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1. 发明公开

EP2791324A4 METHOD OF TREATMENT 有权
标题翻译：治疗方法
公开(公告)号：EP2791324A4
公开(公告)日：2015-04-29
申请号：EP12856927
申请日：2012-12-13
申请人： MEDVET SCIENCE PTY LTD
发明人： LOPEZ ANGEL , SCHWARZ QUENTEN
IPC分类号： C12N5/0793 , A61K45/00 , A61P25/18 , A61P25/28 , C12N5/0797
CPC分类号： A61K35/36 , A61K35/12 , A61K35/30 , A61K35/32 , C12N5/0623

2. 发明公开

EP2438167A4 THERAPEUTIC AND DIAGNOSTIC MOLECULES 有权
标题翻译：治疗和诊断分子
公开(公告)号：EP2438167A4
公开(公告)日：2013-11-06
申请号：EP10782840
申请日：2010-06-04
申请人： CENTENARY INST OF CANCER MEDIC , UNIV SYDNEY , MEDVET SCIENCE PTY LTD , WENKART FOUNDATION
发明人： GAMBLE JENNIFER , VADAS MATHEW , GOODALL GREGORY , YOUNG JENNIFER
IPC分类号： C12N15/113 , A61K48/00 , A61P9/10 , A61P35/00 , C07H21/02
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N33/6893 , G01N2800/7014

3. 发明授权

EP1599226B1 A METHOD OF DIAGNOSIS AND TREATMENT 有权
标题翻译：方法进行诊断和治疗
公开(公告)号：EP1599226B1
公开(公告)日：2012-09-19
申请号：EP04713491.1
申请日：2004-02-23
申请人： MEDVET SCIENCE PTY. LTD.
发明人： BROWN, Michael, Paul
IPC分类号： A61K39/385 , A61K39/44 , A61K49/00 , A61P35/00 , G01N33/68
CPC分类号： G01N33/57488 , A61K47/6843 , A61K51/1018 , C07K16/18 , G01N33/5017 , G01N33/6875 , G01N2510/00

4. 发明公开

EP1845971A4 A METHOD OF TREATING CELLULAR DAMAGE 审中-公开
标题翻译：方法细胞损伤的治疗
公开(公告)号：EP1845971A4
公开(公告)日：2009-12-30
申请号：EP06700570
申请日：2006-01-17
申请人： MEDVET SCIENCE PTY LTD
发明人： XIA PU , WANG LIJUN , VADAS MATHEW ALEXANDER
IPC分类号： A61K31/352 , A61K31/133 , A61K31/277 , A61P9/10 , A61P9/14
CPC分类号： A61K31/133 , A61K31/277 , A61K31/352 , C12Y207/01091

5. 发明公开

EP2082235A4 A METHOD OF DIAGNOSIS AND AGENTS USEFUL FOR SAME 审中-公开
标题翻译： DIAGNOSEVERFAHREN UNDDAFÜRGEEIGNETE AGENTIEN
公开(公告)号：EP2082235A4
公开(公告)日：2009-12-02
申请号：EP07815354
申请日：2007-10-11
申请人： MEDVET SCIENCE PTY LTD
发明人： BROWN MICHAEL PAUL , AL-EJEH FARES , DARBY JOCELYN MARGARET
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/57496 , C12Q1/6886 , C12Q2600/158 , G01N2800/52
摘要： The present invention relates generally to a method of screening for a neoplastic cell in a subject. More particularly, the present invention provides a method of screening for both viable neoplastic cells and, still further, cytotoxin induced neoplastic cell death by detecting the level of expression of La protein and/or gene by a cellular population in said subject or in a biological sample derived from said subject. The method of the present invention is useful in a range of applications including, but not limited to, diagnosing, prognosing or assessing a neoplastic condition, monitoring the progression of such a condition, assessing the effectiveness of a therapeutic agent or therapeutic regime and predicting the likelihood of a subject either progressing to a more advanced disease state or entering a remissive state. The present invention also provides diagnostic agents useful for detecting La protein and/or nucleic acid molecules.
摘要翻译：本发明一般涉及筛选受试者中的肿瘤细胞的方法。更具体地，本发明提供了通过检测所述受试者中的细胞群体或生物学中的La蛋白和/或基因的表达水平来筛选活的肿瘤细胞和进一步细胞毒素诱导的赘生性细胞死亡的方法来自所述受试者的样品。本发明的方法可用于一系列应用，包括但不限于诊断，预后或评估肿瘤状况，监测这种病症的进展，评估治疗剂或治疗方案的有效性并预测受试者进展到更晚期的疾病状态或进入缓解状态的可能性。本发明还提供了可用于检测La蛋白和/或核酸分子的诊断剂。

6. 发明公开

EP1765384A4 METHOD OF MODULATING CELLULAR ACTIVITY INVOLVING SPHINGOSINE KINASE AND AGENTS FOR SAME, AND SPHINGOSINE KINASE VARIANTS 审中-公开
标题翻译：方法的细胞活性与鞘氨醇及代理人，以及它们的鞘氨醇变异调制
公开(公告)号：EP1765384A4
公开(公告)日：2009-07-08
申请号：EP05750186
申请日：2005-06-15
申请人： MEDVET SCIENCE PTY LTD
发明人： PITSON STUART M , VADAS MATHEW ALEXANDER , XIA PU , MORETTI PAUL A , LECLERCQ TAMARA , SUTHERLAND CATHERINE
IPC分类号： A61K38/43 , A61K38/00 , A61K38/17 , A61K38/18 , A61K38/19 , A61P29/00 , A61P35/00 , C12N9/12
CPC分类号： C12N9/1205 , A61K38/1709

7. 发明公开

EP2026773A1 METHODS OF MODULATING EPITHELIAL-MESENCHYMAL TRANSITION AND MESENCHYMAL-EPITHELIAL TRANSITION IN CELLS AND AGENTS USEFUL FOR THE SAME 审中-公开
标题翻译：调制上皮 - 间质转化和间充质上皮的过渡方法在细胞和ENSURE有用资源
公开(公告)号：EP2026773A1
公开(公告)日：2009-02-25
申请号：EP07718982.7
申请日：2007-05-25
申请人： MEDVET SCIENCE PTY. LTD.
发明人： KHEW-GOODALL, Yeesim , GOODALL, Greg
IPC分类号： A61K31/00 , A61K31/713 , A61K39/395 , A61P43/00 , A01K67/00 , A61K33/00 , A61P17/02 , C12N15/06 , A61K31/7088 , A61K38/02 , A61P35/04
CPC分类号： A61K31/7088 , A61K31/713 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/321 , C12N2320/50 , C12N2330/10 , C12N2310/3521
摘要： The present invention relates generally to the fields of treatment, prophylaxis and diagnosis of cell-based and fibrotic conditions in animals including mammals. More particularly, the present invention contemplates the use of agents which modulate epithelial-mesenchymal transition (EMT) processes and mesenchymal-epithelial transition (MET) processes and hence are useful in the treatment of a range of conditions including inhibiting metastasis of solid tumors and the development of fibrosis, treating metastatic disease and in promoting wound healing. Diagnostic protocols to assess EMT and MET or its stage of development also form part of the present invention. The EMT and MET modulating agents are also useful in regulating gene expression and, hence, represent useful therapeutic and research tools.

8. 发明公开

EP2017335A1 Mutated Abl kinase domains 有权
标题翻译： Mutante der kinaseDomänedes ABL
公开(公告)号：EP2017335A1
公开(公告)日：2009-01-21
申请号：EP08166771.9
申请日：2002-10-04
申请人： NOVARTIS AG , Université Victor Segalen Bordeaux 2 , Oregon Health and Science University , Technische Universität München , University of Heidelberg , Centre Hospitalier Regional Universitaire de Lille , MEDVET SCIENCE PTY. LTD.
发明人： Barthe, Christophe , Branford, Susan , Corbin, Amie , Druker, Brian Jay , Duyster, Justus , Hochhaus, Andreas , Hughes, Timothy , Kreil, Sebastian , Leguay, Thibaut , Mahon, Francois-Xavier , Marit, Gerald , Mueller, Martin , Peschel, Christian , Preudhomme, Claude , Roche Lestienne, Catherine , Rudzki, Zbigniew
IPC分类号： C12N9/12 , C12N15/00 , C12N5/00 , G01N33/50
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-yl m ethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.
摘要翻译：本发明涉及分离的多肽，其包含功能性激酶结构域，其包含天然人类Abl激酶结构域的氨基酸序列或其基本相似的序列，其中至少一种选自Met244，Leu248，Gly250，Glu252，Tyr253， Val256，Glu258，Phe311，Ile313，Phe317，Met318，Met351，Glu355，Glu359，Ile360，His361，Leu370，Asp381，Phe382，His396，Ser417，Glu459和Phe486被另一个氨基酸取代，所述突变的功能性激酶结构域对通过N- [4-甲基-3-（4-吡啶-3-基 - 嘧啶-2-基氨基） - 苯基] -4-（4-甲基 - 哌嗪-1-基m乙基）对其酪氨酸激酶活性的抑制，苯甲酰胺或其盐，使用这种多肽来筛选抑制这些多肽的酪氨酸激酶活性的化合物，编码这种多肽的核酸分子，重组载体和包含该核酸分子的宿主细胞，以及使用的这种核酸痣制备此类多肽的细胞用于筛选抑制这些多肽的酪氨酸激酶活性的化合物。

9. 发明公开

EP1713462A1 A METHOD OF MODULATING PRO-INFLAMMATORY AND INFLAMMATORY ACTIVITY MEDIATED BY C-REACTIVE PROTEIN 审中-公开
标题翻译：对于调制方法BY C反应蛋白介导的炎症反应和炎症活动
公开(公告)号：EP1713462A1
公开(公告)日：2006-10-25
申请号：EP05700103.4
申请日：2005-01-21
申请人： MEDVET SCIENCE PTY. LTD.
发明人： XIA, Pu , WADHAM, Carol , VADAS, Mathew
IPC分类号： A61K31/20 , A61K31/66 , A61P9/10
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/20 , A61K31/66 , A61K31/685
摘要： The present invention relates generally to a method of modulating the proinflammatory activity of C-reactive protein in endothelial cells. More particularly, the present invention relates to down-regulation of proinflammatory activity of C-reactive protein in vascular endothelial cells. Accordingly, the method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of inflammatory conditions, particularly conditions characterised by proinflammatory activity of C-reactive protein in endothelial cells.

10. 发明公开

EP1290182A4 SPHINGOSINE KINASE AND USES THEREOF 有权
标题翻译： SPHINGOSINE激酶及其用途
公开(公告)号：EP1290182A4
公开(公告)日：2006-01-11
申请号：EP01929118
申请日：2001-05-11
申请人： MEDVET SCIENCE PTY LTD
发明人： VADAS MATHEW , GAMBLE JENNIFER , XIA PU , WANG LIJUN
IPC分类号： C12N15/09 , A61K31/13 , A61K31/133 , A61K35/14 , A61K38/00 , A61K45/00 , A61P35/00 , A61P43/00 , C12N5/06 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/02 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/1205 , A61K31/13 , A61K38/00
摘要： The present invention relates generally to a method of modulating the growth of cells and, more particularly, to a method of down-regulating the growth of neoplastic cells. The present invention is useful, inter alia, in the therapeutic and/or prophylactic treatment of cancers such as, but not limited to, solid cancers such as cancers of the colon, stomach, lung, brain, bone, oesophagus, pancreas, breast, ovary or uterus.

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