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1. 发明公开

EP3209697A1 FN14-BINDING PROTEINS AND USES THEREOF 无效
标题翻译： FN14-结合蛋白及其用途
公开(公告)号：EP3209697A1
公开(公告)日：2017-08-30
申请号：EP15853070.9
申请日：2015-10-23
申请人： La Trobe University
发明人： CASEY, Joanne
IPC分类号： C07K16/30 , C07K19/00 , A61K39/395 , A61P35/00 , A61P37/00 , A61P25/00 , A61P9/00 , A61P21/00
CPC分类号： C07K16/2878 , A61K39/395 , A61K2039/505 , C07K16/30 , C07K19/00 , C07K2317/21 , C07K2317/55 , C07K2317/92
摘要： The present invention provides an isolated or recombinant Fn14-binding protein comprising an antigen binding do main, wherein the antigen binding domain binds specifically to Fn14 or a cell expressing Fn14.
摘要翻译：本发明提供了包含抗原结合结构域的分离的或重组的Fn14结合蛋白，其中抗原结合结构域与Fn14或表达Fn14的细胞特异性结合。

2. 发明授权

EP1385379B1 INSECTICIDE AND METHOD OF CONTROLLING INSECTS 有权
标题翻译：杀虫剂，及其控制方法害虫
公开(公告)号：EP1385379B1
公开(公告)日：2008-08-06
申请号：EP02712624.2
申请日：2002-03-28
申请人： NUFARM AUSTRALIA LIMITED , LA TROBE UNIVERSITY
发明人： SANDEMAN, Richard, Mark , CHANDLER, David, Spencer , DUNCAN, Ann, Maree , HAY, Phillip, Maxwell
IPC分类号： A01N37/44 , A01N37/46 , A01N43/36 , A01N43/80 , A01N57/24 , A01N57/28 , C07F9/38 , C07F9/40 , A01N57/20 , A01N57/16 , A01N47/22 , A01N43/90 , A01N43/24
CPC分类号： C07F9/3808 , A01N37/44 , A01N37/46 , A01N43/36 , A01N43/80 , A01N57/20 , A01N57/24 , A01N57/28 , C07F9/4006 , A01N47/22 , A01N43/90 , A01N43/24 , A01N57/16 , A01N2300/00
摘要： An insecticide of formula (1) and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of: the group OR5 wherein R5 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclic and substituted heterocyclic; the group -NR¿6?OH wherein R?6¿ is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, carbocyclic and substituted carbocyclic; the group NR7R8 wherein R?7 and R8¿ are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl and carbocyclic; and the group wherein R1 is linked to R2 to form a diradical bridging group; R?2 and R3¿ are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, carbocyclic, substituted carbocyclic, aryl, substituted aryl, acyl and substituted acyl; and A is a diradical linking group which has a molecular weight of preferably less than 200 and more preferably less than 100.

3. 发明公开

EP3180365A1 NOVEL POTASSIUM CHANNEL BLOCKERS AND USE THEREOF IN THE TREATMENT OF AUTOIMMUNE DISEASES 有权
标题翻译：维也纳戴维·贝恩德·贝桑德·冯·奥尼蒙·肯尼克
公开(公告)号：EP3180365A1
公开(公告)日：2017-06-21
申请号：EP15832619.9
申请日：2015-08-14
申请人： Monash University , LA TROBE UNIVERSITY , Peptides International, Inc. , Baylor College of Medicine
发明人： NORTON, Raymond, S , CHANG, Shih, Chieh , PENNINGTON, Michael, W , BEETON, Christine , SMITH, Brian, J.
IPC分类号： C07K19/00 , C07K14/46 , C07K4/00 , C12N15/63 , A61K38/17 , A61P35/00 , A61P37/00
CPC分类号： C07K14/43595 , A61K38/00 , A61K38/17 , C07K4/00 , C07K14/43504 , C07K19/00 , C07K2319/21 , C12N15/63
摘要： Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X-4 is D, E or other negatively-charged amino acid or derivative thereof, X-3 is E, I, L, S, V, W or a tryptophan derivative, X-2 is any amino acid, X-1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety.
摘要翻译：公开了海葵Stichodactyla helianthus毒素ShK的新型类似物及其作为例如用于治疗自身免疫疾病的治疗剂的用途。类似物包括ShK毒素多肽和包含根据式（I）的氨基酸序列的N-末端延伸：其中X-4是D，E或其它带负电荷的氨基酸或其衍生物，X-3是E， I，L，S，V，W或色氨酸衍生物，X-2是任何氨基酸，X-1是任何氨基酸，a不存在或第一个附加部分，b不存在或第二附加部分。

4. 发明授权

EP2714075B1 BLOOD STAGE MALARIA VACCINE 有权
标题翻译：疟疾疫苗在血液体育场
公开(公告)号：EP2714075B1
公开(公告)日：2016-11-16
申请号：EP12793152.5
申请日：2012-05-28
申请人： Griffith University , La Trobe University , Lee, Moses
发明人： LEE, Moses , GOOD, Michael , SPITHILL, Terry
IPC分类号： A61K39/015 , A61P33/06
CPC分类号： A61K39/015 , A61K2039/522 , C07K14/445 , Y02A50/412
摘要： An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.

5. 发明公开

EP2499252A1 TRANSGENIC PLANT MALE STERILITY 审中-公开
标题翻译：转基因植物雄性不育
公开(公告)号：EP2499252A1
公开(公告)日：2012-09-19
申请号：EP10829350.7
申请日：2010-11-11
申请人： La Trobe University
发明人： PARISH, Roger, W. , LI, Song Feng
IPC分类号： C12N15/82 , A01H5/00 , C12N15/113
CPC分类号： C12N15/8218 , C12N15/113 , C12N15/8289 , C12N2310/141
摘要： The invention relates to a reversible transgenic plant male sterility system wherein the male sterility is induced by amiRNA and a reversible transgenic plant male sterility system comprising a male sterility construct comprising an isolated nucleic acid encoding a precursor amiRNA encoding an amiRNA targeted to a gene involved in pollen development, and a male fertility restorer construct comprising an isolated nucleic acid encoding a mutated copy of the gene involved in pollen development, or multiple copies of said gene involved in pollen development, or a single copy of said gene involved in pollen development under the control of a strong promoter.

6. 发明公开

EP2476091A2 METHOD AND SYSTEM FOR ENERGY MANAGEMENT 审中-公开
标题翻译：电源管理系统和程序
公开(公告)号：EP2476091A2
公开(公告)日：2012-07-18
申请号：EP10814801.6
申请日：2010-09-09
申请人： La Trobe University
发明人： DESAI, Aniruddha Anil , SINGH, Jugdutt
IPC分类号： G06Q50/00
CPC分类号： G06Q10/06 , G06Q50/06 , H02J3/00 , H02J2003/003 , H02J2003/007
摘要： A method (300) of managing energy consumption associated with premises includes firstly generating (302) and storing an initial energy profile (304) of the premises. The profile (304) includes information characterising the premises, such as occupancy patterns, function of the premises, geographical location, installed appliances (108), and so forth. An expected energy usage (308) associated with the premises is computed over a predetermined time period based upon the information in the initial energy profile (304). Actual energy usage (312) associated with the premises is then recorded over the predetermined time period and the energy profile (304) is adaptively updated based upon the recorded energy usage (312). The energy profile (304) and the actual energy usage (312) are used to manage energy consumption associated with the premises. An installable system (100) and apparatus (102) for implementing the method at premises are also provided.

7. 发明公开

EP2156189A1 TNF GENE EXPRESSION AS A BIOMARKER OF SENSITIVITY TO ANTAGONISTS OF INHIBITOR OF APOPTOSIS PROTEINS 审中-公开
标题翻译：肿瘤坏死因子α - 基因表达灵敏度生物标志物缓蚀剂细胞凋亡的蛋白拮抗剂
公开(公告)号：EP2156189A1
公开(公告)日：2010-02-24
申请号：EP08747784.0
申请日：2008-05-07
申请人： Tetralogic Pharmaceuticals Corp. , LA TROBE UNIVERSITY
发明人： ALAVI, Alireza , MCKINLAY, Mark, A. , CHUNDURU, Srinivas, K. , SILKE, John , VINCE, James , VAUX, David
IPC分类号： G01N33/574 , G01N33/68 , A61K31/40 , A61P35/00
CPC分类号： G01N33/6863 , A61K31/40 , G01N2333/525
摘要： TNFα gene expression can be used as a biomarker of a cell's sensitivity to antagonists of inhibitor of apoptosis proteins (IAPs). Methods of the invention are useful for screening patients to identify those who could benefit from administration of an IAP antagonist to treat various malignant or benign tumors, benign proliferative diseases, or autoimmune diseases.

8. 发明公开

EP1322756A1 MANIPULATION OF PLANT SENESCENCE USING AN i MYB /i GENE PROMOTER AND CYTOKININ BIOSYNTHESIS GENES 有权
标题翻译：老化过程在使用我MYB植物MANIPULATION / I GEN启动子及细胞分裂素生物合成基因
公开(公告)号：EP1322756A1
公开(公告)日：2003-07-02
申请号：EP01962486.5
申请日：2001-08-30
申请人： Agriculture Victoria Services Pty Ltd , LA TROBE UNIVERSITY
发明人： SPANGENBERG, German , LIN, Yi, Han , PARISH, Roger, W. , LI, Song, Feng , HEAZLEWOOD, Joshua , PALLAGHY, Charles, K.
IPC分类号： C12N15/11 , C12N15/63 , A01H1/00 , A01H3/00 , A01H5/00
CPC分类号： C12N15/8249 , C12N15/8271
摘要： The present invention relates to methods of manipulating senescence in plants. The invention also relates to vectors useful in such methods, transformed plants with modified senescence characteristics and plant cells, seeds and other parts of such plants. Specifically the present invention provides a method of manipulating senescence in a plant, said method including introducing into said plant a genetic construct including a myb gene promoter, or functionally active fragment or variant thereof, operably linked to a gene encoding an enzyme involved in biosynthesis of a cytokinin, or a functionally active fragment or variant thereof.

9. 发明公开

EP0707640A1 (1 $m(7) 3, 1 $m(7) 4)-$g(b)-GLUCANASE OF ENHANCED STABILITY 失效
标题翻译：（1 -m（7）3，1 -m（7）4） - 图9（b）-GLUCANOX具有增加的稳定性
公开(公告)号：EP0707640A1
公开(公告)日：1996-04-24
申请号：EP94920335.0
申请日：1994-07-06
申请人： BIOMOLECULAR RESEARCH INSTITUTE LTD. , LA TROBE UNIVERSITY , LUMINIS PTY. LIMITED
发明人： VARGHESE, Joseph Noozhumurry , GARRETT, Thomas Peter John , FINCHER, Geoffrey Bruce , HOJ, Peter Bordier , CHEN, Lin
IPC分类号： A01H5 , A23K1 , C12N1 , C12N9 , C12N15 , C12R1
CPC分类号： C12Y302/01073 , A23K10/14 , C12N9/244 , C12N9/2448 , C12N15/8242 , C12Y302/01006
摘要： This invention relates to a (1 → 3, 1 → 4)-β-glucanase (glucanase EII endohydrolase) enzyme, whose amino acid sequence has been modified in order to provide an enzyme whose three-dimensional structure confers improved thermostability and/or pH stability. Specific modifications are based upon a comparison between the three-dimensional structure of (1 → 3, 1 → 4)-β-glucanase and that of (1 → 3)-β-glucanase. The (1 → 3, 1 → 4)-β-glucanase gene has been modified by site-directed mutagenesis, and modified enzymes have been expressed in Escherichia coli. Modified sequences, DNA molecules encoding them, plasmids, expression vectors and transgenic plants are disclosed and claimed.

10. 发明公开

EP0168440A1 PREPARATION OF PENICILLIN SULFOXIDE 失效
标题翻译：青霉素的制备
公开(公告)号：EP0168440A1
公开(公告)日：1986-01-22
申请号：EP85900585.0
申请日：1985-01-15
申请人： LA TROBE UNIVERSITY
发明人： DAVIS, Michael , WU, Wen-yang
IPC分类号： C07D499
CPC分类号： C07D499/00
摘要： Procédé de préparation de beta-sulfoxyde de pénicilline V par oxydation de la pénicilline V dans un système liquide à deux phases comprenant une solution aqueuse de péroxyde d'hydrogène et un solvant organique ou un mélange de solvants organiques. Le procédé se caractérise par le fait que (I) la solution aqueuse de péroxyde d'hydrogène est exempte de tout promoteur d'acide organique, présente une concentration de 20 à 50% p/v H2O2 dans l'eau, et le rapport molaire entre le H2O2 et la pénicilline V est compris entre 1,5:1 et 7:1; (II) le solvant organique ou le mélange de solvants organiques n'est pas mélangeable à l'eau, est inerte au péroxyde d'hydrogène, peut dissoudre la pénicilline V et présente une solubilité inférieure par rapport au beta-sulfoxyde de pénicilline V que par rapport à la pénicilline V; (III) la pénicilline V est présente dans le solvant organique ou mélange de solvants organiques non mélangeable à l'eau sous la forme d'une solution concentrée dans la plage de 35 à 120% p/v. Le beta-sulfoxyde de pénicilline V ainsi formé cristallise à partir du système liquide à deux phases à mesure que l'oxydation se poursuit, avec un rendement et une pureté relativement élevés.
摘要翻译：一种通过在包含过氧化氢水溶液和有机溶剂或有机溶剂混合物的两相液体体系中氧化青霉素V来制备青霉素Vβ-亚砜的方法。该方法的特征在于（I）过氧化氢水溶液不含有任何有机酸促进剂，其在水中的浓度为20至50％w / v H 2 O 2，摩尔比 H 2 O 2与青霉素V之间的比例在1.5：1和7：1之间; （II）有机溶剂或有机溶剂混合物不是水可混合的，是过氧化氢惰性的，可溶解青霉素V并且与青霉素-Vβ-亚砜相比溶解度低于与青霉素V相比; （III）青霉素V作为35-120％w / v范围内的浓缩溶液存在于有机溶剂或非水可混合有机溶剂混合物中。由此形成的青霉素B-亚砜随着氧化的继续从两相液体体系中结晶出来，具有较高的收率和纯度。

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