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1. 发明公开

EP3711749A1 METHOD OF MAKING LIPID NANOPARTICLES 审中-公开
公开(公告)号：EP3711749A1
公开(公告)日：2020-09-23
申请号：EP19163780.0
申请日：2019-03-19
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： Wagner, Andreas , Aichinger, Frances-Dee , Loidl, Harald
IPC分类号： A61K9/127 , A61K38/00 , A61K9/51
摘要： What is described is a method of producing lipid nanoparticles having an average diameter of less than 100 nm, comprising pumping an aqueous buffer solution through a 1 st tube by a 1 st HPLC pump, pumping an organic lipid solution through a 2 nd tube by a 2 nd HPLC pump, wherein the 2 nd tube intersects the 1 st tube perpendicularly within a mixing module, and wherein the organic lipid solution is mixed with the aqueous solution in a turbulent flow within the mixing module.

2. 发明授权

EP1423417B1 ANTIBODIES RECOGNIZING A PEPTIDE MIMICKING A CRYPTIC EPITOPE OF GP41 OF HIV-1 有权
标题翻译：针对肽的gp41 HIV-1抗体针对模拟的表位的隐蔽
公开(公告)号：EP1423417B1
公开(公告)日：2006-10-25
申请号：EP02774586.8
申请日：2002-09-09
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： STIEGLER, Gabriela , KUNERT, Renate , KATINGER, Hermann
IPC分类号： C07K14/16 , C07K16/10 , C07K16/42 , A61K38/04 , A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1063 , C07K2317/21 , C07K2317/34 , C12N2740/16122
摘要： The present invention relates to neutralizing anti-HIV-1 antibodies, particularly to mAb 4E1O-lgG1, which has an HIV-1 neutralizing potency comparable to the one of mAb 2F5 and 2G12.4E1O-lgG1 binds to a novel conserved epitope (NWFDIT) C-terminal of the ELDKWA epitope recognized by 2F5.1 appears that both epitopes are cryptic epitopes within a region that may be accessible in a virus-cell fusion intermediate state only. 4E1O-lgG1 potently neutralizes tissue culture adapted strains but also primary isolates of different clades, including A, B, C, D, and E, inclusing viruses that were found to be resistant to 2F5. None of the tested isolates was resistant to both anti-gp41-antibodies. The invention therefore also relates to peptides containing the 4E10 epitope and to compositions made thereof, as well as to anti-idiotypic antibodies that are reactive with the paratope of 4E10-lgG1 , to compositions containing an antiidiotypic antibody optionally in combination with a peptide containing the 4E10 epitope, and to anti-HIV-1 compositions comprising 4E1O-lgG1, optionally in combination with another neutralizing antibody such as 2F5 and/or 2G12.

3. 发明授权

EP0789584B1 APPLIKATION VON SOD IN LIPOSOMEN 失效
标题翻译： SOD的脂质体中的应用
公开(公告)号：EP0789584B1
公开(公告)日：2001-09-19
申请号：EP95938419.9
申请日：1995-11-06
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： KATINGER, Hermann , VORAUER-UHL, Karola , FÜRNSCHLIEF, Eckhard
IPC分类号： A61K38/44 , A23L1/015 , A61K9/127
CPC分类号： A61K9/0019 , A23L5/25 , A61K8/14 , A61K8/66 , A61K9/0014 , A61K9/127 , A61K38/446 , A61K47/36 , A61K2800/52 , A61Q17/00 , A61Q19/00 , A61Q19/004
摘要： Superoxide dismutase (SOD), preferably rhSOD, is used in liposomes, optionally mixed with hyaluronic acid and/or at least one physiologically acceptable carrier, and other optional additives, to prepare a pharmaceutical composition useful against increased concentrations of superoxide radicals and/or the damage caused thereby. These compositions can be administered topically, orally and/or parenterally to prevent and/or heal in particular burns, skin lesions due to radiation, inflammations, rheumatic and arthritic diseases, bronchitis, ARDS, emphysema, allergic oedemas and other inflammatory process, possibly trigged by microbial infections. They may also be used in the cosmetic treatment of furuncles, acne and the like. Also disclosed is a process for improving the preservability of organic, preferably biogenic, materials, in particular organ transplants and liquids with organic components, as well as foodstuffs, by using the disclosed compositions.

4. 发明授权

EP0725825B1 PEPTIDES THAT ELICIT NEUTRALIZING ANTIBODIES AGAINST GENETICALLY DIVERGENT HIV-1 STRAINS 失效
标题翻译：中和抗体反对基因渐扩HIV-1毒株肽，INDUCE
公开(公告)号：EP0725825B1
公开(公告)日：2001-02-21
申请号：EP94927602.6
申请日：1994-09-12
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： KATINGER, Hermann , MUSTER, Thomas
IPC分类号： C12N15/48 , C07K14/16 , A61K39/21 , A61K39/395 , C07K16/10
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： Peptides are described which elicit antibodies, preferably including secretory antibodies secreted by mucosal surfaces, that show neutralizing activity against different strains and clinical isolates of HIV-1 and that inhibit the fusion of cells caused by HIV-1, which peptides are composed of a sequence of seven or eight amino acids corresponding to the ones on gp41 of gp160 of the HIV isolate BH10 at the position 662 to 668 (ELDKWAS) or at the position 661 to 668 (LELDKWAS) respectively, preferably including peptides being composed of the sequence ELDNWAS, ELNKWAS, LELDNWAS or LELNKWAS, or that are genetically encoded by nucleotide sequences corresponding to said amino acid sequences, or by sequences hybridizing to said nucleotide sequences, or by sequences deduced from said nucleotide sequences by degeneration. Preferably, the peptides substitute one or more parts of the amino acid sequence of a viral protein or are inserted into antigenic sites of a viral protein, e.g. by fusion of the respective nucleotide sequences, and subsequent expression of the fusion genes is carried out in a biological expression system.

5. 发明公开

EP0789584A1 APPLIKATION VON SOD IN LIPOSOMEN 失效
标题翻译： SOD的脂质体中的应用
公开(公告)号：EP0789584A1
公开(公告)日：1997-08-20
申请号：EP95938419.0
申请日：1995-11-06
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： KATINGER, Hermann , VORAUER-UHL, Karola , FÜRNSCHLIEF, Eckhard
IPC分类号： A23L1 , A61K8 , A61K9 , A61K38 , A61Q19 , A61K47 , A61Q17
CPC分类号： A61K9/0019 , A23L5/25 , A61K8/14 , A61K8/66 , A61K9/0014 , A61K9/127 , A61K38/446 , A61K47/36 , A61K2800/52 , A61Q17/00 , A61Q19/00 , A61Q19/004
摘要： Superoxide dismutase (SOD), preferably rhSOD, is used in liposomes, optionally mixed with hyaluronic acid and/or at least one physiologically acceptable carrier, and other optional additives, to prepare a pharmaceutical composition useful against increased concentrations of superoxide radicals and/or the damage caused thereby. These compositions can be administered topically, orally and/or parenterally to prevent and/or heal in particular burns, skin lesions due to radiation, inflammations, rheumatic and arthritic diseases, bronchitis, ARDS, emphysema, allergic oedemas and other inflammatory process, possibly trigged by microbial infections. They may also be used in the cosmetic treatment of furuncles, acne and the like. Also disclosed is a process for improving the preservability of organic, preferably biogenic, materials, in particular organ transplants and liquids with organic components, as well as foodstuffs, by using the disclosed compositions.

6. 发明授权

EP1358319B1 LIVE INFLUENZA VACCINE AND METHOD OF MANUFACTURE 有权
标题翻译：活流感疫苗及其制备方法
公开(公告)号：EP1358319B1
公开(公告)日：2009-06-17
申请号：EP01985267.2
申请日：2001-09-25
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： KATINGER, Hermann , EGOROV, Andre , FERKO, Boris , ROMANOVA, Julia , KATINGER, Dietmar
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K2039/5254 , A61K2039/543 , A61K2039/70 , C12N2760/16134 , C12N2760/16161 , C12N2760/16234
摘要： The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to adpative selection are minimized or prevented. The process does not require purification of the virus-containing supernatant harvested from the cell culture nor post-incubation treatment of the viruses for HA activation. The invention further relates to influenza A and B master strain candidates and to vaccines made thereof.

7. 发明公开

EP1961821A1 Erythropoietin fusion protein 有权
标题翻译：促红细胞生成素融合蛋白
公开(公告)号：EP1961821A1
公开(公告)日：2008-08-27
申请号：EP07003659.5
申请日：2007-02-22
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： Weik, Robert , Hemetsberger, Thomas , Redl, Heinz
IPC分类号： C12N15/62 , C07K14/505 , A61K38/18
CPC分类号： C07K14/505 , A61K38/1816 , C07K2319/30
摘要： The present invention relates to recombinant fusion proteins wherein erythropoietin (EPO) is linked via its C-terminus to an Fc fragment, and wherein said recombinant fusion proteins are further carbamoylated at the primary amines of the fusion protein. More specifically the invention relates to carbamoylated EPO-Fc fusion proteins, wherein at least one, preferably two or more, lysine amine residues and/or the N-terminal amino acid of said fusion protein are carbamoylated. The carbamoylated EPO-Fc fusion proteins of the present invention having a reduced hematopoietic activity whereas the tissue regenerative activity, i.e. the nerval cell regenerative activity remains unaltered or is even enhanced as compared to unmodified EPO-Fc fusion proteins.
The invention further relates to a process for the manufacture of such fusion proteins and to pharmaceutical compositions containing them, as well as to the use of such fusion proteins and pharmaceutical compositions for medical therapy.
摘要翻译：本发明涉及重组融合蛋白，其中促红细胞生成素（EPO）通过其C-末端与Fc片段连接，并且其中所述重组融合蛋白在融合蛋白的伯胺处进一步氨甲酰化。更具体地说，本发明涉及氨基甲酰化EPO-Fc融合蛋白，其中所述融合蛋白的至少一个，优选两个或更多个赖氨酸胺残基和/或N-末端氨基酸被氨基甲酰化。与未修饰的EPO-Fc融合蛋白相比，本发明的氨甲酰化EPO-Fc融合蛋白具有降低的造血活性，而组织再生活性即神经细胞再生活性保持不变或甚至增强。本发明还涉及制造这种融合蛋白的方法和含有它们的药物组合物，以及这种融合蛋白和药物组合物用于医学治疗的用途。

8. 发明公开

EP1627920A1 Method for the manufacture of recombinant trypsin 审中-公开
标题翻译： Verfahren zur Herstellung von rekombinantem胰蛋白酶
公开(公告)号：EP1627920A1
公开(公告)日：2006-02-22
申请号：EP05021863.5
申请日：2001-01-24
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： Mattanovich, Diethard , Katinger, Hermann , Hohenblum, Hubertus , Naschberger, Stefan , Weik, Robert
IPC分类号： C12N15/57 , C12N9/76 , C12M1/00
CPC分类号： C12N9/6427
摘要： The present invention relates to an improved method and apparatus for carrying out protein refolding specifically useful for processing trypsinogen that has accumulated intracellularly in the form of inclusion bodies.
摘要翻译：本发明涉及一种用于进行蛋白质重折叠的改进方法和装置，其特别可用于加工在细胞内以包涵体的形式累积的胰蛋白酶原。

9. 发明授权

EP0822941B1 MONOCLONAL ANTIBODIES AGAINST HIV-1 AND VACCINES MADE THEREOF 失效
标题翻译：抗HIV-1和单克隆抗体生产的疫苗
公开(公告)号：EP0822941B1
公开(公告)日：2002-06-12
申请号：EP95916676.0
申请日：1995-04-19
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： KATINGER, Hermann , BUCHACHER, Andrea , ERNST, Wolfgang , BALLAUN, Claudia , PURTSCHER, Martin , TRKOLA, Alexandra , PREDL, Renate , SCHMATZ, Christine , KLIMA, Annelies , STEINDL, Franz , MUSTER, Thomas
IPC分类号： C07K16/10 , C07K16/42 , C12N5/24 , C07K14/16 , C07K19/00 , A61K39/44 , A61K39/21 , G01N33/577 , G01N33/68
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , C07K16/1063 , C07K16/4225 , C07K2319/00 , C12N2740/16122 , G01N33/56988
摘要： The present invention discloses antibodies which can be used for the manufacture of vaccines for active and/or passive immunization of persons in need of such treatment. The invention also provides for human monoclonal antibodies that are functionally equivalent to the above-mentioned antibodies produced by any one of the cell lines CL1 through CL6 (deposited at the European Collection of Animal Cell Cultures (ECACC) at the PHLS in Porton Down, Salisbury, UK). It is also a goal of the present invention to provide for hybridoma and/or CHO cell lines producing any one of the antibodies disclosed and claimed herein. The invention is further directed to mixtures of the antibodies of the present invention, as well as to methods of using individual antibodies or mixtures thereof for the detection, prevention and/or therapeutical treatment of HIV-1 infections in vitro and in vivo.

10. 发明公开

EP0570357A3 Peptides that induce antibodies which neutralize genetically divergent HIV-1 isolates 失效转让
标题翻译：诱导抗体中和遗传分化的HIV-1分离物的肽
公开(公告)号：EP0570357A3
公开(公告)日：1994-04-20
申请号：EP93890100.6
申请日：1993-05-13
申请人： Polymun Scientific Immunbiologische Forschung GmbH
发明人： Katinger, Hermann , Rüker, Florian , Himmler, Gottfried , Muster, Thomas , Purtscher, Martin , Maiwald, Georg , Steindl, Franz , Trkola, Alexandra
IPC分类号： C12N15/49 , C12N15/62 , A61K39/21 , G01N33/569 , A61K39/295 , A61K39/145 , A61K39/29 , C07K14/16 , C07K14/02
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1063 , C07K16/4225 , C07K2319/00 , C12N2740/16122 , Y02A50/466
摘要： This invention refers to peptides binding to antibodies that show neutralizing activity against different strains and clinical isolates of HIV-1 and that inhibit the fusion of cells caused by HIV-1. These peptides are applied with an adjuvant, as recombinant fusion proteins, chemically coupled to carrier molecules, as recombinant chimeric viruses or as recombinant antibodies.
摘要翻译：本发明涉及结合抗体的肽，其显示针对HIV-1的不同毒株和临床分离株的中和活性，并抑制由HIV-1引起的细胞融合。这些肽与佐剂一起施用，作为重组融合蛋白，与载体分子化学偶联，作为重组嵌合病毒或作为重组抗体。

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