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1. 发明公开

EP4183447A1 RIDGE FILTER AND METHOD FOR DESIGNING SAME IN A PBS TREATMENT SYSTEM 有权
公开(公告)号：EP4183447A1
公开(公告)日：2023-05-24
申请号：EP21208699.5
申请日：2021-11-17
申请人： Ion Beam Applications
发明人： LABARBE, Rudi , HOTOIU, Lucian , PIN, Arnaud
IPC分类号： A61N5/10 , G21K1/04
摘要： The present invention concerns a method for designing a ridge filter for a charged particle accelerator, for depositing with beams of accelerated particles (100.i) specific doses (Dij) into specific locations within a treatment volume (V) of tissue comprising tumoral cells (3t) by single layer pencil beam scanning (PBS), according to a predefined treatment plan (TP), the method comprising the following steps,
• Defining an array of spots (Si) defining the bases of cylindrical subvolumes (Vi) defining the treatment volume (V); the subvolumes (Vi) are divided into N cells (Cij).
• The ridge filter is designed comprising the same number of energy degrading units (11.i) as there are spots (Si). Each energy degrading unit (11.i) is formed by N cylindrical degrading subunits (11.ij) of lengths (Lij) and area (Aij).
• The lengths (Lij) of each degrading subunit (11.ij) are calculated as Lij = Wij / Wu, and Wij = W0 ― dij, wherein
∘ Wij is the desired subunit water equivalent thickness (Wij),
∘ Wu is the subunit water equivalent thickness per unit length (Wu),
∘ W0 is the maximum beam range and
∘ dij is the desired position of the Bragg peak along the irradiation axis (X)..

• The area (Aij) of each degrading subunit (11.ij) is obtained by determining the area boundary (Aij) of the integral at the numerator satisfying the following Equation (1). ω ij ∑ j ω ij = ∬ Aij F y z . dy . dz ∬ Abi F y z . dy . dz , wherein
∘ ω ij / ∑ j ω ij is the normalized beam weight,
∘ F(y,z) is the fluence of the beam,
∘ Abi is the base area (Abi) of the degrading unit (11.i).

2. 发明公开

EP4175709A1 CONFORMAL PARTICLE THERAPY SYSTEM 审中-实审
公开(公告)号：EP4175709A1
公开(公告)日：2023-05-10
申请号：EP21734017.3
申请日：2021-06-24
申请人： Ion Beam Applications S.A.
发明人： LABARBE, Rudi , HOTOIU, Lucian , DE NEUTER, Sebastien , COLLIGNON, Laurent , PIN, Arnaud
IPC分类号： A61N5/10

3. 发明公开

EP3932482A1 CHARGED PARTICLE TREATMENT PLANNING SYSTEM WITH PBS BEAMLETS SEQUENCE OPTIMIZED FOR HIGH DOSE DEPOSITION RATE 有权
公开(公告)号：EP3932482A1
公开(公告)日：2022-01-05
申请号：EP20194440.2
申请日：2020-09-03
申请人： Ion Beam Applications S.A.
发明人： LABARBE, Rudi , HOTOIU, Lucian , PIN, Arnaud
IPC分类号： A61N5/10
摘要： The present invention concerns a treatment planning system (TPS) for generating a plan for treatment by radiation with charged particles beams, preferably with proton beams, applied by pencil beam scanning (PBS) onto a target tissue (3t) comprising tumoral cells enclosed within a peripheral surface, wherein the TPS comprises,
• a dose definition stage defining the doses to be deposited within the peripheral surface
• a beam definition stage defining positions and dimensions of the beamlets of the PBS during the at least one high rate fraction, the beams definition stage comprising
• a dose rate definition stage comprising at least one high rate fraction j, wherein specific volumes (Vs) comprising healthy cells are irradiated at a ultra-high dose deposition rate (HDR), wherein HDR = Dj / t ≥ 1 Gy / s, j, and
• a beamlets scanning sequence stage defining a scanning sequence of irradiation of the beamlets.
The beamlets scanning sequence stage aims at optimizing a time sequence of beamlets emission such that at the end of a fraction j, a dose is deposited onto at least a predefined fraction of each specific volume at a mean deposition rate (DRa) superior or equal to a predefined value (DRa0) of a mean ultra-high dose deposition rate boundary (DRa ≥ DRa0), wherein DRa is defined as, DRa = ∑Dj/Δt ≥ DRa0 ≥ 1 Gy / s, wherein ∑Dj is a sum of a percentile of at least 95%, preferably at least 98% of all the doses deposited by one or more beamlets onto a given volume and Δt is the time between the first and last doses deposited onto the given volume.

4. 发明公开

EP3661335A1 VARIO-ENERGY ELECTRON ACCELERATOR 有权
公开(公告)号：EP3661335A1
公开(公告)日：2020-06-03
申请号：EP18208924.3
申请日：2018-11-28
申请人： Ion Beam Applications
发明人： ABS, Michel , BRISON, Jeremy , KLEEVEN, Willem
IPC分类号： H05H13/10
摘要： The present invention concerns an electron accelerator comprising:
(a) a resonant cavity (1) consisting of a hollow closed conductor symmetrical with respect to a mid-plane, Pm, normal to a central axis, Zc,
(b) an electron source (20) adapted for radially injecting a beam of electrons (40) into the resonant cavity,
(c) an RF system coupled to the resonant cavity and adapted for generating an electric field, E, in the resonant cavity,
(d) N magnet units (30i), each one being centred on the mid-plane, Pm, and adapted for generating a magnetic field in a deflecting chamber (31) in fluid communication with the resonant cavity by a cavity outlet aperture and an cavity inlet aperture (31w), the magnetic field being adapted for, deflecting along a first deflecting trajectory of adding length, L+, an electron beam exiting the resonant cavity along a first radial trajectory to reintroduce it into the resonant cavity along a second radial trajectory different from the first radial trajectory,
(e) an outlet (50) for extracting along an extraction path an accelerated electron beam of energy, W, from the resonant cavity towards a target (100),
characterized in that, at least one of the N magnet units (30i) is adapted for modifying the corresponding first deflecting trajectory to a second deflecting trajectory of second length (L2) different from and preferably larger than the adding length (L+), thus allowing a variation of the energy, W, of the accelerated electron beam extracted from the outlet (50).

5. 发明授权

EP3307031B1 METHOD AND SYSTEM FOR CONTROLLING ION BEAM PULSES EXTRACTION 有权
公开(公告)号：EP3307031B1
公开(公告)日：2019-04-17
申请号：EP16192454.3
申请日：2016-10-05
申请人： Ion Beam Applications S.A.
发明人： KRIER, Gabriel , HENROTIN, Sébastien , CLAEREBOUDT, Yves
IPC分类号： H05H7/00 , H05H13/02

6. 发明授权

EP3169401B1 METHOD AND DEVICE FOR QUALITY ASSURANCE OF A RADIATION THERAPY APPARATUS 有权转让
公开(公告)号：EP3169401B1
公开(公告)日：2019-02-13
申请号：EP15735980.3
申请日：2015-07-15
申请人： Ion Beam Applications S.A.
发明人： ARICAN, Salih , CELI, Juan Carlos
IPC分类号： A61N5/10

7. 发明公开

EP3421909A1 A PRECOOLING DEVICE FOR COOLING THE SUPERCONDUCTIVE COILS OF A SUPERCONDUCTIVE MAGNET AND METHOD THEREOF 审中-公开
公开(公告)号：EP3421909A1
公开(公告)日：2019-01-02
申请号：EP17178598.3
申请日：2017-06-29
申请人： Ion Beam Applications
发明人： PARADIS, Yves
IPC分类号： F25D19/00 , G01R33/38 , H01F6/04 , F25D16/00 , F25D3/10
摘要： The present invention relates to a precooling device (60) for cooling the superconductive coils of a superconductive magnet (10). The precooling device (60) is able to be lodged into a housing (50), thereby forming a cooling chamber (66) where a cryogen fluid can be supplied and removed though ports (61, 62). The cooling system (1) allows reduction of the thermal link between the superconductive coils and the externa environment of the superconductive magnet (10).

8. 发明授权

EP2978495B1 ACCESSORY HOLDER FOR PARTICLE BEAM APPARATUS 有权转让
标题翻译：用于粒子束装置的配件夹具
公开(公告)号：EP2978495B1
公开(公告)日：2018-05-09
申请号：EP14715233.4
申请日：2014-03-26
申请人： Ion Beam Applications S.A.
发明人： AMELIA, Jean-Claude , COLMANT, Thomas , DE ROECK, Sven
IPC分类号： A61N5/10
CPC分类号： A61N5/1083 , A61N5/1042 , A61N5/1043 , A61N5/1077 , A61N2005/1074 , A61N2005/1087 , A61N2005/1095
摘要： The present disclosure relates to an accessory holder attachable to or integrated in the nozzle of an apparatus for particle beam irradiation treatment. The accessory may be an aperture piece, a range shifter or any other element that can be placed in the beam path between the outer end of the nozzle and the irradiated target. The accessory holder may be equipped with first displacement means for moving the accessory away from or towards the nozzle, thereby moving the accessory forwards and backwards in the direction of the beam and second displacement means for moving the accessory into or out of the beam path. Measurements or treatment steps may be performed with and without the accessory in the beam path, without interrupting the treatment.

9. 发明公开

EP3307031A1 METHOD AND SYSTEM FOR CONTROLLING ION BEAM PULSES EXTRACTION 有权
标题翻译：控制离子束脉冲提取的方法和系统
公开(公告)号：EP3307031A1
公开(公告)日：2018-04-11
申请号：EP16192454.3
申请日：2016-10-05
申请人： Ion Beam Applications S.A.
发明人： KRIER, Gabriel , HENROTIN, Sébastien , CLAEREBOUDT, Yves
IPC分类号： H05H7/00 , H05H13/02
CPC分类号： H05H13/02 , A61N5/1043 , A61N2005/1087 , H05H7/001 , H05H7/02 , H05H7/04 , H05H2007/008 , H05H2007/022 , H05H2007/025 , H05H2007/046 , H05H2277/10
摘要： A first aspect of present invention is related to a method for controlling the extraction of ion beam pulses produced by a synchrocyclotron according to an irradiation plan. The synchrocyclotron comprises electrodes configured to be placed in a magnetic field, wherein an alternating voltage is applied between the electrodes, and wherein the frequency of the alternating voltage is modulated in a cyclic manner. The method comprises the steps of starting an acceleration cycle of the synchrocyclotron (12), generating a reference signal (38) when the modulated frequency reaches a predefined value (42), communicating the time, at which the reference signal (38) is generated, to the one or more beam control elements (20, 22), assessing one or more status parameters of the one or more beam control elements (20, 22), wherein the assessment is synchronised with the generation of the reference signal (38), cancelling or proceeding with the extraction of the beam pulse depending on the results of the assessment. A second aspect of the present invention is related to an ion beam extraction system configured to perform the method according to the first aspect of the present invention.
摘要翻译：本发明的第一方面涉及一种用于根据照射计划来控制由同步回旋加速器产生的离子束脉冲的提取的方法。同步回旋加速器包括被配置为放置在磁场中的电极，其中交流电压被施加在电极之间，并且其中交流电压的频率以循环的方式被调制。该方法包括步骤：启动同步回旋加速器（12）的加速周期，当调制频率达到预定值（42）时产生参考信号（38），传送参考信号（38）产生的时间向所述一个或多个射束控制元件（20,22）发送所述一个或多个射束控制元件（20,22）的一个或多个状态参数，其中所述评估与所述参考信号（38）的生成同步，，根据评估结果取消或继续提取光束脉冲。本发明的第二方面涉及配置成执行根据本发明的第一方面的方法的离子束提取系统。

10. 发明授权

EP2446718B1 DEVICE FOR PARTICLE BEAM PRODUCTION 有权
标题翻译：用于粒子束生产的装置
公开(公告)号：EP2446718B1
公开(公告)日：2018-03-28
申请号：EP10726970.6
申请日：2010-06-24
申请人： Ion Beam Applications S.A.
发明人： JONGEN, Yves
IPC分类号： H05H7/00 , H05H7/12 , A61N5/10
CPC分类号： H05H7/00 , A61N5/1048 , A61N5/1067 , A61N2005/1087
摘要： The present invention relates to a pulsed beam particle accelerator which can be used for particle radiation therapy. More particular, a device and method are provided to control the number of particles within a beam pulse. The particle accelerator comprises means for varying the number of particles within each beam pulse of said pulsed ion beam from a minimum value to a maximum value as function of the value of a beam control parameter. For each particle irradiation the required number of particles for each beam pulse is controlled by defining a value for said beam control parameter based on calibration data.

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