019957A1 MASS SPECTROMETRY METHOD USING CHROMATOGRAPHY-MASS SPECTROMETRY DEVICE 审中-实审
公开(公告)号：EP4019957A1
公开(公告)日：2022-06-29
申请号：EP20813227.4
申请日：2020-05-21
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： SENDA, Naoto , TSUKAZAKI, Yasuko
IPC分类号： G01N27/62 , G01N30/72 , G01N30/86 , G01N30/88
摘要： [Problem] To provide a mass spectrometry method that uses a chromatography-mass spectrometry device, wherein mass spectrometry can be performed with a convenient method at low cost. [Solution] A mass spectrometry method for a target object, using a chromatography-mass spectrometry device that includes, in order, a chromatograph, an ionization unit, a first mass separation unit, a collision cell, a second mass separation unit, and an ion detection unit, wherein an ion pair agent and Htinig's base are added to a mobile phase of the chromatograph, and the absolute value of an applied voltage of the collision cell is 20V to 250V.

2. 发明公开

EP3876081A1 CONFERENCE SUPPORT SYSTEM 无效
公开(公告)号：EP3876081A1
公开(公告)日：2021-09-08
申请号：EP19878317.7
申请日：2019-09-30
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： NAGATA Ryoichi
IPC分类号： G06F3/01 , G06F3/16 , G06T7/00 , G06T7/20 , G10L15/00 , G10L15/22
摘要： [Problem] To enable a person intended by a chairperson to be effectively determined as a speaker by matching the hand-raising of the speaker and an indicating direction of the chairperson, and turning ON only a microphone of the matched speaker. [Solution] Provided is a conference support system including: a plurality of voice input means which receive voices as an input; a plurality of ON/OFF control means which control the plurality of voice input means to be respectively turned ON/OFF and which respectively correspond to the plurality of voice input means; a hand-raising recognition means which recognizes hand-raising positions of participants, which respectively corresponds to the plurality of voice input means; a designated direction recognition means which recognizes a direction designated by a specified person; and a speaker determination means which turns ON an ON/OFF control means for a voice input means that corresponds to a participant, when the hand-raising position of the participant, which is recognized by the hand-raising recognition means, matches the direction designated by the specified person, which is recognized by the designated direction recognition means.

4. 发明公开

EP3095460A1 CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT 审中-公开
标题翻译： CHIRALESNUKLEINSÄUREADJUVANSMIT ANTIALLERGISCHER WIRKUNG UND ANTIALLERGIKUM
公开(公告)号：EP3095460A1
公开(公告)日：2016-11-23
申请号：EP15737209.5
申请日：2015-01-14
申请人： Shin Nippon Biomedical Laboratories, Ltd. , Wave Life Sciences Japan, Inc.
发明人： GEMBA Takefumi , NAGATA Ryoichi
IPC分类号： A61K39/39 , A61K31/7125 , A61K48/00 , A61P11/02 , A61P37/08 , C12N15/117
CPC分类号： A61K39/39 , A61K31/7125 , A61K48/00 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2310/344
摘要： Problem
To provide a chiral nucleic acid adjuvant and anti-allergic agent having anti-allergic effect.
Solution
An adjuvant which comprises oligonucleotides which comprise two to four CpG motifs each represented by 5'-X 1 CpGX 2 -3' and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3' end side of at least two CpG motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3' end and 5' end of the oligonucleotide is S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an adjuvant comprising the oligonucleotide represented by the sequence number 67. The present invention relates to an anti-allergic agent comprising these adjuvant.
摘要翻译：问题提供具有抗过敏作用的手性核酸佐剂和抗过敏剂。溶液一种佐剂，其包含含有2至4个CpG基序的寡核苷酸，每个CpG基序各自由5'-X 1 CpGX 2 -3'表示，长度为14至32个核苷酸，其中至少两个CpG的3'端侧的核酸基序通过硫代磷酸酯键连接，其中寡核苷酸的3'端和5'端的每个核酸是通过硫代磷酸连接连接的S型核酸，并且其中寡核苷酸包含至少一种没有硫代磷酸酯修饰的核酸。本发明涉及包含由序列号67表示的寡核苷酸的佐剂。本发明涉及包含这些佐剂的抗过敏剂。

5. 发明公开

EP2670462A1 INTRANASAL DELIVERY DEVICES 有权
标题翻译：鼻内电源器件
公开(公告)号：EP2670462A1
公开(公告)日：2013-12-11
申请号：EP12742112.1
申请日：2012-01-31
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： TSUTSUI, Tatsuo
IPC分类号： A61M15/08 , A61M13/00
CPC分类号： A61M15/08 , A61M11/02 , A61M15/0028 , A61M15/0043 , A61M16/0045 , A61M2202/064 , A61M2205/075 , A61M2206/16
摘要： Devices for delivery of dry powder formulations are also provided. Devices can be single-use devices. Formulations and methods of manufacture are provided for dry powder compositions suitable for intranasal administration. Also provided are methods of use for preventing or controlling emesis and other diseases and disorders and devices, compositions, and methods for nasal delivery of therapeutic formulations.

6. 发明公开

EP1978085A1 GENE EXPRESSION ANALYSIS TOOL 审中-公开
标题翻译： GENEXPRESSIONS-ANALYSEWERKZEUG
公开(公告)号：EP1978085A1
公开(公告)日：2008-10-08
申请号：EP07707515.8
申请日：2007-01-26
申请人： Takeda Pharmaceutical Company Limited , Shin Nippon Biomedical Laboratories, Ltd.
发明人： MIYAJIMA, Nobuyuki , HORINOUCHI, Akira , TAKAMI, Kenji , ISE, Ryota
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/02 , C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/47 , C12Q2600/158
摘要： The present invention provides a tool for analysis of expression of Macaca fascicularis gene.
The present invention provides a Macaca fascicularis gene expression analysis tool containing a set of nucleic acids containing base sequences the same or substantially the same as two or more base sequences selected from the group consisting of the base sequences shown by SEQ ID NOs: 1 - 14, or partial sequences thereof, and a method of analyzing the expression of Macaca fascicularis gene, including measuring a gene transcription product in a Macaca fascicularis sample using the tool.
摘要翻译：本发明提供了用于分析猕猴猕猴的基因表达的工具。本发明提供了一种含有一组含有与SEQ ID NO：1-14所示的碱基序列相同或基本上相同的两个或多个碱基序列的碱基序列的核酸的猕猴绦虫基因表达分析工具或其部分序列，以及分析猕猴猕猴属基因表达的方法，包括使用该工具测量猕猴属绦虫样品中的基因转录产物。

7. 发明公开

EP3970696A1 POWDER PREPARATION FOR TRANSNASAL ADMINISTRATION AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：EP3970696A1
公开(公告)日：2022-03-23
申请号：EP20806255.4
申请日：2020-05-01
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： HARUTA, Shunji , SONODA, Yo
IPC分类号： A61K9/14 , A61K9/19 , A61K47/36 , A61K47/38 , A61K31/192 , A61K31/198 , A61K31/405
摘要： An object of the present invention is to provide a powder formulation for intranasal administration, which efficiently exhibits a medicinal effect, and the like. The object can be achieved by a powder formulation for intranasal administration comprising composite particles in which an active ingredient and a water-insoluble polysaccharide are cohered to each other.

8. 发明公开

EP3563678A1 BREEDING WATER FOR ANGUILLIFORMES AND METHOD FOR REARING ANGUILLIFORMES 无效
公开(公告)号：EP3563678A1
公开(公告)日：2019-11-06
申请号：EP17887786.6
申请日：2017-12-27
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： NAGATA, Ryoichi , KAWAKAMI, Yutaka
IPC分类号： A01K61/10 , A23K20/174 , A23K20/184 , A23K50/80
摘要： [Problem] To provide breeding water for anguilliformes, and a method for rearing anguilliformes using the breeding water, in order to artificially control the transformation of glass eels and the like and produce glass eels and the like in the same size and form with a shorter period until birth. [Solution] Anguilliformes breeding water containing a thyroid hormone such as thyroxine, and a method for rearing anguilliformes including a step for administering a thyroid hormone such as thyroxine, wherein the amount of the thyroid hormone to be administered changes as the anguilliforme fingerling changes from a transformation start phase (stage 1) to a transformation final phase (stage 2), and the amount of the thyroid hormone to be administered in the transformation final phase (stage 2) is less than the amount of the thyroid hormone to be administered in the transformation start phase (stage 1).

9. 发明授权

EP2939675B1 OCT3 ACTIVITY INHIBITOR CONTAINING IMIDAZOPYRIDINE DERIVATIVE AS ACTIVE COMPONENT, AND OCT3 DETECTION AGENT 有权
公开(公告)号：EP2939675B1
公开(公告)日：2019-09-04
申请号：EP13868302.4
申请日：2013-12-17
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： YAMASHITA, Hidetoshi , SUZUKI, Nobuyuki
IPC分类号： A61K31/437 , A61K31/444 , A61K31/4453 , A61K31/496 , A61P25/24 , A61P43/00 , G01N33/68 , C07D471/04

10. 发明公开

EP2853157A1 RESTRAINER FOR PRIMATES 有权
标题翻译： HALTEVORRICHTUNGFÜRPRIMATEN
公开(公告)号：EP2853157A1
公开(公告)日：2015-04-01
申请号：EP12877123.5
申请日：2012-10-01
申请人： Shin Nippon Biomedical Laboratories, Ltd.
发明人： NAGATA, Ryoichi , KASHIMA, Masatoshi , MAGOTANI, Hiroaki
IPC分类号： A01K67/00 , A01K15/04
CPC分类号： A01K1/031 , A01K1/0613
摘要： The present invention reduces or eliminates injuries such as those to the base of the limbs of a primate in a restrainer caused by friction with vertical bars in the grid of a barrier that is movable in a front-back direction, by reducing the friction when using the barrier to restrain the primate. A restrainer (10) for primates has: a storage body (20) having two side surfaces, a top surface, and a bottom surface; a rear surface door (50) which can open and close the rear surface side of the storage body (20); and a barrier (30) that is formed so as to be movable inside the storage body (20) in a front-back direction, and that is formed so as to be fixable at a desired position inside the storage body (20). Protective tubing (33) is rotatably inserted onto vertical bar members (31) of the barrier (30) at locations on the vertical bar members (31) where the base parts of the limbs of a primate would make contact when the limbs of the primate are extended in the frontal direction and restrained.
摘要翻译：本发明通过在使用时减少摩擦来减少或消除诸如那些到障碍物的网格中的垂直杆与前后方向可移动导致的与限制器中的灵长类动物肢体的基部的伤害限制灵长类动物的障碍。用于灵长类动物的限制器（10）具有：具有两个侧表面，顶表面和底表面的存储体（20）; 能够打开和关闭储存体（20）的后表面侧的后表面门（50）; 以及形成为能够在所述收纳体（20）内沿前后方向移动并且形成为能够固定在所述收纳体（20）内的期望位置的障碍物（30）。在垂直杆构件（31）上的位置处，保护管（33）可旋转地插入到屏障（30）的垂直杆构件（31）上，当灵长类动物的肢体在正面方向延伸并受到限制。

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