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1. 发明公开

EP2628488A1 SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION 有权转让
标题翻译：药剂师ZUSAMMENSETZUNG MITVERZÖGERTERFREISETZUNG
公开(公告)号：EP2628488A1
公开(公告)日：2013-08-21
申请号：EP11832614.9
申请日：2011-10-14
申请人： Kyoto University , Kyoto Prefectural Public University Corporation , Kaken Pharmaceutical Co., Ltd. , Koken Co., Ltd.
发明人： FUKUSHIMA, Masanori , MATSUBARA, Hiroaki , MATOBA, Satoaki , HIJIKATA, Shigeki , ASO, Yu , SATO, Tsutomu
IPC分类号： A61K47/42 , A61K9/08 , A61K38/00 , A61K38/27 , A61K45/00 , A61K47/26 , A61K47/36 , A61P1/02 , A61P9/00 , A61P9/10 , A61P17/02 , A61P19/00 , A61P35/00 , A61P43/00
CPC分类号： A61K9/0002 , A61K9/0024 , A61K9/5123 , A61K31/7004 , A61K31/7008 , A61K38/1808 , A61K38/1816 , A61K38/1825 , A61K38/1858 , A61K38/27 , A61K38/39 , A61K45/06 , A61K47/26 , A61K47/42 , A61K2300/00
摘要： Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected frommonosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.
摘要翻译：本发明提供包含药物和胶原的药物组合物，其组合物的操作性良好且具有缓释性。缓释药物组合物包括：药物; 胶原蛋白和选自单糖，二糖，三糖和四糖中的至少一种糖。本发明的发明人已经发现，含有糖的胶原溶液的体内施用导致胶原蛋白的凝胶化。基于该发现，发明人已经发现含有药物，胶原和糖的组合物可以控制药物的释放速度，并且这种组合物可以用作缓释药物组合物。

2. 发明公开

EP1811027A1 POLYNUCLEOTIDE FOR PRODUCTION OF RECOMBINANT PROTEIN BY SILKWORM 有权转让
标题翻译：多瑙河ZER HERSTELLUNG VON REKOMBINANTEM蛋白DURCH SEIDENRAUPEN
公开(公告)号：EP1811027A1
公开(公告)日：2007-07-25
申请号：EP05795112.1
申请日：2005-10-14
申请人： Hiroshima Industrial Promotion Organization , BIOINTEGRENCE INC. , KOKEN CO., LTD.
发明人： TOMITA, Masahiro , SHIMIZU, Katsuhiko , OGAWA, Shingo , HINO, Rika , IIZUKA, Masashi , ADACHI, Takahiro , YOSHIZATO, Katsutoshi
IPC分类号： C12N15/09 , C12P21/00 , A01K67/033
CPC分类号： C12P21/02 , A01K67/0339 , A01K67/04 , A01K2217/05 , A01K2227/706 , A01K2267/01 , C07K14/43586
摘要： As a novel means capable of secreting a recombinant protein produced in silkworm middle silk gland into a cocoon and extracting the recombinant protein easily without denaturing the steric structure of the protein, there is provided a polynucleotide functionally linked to a recombinant protein structural gene in an expression cassette for expressing the recombinant protein in silkworm middle silk gland, wherein a polynucleotide constituting a promoter region of sericin 1 or sericin 2 gene and a polynucleotide constituting baculovirus homologous regions are functionally linked.
摘要翻译：作为能够将蚕中间丝腺中产生的重组蛋白质分泌成茧并且容易提取重组蛋白质而不使蛋白质的空间结构变性的新颖手段，提供了与表达中的重组蛋白质结构基因功能性连接的多核苷酸用于在蚕丝绸中表达重组蛋白的盒，其中构成丝胶蛋白1或丝胶蛋白2基因的启动子区的多核苷酸和构成杆状病毒同源区的多核苷酸是功能连接的。

3. 发明公开

EP1623723A2 Stable gene formulations 审中-公开
标题翻译：稳定的基因制剂
公开(公告)号：EP1623723A2
公开(公告)日：2006-02-08
申请号：EP05021713.2
申请日：1999-05-19
申请人： Dainippon Sumitomo Pharma Co., Ltd. , KOKEN CO., LTD.
发明人： Terada, Masaaki , Ochiya, Takahiro, Nat'l. Cancer Ctr. Res. Inst. , Sano, Akihiko , Hisada, Akihiko , Nagahara, Shunji
IPC分类号： A61K48/00
CPC分类号： A61K48/0025 , A61K48/0008 , A61K48/0091
摘要： The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation.
In the invention, at least one saccharide and/or at least one non-hydrophobic amino acid and/or at least one organic acid having two or more carboxyl groups except amino acids, or a collagen or a gelatin and at least one amino acid are added to a gene formulation.
摘要翻译：本发明涉及在制备和保存过程中保持用于基因疗法的制剂的稳定性。在本发明中，除氨基酸以外的至少一种糖和/或至少一种非疏水性氨基酸和/或具有两个或更多个羧基的有机酸，或胶原蛋白或明胶和至少一种氨基酸为添加到基因制剂中。

4. 发明授权

EP0987633B1 COMMUNICATION SYSTEM 失效
标题翻译：通讯系统
公开(公告)号：EP0987633B1
公开(公告)日：2006-01-25
申请号：EP98923061.0
申请日：1998-06-01
申请人： KOKEN CO., LTD. , Nagoya, Mitsugu
发明人： NAGOYA, Mitsugu
IPC分类号： G06F11/22 , G01R31/28 , G01R31/3185
CPC分类号： G01R31/318536 , G01R31/2815 , G01R31/318533 , G01R31/318572
摘要： There are provided a boundary scan element including a plurality of input-terminal-side boundary cells connected in series and assigned individually to respective input terminals, a plurality of output-terminal-side boundary cells connected in series and assigned individually to respective output terminals, a TAP circuit for controlling input and output of data to or from the input-terminal-side and output-terminal-side boundary cells, a TDI terminal for inputting serial data to be provided to the boundary cells, a TDO terminal for outputting data from the boundary cells as serial data, a TCK terminal to which a clock signal is input, and a TMS terminal to which a mode signal is input to switch an operation mode of the TAP circuit, characterized in that the input-terminal-side boundary cells and the output-terminal-side boundary cells are connected in parallel between the TDI terminal and the TDO terminal; and a communication system using the same.
摘要翻译：提供了一种边界扫描元件，该边界扫描元件包括多个串联连接并分别分配给各个输入端的输入端侧边界单元，多个输出端侧边界单元串联连接并分别分配给各个输出端，用于控制输入和输出来自输入端侧和输出端侧边界单元的数据的TAP电路，用于输入要提供给边界单元的串行数据的TDI端，用于从输入端输出数据的TDO端作为串行数据的边界单元，输入时钟信号的TCK端子以及输入模式信号以切换TAP电路的操作模式的TMS端子，其特征在于，输入端子侧边界单元并且输出端侧边界单元在TDI端子和TDO端子之间并联连接; 以及使用其的通信系统。

5. 发明公开

EP1026512A3 Test circuit for a communication element 有权
标题翻译：用于通信元件测试电路
公开(公告)号：EP1026512A3
公开(公告)日：2002-08-07
申请号：EP99310626.9
申请日：1999-12-29
申请人： KOKEN CO., LTD.
发明人： Nagoya,Mitsugu
IPC分类号： G01R31/3185
CPC分类号： G01R31/318536
摘要： A communication element (A) having a plurality of input-side boundary cells (1) and output-side boundary cells (2), and a TAP circuit (3) for controlling the input and output of data to/from said input-side and output-side boundary cells (1,2), in which the input-side boundary cells (1) are connected in parallel to said corresponding output-side boundary cells (2) through the TAP circuit (3), and a communication apparatus (B) having a plurality of the communication elements (A1-A4), terminal equipments (C1-C4) separately connected to each of said communication elements (A1-A4), for inputting and outputting the data to/from said communication elements through said data input and output lines (12, 13); and a host computer (11), in which the communication elements (A1-A4) are connected in series to the host computer (11).

7. 发明公开

EP0393788A3 Vascular prosthesis and manufacturing method of the same 失效
标题翻译：血管造影，其制造方法和用于血管造影的基底
公开(公告)号：EP0393788A3
公开(公告)日：1992-07-08
申请号：EP90200957.0
申请日：1990-04-17
申请人： KOKEN CO. LTD.
发明人： Noishiki, Yasuhara , Miyata, Teruo
IPC分类号： A61F2/04 , A61F2/06 , A61L27/00
CPC分类号： A61L27/507 , A61F2/06 , A61F2/062 , A61L27/36 , Y10S623/901 , Y10S623/921
摘要： The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells are deposited and captured within the wall of a vascular prosthesis substrate (1); a manufacturing method comprising the steps of immersing a vascular prosthesis substrate into a dispersed solution of fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle cells and fibroblast cells, and depositing and capturing the cells and/or tissue fragments on the inner wall and within the wall of the vascular prosthesis from one side to the other side of the vascular prosthesis substrate wall by providing a pressure differential between the outside and the inside of the vascular prosthesis substrate; and a substrate suitable for manufacturing a vascular prosthesis having a porous membrane having pores capable of trapping tissue fragments, or a laminate structure with such a membrane and another porous membrane having pores not large enough to pass the cells or tissue fragments.

8. 发明公开

EP0460232A1 TUMOR CELL GROWTH INHIBITOR 失效
标题翻译： WACHSTUMSINHIBITOR VON TUMORZELLEN。
公开(公告)号：EP0460232A1
公开(公告)日：1991-12-11
申请号：EP91900944.9
申请日：1990-12-21
申请人： KOKEN CO., LTD.
发明人： IIJIMA, Kunihito , KATO, Haruki , NAGASU, Yoichiro
IPC分类号： A61K37/02 , A61K31/215 , A61K31/765
CPC分类号： A61K9/0019 , A61K38/04 , A61K47/26 , A61K47/34 , A61K31/765 , A61K2300/00
摘要： A tumor cell growth inhibitor which comprises 10 parts by weight of a low condensate and polymer of an α-hydroxy acid, 1 to 4 parts by weight of an oligopeptide containing at least one pyroglutamic acid residue, and 1 to 3 parts by weight of a stabilizer. Said α-hydroxy acid condensate and polymer mainly comprise a condensate of 2 to 10 molecules of an α-hydroxy acid, a polymer thereof, and metal salts thereof; said oligopeptide comprises an oligopeptide composed of 2 to 8 amino acid residues and containing at least one pyroglutamic acid residue and metal salts thereof; and said stabilizer comprises a sugar and a sugar alcohol.
摘要翻译：一种肿瘤细胞生长抑制剂，其包含10重量份的低浓缩物和α-羟基酸的聚合物，1至4重量份含有至少一个焦谷氨酸残基的寡肽和1至3重量份的稳定剂。所述α-羟基酸缩合物和聚合物主要包含2-10分子的α-羟基酸，其聚合物及其金属盐的缩合物; 所述寡肽包含由2至8个氨基酸残基组成并含有至少一个焦谷氨酸残基及其金属盐的寡肽; 并且所述稳定剂包括糖和糖醇。

9. 发明授权

EP0243132B1 Artificial skin and its production 失效
标题翻译：人造皮及其生产
公开(公告)号：EP0243132B1
公开(公告)日：1991-03-20
申请号：EP87303441.7
申请日：1987-04-16
申请人： KOKEN CO. LTD.
发明人： Katsutoshi, Yoshizato , Toshio Taira , Teruo, Miyata
IPC分类号： A61F2/10 , A61M29/00 , C12N15/00
CPC分类号： A61L27/24 , A61F2/10 , A61F2/105 , A61F2310/00365 , A61L27/36 , A61L27/60 , Y10S623/901
摘要： An artificial skin comprising an insoluble atelocollagen sheet and an epidermal cell layer cultured only on one surface of the sheet, and a method of producing the same are disclosed, which method includes the steps of: forming an insoluble atelocollagen sheet; inoculating epidermal cells only on one surface of the atelocollagen sheet; and suspending the atelocollagen sheet in a liquid culture medium to culture the epidermal cells, thereby forming an epidermal cell layer.

10. 发明公开

EP0318286A3 A substratum for cell culture and its production and use 失效
标题翻译：细胞培养基及其生产和使用的基础
公开(公告)号：EP0318286A3
公开(公告)日：1990-10-31
申请号：EP88311132.0
申请日：1988-11-24
申请人： KATAKURA CHIKKARIN CO., LTD. , KOKEN CO. LTD.
发明人： Miyata, Teruo , Taira, Taira , Kimura, Takashi , Izume, Masato
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C08B37/003 , C08L5/08 , C12N2533/54 , C12N2533/72 , C08L2666/02
摘要： A novel substratum for cell culture, capable of satisfactorily effecting an initial adhesion and proliferation of cells, is provided which comprises a chitosan-collagen composite material as an effective component.

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