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    • 7. 发明公开
    • Fermentation processes and their products
    • Fermentationsverfahren und erhaltene Produkte。
    • EP0147198A2
    • 1985-07-03
    • EP84308981.4
    • 1984-12-20
    • Delta Biotechnology Limited
    • Molzahn, Stuart, William
    • C12N15/81C12C11/00C12P7/06C12P21/02
    • C12Y302/01073C12N9/2405C12N9/2434C12N9/2471C12N9/86C12N15/81C12P7/06C12Y302/01023C12Y305/02006Y02E50/17
    • The invention provides a process for the production of ethanol and a protein or peptide which is heterologous to yeast which comprises fermenting an aqueous sugar-containing medium with an industrial yeast strain which has been genetically modified to be capable of expressing a heterologous protein or peptide, recovering the ethanol so-formed, and obtaining the said heterologous protein or peptide from the fermentation products. The process may be applied to the industrial production of alcoholic beverages such as beer or distilled alcohol. The yeast inevitably obtained as a by-product in the process has improved value because of the heterologous protein or peptide which it contains and provides a source of the latter. Heterologous protein and peptides which may be produced by the new process include enzymes such as beta-lactamase, beta-glucanase and beta-galactosidase and proteins of therapeutic value such as human serum albumen.
    • 本发明提供了一种用于生产与酵母异源的乙醇和蛋白质或肽的方法,该方法包括用已经被遗传修饰以能够表达异源蛋白质或肽的工业酵母菌株发酵含水的含糖培养基, 回收如此形成的乙醇,并从发酵产物获得所述异源蛋白质或肽。 该方法可以应用于酒精饮料如啤酒或蒸馏酒的工业生产。 在该方法中不可避免地作为副产物获得的酵母由于其含有的异源蛋白质或肽而提供了价值,并提供了后者的来源。 可以通过新方法产生的异源蛋白质和肽包括诸如β-内酰胺酶,β-葡聚糖酶和β-半乳糖苷酶的酶和具有治疗价值的蛋白质如人血清白蛋白。