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1. 发明公开

EP2949347A4 ARTIFICIAL DERMIS FOR TRANSPLANTATION AND METHOD FOR PRODUCING SAME 有权转让
标题翻译： KÜNSTLICHEDERMISFÜR移植与VERFAHREN ZUR HERSTELLUNG DAVON
公开(公告)号：EP2949347A4
公开(公告)日：2017-07-05
申请号：EP14742948
申请日：2014-01-21
申请人： FUJIFILM CORP , JAPAN TISSUE ENG CO LTD
发明人： OGIWARA KAZUTAKA , YAMAGUCHI KAZUHIRO , SASAKI TASUKU , GOTO EIKO , SUGAWARA KATSURA , HATA KEN-ICHIRO
IPC分类号： A61L27/56 , A61F2/10 , A61L27/58 , A61L27/60
CPC分类号： A61L27/222 , A61F2/105 , A61F2210/0076 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2430/34
摘要： Artificial dermis for transplantation includes a wound contact layer that includes a porous sheet consisting of a biodegradable material, the porous sheet satisfying the following Equation, Equation: X2/X1 ‰¤ 0.8. In the porous sheet, when a line parallel to a wound contact face and a line perpendicular to a wound contact face of equal length are drawn, X1 represents a number of points of intersection between the line parallel to the wound contact face and pore walls; and X2 represents a number of points of intersection between the line perpendicular to the wound contact face and pore walls.
摘要翻译：用于移植的人造真皮包括伤口接触层，所述伤口接触层包括由可生物降解材料组成的多孔片，所述多孔片满足以下等式，等式：X2 /X1≤0.8。在多孔片中，当绘制平行于伤口接触面的线和与长度相等的伤口接触面垂直的线时，X1表示平行于伤口接触面的线与孔壁之间的交点的数目; X2代表垂直于伤口接触面的线与孔壁之间的交点的数目。

2. 发明公开

EP2801610A4 CELL SEPARATION CONTAINER 有权
标题翻译： ZELLTRENNUNGSBEHÄLTER
公开(公告)号：EP2801610A4
公开(公告)日：2015-10-14
申请号：EP12864255
申请日：2012-12-25
申请人： JAPAN TISSUE ENG CO LTD
发明人： SUGIURA MAKOTO
IPC分类号： C12M3/08 , C12M1/00 , C12N5/071
CPC分类号： C12M47/04 , C12M45/06 , C12M45/09 , C12M47/02
摘要： A cell separation container 10 includes a collection chamber 20 and a tissue holding chamber 30 which are partitioned by a filter 40. The cell separation container 10 includes a first air pressure adjuster 60 configured to adjust the inflow and outflow of gas in the collection chamber 20 and a second air pressure adjuster 70 configured to adjust the inflow and outflow of gas in the tissue holding chamber 30. Thus, the inflow and outflow of the outside air and the gases in the collection chamber 20 and the tissue holding chamber 30 can be adjusted. In the cell separation container 10, switching between holding a treatment liquid in the tissue holding chamber 30 and ejecting a treatment liquid to the collection chamber 20 can be performed by adjusting the inflow and outflow of the outside air and the gas in the connection chamber 20.

3. 发明公开

EP1228773A4 TRANSPLANT MATERIAL AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：移植材料和的制造工艺的
公开(公告)号：EP1228773A4
公开(公告)日：2003-07-23
申请号：EP00974869
申请日：2000-11-09
申请人： JAPAN TISSUE ENG CO LTD , OHGUSHI HAJIME
发明人： OHGUSHI HAJIME
IPC分类号： A61L27/36 , A61L27/38
CPC分类号： A61L27/3821 , A61L27/365 , A61L27/3847 , A61L27/3895 , A61L2430/02
摘要： A transplant material which is capable of imparting desired mechanical properties, elevating bone tissue repair speed and improving biocompatibility. This transplant material comprises an artificial and biologically inactive material, which is to be implanted in vivo as a substitute for bone tissue, and at least one type of cells selected from among osteoblasts and precursory osteoblasts which are adhered to the surface of the artificial material so that the artificial material is coated with the bone matrix produced by the cells. The artificial material involves not only a biologically inactive material but also a biologically inactive material coated with a biologically active substrate. This transplant material is produced by culturing mesenchymal stem cells collected from a living body to differentiate into at least one type of cells selected from among osteoblasts and precursory osteoblasts and then culturing the cells together with the artificial material to thereby adhere the differentiated cells on the surface of the artificial material and coat the surface of the artificial material with the bone matrix produced by the differentiated cells.

4. 发明公开

EP3072953A4 CELL CULTURE CONTAINER AND CONTAINER IN WHICH CELL CULTURE HAS BEEN ACCOMMODATED 有权
标题翻译： ZELLKULTURBEHÄLTERUNDBEHÄLTERMIT EINER ZELLKULTUR
公开(公告)号：EP3072953A4
公开(公告)日：2017-08-02
申请号：EP14864638
申请日：2014-11-06
申请人： JAPAN TISSUE ENG CO LTD
发明人： SUGIURA MAKOTO
IPC分类号： C12M3/00
CPC分类号： C12M23/14 , C12M23/10 , C12M23/34 , C12M23/38 , C12M23/58 , C12M33/04
摘要： An inner bag 20 of a cell culture package 10 is enclosed in an outer bag 50 such that a rubber stopper 24 is exposed to the outside. A closed space 56 surrounded by the outer surface of the inner bag 20 and the inner surface of the outer bag 50 is sterile. This allows the outer surface of the inner bag 20, which is used for containing cell-containing deformable materials, to be maintained in a sterile condition. Since the cell culture package 10 can be sterilized before a cell-containing deformable material is placed therein, the sterilization conditions can be relatively easily determined without considering the influence on the cell-containing deformable material. In addition, a holder 30 allows liquid to pass through the bottom surface and side surface of a recess and the bottom surface and the side surface of a cover. After a cell-containing deformable material is held in a holding space 30a, a liquid medium is added to the inner bag 20. During the culturing of the cell-containing deformable material, cells grow evenly over the entire cell-containing deformable material.
摘要翻译：细胞培养用包装10的内袋20被封入外袋50中，橡胶塞24露出到外部。由内袋20的外表面和外袋50的内表面围绕的封闭空间56是无菌的。这允许用于容纳含有细胞的可变形材料的内袋20的外表面保持无菌状态。由于细胞培养包装10可以在将含有细胞的可变形材料置于其中之前进行灭菌，所以可以相对容易地确定灭菌条件而不考虑对含细胞可变形材料的影响。另外，支架30允许液体通过凹部的底面和侧面以及盖的底面和侧面。在将含有细胞的可变形材料保持在容纳空间30a中之后，将液体培养基添加到内部袋20中。在培养含有细胞的可变形材料期间，细胞均匀地生长在整个含有细胞的可变形材料上。

5. 发明公开

EP3062030A4 CLEANING WORK DEVICE 有权
标题翻译： REINIGUNGSARBEITSVORRICHTUNG
公开(公告)号：EP3062030A4
公开(公告)日：2017-06-14
申请号：EP14856546
申请日：2014-10-23
申请人： JAPAN TISSUE ENG CO LTD
发明人： HATA KEN-ICHIRO , SUGIURA MAKOTO
IPC分类号： F24F7/06 , B01L1/00 , B01L1/04 , C12M1/00 , F24F9/00
CPC分类号： F24F7/08 , B01L1/00 , B01L1/04 , B01L9/06 , B01L9/543 , B01L2200/141 , C12M39/00 , F24F3/1607 , F24F9/00
摘要： A clean work device 10 includes a work area 30, a conveyor 25 in the work area, and a cleaning device 40. The work area 30 is disposed in a conveyance path P for cells C, and has an inlet 30a provided on the upstream side and an outlet 30b provided on the downstream side in a conveyance path P, with a downflow air curtain 50 provided at least at the inlet 30a and the outlet 30b. The conveyor 25 in the work area repeatedly performs an operation that moves a placement surface 25S having a culture vessel V thereon from the inlet 30a side into the work area 30, moves the placement surface 25S from the outlet 30b side to the outside of the work area 30, and, subsequently, moves back the placement surface 25S to the inlet 30a side. The cleaning device 40 cleans the placement surface 25S during the period from when the conveyor 25 in the work area moves the placement surface 25S to the outside of the work area 30 until the conveyor moves back the placement surface to the inlet 30a side of the work area 30.
摘要翻译：清洁作业装置10具有作业区域30，作业区域的输送带25以及清洁装置40.作业区域30配置在电池C的输送路径P上，具有设置在上游侧的入口30a 以及设置在输送路径P的下游侧的出口30b，并且至少在入口30a和出口30b处设置有下流式空气幕50。工作区域内的传送带25反复进行使具有培养容器V的载置面25S从入口30a侧向工作区域30移动的动作，使载置面25S从出口30b侧向工件外侧移动区域30，并且随后将放置表面25S移回入口30a侧。清扫装置40在从工作区域内的输送机25使载置面25S移动到作业区域30的外部的期间，清扫装载面25S，直到输送机使载置面向工件的入口30a侧移动区域30。

6. 发明公开

EP1358895A4 TISSUE EQUIVALANT FOR TRANSPLANTATION AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：组织替代物用于生产的移植和方法
公开(公告)号：EP1358895A4
公开(公告)日：2007-02-28
申请号：EP01999395
申请日：2001-12-04
申请人： JAPAN TISSUE ENG CO LTD , OCHI MITSUO
发明人： OCHI MITSUO , UCHIO YUJI , KAWASAKI KENZO , KATOH M , YAMAMOTO T , FUKUSHIMA R , KURUSHIMA T
IPC分类号： A61L27/38 , C12N11/02 , A61K35/32 , A61L27/00 , A61L27/14 , A61L27/24 , A61P19/00 , C12N5/06
CPC分类号： A61L27/3821 , A61L27/3633 , A61L27/3817 , A61L27/3895
摘要： A tissue equivalent for transplantation having a three-dimensional structure which is incubated in vitro, contains cells to be transplanted and can be transplanted into a living body after the incubation, characterized by consisting of a support layer mainly comprising a cell incubation support constituting the three-dimensional structure and a cell layer which is localized at least in a part of the tissue equivalent for transplantation continuously with the support layer and contains the cells to be transplanted or cell matrix in a larger amount than the support layer. This tissue equivalent is appropriately employed as a tissue equivalent for transplantation in a relatively large size. This tissue equivalent enables early fixation to the neighborhood of the transplanted tissue and prevention of falling off.

7. 发明公开

EP1234581A4 WOUND CONTRACTION INHIBITORS 有权
标题翻译：伤口收缩抑制剂
公开(公告)号：EP1234581A4
公开(公告)日：2004-09-22
申请号：EP00970076
申请日：2000-10-25
申请人： JAPAN TISSUE ENG CO LTD , UEDA MINORU
发明人： UEDA MINORU , SUMI YUKIO , HATA KENICHIRO , MURAMATSU HISAKO , MURAMATSU TAKASHI
IPC分类号： A61K38/57 , A61P9/06 , A61P9/08 , A61P17/02 , A61K45/00 , A61K9/06 , A61K9/08 , A61K35/24
CPC分类号： A61K38/57
摘要： Wound contraction inhibitors containing a secretory leukocyte protease inhibitor (SLPI) as the active ingredient. The SLPI concentration in these drugs preferably ranges from 1 to 5000 ng/ml, still preferably from 1 to 100 ng/ml. These drugs may be in the form of external preparations which contain the SLPI as the active ingredient and a base. It is also possible that these drugs are in the form of injections containing the SLPI as the active ingredient. It is favorable that the above-described external preparations further contain preservatives while the above-described injections further contain stabilizers (antioxidants), preservatives and soothing agents.

8. 发明公开

EP2857492A4 CELL CONTENT CONTAINER AND CONTAINER ALREADY HOUSING CELL CONTENT 有权转让
标题翻译：细胞内容物容器和容器与已经包含单元格内容
公开(公告)号：EP2857492A4
公开(公告)日：2016-01-27
申请号：EP13794337
申请日：2013-05-07
申请人： JAPAN TISSUE ENG CO LTD
发明人： SUGIURA MAKOTO
IPC分类号： C12M1/00 , A01N1/02 , B65D33/16
CPC分类号： C12M45/22 , A01N1/0263 , B65D33/1691
摘要： A package 10 for cell-containing material includes an inner bag 12 and an outer bag 16. The periphery of the inner bag 12 except an opening 14 is sealed. The periphery of the outer bag 16 except an opening 24 is sealed. The outer bag 16 contains the inner bag 12 such that the opening 14 faces outward. A portion of the opening 24 outside the inner bag 12 is sealed and forms an outer bag sealed portion 28. A portion of the opening 24 that overlaps the inner bag 12 is sealed and forms an inter-bag sealed portion 18. A space surrounded by the outer surface of the inner bag 12 and the inner surface of the outer bag 16 is a sterilized closed space 20. The material of the inner bag 12 and the material of the outer bag 16 are selected such that the adhesive strength of heat sealing of the inner surfaces of the opening 14 of the inner bag 12 is greater than the adhesive strength of the inter-bag sealed portion 18 and the adhesive strength of the outer bag sealed portion 28.

9. 发明公开

EP1801199A4 CYTODETACHING AGENT AND METHOD OF DETACHING CELL SHEET 有权
标题翻译：元分离手段和方法用于分离的细胞层
公开(公告)号：EP1801199A4
公开(公告)日：2008-04-23
申请号：EP05782343
申请日：2005-09-09
申请人： JAPAN SCIENCE & TECH AGENCY , JAPAN TISSUE ENG CO LTD , JAPAN ADV INST SCIENCE & TECH
发明人： TACHABOONYAKIAT WANPEN , KATO MASAKAZU , OOYA TOORU , YUI NOBUHIKO
IPC分类号： C12N1/02 , C12N5/06 , C12N5/10
CPC分类号： C12N1/02 , C08B37/0012 , C08B37/0015 , C12M33/00
摘要： A cell sheet detaching agent comprising an aminated polyrotaxane. The polyrotaxane constituting the skeleton of this cytodetaching agent has such a structure that multiple cyclic molecules are arranged so as to have a linear molecule pass therethrough, the linear molecule at both ends thereof having bulky caps bonded thereto so as to prevent dropping of the cyclic molecules therefrom. The aminated polyrotaxane contained in the cytodetaching agent is a compound resulting from replacement of at least some of hydroxyls of the cyclodextrin skeleton contained in the polyrotaxane by an amino-having substituent. By the use of this cell sheet detaching agent, cultured cells adhering to a container surface can be detached without causing any cell damaging and without the need to conduct temperature control.

10. 发明公开

EP1239036A4 POLYNUCLEOTIDES, POLYPEPTIDES, REMEDIES FOR CANCER AND VACCINES 审中-公开
标题翻译：多核苷酸，多肽，治疗癌症的药物和疫苗
公开(公告)号：EP1239036A4
公开(公告)日：2004-04-07
申请号：EP00981683
申请日：2000-12-13
申请人： JAPAN TISSUE ENG CO LTD , ABE AKIHIRO
发明人： ABE AKIHIRO , EMI NOBUHIKO , SAITO HIDEHIKO
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P35/00 , C07K14/435 , C07K14/47 , C12N7/01 , C12N15/12 , C12P21/08 , G01N33/53 , G01N33/548
CPC分类号： C07K14/4713 , A61K38/00 , A61K39/00 , A61K2039/53
摘要： Polynucleotides, polypeptides, remedies for cancer and vaccines which are usable in diagnosing autoimmune diseases (graft-versus-host disease, graft-versus-leukemia, etc.) and treating and preventing acute or chronic myeloid leukemia, etc. The polynucleotides comprise base sequences which are identical or substantially identical with the base sequences represented by SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 or SEQ ID NO:10. The polypeptides comprise amino acid sequences which are identical or substantially identical with the amino acid sequences encoded by the above polynucleotides. The remedies for cancer contain the above-described polynucleotides or polypeptides and strengthen the defensive mechanism in living bodies to thereby treat cancer. The vaccines contain the above-described polynucleotides or polypeptides and make living bodies to acquire the defensive mechanism to thereby prevent the onset of cancer.

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