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2. 发明公开

EP4206673A1 LATERAL FLOW ASSAY DEVICE 审中-实审
公开(公告)号：EP4206673A1
公开(公告)日：2023-07-05
申请号：EP23157393.2
申请日：2015-08-07
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： DING, Zhong , HOSIMER, Philip, C. , SCALICE, Edward, R. , SALOTTO, Daniel, P. , HEAVNER, David, A.
IPC分类号： G01N33/558
摘要： A lateral flow assay device includes a substrate having a top surface, as well as a sample receiving area disposed upon the top surface. At least one fluid flow path extends along the substrate from the sample receiving area, wherein the sample receiving area can be placed in contact with a peripheral reservoir formed at a sample addition area to draw sample therefrom in a controlled manner. The device can further include a reagent area that is designed to promote uniform dissolution of a deposited detection material by a sample moved through the device along the fluid flow path as well, as a flow channel configure to promote mixing of sample and reagent and an absorbing or wicking zone configured to affect various flow characteristics.

3. 发明授权

EP3076176B1 IMPROVING GLASS BEAD FLOW RATES TO FACILITATE IMMUNODIAGNOSTIC TEST ELEMENT MANUFACTURE 失效
公开(公告)号：EP3076176B1
公开(公告)日：2018-11-28
申请号：EP16170272.5
申请日：2013-10-15
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： CROWTHER, Jonathan Burr , SUROWITZ, Amy Louise , LUCZAK, Anna Krystyna
IPC分类号： G01N33/53 , G01N33/80 , G01N21/82
CPC分类号： G01N33/552 , G01N33/5304 , G01N33/531 , G01N33/80 , G01N2021/825 , Y10T29/49982 , Y10T436/25
摘要： A method of preparing a glass bead mixture using inert nanoparticles to improve flow rates of the glass beads for purposes of manufacturing an immunodiagnostic test element, such as a column agglutination test cassette, and a test element made in accordance with the method.

4. 发明公开

EP3322346A1 PACKAGING THAT FACILITATES SAMPLE COLLECTION 有权
公开(公告)号：EP3322346A1
公开(公告)日：2018-05-23
申请号：EP16825017.3
申请日：2016-07-12
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： GOTTERMEIER, William , KIRSCH, Andrew, M. , DECLERCK, Charles, E. , SWICK, Aaron, M.
IPC分类号： A61B10/00 , A61B5/145 , A61B5/15 , A61B5/157 , B01L3/00 , G01N1/00 , G01N1/10 , G01N1/14
摘要： An article of manufacture composed of tray-like packaging unit characterized by a first section designed to hold a sample analysis slide and a second section designed to hold a sample collection device. Molded into the tray-like packaging unit are a thermoformed well designed to accept a patient's liquid sample from a pipette or syringe, a splash wall formed between the first section and the second section designed to contain the patient's liquid sample in the thermoformed well, and an overflow reservoir designed to hold excess patient sample placed in the thermoformed well. Also molded into the sidewalls of tray-like packaging unit are projections designed to allow the sample analysis slide and the sample collection device to be snapped into the packaging unit resulting in a secure configuration for transport.

5. 发明公开

EP3290115A1 SINGLE COLUMN IMMUNOLOGICAL TEST ELEMENTS 无效
标题翻译：单柱免疫测试元件
公开(公告)号：EP3290115A1
公开(公告)日：2018-03-07
申请号：EP17186947.2
申请日：2009-07-17
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： JAKUBOWICZ, Raymond F. , SAWCZUK, Mark
IPC分类号： B01L3/00
CPC分类号： B01J19/0046 , B01L3/021 , B01L9/523 , B01L2300/021 , B01L2300/044 , B01L2300/0654 , B01L2300/0825 , B01L2300/0829 , B01L2300/0841 , B01L2400/0409 , G01N35/025 , Y10S436/809
摘要： A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access the contents of the test column. Individual test elements can be stored, retained and dispensed for testing patient samples.
摘要翻译：提供多个单独的单柱测试元件用于临床测试设备。每个测试元件由单个测试柱限定，该测试柱包括一定量的测试材料，例如凝胶材料或珠基体，包括用于访问测试柱内容物的盖条。可以存储，保留和分配单独的测试元件以测试患者样本。

6. 发明公开

EP3194914A4 NORMALIZING THE RESPONSE OF A FLUORESCENCE INSTRUMENT USING SPECTRAL RESPONSE 有权
标题翻译：常规化学回收EINES FLUORESZENZUMTRUMENTS MIT SPEKTRALER REAKTION
公开(公告)号：EP3194914A4
公开(公告)日：2017-08-16
申请号：EP15841304
申请日：2015-09-17
申请人： ORTHO-CLINICAL DIAGNOSTICS INC
发明人： HEAVNER DAVID A
IPC分类号： G01J3/00 , G01J3/44 , G01N21/27 , G01N21/64 , G01N35/00
CPC分类号： G01N21/274 , G01J3/4406 , G01N21/6428 , G01N21/645 , G01N35/00693 , G01N2021/6439 , G01N2201/12746
摘要： A method to normalize at least one of a population of subordinate clinical diagnostic analyzer to a master clinical diagnostic analyzer such that an assay result from a subordinate clinical diagnostic analyzer can be converted to the equivalent result of the master clinical diagnostic analyzer by using a simple multiplicative factor when the assay executed on each analyzer uses a common fluorescently labeled dye. Also a method to re-normalize a subordinate clinical diagnostic analyzer assay result to a master clinical diagnostic analyzer assay result by using a simple multiplicative factor when the assay executed on the subordinate clinical diagnostic analyzer uses a different fluorescently labeled dye than the assay executed on the master clinical diagnostic analyzer.
摘要翻译：一种将主从临床诊断分析仪的群体中的至少一个归一化为主临床诊断分析仪的方法，使得来自从属临床诊断分析仪的测定结果可以通过使用简单乘法转换成主临床诊断分析仪的等效结果当在每个分析仪上执行的测定使用常见的荧光标记染料时，该因子是可用的当在附属临床诊断分析仪上执行的测定使用不同于荧光标记染料的不同荧光标记染料时，通过使用简单乘法因子将从属临床诊断分析仪测定结果重新归一化为主临床诊断分析仪测定结果的方法也是掌握临床诊断分析仪。

7. 发明公开

EP3194914A1 NORMALIZING THE RESPONSE OF A FLUORESCENCE INSTRUMENT USING SPECTRAL RESPONSE 有权
标题翻译：利用谱响应来规范荧光仪器的响应
公开(公告)号：EP3194914A1
公开(公告)日：2017-07-26
申请号：EP15841304.7
申请日：2015-09-17
申请人： Ortho-Clinical Diagnostics, Inc.
发明人： HEAVNER, David A.
IPC分类号： G01J3/00
CPC分类号： G01N21/274 , G01J3/4406 , G01N21/6428 , G01N21/645 , G01N35/00693 , G01N2021/6439 , G01N2201/12746
摘要： A method to normalize at least one of a population of subordinate clinical diagnostic analyzer to a master clinical diagnostic analyzer such that an assay result from a subordinate clinical diagnostic analyzer can be converted to the equivalent result of the master clinical diagnostic analyzer by using a simple multiplicative factor when the assay executed on each analyzer uses a common fluorescently labeled dye. Also a method to re-normalize a subordinate clinical diagnostic analyzer assay result to a master clinical diagnostic analyzer assay result by using a simple multiplicative factor when the assay executed on the subordinate clinical diagnostic analyzer uses a different fluorescently labeled dye than the assay executed on the master clinical diagnostic analyzer.
摘要翻译：一种将主从临床诊断分析仪的群体中的至少一个归一化为主临床诊断分析仪的方法，使得来自从属临床诊断分析仪的测定结果可以通过使用简单乘法转换成主临床诊断分析仪的等效结果当在每个分析仪上执行的测定使用常见的荧光标记染料时，该因子是可用的当在附属临床诊断分析仪上执行的测定使用不同于荧光标记染料的不同荧光标记染料时，通过使用简单乘法因子将从属临床诊断分析仪测定结果重新归一化为主临床诊断分析仪测定结果的方法也是掌握临床诊断分析仪。

8. 发明授权

EP2663642B1 TREPONEMA PALLIDUM TRIPLET ANTIGEN 有权
标题翻译：梅毒螺旋体 - 苍白球-TRIP ELAN TERM
公开(公告)号：EP2663642B1
公开(公告)日：2017-03-01
申请号：EP12733941.4
申请日：2012-01-13
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： ZHENG, Jian , YURA, Renee , YANG, Jianping
IPC分类号： C12N15/63 , C12N15/15 , C07H21/00 , G01N33/53 , C07K14/20 , C07K19/00
CPC分类号： C07K14/20 , C07K2319/00 , C07K2319/40 , G01N33/56911 , G01N33/571 , G01N2333/20 , G01N2800/26

9. 发明授权

EP2722671B1 Improving glass bead flow rates to facilitate immunodiagnostic test element manufacture 有权
标题翻译：玻璃珠流量的改进，以方便生产免疫诊断测试元件
公开(公告)号：EP2722671B1
公开(公告)日：2016-05-25
申请号：EP13188722.6
申请日：2013-10-15
申请人： ORTHO-CLINICAL DIAGNOSTICS, INC.
发明人： Crowther, Jonathan Burr , Surowitz, Amy Louise , Luczak, Anna Krystyna
IPC分类号： G01N33/53 , G01N33/80 , G01N21/82
CPC分类号： G01N33/552 , G01N33/5304 , G01N33/531 , G01N33/80 , G01N2021/825 , Y10T29/49982 , Y10T436/25

10. 发明公开

EP2888277A4 ANTIBODIES TO PALIPERIDONE AND USE THEREOF 审中-公开
标题翻译：抗体，其使用的帕潘立酮和
公开(公告)号：EP2888277A4
公开(公告)日：2016-05-18
申请号：EP13831719
申请日：2013-08-20
申请人： ORTHO CLINICAL DIAGNOSTICS INC , JANSSEN PHARMACEUTICA NV
发明人： HRYHORENKO ERIC , SANKARAN BANUMATHI , DECORY THOMAS R , TUBBS THERESA , COLT LINDA , VLIEGEN MAARTEN , HASPESLAGH PIETER RIK
IPC分类号： C07K16/00 , G01N33/94
CPC分类号： G01N33/9413 , C07K16/44 , C07K2317/33 , C07K2317/56 , C07K2317/565 , G01N33/9406
摘要： Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.

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