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1. 发明授权

EP2298696B1 THREE-DIMENSIONAL MATRICES OF STRUCTURED POROUS MONETITE FOR TISSUE ENGINEERING AND OSSEOUS REGENERATION, AND METHOD FOR THE PREPARATION THEREOF 有权
标题翻译：用于组织工程和再生再生的结构化多孔硅酮的三维矩阵及其制备方法
公开(公告)号：EP2298696B1
公开(公告)日：2018-03-21
申请号：EP09793974.8
申请日：2009-07-08
申请人： Histocell, S.L.
发明人： FONT PÉREZ, Julio , CASTRO FEO, María Begoña , DEL OLMO BASTERRECHEA, Maite , GARCÍA VÁZQUEZ, María Dolores , RUBIO RETAMA, Jorge , LÓPEZ CABARCOS, Enrique , RUEDA RODRÍGUEZ, Carmen , TAMIMI MARIÑO, Faleh , HAMDAN ALI ALKHRAISAT, Mohammad
IPC分类号： C01B25/32 , A61L27/12 , A61F2/02 , A61F2/28 , A61L27/56
CPC分类号： A61L27/12 , A61F2/28 , A61L27/3804 , A61L27/3847 , A61L27/56 , A61L27/58 , A61L2430/02 , C01B25/32 , Y10T428/24744
摘要： The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.

3. 发明授权

EP2369917B1 CELL TRANSPORT SYSTEM 有权
标题翻译： CELL运输系统
公开(公告)号：EP2369917B1
公开(公告)日：2012-11-28
申请号：EP09795717.9
申请日：2009-12-18
申请人： Histocell, S.L.
发明人： GARTZIA ARANAGA, Miren Itxaso , DEL OLMO BASTERRECHEA, Maite , CASTRO FEO, María Begoña , ACILU PÉREZ, Marta
IPC分类号： A01N1/02
CPC分类号： A01N1/0231 , C12N5/0068

4. 发明公开

EP2351538A1 NEW BIOMATERIAL BASED ON WHARTON'S JELLY FROM THE HUMAN UMBILICAL CORD 有权
标题翻译：消除生物学材料AUF基础肛门黄色澳大利亚美国人NABELSCHNUR
公开(公告)号：EP2351538A1
公开(公告)日：2011-08-03
申请号：EP08874660.7
申请日：2008-10-10
申请人： Histocell S.L.
发明人： FONT PEREZ, Julio , DEL OLMO BASTERRECHEA, Maite , CASTRO FEO, Maria, Begoña , INFANTE MARTINEZ, Arantza , ALONSO VARONA, Ana, Isabel , PALOMARES CASADO, Teodoro
IPC分类号： A61F2/02 , C08L5/08 , C08L5/10 , A61L27/44 , A61L27/52
CPC分类号： A61L27/52 , A61F2/0059 , A61L27/26 , A61L27/3604 , A61L27/3804 , A61L2430/40 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08J3/075 , C08J3/24 , C08J2305/00 , C08L5/00 , C08L5/08 , C08L5/10
摘要： The present invention relates to a biomaterial, specifically a hydrogel, formed from the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans isolated exclusively from the Wharton's jelly of the umbilical cord which can optionally contain cells, and also to the methods for the production and use thereof.
摘要翻译：本发明涉及由脐带的细胞外基质形成的生物材料，特别是水凝胶，用于再生医学。本发明特别涉及一种生物材料，该生物材料由专门从沃顿的脐带果冻中分离出来的糖胺聚糖组成，其可任选地含有细胞，以及其生产和使用方法。

5. 发明公开

EP3209341A1 A BIOMATERIAL SCAFFOLD FOR REGENERATING THE ORAL MUCOSA 有权转让
标题翻译：用于再生口腔粘膜的生物材料支架
公开(公告)号：EP3209341A1
公开(公告)日：2017-08-30
申请号：EP15784393.9
申请日：2015-10-23
申请人： Histocell, S.L.
发明人： CASTRO FEO, Begoña , BAIGET ORTS, Amparo
IPC分类号： A61L27/26 , A61L27/56
摘要： The present invention refers to a process for preparing a biomaterial scaffold said method comprising, (a) providing a hydrogel comprising a fibrin network and a polysaccharide network; (b) optionally, subjecting the hydrogel of step a) to a freeze-thawing process to physically crosslink the hydrogel; and (c) subjecting the hydrogel provided in step a), or the physically cross-linked hydrogel obtained after conducting the step b), to a lyophilization. The invention also relates to the biomaterial scaffold obtainable by the process as defined above, as well said biomaterial scaffold for its use to partially or completely increase, restore or replace the functional activity of a diseased or damaged oral mucosa.
摘要翻译：本发明涉及制备生物材料支架的方法，所述方法包括：（a）提供包含纤维蛋白网络和多糖网络的水凝胶; （b）任选地，使步骤a）的水凝胶进行冻融过程以物理交联水凝胶; 和（c）使步骤a）中提供的水凝胶或进行步骤b）后获得的物理交联水凝胶进行冻干。本发明还涉及可通过如上定义的方法获得的生物材料支架以及所述生物材料支架用于部分或完全增加，恢复或替代患病或受损口腔粘膜的功能活性。

6. 发明公开

EP2730650A1 METHOD FOR PROCESSING MESENCHYMAL STEM CELLS AND THE USE THEREOF IN THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATIVE STRESS 有权
标题翻译：治疗骨髓间充质干细胞及其用于疾病的治疗方法，它的氧化应激被释放
公开(公告)号：EP2730650A1
公开(公告)日：2014-05-14
申请号：EP11764794.1
申请日：2011-07-06
申请人： Histocell, S.L.
发明人： CASTRO, María Begoña , DÍEZ GARCÍA, Javier
IPC分类号： C12N5/0775 , C11D3/39
CPC分类号： C12N5/0667 , A61K35/28 , C12N2500/02
摘要： The present invention relates to a method of treatment of mesenchymal stem cells, preferably from adipose origin, comprising mainly two stages, firstly the collection and isolation of mesenchymal stem cells, and secondly, a period of growth and specific treatment of cells in a conditioning or treatment medium with an oxidizing agent. The invention also comprises the cells obtained directly through the method and its use in treating diseases caused by or associated with oxidative stress.

7. 发明公开

EP2298696A1 THREE-DIMENSIONAL MATRICES OF STRUCTURED POROUS MONETITE FOR TISSUE ENGINEERING AND OSSEOUS REGENERATION, AND METHOD FOR THE PREPARATION THEREOF 有权
标题翻译：三个模具从结构多孔Monetit用于生产组织重建和骨再生和方法
公开(公告)号：EP2298696A1
公开(公告)日：2011-03-23
申请号：EP09793974.8
申请日：2009-07-08
申请人： Histocell, S.L.
发明人： FONT PÉREZ, Julio , CASTRO FEO, María Begoña , DEL OLMO BASTERRECHEA, Maite , GARCÍA VÁZQUEZ, María Dolores , RUBIO RETAMA, Jorge , LÓPEZ CABARCOS, Enrique , RUEDA RODRÍGUEZ, Carmen , TAMIMI MARIÑO, Faleh , HAMDAN ALI ALKHRAISAT, Mohammad
IPC分类号： C01B25/32 , A61L27/12 , A61F2/02 , A61F2/28
CPC分类号： A61L27/12 , A61F2/28 , A61L27/3804 , A61L27/3847 , A61L27/56 , A61L27/58 , A61L2430/02 , C01B25/32 , Y10T428/24744
摘要： The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.
摘要翻译：另外，本发明的组织工程内包括，具体而言，骨再生中。本发明涉及三斜所有其是生物相容的，具有结构化孔隙率的多孔质三维矩阵和是预定义的可再吸收的，以及涉及能够生产所述材料和它们的应用的合成方法。这些基质是用于细胞定居和增殖的完美基地，允许其在组织工程和骨再生的应用程序作为它们的生物相容性，再吸收，骨诱导，再血管化等有利性质的结果

8. 发明授权

EP3209341B1 A BIOMATERIAL SCAFFOLD FOR REGENERATING THE ORAL MUCOSA 有权转让
公开(公告)号：EP3209341B1
公开(公告)日：2020-01-01
申请号：EP15784393.9
申请日：2015-10-23
申请人： Histocell, S.L.
发明人： CASTRO FEO, Begoña , BAIGET ORTS, Amparo
IPC分类号： A61L27/26 , A61L27/56 , A61L27/38 , A61L27/52

9. 发明授权

EP2351538B1 NEW BIOMATERIAL BASED ON WHARTON'S JELLY FROM THE HUMAN UMBILICAL CORD 有权
标题翻译：基于人脐带的麦氏脐带的新生物材料
公开(公告)号：EP2351538B1
公开(公告)日：2018-03-21
申请号：EP08874660.7
申请日：2008-10-10
申请人： Histocell S.L.
发明人： FONT PEREZ, Julio , DEL OLMO BASTERRECHEA, Maite , CASTRO FEO, Maria, Begoña , INFANTE MARTINEZ, Arantza , ALONSO VARONA, Ana, Isabel , PALOMARES CASADO, Teodoro
IPC分类号： A61F2/02 , C08L5/08 , C08L5/10 , A61L27/44 , A61L27/52
CPC分类号： A61L27/52 , A61F2/0059 , A61L27/26 , A61L27/3604 , A61L27/3804 , A61L2430/40 , C08B37/0063 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08J3/075 , C08J3/24 , C08J2305/00 , C08L5/00 , C08L5/08 , C08L5/10
摘要： The present invention relates to a biomaterial, specifically a hydrogel, formed from the extracellular matrix of the umbilical cord for its application in regenerative medicine. The invention particularly relates to a biomaterial made up of glycosaminoglycans isolated exclusively from the Wharton's jelly of the umbilical cord which can optionally contain cells, and also to the methods for the production and use thereof.

10. 发明授权

EP2730650B1 METHOD FOR PROCESSING MESENCHYMAL STEM CELLS AND THE USE THEREOF IN THE TREATMENT OF DISEASES ASSOCIATED WITH OXIDATIVE STRESS 有权
标题翻译：治疗骨髓间充质干细胞及其用于疾病的治疗方法，它的氧化应激被释放
公开(公告)号：EP2730650B1
公开(公告)日：2017-01-04
申请号：EP11764794.1
申请日：2011-07-06
申请人： Histocell, S.L.
发明人： CASTRO, María Begoña , DÍEZ GARCÍA, Javier
IPC分类号： A61K35/28 , C12N5/0775
CPC分类号： C12N5/0667 , A61K35/28 , C12N2500/02

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