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1. 发明公开

EP3402798A1 COMPOUNDS ANTAGONIZING A3 ADENOSINE RECEPTOR, METHOD FOR PREPARING THEM, AND MEDICAL-USE THEREOF 有权
公开(公告)号：EP3402798A1
公开(公告)日：2018-11-21
申请号：EP17738687.7
申请日：2017-01-13
申请人： Handok Inc.
发明人： LEE, Jinhwa , KIM, Seungyong , KIM, Doran , AHN, Koo Hyeon , LEE, Gwi Bin , KIM, Dooseop , HWANG, Hyun Sook
IPC分类号： C07D487/04 , C07D471/04 , A61K31/4985 , A61K31/437 , A61K31/4196
CPC分类号： C07D487/04 , A61K31/706 , A61K31/7064 , A61K31/7068 , C07D519/00
摘要： The present disclosure provides compounds useful in the amelioration, prevention or treatment of A3 adenosine receptor mediated diseases, such as glaucoma and glaucoma-related ocular disorders, having the structure of Formula I as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for ameliorating, preventing or treating A3 adenosine receptor mediated diseases using the compound.

2. 发明授权

EP1951211B1 TRANSDERMAL PREPARATIONS CONTAINING HYDROPHOBIC NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 有权转让
标题翻译：转基因化合物麻醉剂盐酸尼泊尔NIC EN EN EN N N N N N N N N N N N N N N N
公开(公告)号：EP1951211B1
公开(公告)日：2017-06-14
申请号：EP06799399.8
申请日：2006-10-23
申请人： Handok Inc.
发明人： CHOI, Yang Gyu , AH, Young Chang , CHOI, Woo Jeong , KIM, Jung Ju
IPC分类号： A61K9/70 , A61K31/19 , A61K31/192 , A61K31/196
摘要： Disclosed is a transdermal preparation containing a hydrophobic drug. As a method of continuing the high drug permeation, it is used an unique hydrophilic polymer system in which the drug can be contained in a high concentration under no water environment, a solubility of the hydrophobic drug is decreased as the water is introduced to the patch from the skin, so that the drug is maintained at the saturation concentration even though the drug content is decreased as the drug is permeated to the skin. During the application of the transdermal preparation to the skin, it is possible to continuously permeate the high amount of drug, to maintain the sufficient adhesion during the use and to minimize the skin side effect, because the hydrophilic polymer absorbs the water from the skin. The hydrophilic polymer system can serve the function thereof through the hydrophobic adhesive layer capable of preventing the water quickly absorbed from the skin from being evaporated to the outside of the patch.
摘要翻译：公开了含有疏水性药物的透皮制剂。作为持续高药物渗透的方法，使用独特的亲水性聚合物体系，其中药物可以在无水环境下以高浓度包含，疏水性药物的溶解度随着水被引入贴剂而降低即使在药物渗入皮肤时药物含量降低，药物也保持在饱和浓度。在将透皮制剂施用于皮肤时，由于亲水性聚合物从皮肤吸收水分，因此可以连续渗透大量的药物，以在使用过程中保持足够的粘附力和最小化皮肤的副作用。亲水性聚合物体系可以通过能够防止皮肤快速吸收的水蒸发到贴片外部的疏水粘合剂层来发挥功能。

3. 发明公开

EP3053923A1 NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF 有权
标题翻译：在维也纳DAVON上消灭三氟乙烯
公开(公告)号：EP3053923A1
公开(公告)日：2016-08-10
申请号：EP13894061.4
申请日：2013-09-30
申请人： Korea Research Institute of Chemical Technology , Handok Inc.
发明人： JUNG, Hee Jung , HA, Jae Du , CHO, Sung Yun , KIM, Hyoung Rae , LEE, Kwang Ho , LEE, Chong Ock , CHOI, Sang Un , PARK, Chi Hoon
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00 , A61P3/00 , A61P9/00 , A61P29/00
CPC分类号： C07D487/04 , A61K31/4985
摘要： The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.
摘要翻译：本发明涉及一种新的三唑并吡嗪衍生物或其药学上可接受的盐，以及含有其作为预防或治疗高增殖性病症的活性成分的药物组合物。通过有效抑制c-Met酪氨酸激酶活性，本发明可用作与异常激酶活性如癌症，牛皮癣，类风湿性关节炎和糖尿病性视网膜病引起的过度细胞增殖和生长相关的各种高增殖性疾病的治疗剂。

4. 发明公开

EP4438035A1 HIGH CONCENTRATION ADMINISTRATION FORMULATION OF HGH FUSION PROTEIN 审中-实审
公开(公告)号：EP4438035A1
公开(公告)日：2024-10-02
申请号：EP22899157.6
申请日：2022-10-19
申请人： Genexine, Inc. , Handok Inc.
发明人： PARK, Chanwoong , KIM, Ki-Yong
IPC分类号： A61K9/08 , A61K47/10 , A61K47/26 , A61K38/00 , A61K38/27 , A61K47/64
CPC分类号： A61K38/00 , A61K47/64 , A61K47/10 , A61K47/26 , A61K38/27 , A61K9/08
摘要： The present invention relates to a high-concentration administration formulation of hGH fusion protein containing poloxamer 188 and polysorbate 80. When containing poloxamer 188 and polysorbate 80 according to the present invention, a high-concentration formulation of hGH fusion protein having significantly reduced aggregation reactions and improved storage stability can be prepared.

5. 发明授权

EP1951211B2 TRANSDERMAL PREPARATIONS CONTAINING HYDROPHOBIC NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 有权转让
公开(公告)号：EP1951211B2
公开(公告)日：2020-06-24
申请号：EP06799399.8
申请日：2006-10-23
申请人： Handok Inc.
发明人： CHOI, Yang Gyu , AH, Young Chang , CHOI, Woo Jeong , KIM, Jung Ju
IPC分类号： A61K9/70 , A61K31/19 , A61K31/192 , A61K31/196

6. 发明公开

EP3233863A1 FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS 有权
标题翻译：融合环杂环化合物及其作为TRK抑制剂的用途
公开(公告)号：EP3233863A1
公开(公告)日：2017-10-25
申请号：EP15869420.8
申请日：2015-12-14
申请人： CMG Pharmaceutical Co., Ltd. , Handok Inc.
发明人： KIM, Moonsoo , LEE, Chaewoon , LEE, Gilnam , YOON, Cheolhwan , SEO, Jeongbeob , KIM, Jay, Hak , LEE, Minwoo , JEONG, Hankyul , CHOI, Hyang , JUNG, Myung, Eun , LEE, Ki, Nam , KIM, Hyun, Jung , KIM, Hye, Kyoung , LEE, Jae, Il , KIM, Misoon , CHOI, Soongyu
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C07D487/04 , A61P29/00 , A61P35/00 , A61P37/00
摘要： The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or
摘要翻译：本公开提供了由式（I）表示的新型化学化合物或其药学上可接受的盐，溶剂化物，多晶型物，酯，互变异构体或前药。这些化合物可以用作Trk的抑制剂，可用于治疗疼痛，癌症，炎症，神经退行性疾病和某些传染病。在一些式I化合物中，Q为-CH = CR 3C（O）Nr 4 R 5，-C = CC（O）NR 4 R 5，-C≡CC（O）NR 4 R 5或（II）。

7. 发明公开

EP4420732A2 FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS 审中-实审
公开(公告)号：EP4420732A2
公开(公告)日：2024-08-28
申请号：EP24169331.6
申请日：2015-12-14
申请人： CMG Pharmaceutical Co., Ltd. , Handok Inc.
发明人： KIM, Moonsoo , LEE, Chaewoon , LEE, Gilnam , YOON, Cheolhwan , SEO, Jeongbeob , KIM, Jay, Hak , LEE, Minwoo , JEONG, Hankyul , CHOI, Hyang , JUNG, Myung, Eun , LEE, Ki, Nam , KIM, Hyun, Jung , KIM, Hye, Kyoung , LEE, Jae, Il , KIM, Misoon , CHOI, Soongyu
IPC分类号： A61P37/00
CPC分类号： A61P29/00 , A61P35/00 , A61P37/00 , C07D487/04
摘要： The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases.

In some compounds of Formula I, Q is -CH=CR3C(O)NR4R5, -C≡CC(O)NR4R5, or

8. 发明公开

EP3233863A4 FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS 有权
公开(公告)号：EP3233863A4
公开(公告)日：2018-06-06
申请号：EP15869420
申请日：2015-12-14
申请人： CMG PHARMACEUTICAL CO LTD , HANDOK INC
发明人： KIM MOONSOO , LEE CHAEWOON , LEE GILNAM , YOON CHEOLHWAN , SEO JEONGBEOB , KIM JAY HAK , LEE MINWOO , JEONG HANKYUL , CHOI HYANG , JUNG MYUNG EUN , LEE KI NAM , KIM HYUN JUNG , KIM HYE KYOUNG , LEE JAE IL , KIM MISOON , CHOI SOONGYU
IPC分类号： C07D487/04 , A61K31/519 , A61P11/06 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： C07D487/04 , A61P29/00 , A61P35/00 , A61P37/00
摘要： The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases. In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or

9. 发明公开

EP3053923A4 NOVEL TRIAZOLOPYRAZINE DERIVATIVE AND USE THEREOF 有权
标题翻译：新型它们的用途TRIAZOLOPYRAZINDERIVAT AND
公开(公告)号：EP3053923A4
公开(公告)日：2017-04-12
申请号：EP13894061
申请日：2013-09-30
申请人： KOREA RES INST CHEMICAL TECH , HANDOK INC
发明人： JUNG HEE JUNG , HA JAE DU , CHO SUNG YUN , KIM HYOUNG RAE , LEE KWANG HO , LEE CHONG OCK , CHOI SANG UN , PARK CHI HOON
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4985
摘要： The present invention relates to a novel triazolopyrazine derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating hyper proliferative disorder. The present invention can be useful as a therapeutic agent for various hyper proliferative disorders associated with excessive cell proliferation and growth caused by abnormal kinase activity, such as cancer, psoriasis, rheumatoid arthritis, and diabetic retinopathy, by efficiently inhibiting c-Met tyrosine kinase activity.

10. 发明公开

EP3506923A1 PHARMACEUTICAL COMPOSITION FOR TREATING GROWTH HORMONE DEFICIENCY CONTAINING hGH FUSION PROTEIN 有权
公开(公告)号：EP3506923A1
公开(公告)日：2019-07-10
申请号：EP17846985.4
申请日：2017-08-30
申请人： Genexine, Inc. , Handok Inc.
发明人： KIM, Tae Kyung , WOO, Jung Won , LEE, Joan Yoon Ji , AHN, Young-Joo , CHA, Ji-Eun , RHIM, Hyou Young , JANG, Woo Ick
IPC分类号： A61K38/16 , A61K38/27

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