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1. 发明授权

EP2604629B1 COMPOSITION FOR PREVENTING OR TREATING CERVICAL CANCER HAVING HUMAN PAPILLOMAVIRUS IMMUNITY ENHANCER 有权转让
标题翻译：用于预防或治疗具有人类乳头状瘤病毒免疫增强剂的宫颈癌的组合物
公开(公告)号：EP2604629B1
公开(公告)日：2018-02-28
申请号：EP10855938.6
申请日：2010-08-13
申请人： Genexine, Inc.
发明人： SUNG, Young Chul , SEO, Sang Hwan , SUH, You Suk
IPC分类号： C07K19/00 , C12N15/62 , C12N15/63 , A61P15/02 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , C07K14/01 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
摘要： A composition for preventing or treating cervical cancer comprising a human papillomavirus plasmodium and an immunity enhancer is provided. A fusion protein including a fusion polypeptide recombined to transform a 3D structure of E6 and E7, which are antigens against types 16 and 18 human papillomavirus (HPV), a signal peptide for secreting the fusion polypeptide outside the cells and an immunity enhancer peptide present in an individual is also provided. The fusion protein may be useful in treating HPV-triggered tumors by inducing an immune response specific to the antigens against the HPV types 16 and 18.

2. 发明公开

EP3147298A1 PD-L1 FUSION PROTEIN AND USE THEREOF 无效
标题翻译： PD-L1-FUSIONSPROTEIN UND VERWENDUNG DAVON
公开(公告)号：EP3147298A1
公开(公告)日：2017-03-29
申请号：EP15795999.0
申请日：2015-05-26
申请人： Genexine, Inc. , Postech Academy-Industry Foundation
发明人： SUNG, Young Chul , LEE, Ji Yeung , SONG, Mi-Young , LIM, Hye Seong , LEE, Byung Ha
IPC分类号： C07K19/00 , C12N15/62 , A61K38/17 , A61K39/395 , A61P37/02
CPC分类号： A61K38/17 , A61K38/00 , A61K39/0005 , C07K14/70596 , C07K2317/52 , C07K2319/30
摘要： The present invention relates to a fusion protein composed of the extracellular domain of PD-L1 and a modified immunoglobulin Fc region. The extracellular domain of PD-L1 and a fragment thereof have excellent immunomodulatory activity, and can be used as an immunomodulatory agent if a modified immunoglobulin Fc region is coupled thereto. Accordingly, the PD-L1 fusion protein according to the present invention demonstrated its excellent effect in disease models of inflammatory bowel disease, colitis, psoriasis, asthma and arthritis, and thus can be very effectively used for the treatment of such diseases.
摘要翻译：本发明涉及由PD-L1的细胞外结构域和修饰的免疫球蛋白Fc区组成的融合蛋白。 PD-L1及其片段的细胞外结构域具有优异的免疫调节活性，如果将修饰的免疫球蛋白Fc区偶联，则可用作免疫调节剂。因此，本发明的PD-L1融合蛋白在炎症性肠病，结肠炎，牛皮癣，哮喘，关节炎的疾病模型中表现出优异的效果，因此可以非常有效地用于治疗这些疾病。

3. 发明授权

EP1670923B1 METHOD FOR MASS PRODUCTION OF HUMAN FOLLICLE STIMULATING HORMONE 失效转让
标题翻译：方法人卵泡刺激素批量生产
公开(公告)号：EP1670923B1
公开(公告)日：2014-09-10
申请号：EP04774724.1
申请日：2004-09-24
申请人： Genexine, Inc.
发明人： YANG, Se Hwan , SUNG, Young Chul, 101-601 Hyundai Edong Hometown , NA, Kyu-Heum, 312-1303 Cheongmyeong Dongshin Apt. , LEE, Sung Hee, 101-306 Nakseongdae Hyundai Apt. , KIM, Won Bae, 1801 Daelim Acrovill Apt.
IPC分类号： A61K38/44
CPC分类号： A61K38/44 , A61K38/00 , A61K48/00 , C07K14/59 , C12N15/85 , C12N2840/203 , C12Y105/01003

4. 发明公开

EP2604629A4 COMPOSITION FOR PREVENTING OR TREATING CERVICAL CANCER HAVING HUMAN PAPILLOMAVIRUS PLASMODIUM AND IMMUNITY ENHANCER 有权转让
标题翻译：组成预防和治疗宫颈癌与HPV疟原虫和免疫力BOOSTER
公开(公告)号：EP2604629A4
公开(公告)日：2014-01-15
申请号：EP10855938
申请日：2010-08-13
申请人： GENEXINE INC , BIOD CO LTD
发明人： SUNG YOUNG CHUL , SEO SANG HWAN , SUH YOU SUK
IPC分类号： C07K19/00 , A61P15/02 , A61P35/00 , C12N15/62 , C12N15/63
CPC分类号： C07K14/005 , A61K39/12 , C07K14/01 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C12N7/00 , C12N15/62 , C12N2710/20022 , C12N2710/20034
摘要： A composition for preventing or treating cervical cancer comprising a human papillomavirus plasmodium and an immunity enhancer is provided. A fusion protein including a fusion polypeptide recombined to transform a 3D structure of E6 and E7, which are antigens against types 16 and 18 human papillomavirus (HPV), a signal peptide for secreting the fusion polypeptide outside the cells and an immunity enhancer peptide present in an individual is also provided. The fusion protein may be useful in treating HPV-triggered tumors by inducing an immune response specific to the antigens against the HPV types 16 and 18.
摘要翻译：提供了一种用于预防或治疗子宫颈癌包含人乳头瘤病毒疟原虫和免疫增强组合物。一种融合蛋白，包括重组，以变换E6和E7，它们是针对16和18个型人乳头瘤病毒（HPV），为分泌融合多肽的细胞外和本免疫增强肽的信号肽抗原的三维结构的融合多肽在个别因此提供。融合蛋白可以通过诱导针对HPV类型16和第18至特异性免疫应答的抗原可用于治疗人乳头瘤病毒引起的肿瘤有用

5. 发明公开

EP4438035A1 HIGH CONCENTRATION ADMINISTRATION FORMULATION OF HGH FUSION PROTEIN 审中-实审
公开(公告)号：EP4438035A1
公开(公告)日：2024-10-02
申请号：EP22899157.6
申请日：2022-10-19
申请人： Genexine, Inc. , Handok Inc.
发明人： PARK, Chanwoong , KIM, Ki-Yong
IPC分类号： A61K9/08 , A61K47/10 , A61K47/26 , A61K38/00 , A61K38/27 , A61K47/64
CPC分类号： A61K38/00 , A61K47/64 , A61K47/10 , A61K47/26 , A61K38/27 , A61K9/08
摘要： The present invention relates to a high-concentration administration formulation of hGH fusion protein containing poloxamer 188 and polysorbate 80. When containing poloxamer 188 and polysorbate 80 according to the present invention, a high-concentration formulation of hGH fusion protein having significantly reduced aggregation reactions and improved storage stability can be prepared.

6. 发明公开

EP4138900A1 METHOD FOR TREATING CERVICAL CANCER 审中-实审
公开(公告)号：EP4138900A1
公开(公告)日：2023-03-01
申请号：EP21793447.0
申请日：2021-04-26
申请人： Genexine, Inc. , MSD International GmbH
发明人： SUNG, Young Chul , WOO, Jung Won , PARK, Jong Sup , YOUN, Jin Won
IPC分类号： A61K39/12 , A61K39/395 , A61K45/06 , A61P35/00

7. 发明公开

EP4025241A1 METHOD FOR INCREASING LYMPHOCYTE COUNT BY USING IL-7 FUSION PROTEIN IN TUMORS 审中-实审
公开(公告)号：EP4025241A1
公开(公告)日：2022-07-13
申请号：EP20861124.4
申请日：2020-09-04
申请人： Genexine, Inc. , Neoimmune Tech, Inc.
发明人： SUNG, Young Chul , WOO, Jung Won , HEO, Min Kyu , YANG, Sang In , YANG, SeHwan
IPC分类号： A61K38/20 , C07K14/54

8. 发明授权

EP3241850B1 GLP AND IMMUNOGLOBULIN HYBRID FC FUSED POLYPEPTIDE AND USE THEREOF 有权
公开(公告)号：EP3241850B1
公开(公告)日：2019-09-04
申请号：EP15875748.4
申请日：2015-12-31
申请人： Genexine, Inc.
发明人： SUNG, Young Chul , YANG, Se Hwan , BYUN, Mi Sun , YANG, Sang In , SHIN, Eun Ju
IPC分类号： C07K19/00 , C07K14/605 , C07K16/00 , A61K38/26 , A61P1/00 , A61P1/12 , A61P3/08 , A61P3/10

9. 发明公开

EP3241850A1 GLP AND IMMUNOGLOBULIN HYBRID FC FUSED POLYPEPTIDE AND USE THEREOF 有权
标题翻译： GLP和免疫球蛋白混合FC融合多肽及其用途
公开(公告)号：EP3241850A1
公开(公告)日：2017-11-08
申请号：EP15875748.4
申请日：2015-12-31
申请人： Genexine, Inc.
发明人： SUNG, Young Chul , YANG, Se Hwan , BYUN, Mi Sun , YANG, Sang In , SHIN, Eun Ju
IPC分类号： C07K19/00 , C07K14/605 , C07K16/00 , A61K38/26
CPC分类号： C07K14/605 , A61K38/26 , A61K2039/505 , A61P1/00 , A61P1/12 , A61P3/08 , A61P3/10 , C07K16/00 , C07K19/00 , C07K2317/52 , C07K2317/53 , C07K2317/76 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a fusion polypeptide containing a glucagon-like peptide (GLP) and an immunoglobulin hybrid Fc, and more specifically, to a fusion polypeptide with an increased half-life and improved efficacy compared to the conventional fusion polypeptide based on the discovery of an immunoglobulin hybrid Fc suitable for GLP or analogs thereof, and a pharmaceutical composition for treating diabetes, inflammatory bowel disease, endoenteritis or diarrhea caused by anticancer chemotherapy, or short bowel syndrome, containing the fusion polypeptide. The fusion polypeptide of the present invention has an increased half-life and improved resistance to DPP-4 enzyme compared to those of GLP-1 and GLP-2, and it thus has improved drug efficacy in treating diabetes, inflammatory bowel disease, endoenteritis or diarrhea caused by anticancer chemotherapy, or short bowel syndrome, compared to those of the conventional drugs. Accordingly, the fusion polypeptide of the present invention can be effectively applied to pharmaceutical drugs.
摘要翻译：本发明涉及含有胰高血糖素样肽（GLP）和免疫球蛋白杂合Fc的融合多肽，并且更具体地涉及与基于发现的常规融合多肽相比具有增加的半衰期和改善的功效的融合多肽适用于GLP的免疫球蛋白杂交体Fc或其类似物，以及用于治疗含有融合多肽的糖尿病，炎症性肠病，肠胃炎或由抗癌化疗或短肠综合征引起的腹泻的药物组合物。与GLP-1和GLP-2相比，本发明的融合多肽具有增加的半衰期和改进的对DPP-4酶的抗性，并且因此在治疗糖尿病，炎性肠病，肠道炎或与传统药物相比，由抗癌化疗引起的腹泻或短肠综合症。因此，本发明的融合多肽可以有效地应用于药物。

10. 发明授权

EP2662449B1 Immunoglobulin fusion proteins 有权
标题翻译：免疫球蛋白融合蛋白
公开(公告)号：EP2662449B1
公开(公告)日：2017-02-15
申请号：EP12198380.3
申请日：2008-05-30
申请人： Postech Academy-Industry- Foundation , Genexine, Inc.
发明人： Sung, Young Chul , Yang, Sehwan
IPC分类号： C12N15/62 , C07K19/00 , C07K16/46 , A61K38/16 , A61K38/00
CPC分类号： C12N15/62 , A61K38/00 , C07K2317/52 , C07K2317/53 , C07K2317/60 , C07K2319/30

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